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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

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FORM 10-Q

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(Mark One)

☒QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2021

OR

☐TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from _________ to ___________

Commission File Number: 001-40367

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VACCITECH PLC

(Exact Name of Registrant as Specified in its Charter)

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England and Wales | Not Applicable
(State or other jurisdiction of incorporation or organization) | (I.R.S. Employer Identification No.)
The Schrodinger Building Heatley Road The Oxford Science Park Oxford, United Kingdom | OX4 4GE
(Address of principal executive offices) | (Zip Code)

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Registrant’s telephone number, including area code: +44 (0) 1865 818 808

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Securities registered pursuant to Section 12(b) of the Act:

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Title of each class | Trading Symbol(s) | Name of each exchange on which registered
American Depositary Shares* | VACC | The Nasdaq Global Market
Ordinary shares, nominal value £0.000025 per share** | ​ | ​

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*American Depositary Shares may be evidenced by American Depositary Receipts. Each American Depositary Share represents one (1) ordinary share.

**Not for trading, but only in connection with the listing of American Depositary Shares on The Nasdaq Global Market.

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☐ | Accelerated filer ☐
Non-accelerated filer ☒ | Smaller reporting company ☒
​ | Emerging growth company ☒

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).Yes ☐ No ☒

As of November 12, 2021, the registrant had 34,852,426 ordinary shares, nominal value £0.000025 per share, outstanding.

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Table of Contents

Table of Contents

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​ | ​ |
​ | ​ | Page
PART I - FINANCIAL INFORMATION | 1
Item 1. | Financial Statements | 1
Item 2. | Management’s Discussion and Analysis of Financial Condition and Results of Operations | 16
Item 3. | Quantitative and Qualitative Disclosure About Market Risk | 28
Item 4. | Controls and Procedures | 28
PART II - OTHER INFORMATION | 29
Item 1. | Legal Proceedings | 29
Item 1A | Risk Factors | 29
Item 2. | Unregistered Sales of Equity Securities and Use of Proceeds | 30
Item 3. | Defaults Upon Senior Securities | 31
Item 4. | Mine Safety Disclosures | 31
Item 5. | Other Information | 31
Item 6. | Exhibits | 32
SIGNATURES | 33

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We own various trademark registrations and applications, and unregistered trademarks, including our name and our corporate logo. We have an exclusive license to use and display the Vaccitech registered trademark in order to commercialize Vaccitech in the United Kingdom. All other trade names, trademarks and service marks of other companies appearing in this prospectus are the property of their respective holders. Solely for convenience, the trademarks and trade names in this prospectus may be referred to without the ® and ™ symbols, but such references should not be construed as any indicator that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. We do not intend to use or display other companies’ trademarks and trade names to imply a relationship with, or endorsement or sponsorship of us by, any other companies.

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From time to time, we may use our website, our Facebook page at Facebook.com/Vaccitech, our Twitter account at @Vaccitechplc and our LinkedIn account at linkedin.com/company/Vaccitech-plc/to distribute material information. Our financial and other material information is routinely posted to and accessible on the Investors section of our website, available at www.vaccitech.co.uk. Investors are encouraged to review the Investors section of our website because we may post material information on that site that is not otherwise disseminated by us. Information that is contained in and can be accessed through our website, our Facebook page, our Twitter posts and our LinkedIn posts are not incorporated into, and does not form a part of, this Quarterly Report.

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Table of Contents

PART I -  FINANCIAL INFORMATION

Item 1. Financial Statements.

INDEX TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)

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Condensed Consolidated Financial Statements (Unaudited) | Page
Condensed Consolidated Balance Sheets | 2
Condensed Consolidated Statements of Operations and Comprehensive Loss | 3
Condensed Consolidated Statements of Changes in Redeemable Convertible Preferred Shares and Shareholders’ Equity (Deficit) | 4
Condensed Consolidated Statements of Cash Flows | 6
Notes to Condensed Consolidated Financial Statements | 7

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1

Table of Contents

VACCITECH PLC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(IN THOUSANDS, EXCEPT NUMBER OF SHARES AND PER SHARE AMOUNTS)

(UNAUDITED)

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​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | September 30, |  | December 31, |
​ |  | 2021 |  | 2020 |
ASSETS |  | ​ |  |  | ​ |  | ​
Current assets: |  | ​ |  |  | ​ |  | ​
Cash and cash equivalents | ​ | $ | 233,871 | ​ | $ | 43,266 | ​
Accounts receivable | ​ |  | 42 | ​ |  | 518 | ​
Research and development incentives receivable | ​ |  | 5,382 | ​ |  | 2,708 | ​
Prepaid expenses and other current assets | ​ |  | 6,684 | ​ |  | 1,409 | ​
Total current assets | ​ |  | 245,979 | ​ |  | 47,901 | ​
Property and equipment, net | ​ |  | 1,033 | ​ |  | 629 | ​
Right of use assets, net | ​ |  | 8,780 | ​ |  | 2,136 | ​
Deferred tax assets | ​ | ​ | 60 | ​ | ​ | — | ​
Other assets | ​ | ​ | 719 | ​ | ​ | — | ​
Total assets | ​ | $ | 256,571 | ​ | $ | 50,666 | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
LIABILITIES, REDEEMABLE PREFERRED SHARES AND SHAREHOLDERS’ DEFICIT | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Current liabilities: | ​ |  |  | ​ |  |  | ​
Accounts payable | ​ | $ | 1,337 | ​ | $ | 4,667 | ​
Accrued expenses and other current liabilities | ​ |  | 4,404 | ​ |  | 2,537 | ​
Deferred revenue | ​ |  | 196 | ​ |  | 245 | ​
Current portion of lease liability | ​ |  | 435 | ​ |  | 192 | ​
Total current liabilities | ​ |  | 6,372 | ​ |  | 7,641 | ​
Convertible loan notes – non current | ​ |  | — | ​ |  | 44,700 | ​
Lease liability – non current | ​ |  | 7,728 | ​ |  | 1,472 | ​
Total liabilities | ​ | $ | 14,100 | ​ | $ | 53,813 | ​
Commitments and contingencies (Note 11) | ​ |  |  | ​ |  |  | ​
Series A redeemable convertible preferred shares (Series A shares); £0.10 nominal value; no shares issued and outstanding; (December 31, 2020: issued and outstanding: 22,065) | ​ | $ | — | ​ | $ | 33,765 | ​
Series B redeemable convertible preferred shares (Series B shares); £0.10 nominal value; no shares issued and outstanding; (December 31, 2020: issued and outstanding: no shares issued or outstanding) | ​ | $ | — | ​ | $ | — | ​
Shareholders’ equity: | ​ |  |  | ​ |  |  | ​
Ordinary shares, £0.000025 nominal value; 34,328,231 shares authorized, issued and outstanding (December 31, 2020: authorized, issued and outstanding: 7,960,458) | ​ |  | 1 | ​ |  | 0 | 1
Deferred A shares, £1 nominal value; 63,443 shares authorized, issued and outstanding (December 31, 2020: no shares issued or outstanding) | ​ |  | 86 | ​ |  | — | ​
Deferred B shares, £1 nominal value; 570,987 shares authorized, issued and outstanding (December 31, 2020: no shares issued or outstanding) | ​ | ​ | 8 | ​ | ​ | — | ​
Deferred C shares, £0,000007 nominal value, 27,828,231 shares authorized, issued and outstanding (December 31, 2020: authorized, issued and outstanding: 7,960,458) | ​ |  | 0 | 1 |  | 0 | 1
Additional paid-in capital | ​ |  | 344,396 | ​ |  | 21,660 | ​
Accumulated deficit | ​ |  | (93,472) | ​ |  | (57,720) | ​
Accumulated other comprehensive loss – foreign currency translation adjustments | ​ |  | (9,041) | ​ |  | (1,243) | ​
Noncontrolling interest | ​ |  | 493 | ​ |  | 391 | ​
Total shareholders’ equity | ​ | $ | 242,471 | ​ | $ | (36,912) | ​
Total liabilities, redeemable convertible preferred shares and shareholders’ equity | ​ | $ | 256,571 | ​ | $ | 50,666 | ​

1 indicates amount less than thousand

​

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

​

2

Table of Contents

VACCITECH PLC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

(IN THOUSANDS, EXCEPT NUMBER OF SHARES AND PER SHARE AMOUNTS)

(UNAUDITED)

​

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three months ended | ​ | Nine months ended
​ |  | September 30, 2021 |  | September 30, 2020 |  | September 30, 2021 |  | September 30, 2020
License revenue | ​ | $ | 16 | ​ | $ | 2,663 | ​ | $ | 48 | ​ | $ | 2,705
Service revenue | ​ |  | — | ​ |  | 60 | ​ |  | 21 | ​ |  | 376
Research grants and contracts | ​ |  | 3 | ​ |  | 528 | ​ |  | 200 | ​ |  | 1,386
Total revenue | ​ |  | 19 | ​ |  | 3,251 | ​ |  | 269 | ​ |  | 4,467
Operating expenses | ​ |  | ​ | ​ |  | ​ | ​ |  | ​ | ​ |  | ​
Research and development | ​ |  | 4,371 | ​ |  | 3,702 | ​ |  | 13,490 | ​ |  | 11,821
General and administrative | ​ |  | 1,184 | ​ |  | 977 | ​ |  | 15,332 | ​ |  | 3,059
Total operating expenses | ​ |  | 5,555 | ​ |  | 4,679 | ​ |  | 28,822 | ​ |  | 14,880
Loss from operations | ​ |  | (5,536) | ​ |  | (1,428) | ​ |  | (28,553) | ​ |  | (10,413)
Other income (expense): | ​ |  | ​ | ​ |  | ​ | ​ |  | ​ | ​ |  | ​
Change in fair value of derivatives | ​ |  | — | ​ |  | 3 | ​ |  | 5,994 | ​ |  | 3
Unrealized exchange gain on convertible loan notes | ​ |  | — | ​ |  | 982 | ​ |  | 209 | ​ |  | 982
Loss on extinguishment of convertible loan notes | ​ |  | — | ​ |  | — | ​ |  | (13,789) | ​ |  | —
Interest income | ​ |  | — | ​ |  | — | ​ |  | 2 | ​ |  | —
Interest expense | ​ |  | — | ​ |  | (969) | ​ |  | (2,650) | ​ |  | (969)
Research and development incentives | ​ |  | 959 | ​ |  | 1,612 | ​ |  | 2,789 | ​ |  | 2,989
Other | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (3) | ​ | ​ | —
Total other (expense) income | ​ |  | 959 | ​ |  | 1,628 | ​ |  | (7,448) | ​ |  | 3,005
Tax (expense)/benefit | ​ |  | 7 | ​ |  | — | ​ |  | 60 | ​ |  | —
Net (loss)/ income | ​ |  | (4,570) | ​ |  | 200 | ​ |  | (35,941) | ​ |  | (7,408)
Net loss/ (income) attributable to noncontrolling interest | ​ |  | 13 | ​ |  | (42) | ​ |  | 189 | ​ |  | 157
Net (loss)/ income attributable to Vaccitech plc Shareholders | ​ |  | (4,557) | ​ |  | 158 | ​ |  | (35,752) | ​ |  | (7,251)
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Weighted-average ordinary shares outstanding, basic | ​ |  | 34,843,154 | ​ |  | 7,937,384 | ​ |  | 22,697,462 | ​ |  | 7,886,488
Weighted-average ordinary shares outstanding, diluted | ​ | ​ | 34,843,154 | ​ | ​ | 15,867,533 | ​ | ​ | 22,697,462 | ​ | ​ | 7,886,488
Net( loss)/ income per share attributable to ordinary shareholders, basic | ​ | $ | (0.13) | ​ | $ | 0.02 | ​ | $ | (1.58) | ​ | $ | (0.92)
Net (loss)/ income per share attributable to ordinary shareholders, diluted | ​ | $ | (0.13) | ​ | $ | 0.01 | ​ | $ | (1.58) | ​ | $ | (0.92)
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Net (loss)/ income | ​ | $ | (4,570) | ​ | $ | 200 | ​ | $ | (35,941) | ​ | $ | (7,408)
Other comprehensive (loss)/ income – foreign currency translation adjustments | ​ |  | (6,473) | ​ |  | 68 | ​ |  | (7,803) | ​ |  | (759)
Comprehensive (loss)/ income | ​ |  | (11,043) | ​ |  | 268 | ​ |  | (43,744) | ​ |  | (8,167)
Comprehensive loss/ (income) attributable to noncontrolling interest | ​ |  | 25 | ​ |  | (49) | ​ |  | 194 | ​ |  | 169
Comprehensive (loss)/ income attributable to Vaccitech plc shareholders | ​ | $ | (11,018) | ​ | $ | 219 | ​ | $ | (43,550) | ​ | $ | (7,998)

