Exhibit 23.1

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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-238311) and Form S-8 (Nos. 333-230995 and 333-237285) of HOOKIPA Pharma Inc. of our report dated March 24, 2022 relating to the financial statements, which appears in this Form 10-K.

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Vienna, Austria

March 24, 2022

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PwC Wirtschaftsprüfung GmbH

/s/ Stefano Mulas

German Certified Public Accountant