​

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

​

​

3

Table of Contents

VACCITECH PLC.

CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN REDEEMABLE CONVERTIBLE PREFERRED SHARES

AND SHAREHOLDERS’ EQUITY (DEFICIT)

(IN THOUSANDS, EXCEPT NUMBER OF SHARES)

(UNAUDITED)

​

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months ended September 30, 2021 | ​
​ | ​ | Series A | ​ | Series B | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Redeemable | ​ | Redeemable | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Accumulated | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Convertible Preferred | ​ | Convertible | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Additional | ​ | ​ | ​ | ​ | Other | ​ | ​ | ​ | ​ | Total | ​
​ | ​ | Shares | ​ | Preferred Shares | ​ | ​ | Ordinary Shares | ​ | Deferred A Shares | ​ | Deferred B Shares | ​ | Deferred C Shares | ​ | Paid-in- | ​ | Accumulated | ​ | Comprehensive | ​ | Noncontrolling | ​ | Shareholders’ | ​
​ |  | Shares |  | Amount |  | Shares |  | Amount |  |  | Shares |  | Amount |  | Shares |  | Amount |  | Shares |  | Amount |  | Shares |  | Amount |  | capital |  | Deficit |  | Loss |  | Interest |  | (Deficit)/Equity | ​
Balance, January 1, 2021, as previously reported |  | 22,065 | ​ | $ | 33,765 |  | — | ​ | $ | — |  | ​ | 7,960,458 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,960,458 | ​ | $ | 0 | 1 | $ | 19,531 | ​ | $ | (55,591) | ​ | $ | (1,243) | ​ | $ | 391 | ​ | $ | (36,912) | ​
Share-based compensation – restatement (see note 1) | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 2,129 | ​ | ​ | (2,129) | ​ | ​ | — | ​ | ​ | — | ​ | $ | — | ​
Balance, January 1, 2021, as restated | ​ | 22,065 | ​ | $ | 33,765 | ​ | — | ​ | $ | — | ​ | ​ | 7,960,458 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,960,458 | ​ | $ | 0 | 1 | $ | 21,660 | ​ | $ | (57,720) | ​ | $ | (1,243) | ​ | $ | 391 | ​ | $ | (36,912) | ​
Share-based compensation |  | — | ​ |  | — |  | — | ​ |  | — |  | ​ | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | 797 | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | 797 | ​
Issue of Series B shares, net of issuance costs |  | — | ​ |  | — |  | 28,957 | ​ |  | 121,837 |  | ​ | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​
Series B Shares issued on conversion of convertible notes |  | — | ​ |  | — |  | 12,421 | ​ |  | 53,721 |  | ​ | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​
Issue of Deferred A shares |  | — | ​ |  | (29) |  | — | ​ |  | (57) |  | ​ | — | ​ |  | — |  | 63,443 | ​ |  | 86 | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | 86 | ​
Issue of ordinary shares |  | — | ​ |  | — |  | — | ​ |  | — |  | ​ | 263,886 | ​ |  | 0 | 1 | — | ​ |  | — | ​ | — | ​ |  | — | ​ | 263,886 | ​ |  | 0 | 1 |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | 0 | 1
Foreign currency translation adjustments |  | — | ​ |  | — |  | — | ​ |  | — |  | ​ | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (1,420) | ​ |  | 4 | ​ |  | (1,416) | ​
Net loss | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (15,268) | ​ | ​ | — | ​ | ​ | (118) | ​ | ​ | (15,386) | ​
Balance, March 31, 2021 | ​ | 22,065 | ​ | $ | 33,736 | ​ | 41,378 | ​ | $ | 175,501 | ​ | ​ | 8,224,344 | ​ | $ | 0 | 1 | 63,443 | ​ | $ | 86 | ​ | — | ​ | $ | — | ​ | 8,224,344 | ​ | $ | 0 | 1 | $ | 22,457 | ​ | $ | (72,988) | ​ | $ | (2,663) | ​ | $ | 277 | ​ | $ | (52,831) | ​
Share-based compensation | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 8,736 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 8,736 | ​
Initial public offering, net of underwriting discounts | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 6,500,000 | ​ | ​ | 0 | 1 | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 102,765 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 102,765 | ​
Offering Cost | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | (2,394) | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (2,394) | ​
Conversion of Series A shares | ​ | (22,065) | ​ | ​ | (33,736) | ​ | — | ​ | ​ | — | ​ | ​ | 6,818,085 | ​ | ​ | 0 | 1 | — | ​ | ​ | — | ​ | 198,585 | ​ | ​ | 3 | ​ | 6,818,085 | ​ | ​ | 0 | 1 | ​ | 33,733 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 33,736 | ​
Conversion of Series B shares | ​ | — | ​ | ​ | — | ​ | (41,378) | ​ | ​ | (175,501) | ​ | ​ | 12,785,802 | ​ | ​ | 0 | 1 | — | ​ | ​ | — | ​ | 372,402 | ​ | ​ | 5 | ​ | 12,785,802 | ​ | ​ | 0 | 1 | ​ | 175,496 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 175,501 | ​
Issue of share to non-controlling interest | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 296 | ​ | ​ | 296 | ​
Foreign currency translation adjustments | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 83 | ​ | ​ | 3 | ​ | ​ | 86 | ​
Net loss | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (15,927) | ​ | ​ | — | ​ | ​ | (58) | ​ | ​ | (15,985) | ​
Balance, June 30, 2021 | ​ | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | ​ | 34,328,231 | ​ | $ | 1 | ​ | 63,443 | ​ | $ | 86 | ​ | 570,987 | ​ | $ | 8 | ​ | 27,828,231 | ​ | $ | 0 | 1 | $ | 340,793 | ​ | $ | (88,915) | ​ | $ | (2,580) | ​ | $ | 518 | ​ | $ | 249,911 | ​
Share-based compensation | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 3,374 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 3,374 | ​
Offering cost refund | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 229 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 229 | ​
Foreign currency translation adjustments | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (6,461) | ​ | ​ | (12) | ​ | ​ | (6,473) | ​
Net loss | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (4,557) | ​ | ​ | — | ​ | ​ | (13) | ​ | ​ | (4,570) | ​
Balance, September 30, 2021 | ​ | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | ​ | 34,328,231 | ​ | $ | 1 | ​ | 63,443 | ​ | $ | 86 | ​ | 570,987 | ​ | $ | 8 | ​ | 27,828,231 | ​ | $ | 0 | 1 | $ | 344,396 | ​ | $ | (93,472) | ​ | $ | (9,041) | ​ | $ | 493 | ​ | $ | 242,471 | ​

​

1 Indicates amount less than thousand

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements

4

Table of Contents

VACCITECH PLC.

CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN REDEEMABLE CONVERTIBLE PREFERRED SHARES

AND SHAREHOLDERS’ EQUITY (DEFICIT)

(IN THOUSANDS, EXCEPT NUMBER OF SHARES)

(UNAUDITED)

​

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months ended September 30, 2020 |
​ | ​ | Series A | ​ | Series B | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ |
​ | ​ | Redeemable | ​ | Redeemable | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Accumulated | ​ | ​ | ​ | ​ | ​ | ​ |
​ | ​ | Convertible Preferred | ​ | Convertible | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Additional | ​ | ​ | ​ | ​ | Other | ​ | ​ | ​ | ​ | Total |
​ | ​ | Shares | ​ | Preferred Shares | ​ | ​ | Ordinary Shares | ​ | Deferred A Shares | ​ | Deferred B Shares | ​ | Deferred C Shares | ​ | Paid-in- | ​ | Accumulated | ​ | Comprehensive | ​ | Noncontrolling | ​ | Shareholders’ | ​
​ |  | Shares |  | Amount |  | Shares |  | Amount |  | ​ | Shares |  | Amount |  | Shares |  | Amount |  | Shares |  | Amount |  | Shares |  | Amount |  | capital |  | Deficit |  | Loss |  | Interest |  | Deficit |
Balance, January 1, 2020, as previously reported |  | 22,065 | ​ | $ | 33,765 |  | — | ​ | $ | — | ​ |  | 7,276,332 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,276,332 | ​ | $ | 0 | 1 | $ | 15,906 | ​ | $ | (37,885) | ​ | $ | (467) | ​ | $ | 367 | ​ | $ | (22,079) | ​
Share-based compensation - restatement (see note 1) | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ |  | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 2,129 | ​ | ​ | (2,129) | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​
Balance, January 1, 2020, as restated | ​ | 22,065 | ​ | $ | 33,765 | ​ | — | ​ | $ | — | ​ | ​ | 7,276,332 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,276,332 | ​ | $ | 0 | 1 | $ | 18,035 | ​ | $ | (40,014) | ​ | $ | (467) | ​ | $ | 367 | ​ | $ | (22,079) | ​
Share-based compensation |  | — | ​ |  | — |  | — | ​ |  | — | ​ |  | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | 856 | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | 856 | ​
Issue of ordinary shares |  | — | ​ |  | — |  | — | ​ |  | — | ​ |  | 479,568 | ​ |  | 0 | 1 | — | ​ |  | — | ​ | — | ​ |  | — | ​ | 479,568 | ​ |  | 0 | 1 |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | 0 | 1
Exercise of stock options |  | — | ​ |  | — |  | — | ​ |  | — | ​ |  | 148,938 | ​ |  | 0 | 1 | — | ​ |  | — | ​ | — | ​ |  | — | ​ | 148,938 | ​ |  | 0 | 1 |  | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | 0 | 1
Foreign currency translation adjustments |  | — | ​ |  | — |  | — | ​ |  | — | ​ |  | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | — | ​ |  | — | ​ |  | (665) | ​ |  | (18) | ​ |  | (683) | ​
Net loss |  | — | ​ |  | — |  | — | ​ |  | — | ​ |  | — | ​ |  | — |  | — | ​ |  | — | ​ | — | ​ |  | — | ​ | — | ​ |  | — | ​ |  | — | ​ |  | (3,821) | ​ |  | — | ​ |  | (130) | ​ |  | (3,951) | ​
Balance, March 31, 2020 |  | 22,065 | ​ | $ | 33,765 |  | — | ​ | $ | — | ​ |  | 7,904,838 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,904,838 | ​ | $ | 0 | 1 | $ | 18,891 | ​ | $ | (43,835) | ​ | $ | (1,132) | ​ | $ | 219 | ​ | $ | (25,857) | ​
Share-based compensation | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 415 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 415 | ​
Foreign currency translation adjustments | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (143) | ​ | ​ | (1) | ​ | ​ | (144) | ​
Net loss | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (3,588) | ​ | ​ | — | ​ | ​ | (69) | ​ | ​ | (3,657) | ​
Balance, June 30, 2020 | ​ | 22,065 | ​ | $ | 33,765 | ​ | — | ​ | $ | — | ​ | ​ | 7,904,838 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,904,838 | ​ | $ | 0 | 1 | $ | 19,306 | ​ | $ | (47,423) | ​ | $ | (1,275) | ​ | $ | 149 | ​ | $ | (29,243) | ​
Share-based compensation | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 154 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 154 | ​
Exercise of stock options | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | 52,530 | ​ | $ | 0 | 1 | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | 52,530 | ​ | ​ | 0 | 1 | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | 0 | 1
Foreign currency translation adjustments | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 61 | ​ | ​ | 7 | ​ | ​ | 68 | ​
Net income | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 158 | ​ | ​ | — | ​ | ​ | 42 | ​ | ​ | 200 | ​
Balance, September 30, 2020 | ​ | 22,065 | ​ | $ | 33,765 | ​ | — | ​ | $ | — | ​ | ​ | 7,957,368 | ​ | $ | 0 | 1 | — | ​ | $ | — | ​ | — | ​ | $ | — | ​ | 7,957,368 | ​ | $ | 0 | 1 | $ | 19,460 | ​ | $ | (47,265) | ​ | $ | (1,214) | ​ | $ | 198 | ​ | $ | (28,821) | ​

​

1 Indicates amount less than thousand

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements

​

​

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VACCITECH PLC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(IN THOUSANDS)

(UNAUDITED)

​

​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | Nine months ended
​ |  | September 30, 2021 |  | September 30, 2020
CASH FLOWS FROM OPERATING ACTIVITIES: |  | ​ |  | ​ |  |
Net loss | ​ | $ | (35,941) | ​ | $ | (7,408)
Adjustments to reconcile net loss to net cash used in operating activities: | ​ |  | ​ | ​ |  |
Share-based compensation | ​ |  | 12,907 | ​ |  | 1,425
Depreciation and amortization | ​ |  | 281 | ​ |  | 152
ROU asset and liability | ​ |  | (10) | ​ |  | 30
Fair valuation gain on embedded derivatives | ​ |  | (5,994) | ​ |  | (3)
Unrealized foreign exchange gain on convertible loan notes | ​ |  | (209) | ​ |  | (982)
Non-cash interest expense on convertible loan notes | ​ |  | 813 | ​ |  | 969
Deferred tax benefit | ​ | ​ | (62) | ​ | ​ | —
Loss on conversion of convertible loan notes | ​ |  | 13,789 | ​ |  | —
Changes in operating assets and liabilities: | ​ | ​ | ​ | ​ | ​ | ​
Accounts receivable | ​ |  | 486 | ​ |  | 927
Prepaid expenses and other current assets | ​ |  | (5,494) | ​ |  | (862)
Research and development incentives receivable | ​ |  | (2,815) | ​ |  | 621
Accounts payable | ​ |  | (3,414) | ​ |  | (2,017)
Accrued expenses and other current liabilities | ​ |  | 1,846 | ​ |  | 1,202
Deferred revenue | ​ |  | (48) | ​ |  | (186)
Other assets | ​ |  | (746) | ​ |  | —
Net cash used in operating activities | ​ | $ | (24,611) | ​ | $ | (6,132)
CASH FLOWS FROM INVESTING ACTIVITIES: | ​ |  | ​ | ​ |  | ​
Purchases of property and equipment | ​ |  | (722) | ​ |  | (98)
Net cash used in investing activities | ​ | $ | (722) | ​ | $ | (98)
CASH FLOWS FROM FINANCING ACTIVITIES: | ​ |  |  | ​ |  |
Issue of shares and exercise of stock options | ​ |  | — | ​ |  | —
Initial public offering costs | ​ |  | (2,165) | ​ |  | —
Transaction costs for Series B shares | ​ |  | (3,402) | ​ |  | —
Proceeds from issue of Series B shares | ​ |  | 125,239 | ​ |  | —
Proceeds from issue of shares to noncontrolling interest | ​ | ​ | 296 | ​ | ​ | —
Proceeds from issuance of ordinary shares, net of underwriters fees | ​ | ​ | 102,765 | ​ | ​ | —
Transaction costs for convertible loan notes | ​ | ​ | — | ​ | ​ | (20)
Proceeds from convertible loan notes | ​ | ​ | — | ​ | ​ | 24,974
Net cash provided by financing activities | ​ | $ | 222,733 | ​ | $ | 24,954
EFFECT OF EXCHANGE RATES ON CASH AND CASH EQUIVALENTS | ​ |  | (6,795) | ​ |  | (526)
Net increase (decrease) in cash and cash equivalents | ​ |  | 190,605 | ​ |  | 18,198
Cash and cash equivalents, beginning of the period | ​ |  | 43,266 | ​ |  | 11,432
Cash and cash equivalents, end of the period | ​ | $ | 233,871 | ​ | $ | 29,630
​ | ​ | ​ | ​ | ​ | ​ | ​
Supplemental cash flow disclosures: | ​ | ​ | ​ | ​ | ​ | ​
Cash paid for interest | ​ | $ | 1,844 | ​ | $ | —
Cash paid for income taxes | ​ | $ | 150 | ​ | $ | —
Non-Cash investing and financing activities | ​ | ​ | ​ | ​ | ​ | ​
Issue of ordinary shares | ​ | $ | 0 | 1 | $ | —
Issue of deferred A shares | ​ | $ | 86 | ​ | $ | —
Issue of deferred B shares | ​ | $ | 8 | ​ | $ | —
Issue of deferred C shares | ​ | $ | 0 | 1 | $ | —
Issue of Series B shares | ​ | $ | 53,721 | ​ | $ | —
ROU assets obtained in exchange for operating lease liabilities | ​ | $ | 6,819 | ​ | $ | —

​

1 Indicates amounts less than thousand

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

​

​

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

1. | Nature of Business and Basis of Presentation

Vaccitech plc (Vaccitech) is a public limited company incorporated pursuant to the laws of England and Wales in March 2021. Vaccitech is engaged in the discovery and development of novel immunotherapeutics and vaccines for the treatment and prevention of infectious disease and cancer. Vaccitech is headquartered in Oxford, United Kingdom. Vaccitech and its five direct and indirect subsidiaries, Vaccitech (UK) Limited, Vaccitech Australia Pty Limited, Vaccitech Oncology Limited (“VOLT”), Vaccitech USA Inc. and Vaccitech Italia S.R.L, are collectively referred to as the “Company”.

In connection with the initial public offering of American Depositary Shares (“ADSs”), in March 2021, Vaccitech completed a corporate reorganization wherein the shareholders of Vaccitech (UK) Limited (formerly Vaccitech Limited) exchanged each of their ordinary shares, Series A Shares and Series B Shares of the Company for the same quantity of ordinary shares, series A shares (“Vaccitech plc Series A Shares”) and series B shares (“Vaccitech plc Series B Shares”) in Vaccitech plc (resulting in the shareholders of the Company holding the same percentage and class of shares in Vaccitech plc (formerly Vaccitech Rx Limited) as they had in Vaccitech (UK) Limited (formerly Vaccitech Limited). The group reorganization under common control constitutes a change in reporting entity and has been given retrospective effect reflecting the net assets of Vaccitech (UK) Limited (formerly Vaccitech Limited) and its subsidiaries and Vaccitech plc at their historical carrying amounts. As a result of the reorganization these unaudited condensed consolidated financial statements have been presented for all periods as if Vaccitech plc was the holding company of the group.

The Company operates in an environment of rapid technological change and substantial competition from pharmaceutical and biotechnology companies. The Company is subject to risks common to companies in the biopharmaceutical industry in similar stage of its life cycle including, but not limited to, the need to obtain adequate additional funding, possible failure of preclinical testing or clinical trials, the need to obtain marketing approval for its vaccine product candidates, competitors developing new technological innovations, the need to successfully commercialize and gain market acceptance of any of its products that are approved, and protection of proprietary technology. There can be no assurance that the Company’s research and development will be successfully completed, that adequate protection for the Company’s intellectual property will be obtained, that any products developed will obtain required regulatory approval or that any approved products will be commercially viable. Even if the Company’s development efforts are successful, it is uncertain when, if ever, the Company will generate significant product sales. If the Company does not successfully commercialize any of its products or mitigate any of these other risks, it will be unable to generate revenue or achieve profitability.

Basis of presentation

The Company’s unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“GAAP”) and pursuant to the rules and regulations of the Securities and Exchange Commission for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. The accompanying unaudited condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiary. All intercompany accounts and transactions have been eliminated in consolidation.

Certain notes or other information that are normally required by GAAP have been omitted if they substantially duplicate the disclosures contained in the Company’s annual audited consolidated financial statements. Accordingly, the unaudited condensed consolidated financial statements should be read in connection with the Company’s audited financial statements and related notes as of and for the year ended December 31, 2020 contained in our prospectus dated April 30, 2021.

On May 4, 2021, the Company effected a 309-for-1 stock split of ordinary shares. Each resultant ordinary share from the stock split was redesignated as one ordinary share and one deferred C share. Accordingly, all ordinary share and per share amounts for all periods presented in the accompanying unaudited condensed consolidated financial statements and notes thereto have been retroactively adjusted, where applicable, to reflect the stock split.

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

The condensed consolidated balance sheet and statement of changes in redeemable convertible preferred shares and shareholders’ equity include the correction of an error related to the Company’s consolidated financial statements for the period ended December 31, 2019. The error related to the omission of share-based compensation expense totaling $2,129 thousand in the period ended December 31, 2019. The correction of this error has been recorded as an adjustment to previously reported additional paid-in-capital and accumulated deficit as of January 1, 2020 and consequently as of December 31, 2020. There is no impact on net loss or cash flows, and no material impact on financial position for the periods presented.

The accompanying unaudited condensed consolidated financial statements have been prepared assuming the Company will continue as a going concern, which contemplates, among other things, the realization of assets and the satisfaction of liabilities and commitments in the ordinary course of business.

Unaudited Condensed Financial Information

The accompanying Condensed Consolidated Balance Sheet as of September 30, 2021, the Condensed Consolidated Statements of Operations and Comprehensive loss and Condensed Consolidated Statements Of Changes In Redeemable Convertible Preferred Shares and Shareholders’ Equity (Deficit) for the three months and nine months ended September 30, 2021 and 2020 and the Condensed Consolidated Statements of Cash Flows for the nine months ended September 30, 2021 and 2020 are unaudited. These unaudited condensed consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements. In our opinion, the unaudited condensed consolidated financial statements include all adjustments of a normal recurring nature necessary for the fair presentation of our financial position as of September 30, 2021, our results of operations for the three and nine months ended September 30, 2021 and 2020, and our cash flows for the nine months ended September 30, 2021 and 2020. The results of operations for the three and nine months ended September 30, 2021 are not necessarily indicative of the results to be expected for the year ending December 31, 2021, or any other interim periods.

2. | Summary of Significant Accounting Policies

The accounting policies of the Company are set forth in Note 2 to the consolidated financial statements as of and for the year ended December 31, 2020 except as discussed below related to newly adopted accounting pronouncements.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the unaudited condensed consolidated financial statements and the reported amounts of costs and expenses during the reporting period. The Company bases estimates and assumptions on historical experience when available and on various factors that it believes to be reasonable under the circumstances. The Company evaluates its estimates and assumptions on an ongoing basis. The Company’s actual results may differ from these estimates under different assumptions or conditions.

We have experienced and expect to continue to experience disruptions as a result of the COVID-19 pandemic that could severely impact the Company’s clinical and pre-clinical development timelines for the Company’s clinical and pre-clinical programs. Estimates and assumptions about future events and their effects cannot be determined with certainty and therefore require the exercise of judgment. As of the date of issuance of these unaudited condensed consolidated financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. These estimates may change as new events occur and additional information is obtained and are recognized in the unaudited condensed consolidated financial statements as soon as they become known. Actual results could differ from those estimates and any such differences may be material to the Company’s financial statements.

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

Recently issued accounting pronouncements

From time to time, new accounting pronouncements are issued by the FASB or other standard setting bodies that the Company adopts as of the specified effective date. The Company qualifies as an “emerging growth company” as defined in the Jumpstart Our Business Startups Act of 2012 and has elected not to “opt out” of the extended transition related to complying with new or revised accounting standards, which means that when a standard is issued or revised and it has different application dates for public and nonpublic companies, the Company can adopt the new or revised standard at the time nonpublic companies adopt the new or revised standard and can do so until such time that the Company either (i) irrevocably elects to “opt out” of such extended transition period or (ii) no longer qualifies as an emerging growth company.

The Company adopted ASU No. 2018-15, Intangibles-Goodwill and Other-Internal-Use Software (Subtopic 350-40): Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract (“ASU 2018-15”) on January 1, 2021. The new standard did not have an impact on the Company’s financial position and results of operations.

3. | Net Loss Per Share

Because the Company has reported a net loss attributable to ordinary shareholders for the periods presented, basic and diluted net loss per share attributable to ordinary shareholders are the same for the periods presented, except for the period ended September 30, 2020 in which the Company reported net income attributable to ordinary shareholders.

The following table sets forth the computation of basic and diluted net loss per share for the three months and nine months ended September 30, 2021 and 2020 (in thousands, except number of shares):

​

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three months ended September 30, |  | Nine months ended September 30,
​ |  | 2021 |  | 2020 |  | 2021 |  | 2020
Numerator: |  | ​ |  |  | ​ |  | ​ | ​ |  |  | ​ |
Net (loss)/income | ​ | $ | (4,570) | ​ | $ | 200 | ​ | $ | (35,941) | ​ | $ | (7,408)
Net (loss)/income attributable to noncontrolling interest | ​ |  | (13) | ​ |  | 42 | ​ |  | (189) | ​ |  | (157)
Net (loss)/income attributable to Vaccitech shareholders | ​ | $ | (4,557) | ​ | $ | 158 | ​ | $ | (35,752) | ​ | $ | (7,251)
Denominator: | ​ |  |  | ​ |  |  | ​ |  |  | ​ |  |
Weighted-average ordinary shares outstanding, basic | ​ |  | 34,843,154 | ​ |  | 7,937,384 | ​ |  | 22,697,462 | ​ |  | 7,886,488
Effect of dilutive securities | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Stock Options | ​ | ​ | — | ​ | ​ | 1,112,064 | ​ | ​ | — | ​ | ​ | —
Series A Shares | ​ | ​ | — | ​ | ​ | 6,818,085 | ​ | ​ | — | ​ | ​ | —
Weighted-average ordinary shares outstanding, diluted | ​ | ​ | 34,843,154 | ​ | ​ | 15,867,533 | ​ | ​ | 22,697,462 | ​ | ​ | 7,886,488
Net (loss)/ income per share attributable to ordinary shareholders, basic | ​ | $ | (0.13) | ​ | $ | 0.02 | ​ | $ | (1.58) | ​ | $ | (0.92)
Net (loss)/ income per share attributable to ordinary shareholders, diluted | ​ | $ | (0.13) | ​ | $ | 0.01 | ​ | $ | (1.58) | ​ | $ | (0.92)

​

The weighted-average ordinary shares outstanding for the three months and nine months ended September 30, 2021 includes 514,923 shares issuable on vesting of the restricted stock units with a performance condition linked to the IPO resolution date (see note 11).

​

Potential ordinary shares issuable for stock options that are excluded from the computation of diluted weighted-average shares outstanding because including them would have had an anti-dilutive effect are as follows:

​

​ | ​ | ​ | ​ | ​
​ | ​ | Nine months ended September 30,
​ |  | 2021 |  | 2020
Stock options |  | 3,356,648 |  | 1,113,327
Series A shares |  | — |  | 6,818,085

1. | ​

​

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

4. | Prepaid and other current assets (in thousands)

​

​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | September 30, 2021 |  | December 31, 2020
Prepayments and accrued income | ​ | $ | 5,639 | ​ | $ | 1,075
Value Added Tax receivable | ​ |  | 508 | ​ |  | 305
Current tax receivable | ​ | ​ | 55 | ​ | ​ | —
Others | ​ |  | 482 | ​ |  | 29
Total | ​ | $ | 6,684 | ​ | $ | 1,409

​

​

5. | Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consist of the following (in thousands):

​

​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | September 30, 2021 |  | December 31, 2020
Accrued manufacturing and clinical expenses | ​ | $ | 1,887 | ​ | $ | 462
Accrued board of director compensation | ​ |  | 120 | ​ |  | 4
Accrued bonus | ​ |  | 1,007 | ​ |  | 750
Accrued payroll and employee benefits | ​ |  | 407 | ​ |  | 250
Accrued professional fees | ​ |  | 629 | ​ |  | 806
Accrued other | ​ |  | 354 | ​ |  | 265
Total | ​ | $ | 4,404 | ​ | $ | 2,537

​

​

6. | Ordinary Shares

On May 4, 2021, the Company closed its initial public offering (“IPO”) of 6,500,000 ADS representing 6,500,000 ordinary shares having a nominal value of £0.000025 per share, at a public offering price of $17.00 per share, for aggregate net proceeds of $102,765 thousand after deducting underwriting commissions of $7,735 thousand and incurred offering costs of $2,165 thousand.

All ordinary shares rank pari passu as a single class. The following is a summary of the rights and privileges of the holders of ordinary shares as of September 30, 2021:

Liquidation preference: in the event of the liquidation, dissolution or winding up of the Company, the assets of the Company available for distribution to holders of the ordinary shares shall be distributed amongst all holders of the ordinary shares in proportion to the number of shares held irrespective of the amount paid or credited as paid on any share.

Dividends: holders of the ordinary shares are entitled to dividend, as may be recommended from time to time by the Board and declared by the ordinary shareholders out of legally available funds.

Voting Rights: each holder of ordinary shares is entitled to one vote for each share on all matters to be voted on by ordinary shareholders.

Preemption rights: pursuant to section 561 of the Companies Act 2006, shareholders are granted preemptive rights when new shares are issued for cash. However, it is possible for our Articles, or shareholders at a general meeting representing at least 75% of our ordinary shares present (in person or by proxy) and eligible to vote at that general meeting, to disapply these preemptive rights. Such a disapplication of preemption rights may be for a maximum period of up to five years from the date of the shareholder special resolution. In either case, this disapplication would need to be renewed by our shareholders upon its expiration (i.e., at least every five years) to remain effective.

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

On April 21, 2021, our shareholders approved the disapplication of preemptive rights for a period of five years from the date of approval by way of a special resolution of our shareholders. This included the disapplication of preemption rights in relation to the allotment of our ordinary shares in connection with the IPO. This disapplication will need to be renewed upon expiration (i.e., at least every five years) to remain effective, but may be sought more frequently for additional five-year terms (or any shorter period).

7. | Series A and Series B shares

On March 15, 2021, the Company issued 28,957 Series B preferred shares (“Series B Shares”) amounting to $125,239 thousand and incurred transaction costs of $3,402 thousand.

On March 31, 2021, Vaccitech plc subdivided each of the Series A shares and Series B shares (including the Series B shares issued on conversion of the convertible loan notes) into one share of the same class and one deferred A share with a nominal value of £1.00 per share.

On May 4, 2021 prior to the closing of the Company’s initial public offering and pursuant to the terms of its articles of association, all of the Series A Shares and Series B Shares were converted into 19,603,887 ordinary shares, 570,987 deferred B shares and 19,603,887 deferred C shares.

​

8. | Convertible loan notes

The Company recognized interest expense of $2,650 thousand and a change in fair value of $5,994 thousand in relation to the conversion and redemption features embedded in the convertible loan notes in the condensed consolidated statements of operations and comprehensive loss for the period ended September 30, 2021. For the period ended September 30, 2020, interest expense was $969 thousand and change in fair value in relation to the conversion and redemption features embedded in the convertible loan notes was $3 thousand.

The Series B funding on March 15, 2021 constituted a qualified equity financing in accordance with the terms of the convertible loan notes. As a result, the convertible loan notes were converted on March 15, 2021 into 12,421 Series B Shares with the conversion price being 0.8 times the Series B Shares issue price.

The conversion was accounted for as an extinguishment of the convertible loan notes. As a result, the 12,421 Series B preferred shares issued on conversion was recognized at the settlement-date fair value of the Series B shares ($53,721 thousands) and a loss of $13,789 thousand for the nine month period was recognized in earnings for the difference between (1) the fair value of those shares and (2) the sum of the carrying amounts of the convertible loan notes ($25,557 thousand) and the bifurcated conversion and redemption feature liability ($14,375 thousand).

9. | Deferred Shares

All deferred shares rank pari passu as a single class. The deferred shares do not have rights to dividends or to participate in profits on a return of assets on liquidation, the deferred shares confer on the holders thereof an entitlement to receive out of the assets of the Company available for distribution amongst the shareholders (subject to the rights of any new class of shares with preferred rights) the amount credited as paid up on the deferred shares held by them respectively after (but only after) payment shall have been made to the holders of the ordinary shares of the amounts paid up or credited as paid up on such shares and the sum of £1,000 thousand ($1,373 thousand) in respect of each ordinary share held by them respectively. The deferred shares shall confer on the holders thereof no further right to participate in the assets of the Company.

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

10. | Fair value

The Company’s financial instruments consist of cash and cash equivalents, accounts receivable, accounts payable, accrued expenses, and other liabilities. As of September 30, 2021, and December 31, 2020, the carrying amount of cash and cash equivalents, accounts receivable, accounts payable, accrued expenses, and other liabilities approximated their respective fair value due to the short-term nature and maturity of these instruments.

As of December 31, 2020, the Company had an embedded derivative liability of $20,109 thousand related to the conversion features, the cash redemption feature on maturity and the cash redemption feature upon an exit event that settles in noncash consideration embedded in convertible loan notes. The fair value of the embedded derivatives is a Level 3 valuation with the significant unobservable inputs being the probability of exercise of conversion and cash redemption features. Significant judgment is employed in determining the appropriateness of certain of these inputs. The changes in the fair value of the embedded derivatives was as follows (in thousands):

​

​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months ended September 30,
​ |  | 2021 |  | 2020
Beginning balance | ​ | $ | 20,109 | ​ | $ | 12,977
Change in fair value recognized in net loss | ​ |  | (5,994) | ​ |  | (3)
Settlement via conversion | ​ |  | (14,375) | ​ |  | —
Foreign exchange translation | ​ |  | 260 | ​ |  | 96
Ending balance | ​ | $ | — | ​ | $ | 13,070

​

​

11. | Share-Based Compensation

On April 8, 2021, the Board of the Company adopted the Vaccitech plc Share Award Plan 2021 (“the Plan”) and the Vaccitech plc Non-Employee Sub-Plan which is a sub-plan of the Plan. Under the terms of the Plan, the Board is permitted to grant awards to employees as restricted share units, options, share appreciation rights, restricted shares. The aggregate number of shares initially available for issuance under the Plan and the Vaccitech plc Non-Employee Sub-Plan cannot exceed 3,675,680 ordinary shares (the “Initial Limit”). Beginning calendar year 2022, the total number of ordinary shares available for issuance under the Plan shall be increased on January 1 of each year in an amount equal to the lesser of (i) 4% of the Company’s issued and outstanding ordinary shares (which 4% limit shall be measured as of January 1 of such year) and (ii) such number of ordinary shares as determined by the Board in its discretion (the “Annual Increase”). The awards generally vest based on the grantee’s continued service with the Company during a specified period following grant as determined by the Board and generally expire ten years from the grant date. Option awards generally vest over one to four years, but vesting conditions can vary at the discretion of the Company’s Board. As of September 30, 2021, 2,131,214 ordinary shares are available for future grants.

​

On April 30, 2021, the Company granted 1,513,566 options under the Plan to employees and directors with a grant date fair value $11.33 per option and a weighted average exercise price of $17.00 per option. On September 30, 2021, the Company granted 30,900 options under the Plan with a grant date fair value of $12.83 and a weighted average exercise price of $14.96 per option.

​

For the nine months ended September 30, 2021, the Company granted 1,909,086 options with a weighted average grant date fair value of $ 10.94 per option and a weighted average exercise price of $13.72 of which 364,620 options were issued under the Enterprise Management Incentive Share Option Scheme which has been discontinued on adoption of the Plan. For the nine months ended September 30, 2020, the Company granted 302,820 options to employees and directors under the Enterprise Management Incentive Share Option Scheme with a weighted average grant date fair value of $4.98 and a weighted average exercise price of $0.00036 per share.

​

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

The fair value of each stock option issued to employees was estimated at the date of grant using Black-Scholes with the following weighted-average assumptions:

​

​ | ​ | ​ | ​ | ​ | ​
​ |  | Nine months ended September 30, |
​ |  | 2021 |  | 2020 |
Expected volatility |  | 110.8 | % | 110.8 | %
Expected term (years) |  | 6.31 |  | 6.03 | ​
Risk-free interest rate |  | 1.06 | % | 1.7 | %
Expected dividend yield |  | — | ​ | — | ​

​

On April 22, 2021, the exercise price of 267,903 options was changed from $0.0004 (£0.0003) to $4.84 (£3.49) in order to enable employees to benefit from tax advantages under the Enterprise Management Incentive Scheme. This modification did not result in an incremental compensation cost and the Company continues to recognize compensation cost on these options equal to the grant date fair value of the original award.

At September 30, 2021 3,356,648 options with a weighted average exercise price of $7.98 were outstanding of which 741,219 with a weighted average exercise price of $0.38 were exercisable. At September 30, 2021, there was $16,061 thousand unrecognized compensation cost related to stock options, which is expected to be recognized over a weighted average period of 2.37 years.

During the six months ended June 30, 2021, 514,923 restricted stock units with a performance condition linked to the IPO resolution date vested on occurrence of the IPO resulting in $5,760 thousand recognized as compensation cost.

Share-based compensation expense is classified in the unaudited condensed consolidated statement of operations and comprehensive loss as follows (in thousands):

​

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | Three months ended September 30, | ​ | Nine months ended September 30,
​ |  | 2021 |  | 2020 |  | 2021 |  | 2020
Research and development | ​ | $ | 496 | ​ | $ | 98 | ​ | $ | 1,457 | ​ | $ | 425
General and administrative | ​ |  | 2,878 | ​ |  | 56 | ​ |  | 11,450 | ​ |  | 1,000
Total | ​ | $ | 3,374 | ​ | $ | 154 | ​ | $ | 12,907 | ​ | $ | 1,425

​

​

12. | Contract Assets and Liabilities

The Company discloses Accounts receivable separately in the Condensed Consolidated Balance Sheet at the net amount expected to be collected. Contract assets primarily relate to the Company’s conditional right to consideration for work completed but not billed at the reporting date. As of September 30, 2021, the Company did not have any contract assets.

Contract liabilities primarily relate to payments received from customers in advance of performance under the contract and are disclosed as deferred revenue separately in the Condensed Consolidated Balance Sheet. The Company’s contract liabilities arise when payment is received upfront for various multi-period extended license and service arrangements.

Changes in the contract liabilities during the period are as follows:

​

​ | ​ | ​ | ​
​ |  | September 30,
​ | ​ | 2021
Balance at December 31, 2020 | ​ | $ | 245
Revenue recognized related to contract liability balance | ​ |  | (48)
Foreign exchange translation | ​ |  | (1)
Balance at September 30, 2021 | ​ | $ | 196

​

​

​

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

13. | Commitments and Contingencies

In-License Agreements

The Company is party to a number of licensing agreements most of which are with related parties. These agreements serve to provide the Company with the right to develop and exploit the counterparties’ intellectual property for certain medical indications. As part of execution of these arrangements, the Company paid certain upfront fees, which have been expensed as incurred because the developing technology has not yet reached technical feasibility, the lack of alternative use, and the lack of proof of potential value. The agreements cover a variety of fields, including influenza, cancer, HPV, HBV and MERS. The Company’s obligations for future payments under these arrangements are dependent on its ability to develop promising drug candidates, the potential market for these candidates and potential competing products, and the payment mechanisms in place in countries where the Company retains the right to sell. Each agreement provides for specific milestone payments, typically triggered by achievement of certain testing phases in human candidates, and future royalties ranging from 1 to 5% for direct sales of a covered product to 3 to 7% of net payments received for allowable sublicenses of technology developed by the Company. The obligation to make these payments is contingent upon the Company’s ability to develop candidates for submission for phased testing and approvals, and for the development of markets for the products developed by the Company. The Company has not made any material payments under these license agreements during the periods ended September 30, 2021 and September 30, 2020.

Leases

The Company leases certain laboratory and office space under operating leases, which are described below.

The Oxford Science Park, Oxford

The Company leases an office and laboratory space from a related party in Oxford, England under an operating lease with a contractual term expiring in 2028. The lease does not contain renewal terms. Variable payments include amounts due to the lessor for additional services and cost reimbursements.

The Harwell Science and Innovation Campus, Oxfordshire

On September 3, 2021, the Company entered into a lease agreement for the lease of approximately 31,000 square feet in Harwell, Oxfordshire which expires in September 2031. The Company intends to use the property as its corporate headquarters. As the Company's leases typically do not provide an implicit rate, the Company uses an estimate of its incremental borrowing rate based on the information available at the lease commencement date, being the rate incurred to borrow on a collateralized basis over a similar term at an amount equal to the lease payments in a similar economic environment. The Company has provided the lessor with a refundable security deposit of $719 thousand (£534 thousand) which is included in Other assets.

The Company recorded a right-of-use asset and a lease liability on the effective date of the lease term. The Company’s right-of-use asset and lease liability are as follows (in thousands):

​

​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | September 30, |  | December 31,
​ |  | 2021 |  | 2020
Right-of-use asset | ​ | $ | 8,780 | ​ | $ | 2,136
Lease liability, current |  | ​ | 435 |  | ​ | 192
Lease liability, noncurrent |  | ​ | 7,728 |  | ​ | 1,472

​

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VACCITECH PLC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

​

Other information

​

​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months ended September 30,
​ |  | 2021 |  | 2020
Cash paid for amounts included in the measurement of lease liabilities | ​ | $ | 251 | ​ | $ | 244

​

During the nine months ended September 30, 2021, the Company recorded $372 thousand (nine months ended September 30, 2020: $253 thousand) in operating lease costs (including short-term lease expense and variable lease costs).

Future annual minimum lease payments under operating leases as of September 30, 2021 were as follows (in thousands):

​

​ | ​ | ​ | ​
Remainder of 2021 |  | $ | 141
2022 | ​ |  | 615
2023 | ​ |  | 798
2024 | ​ |  | 1,515
2025 | ​ |  | 1,515
Thereafter | ​ |  | 7,378
Total minimum lease payments | ​ | $ | 11,962
Less: imputed interest | ​ |  | 3,799
Total lease liability | ​ | $ | 8,163

​

Other contingencies

The Company is a party in various contractual disputes, litigation, and potential claims arising in the ordinary course of business. The Company does not believe that the resolution of these matters will have a material adverse effect on its financial position or results of operations.

14. | Related Party Transactions

During the three months and nine months ended September 30, 2021, the Company paid $110 thousand and $236 thousand respectively (three months and nine months ended September 30, 2020: $80 thousand and $250 thousand respectively) to its shareholder, Oxford Sciences Enterprises plc (formerly, Oxford Sciences Innovation plc), mostly related to the lease of a laboratory and office space in Oxford. At September 30, 2021, the Company owed $0 thousand (December 31, 2020: $0) to Oxford Sciences Enterprises plc.

During the nine months ended September 30, 2021, the interest on convertible loans issued to Oxford Sciences Enterprises plc and the University of Oxford, shareholders of the Company was $429 thousand (nine months ended September 30, 2020: $368 thousand). At September 30, 2021 these convertible loan notes including the embedded derivative was $0 (December 31, 2020: $7,356 thousand).

On March 15, 2021 Oxford Sciences Enterprises plc subscribed to 3,468 Series B Shares in an amount of $14,999 thousand. The Company also recognized a loss of $2,125 thousand on the conversion of the convertible loan notes into 2,008 Series B Shares. On May 4, 2021 prior to the closing of the Company’s initial public offering and pursuant to the terms of its articles of association, the Series B Shares were converted into 1,692,084 ordinary shares.

​

​

​

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

You should read the following discussion and analysis of our financial condition and results of operations together with our consolidated financial statements and the related notes appearing elsewhere in this Quarterly Report on Form 10-Q and our audited financial statements and related notes for the year ended December 31, 2020 included in our final prospectus for our initial public offering filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, with the Securities and Exchange Commission, on April 30, 2021. Some of the information contained in this discussion and analysis or set forth elsewhere in this report, including information with respect to our plans and strategy for our business, includes forward-looking statements that involve risks, uncertainties and assumptions. Factors that might cause future results to differ materially from those projected in the forward-looking statements include, but are not limited to, those set forth in our final prospectus for our initial public offering filed pursuant to Rule 424(b), as supplemented by our subsequent filings with the SEC.

Overview

We are a clinical-stage biopharmaceutical company engaged in the discovery and development of novel immunotherapeutics and vaccines for the treatment and prevention of infectious diseases and cancer. We use our proprietary platform to develop product candidates that stimulate powerful, targeted immune responses against pathogens and tumor cells. We design our product candidates to stimulate immune responses that are robust, highly specific, and are differentiated by the magnitude of the T cell populations induced, which exhibit critical functionality and durability. We are focused on applying our platform capabilities and the expertise of our team to address significant unmet medical needs in two settings—the therapeutic setting, for the treatment of chronic infectious diseases and cancer, and the prophylactic setting, for the prevention of infectious diseases, based on our platform’s ability to respond rapidly to epidemic and pandemic threats.

We have a broad pipeline of both clinical and preclinical stage therapeutic and prophylactic programs. Our current therapeutic programs include VTP-300 for the treatment of chronic hepatitis B infection, or CHB, VTP-200 for the treatment of human papilloma virus infection, or HPV, VTP-850 for the treatment of prostate cancer and VTP-600 for the treatment of non-small cell lung cancer, or NSCLC. Our current prophylactic programs include VTP-400 for the prevention of herpes zoster, or shingles, and VTP-500 for the prevention of Middle East respiratory syndrome, or MERS. In addition, we co-invented a COVID-19 vaccine candidate with the University of Oxford, which we assigned to Oxford University Innovation, or OUI, to facilitate the license of those rights by OUI to AstraZeneca UK Limited, or AstraZeneca. The product candidate, which we refer to as AZD1222, is now authorized for use under the name Vaxzevria in a number of countries. As of August 12, 2021, AstraZeneca has announced that AZD1222 has been granted emergency use authorization in the United Kingdom, India and Japan, among other countries. AstraZeneca has exclusive worldwide rights to develop and commercialize AZD1222.

On May 4, 2021, we completed our initial public offering, or IPO, pursuant to which we issued and sold 6,500,000 ADSs at a public offering price of $17.00 per ADS, resulting in net proceeds of $102.8 million, after deducting underwriting discounts and commissions and offering expenses. Prior to our IPO, we funded our operations primarily from private placements of our ordinary and preferred shares, private placements of loan notes convertible into ordinary shares, as well as from grants and licensing agreements, research tax credit payments, investments from non-controlling interest a $2.4 million upfront payment from OUI in July 2020 in connection with the Amendment, Assignment and Revenue Share Agreement, or the OUI License Agreement Amendment, related to the licensing of the COVID-19 vaccine candidate now known as AZD1222, or Vaxzevria. We do not expect to generate revenue from any of our own product candidates until we obtain regulatory authorization for one or more of such product candidates, if at all, and commercialize our products, or we enter into out-licensing agreements with third parties. We may receive some revenue pursuant to the OUI License Agreement Amendment with OUI with respect to the AstraZeneca COVID-19 vaccine candidate AZD1222 in certain circumstances if it receives marketing approval from regulatory authorities and is sold commercially. Substantially all of our net losses have resulted from costs incurred in connection with our research and development activities and from general and administrative costs associated with our operations.

We have incurred net losses each year since inception. For the three and nine months ended September 30, 2021, we incurred net losses of $4.6 million and $35.9 million, respectively. For the three and nine months ended September 30, 2020, we generated a net income of $0.2 million and incurred a net loss of $7.4 million, respectively. As of September 30, 2021, we had an accumulated deficit of $93.5 million and we do not expect positive cash flows from operations in the foreseeable future. We expect to continue to incur net operating losses for at least the next several years as we advance our product candidates through clinical development, seek regulatory approval, prepare for approval, and in some cases proceed to commercialization of our product candidates, as well as continue our research and development efforts and invest to establish a commercial manufacturing facility, as and when appropriate.

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At this time, we cannot reasonably estimate, or know the nature, timing and estimated costs of all of the efforts that will be necessary to complete the development of any of our product candidates that we develop through our programs. We are also unable to predict when, if ever, material net cash inflows will commence from sales of product candidates we develop, if at all. This is due to the numerous risks and uncertainties associated with developing product candidates to approval and commercialization, including the uncertainty of:

| ● | successful completion of preclinical studies and clinical trials;

| ● | sufficiency of our financial and other resources to complete the necessary preclinical studies and clinical trials;

| ● | acceptance of investigational new drug applications, or INDs, for our planned clinical trials or future clinical trials;

| ● | successful enrollment and completion of clinical trials;

| ● | data from our clinical program supporting approvable and commercially acceptable risk/benefit profiles for our product candidates in the intended populations;

| ● | receipt and maintenance of necessary regulatory and marketing approvals from applicable regulatory authorities, in the light of the commercial environment then existent;

| ● | scale-up of our manufacturing processes and formulation of our product candidates for later stages of development and commercial production;

| ● | establishing either our own manufacturing capabilities or satisfactory agreements with third-party manufacturers for clinical supply for later stages of development and commercial manufacturing;

| ● | entry into collaborations where appropriate to further the development of our product candidates;

| ● | obtaining and maintaining intellectual property and trade secret protection or regulatory exclusivity for our product candidates as well as qualifying for, maintaining, enforcing and defending such intellectual property rights and claims;

| ● | successfully launching or assisting with the launch of commercial sales of our product candidates following approval;

| ● | acceptance of each product’s benefits and uses by patients, the medical community and third-party payors following approval;

| ● | the prevalence and severity of any adverse events experienced with our product candidates in development;

| ● | establishing and maintaining a continued acceptable safety profile of the product candidates following approval;

| ● | obtaining and maintaining healthcare coverage and adequate reimbursement from third-party payors if necessary or desirable; and

| ● | effectively competing with other therapies.

A change in the outcome of any of these variables with respect to the development of a product candidate could mean a significant change in the costs and/or timing associated with the development of that product candidate or could prevent continuation of that program being in the company’s interests. For example, if the FDA or another regulatory authority were to require us to conduct clinical trials beyond those that we anticipate will be required for the completion of clinical development of a product candidate, or if we experience significant delays in our clinical trials due to patient enrollment or other reasons, we might be required to expend significant additional financial resources and time on the completion of clinical development. In some circumstances, such as the emergence of a significantly more effective therapy from a competitor, it may be appropriate to discontinue a product candidate program. Including the net proceeds from our IPO, we expect that our cash balance as of September 30, 2021 will enable us to fund our operating expenses and capital requirements into 2024.

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Recent Developments

On September 3, 2021, we announced the publication of new preclinical data indicating that Vaccitech Oncology Limited’s ChAdOx1/MVA prime-boost immunotherapeutic has potential as a novel cancer treatment. This research from the University of Oxford and the Ludwig Institute for Cancer Research shows that the cancer immunotherapeutic generates effective anti-tumor immune responses and, in combination with immunotherapy, decreases tumor size and increases the survival rates in mouse models. The technology is comprised of the ChAdOx vector, which underpins the Oxford-AstraZeneca COVID vaccine. The prime-boost viral vector product is licensed to Vaccitech Oncology Limited (VOLT), a strategic initiative between the Ludwig Institute for Cancer Research and Vaccitech plc. In October 2021, we opened a first-in-human clinical trial of the immunotherapeutic (VTP-600) in patients with non-small cell lung cancer.

On September 7, 2021 we announced that we entered into a lease within the Zeus development at Harwell Science and Innovation Campus, Harwell, United Kingdom. We plan to relocate our headquarters to the site from Oxford by mid-2022.

In October 2021 we completed recruitment for cohorts 1-5 for our Phase 1 (HBV001) clinical trial for VTP-300. We have already presented interim data from cohorts 1 and 2, and further results are expected to be available in the fourth quarter of 2021 and the first quarter of 2022.

On November 4, 2021, VTP-500 results from the Saudi Arabia Phase 1 study were published in The Lancet Microbe. The Phase 1 data showed that VTP-500 was generally well tolerated in patients, and we plan to continue further development of the product candidate.

Impact of the COVID-19 Pandemic

The spread of COVID-19, which we refer to as the COVID-19 pandemic, and the policies and regulations implemented by governments in response to the COVID-19 pandemic have had a significant impact, both directly and indirectly, on the global economy and our business and operations, including continuing disruption to our clinical trial activities. Of note, the initiation of our Phase 1 clinical trial for VTP-500, which is being conducted at the University of Oxford, was paused due to COVID-19. In addition, the COVID-19 pandemic has had a negative affect on the operations of our third-party manufacturers and the supply chain for our product candidates and clinical trial materials, due to limitations on travel imposed or recommended by federal, state/provincial or municipal governments, employers and others.

Our study protocols have been amended so that participants who have previously received Vaxzevria (or any other adenovirus-based vaccine) wait for a minimum of 3 months between their last adenovirus vaccine and injection with our immunotherapeutic product candidates to prevent prior vector immunity affecting the study.

In the VTP-200 program the initiation of investigational sites for the Phase 1/2a clinical trial (HPV001) across all countries has been impacted by COVID-19. The UK is particularly affected as resources to support set up of trials not related to COVID-19 have been low across sites. Other pandemic related issues affecting recruitment include the mass vaccination programs and the adverse publicity early in the second quarter of 2021 specifically around Vaxzevria. Participant recruitment continues to be delayed with last patient first visit anticipated in the first quarter of 2022, and the interim analysis is expected to be available in the third quarter of 2022.

For our Phase 1 (HBV001) clinical trial for VTP-300, recruitment of patients with Chronic Hepatitis B (CHB) in the UK has been challenging, due to COVID-19 lockdowns. We completed recruitment for cohorts 1-5 in October 2021 and results of the study are expected to be available in the first quarter of 2022. For our Phase 1b/2a (HBV002) clinical trial for VTP-300, CHB patient recruitment continues with delays in Taiwan due to the ongoing COVID-19 lockdown in the country. Patient recruitment has also been delayed in South Korea due to the roll out of Vaxzevria vaccine and vaccine hesitancy. Patient recruitment is estimated to be completed in the first quarter of 2022, with interim data also expected toward the beginning of the first quarter of 2022.

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If the disruption due to the COVID-19 pandemic continues, our planned future preclinical and clinical development for our other product candidates could also be delayed due to government orders and site policies as a result of the pandemic. The pandemic and government measures taken in response have also had a significant impact, both direct and indirect, on businesses and commerce, as worker shortages have occurred; supply chains have been disrupted; facilities and production have been suspended; and demand for certain goods and services, such as medical services and supplies, has spiked, while demand for other goods and services, such as travel, has fallen. In response to the spread of COVID-19, we have mandated that our non-laboratory based employees, such as clinical, manufacturing, finance, administrative, quality, regulatory and program managers split their time between working from home and the office, being sure to maintain social distancing and adhere to COVID-19 working guidelines when on the office premises. In addition, we continue to limit the number of staff in any given research and development laboratory at any time to maintain social distancing. Our increased reliance on personnel working from home may negatively impact productivity, increase the potential risks of data privacy or security breaches, or disrupt, delay, or otherwise adversely impact our business.

We are still assessing our business plans and the impact the COVID-19 pandemic may have on our ability to advance the development of our product candidates as a result of adverse impacts on the research sites, service providers, vendors, or suppliers on whom we rely, or to raise financing to support the development of our ongoing product candidate development. No assurances can be given that this analysis will enable us to avoid part or all of any impact from the COVID-19 pandemic, including downturns in business sentiment generally or in our sector in particular. The Delta variant increased, and other variants may increase, COVID-19 case counts significantly, which may further impact our ability to conduct our business. The impact of government regulations, vaccine adoption rates (including boosters), the effectiveness of vaccines, and the continuing economic effects of the pandemic and containment measures may also further adversely impact our business. We cannot currently predict the scope and severity of any potential business shutdowns or disruptions, but if we or any of the third parties on whom we rely or with whom we conduct business were to experience shutdowns or other business disruptions, our ability to conduct our business in the manner and on the timelines presently planned could be materially and adversely impacted.

Components of Our Operating Results

Revenue

To date, we have not generated any revenue from product sales and do not expect to do so in the near future, if at all. Our revenue to date has been derived from a research grant from BARDA, a research collaboration and license agreement with Enara Bio and the OUI License Agreement Amendment with OUI relating to AZD1222.

In April 2020, we entered into the OUI License Agreement Amendment with OUI in respect of our rights to use the ChAdOx1 technology in COVID-19 vaccines to facilitate the license of those rights by OUI to AstraZeneca. Under this agreement, we are entitled to receive from OUI a share of payments, including royalties and milestones, received by OUI from AstraZeneca in respect of this vaccine. As a direct result of the OUI License Agreement Amendment, we received a payment of $2.4 million, of which we have recognized $2.4 million as revenue during the year ended December 31, 2020.

We determined that we have no further performance obligations under the terms of the OUI License Agreement Amendment, which comprised the transfer of intellectual property rights only. Accordingly, we plan to recognize these and any future amounts as revenue when received.

Operating Expenses

Our operating expenses since inception have consisted of research and development costs and general administrative costs.

Research and Development Expenses

Since our inception, we have focused significant resources on our research and development activities, including establishing and building on our adenovirus platform, further enhancing our in-licensed ChAdOx1, ChAdOx2 and MVA vectors, developing a new next-generation adenoviral vector, conducting preclinical studies, developing various manufacturing processes, and advancing clinical development of our programs including Phase 2 clinical trials for VTP-100, which we subsequently discontinued development of, as well as initiating the clinical trials for VTP-200 and VTP-300, and readying VTP-600 and VTP-850 for clinical trials. Research and

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development activities account for the major portion of our operating expenses. Research and development costs are expensed as incurred. These costs include:

| ● | salaries, benefits and other related costs, including share-based compensation, for personnel engaged in research and development functions;

| ● | expenses incurred in connection with the development of our programs including preclinical studies and clinical trials of our product candidates, under agreements with third parties, such as consultants, contractors, academic institutions and CROs;

| ● | the cost of manufacturing drug products for use in preclinical development and clinical trials, including under agreements with third parties, such as CMOs, consultants and contractors;

| ● | laboratory costs;

| ● | leased facility costs, equipment depreciation and other expenses, which include direct and allocated expenses; and

| ● | intellectual property costs incurred in connection with filing and prosecuting patent applications as well as third-party license fees.

General and Administrative Expenses

Our general and administrative expenses consist primarily of personnel costs in our executive, finance, business development and other administrative functions. Other general and administrative expenses include consulting fees and professional service fees for auditing, tax and legal services, rent expenses related to our offices, depreciation, foreign exchange gains and losses on our cash balances and other central non-research costs. We expect our general and administrative expenses to continue to increase in the future as we expand our operating activities and potentially prepare for manufacturing and/or commercialization of our current and future product candidates. These costs would normally increase as our headcount rises to allow full support for our operations as a public company, including increased expenses related to legal, accounting, regulatory and tax-related services associated with maintaining compliance with requirements of the Nasdaq Global Market and the Securities and Exchange Commission, directors’ and officers’ liability insurance premiums and investor relations activities.

Other Income (Expense)

Change in Fair Value of Derivatives

We recognized a change in fair value in relation to the conversion and redemption features embedded in the convertible loan notes in the condensed consolidated statements of operations and comprehensive loss for the nine months ended September 30, 2021. We had an embedded derivative liability related to the conversion features, the cash redemption feature on maturity and the cash redemption feature upon an exit event that settles in noncash consideration embedded in convertible loan notes. The fair value of the embedded derivatives is a Level 3 valuation with the significant unobservable inputs being the probability of exercise of conversion and cash redemption features. Significant judgment is employed in determining the appropriateness of certain of these inputs.

Loss on Extinguishment of Convertible Loan Notes

On March 15, 2021, we issued 28,957 Series B preferred shares, or Series B Shares, amounting to $125.2 million. Each Series B Share is convertible into 309 ordinary shares and nine deferred shares at the holders’ option at any time. The Series B funding constituted a qualified equity financing in accordance with the terms of the convertible loan notes. As a result, the convertible loan notes were converted on March 15, 2021 into 12,421 Series B Shares with the conversion price being 0.8 times the Series B Shares issue price.

The conversion was accounted for as an extinguishment of the convertible loan notes. As a result, the 12,421 Series B preferred shares issued on conversion was recognized at the settlement-date fair value of the Series B shares and a loss was recognized in earnings for the difference between (1) the fair value of those shares and (2) the sum of the carrying amounts of the convertible loan notes and the bifurcated conversion and redemption feature liability.

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Interest Expense

Interest expense results primarily from our convertible loan notes, which carry a market rate of interest. These notes were issued between July and November 2020 and converted on March 15, 2021 into 12,421 Series B Shares with the conversion price being 0.8 times the Series B Shares issue price.

Research and Development Incentives

Research and development incentives contain payments we received from the United Kingdom and Australian governments related to corporation tax relief on research and development projects incentive programs in the United Kingdom and Australia. We account for such relief received as other income.

Critical Accounting Policies and Use of Estimates

This discussion and analysis of financial condition and results of operations is based on our financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States, or US GAAP. The preparation of financial statements requires management to make estimates and judgments that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities as of the date of the financial statements and the reported amounts of expenses during the reporting period. On an ongoing basis, management evaluates its estimates, including those related to accruals for external manufacturing of clinical trial material as well as clinical study conduct, fair value of assets and liabilities, and the fair value of ordinary shares and share-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates.

While our significant accounting policies are more fully described in Note 2 to our annual consolidated financial statements for the year ended December 31, 2020 included in our prospectus on Form S-1 dated April 30, 2021, we believe that revenue recognition, accrued research and development expenses, stock based compensation and fair value of stock options and embedded derivatives are most critical to the process of making significant judgments and estimates in the preparation of our financial statements and understanding and evaluating our reported financial results.

Results of Operations

Comparison of the Three Months Ended September 30, 2021 and September 30, 2020

The following table sets forth the significant components of our results of operations (in thousands):

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three | ​ | Three | ​ | ​
​ | ​ | months | ​ | months | ​ | ​
​ | ​ | ended September 30, | ​ | ended September 30, | ​ | ​
​ |  | 2021 |  | 2020 |  | Change
Revenue from Licenses, Grants & Services | ​ | $ | 19 | ​ | $ | 3,251 |  | (3,232)
Operating expenses: | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Research & development | ​ |  | 4,371 | ​ |  | 3,702 |  | 669
General and administrative | ​ |  | 1,184 | ​ |  | 977 |  | 207
Total operating expenses | ​ |  | 5,555 | ​ |  | 4,679 |  | 876
Loss from operations | ​ |  | (5,536) | ​ |  | (1,428) |  | (4,108)
Other income (expense) | ​ |  | ​ | ​ |  |  |  |
Change in fair value of derivatives | ​ |  | — | ​ |  | 3 |  | (3)
Unrealized exchange gain on convertible loan notes | ​ |  | — | ​ |  | 982 |  | (982)
Interest expense | ​ |  | — | ​ |  | (969) |  | (969)
Research and development incentives | ​ |  | 959 | ​ |  | 1,612 |  | (653)
Total other (expense) income | ​ |  | 959 | ​ |  | 1,628 |  | (669)
Tax (expense)/benefit | ​ |  | 7 | ​ |  | — |  | 7
Net (loss)/income | ​ | $ | (4,570) | ​ | $ | 200 |  | (4,770)

​

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Revenue

For the three months ended September 30, 2021, our revenue consisted of license revenue from a research, collaboration and license agreement with Enara Bio. For the three months ended September 30, 2020, our revenue primarily consisted of $2.4 million from the OUI License Agreement Amendment with respect to the AstraZeneca COVID-19 vaccine candidate AZD1222, $0.5 million of reimbursement of research and development expenses from BARDA and $0.1 million of service revenue from a research, collaboration and license agreement with Enara Bio.

Research and Development Expenses

The following table summarizes our research and development expenses for the three months ended September 30, 2021 and September 30, 2020:

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | Three |  | Three |  | ​
​ | ​ | months | ​ | months | ​ | ​
​ | ​ | ended September 30, | ​ | ended September 30, | ​ | ​
​ |  | 2021 |  | 2020 |  | Change
Direct research and development expenses by program: |  | ​ |  |  | ​ |  |  |
VTP-200 HPV |  | ​ | 787 |  | ​ | 739 |  | (48)
VTP-300 HBV |  | ​ | 1,552 |  | ​ | 716 |  | 836
VTP-600 NSCLC |  | ​ | 43 |  | ​ | 218 |  | (175)
VTP-800/850 Prostate cancer |  | ​ | 634 |  | ​ | 25 |  | 609
Other and earlier stage programs |  | ​ | (124) |  | ​ | 997 |  | (1,121)
Internal research and development expenses: |  | ​ |  |  | ​ |  |  |
Personnel-related (including share-based compensation) |  | ​ | 1,376 |  | ​ | 665 |  | 711
Facility related |  | ​ | 96 |  | ​ | 54 |  | 42
Other internal costs |  | ​ | 7 |  | ​ | 287 |  | (280)
Total research and development expense | ​ | $ | 4,371 | ​ | $ | 3,702 |  | 669

​

Our research and development expenses for the three months ended September 30, 2021 and 2020 were $4.4 million and $3.7 million, respectively. Personnel-related expenses were $1.4 million and $0.7 million, respectively, as a result of the relative increase in our headcount across both the UK and US. Direct expenses for outside services and consultants and laboratory materials were $2.9 million for the three months ended September 30, 2021 and $2.7 million for the three months ended September 30, 2020 and mainly comprised of costs for clinical trials, manufacturing of clinical trial materials, as well as costs for external preclinical services and sample testing. The Other and earlier stage programs for the three months ended September 30, 2021 include a refund of $0.3 million received in respect of the closure of the MVA-based influenza prophylactic, VTP-100, which did not meet defined primary clinical endpoints in 2020.

General and Administrative Expenses

General and administrative expenses for the three months ended September 30, 2021 were $1.2 million, which were mainly attributable to personnel expenses of $4.4 million, including the share-based payment charge of $2.9 million, insurance costs of $1.8 million and legal and professional fees of $0.8 million, netted by unrealized foreign exchange gain on cash revaluation of $5.8 million. For the three months ended September 30, 2020, general and administrative expenses were $1.0 million, including personnel expenses of $0.7 million, and professional fees and consulting fees of $0.3 million.

Research and Development Incentives

For the three months ended September 30, 2021 and 2020, we accrued research and development incentives of $1.0 million and $1.6 million, respectively. Such research and development incentives relate to corporation tax relief on research and development projects incentive programs in the United Kingdom. We account for such relief received as other income.

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Comparison of the Nine Months Ended September 30, 2021 and September 30, 2020

The following table sets forth the significant components of our results of operations (in thousands):

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months | ​ | Nine months | ​ | ​
​ | ​ | ended September | ​ | ended September | ​ | ​
​ |  | 30, 2021 |  | 30, 2020 |  | Change
Revenue from Licenses, Grants & Services Operating expenses: | ​ | $ | 269 | ​ | $ | 4,467 |  | (4,198)
Operating expenses: | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Research & development | ​ |  | 13,490 | ​ |  | 11,821 |  | 1,669
General and administrative | ​ |  | 15,332 | ​ |  | 3,059 |  | 12,273
Total operating expenses | ​ |  | 28,822 | ​ |  | 14,880 |  | 13,942
Loss from operations | ​ |  | (28,553) | ​ |  | (10,413) |  | (18,140)
Other income (expense) | ​ |  | ​ | ​ |  | ​ |  | ​
Change in fair value of derivatives | ​ |  | 5,994 | ​ |  | 3 |  | 5,991
Unrealized exchange gain on convertible loan notes | ​ |  | 209 | ​ |  | 982 |  | (773)
Loss on extinguishment of convertible loan notes | ​ |  | (13,789) | ​ |  | — |  | (13,789)
Interest income | ​ |  | 2 | ​ |  | — |  | 2
Interest expense | ​ |  | (2,650) | ​ |  | (969) |  | (1,681)
Research and development incentives | ​ |  | 2,789 | ​ |  | 2,989 |  | (200)
Others | ​ |  | (3) | ​ |  | — |  | (3)
Total other (expenses) income | ​ |  | (7,448) | ​ |  | 3,005 |  | (10,453)
Tax benefit | ​ |  | 60 | ​ |  | — |  | 60
Net loss | ​ | $ | (35,941) | ​ | $ | (7,408) |  | (28,533)

​

Revenue

For the nine months ended September 30, 2021, our revenue primarily consisted of $0.2 million of reimbursement of research and development expenses from BARDA and $0.05 million of license revenue from a research, collaboration and license agreement with Enara Bio. For the nine months ended September 30, 2020, our revenue primarily consisted of $2.4 million from the OUI License Agreement Amendment with respect to the AstraZeneca COVID-19 vaccine candidate AZD1222, $1.4 million of reimbursement of research and development expenses from BARDA and $0.4 million of service revenue from a research, collaboration and license agreement with Enara Bio.

Research and Development Expenses

The following table summarizes our research and development expenses for the nine months ended September 30, 2021 and September 30, 2020:

​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months | ​ | Nine months | ​ | ​
​ | ​ | ended September | ​ | ended September | ​ | ​
​ |  | 30, 2021 |  | 30, 2020 |  | Change
Direct research and development expenses by program: |  | ​ |  |  | ​ |  |  |
VTP-200 HPV |  | ​ | 2,192 |  | ​ | 2,360 |  | (168)
VTP-300 HBV |  | ​ | 4,630 |  | ​ | 2,537 |  | 2,093
VTP-600 NSCLC |  | ​ | 628 |  | ​ | 1,109 |  | (481)
VTP-800/850 Prostate cancer |  | ​ | 1,342 |  | ​ | 25 |  | 1,317
Other and earlier stage programs |  | ​ | 609 |  | ​ | 2,669 |  | (2,060)
Internal research and development expenses: |  | ​ |  |  | ​ |  |  |
Personnel-related (including share-based compensation) |  | ​ | 3,821 |  | ​ | 2,314 |  | 1,507
Facility related |  | ​ | 182 |  | ​ | 165 |  | 17
Other internal costs |  | ​ | 86 |  | ​ | 642 |  | (556)
Total research and development expense | ​ | $ | 13,490 | ​ | $ | 11,821 |  | 1,669

​

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Our research and development expenses for the nine months ended September 30, 2021 and 2020 were $13.5 million and $11.8 million, respectively. Personnel-related expenses were $3.8 million and $2.3 million, respectively, as result of the relative increase in our headcount across both the UK and US. Direct expenses for outside services and consultants and laboratory materials were $9.4 million for the nine months ended September 30, 2021 and $8.7 million for the nine months ended September 30, 2020 and mainly comprised of costs for clinical trials, manufacturing of clinical trial materials, as well as costs for external preclinical services and sample testing. The Other and earlier stage programs for the nine months ended September 30, 2021 includes a refund of $0.3 million received in respect of the closure of the MVA-based influenza prophylactic, VTP-100, which did not meet defined primary clinical endpoints in 2020.

General and Administrative Expenses

General and administrative expenses for the nine months ended September 30, 2021 were $15.3 million, which were mainly attributable to personnel expenses of $15.5 million, including the share-based payment charge of $11.6 million, insurance costs of $3.0 million and legal and professional fees of $2.2 million, netted by unrealized foreign exchange gain on cash balances of $6.2 million. The share-based payment charge includes a one-off expense relating to the RSUs that vested upon the successful completion of our IPO. For the nine months ended September 30, 2020, general and administrative expenses were $3.1 million, including personnel expenses of $3.3 million, and professional fees and consulting fees of $0.7 million, netted by unrealized foreign exchange gains on our cash balances of $0.4 million.

Change in fair value of derivatives

For the nine months ended September 30, 2021, and 2020, we recognized a change in fair value of $6.0 million and $0.003 million, respectively, in relation to the conversion and redemption features embedded in the convertible loan notes.

Loss on extinguishment of convertible loan notes

For the nine months ended September 30, 2021, we recognized a loss of $13.8 million related to conversion of convertible loan notes into 12,421 Series B preferred shares. The loss is a difference between (1) the fair value of those shares ($53.7 million) and (2) the sum of the carrying amounts of the convertible loan notes ($25.6 million) and the bifurcated conversion and redemption feature liability ($14.4 million).

Interest Expense

For the nine months ended September 30, 2021, and 2020, interest expense was $2.7 million and $1.0 million respectively, which primarily relate to our convertible loan notes, which carry a market rate of interest.

Research and Development Incentives

For the nine months ended September 30, 2021 and 2020, we accrued research and development incentives of $2.8 million and $3.0 million, respectively. Such research and development incentives relate to corporation tax relief on research and development projects incentive programs in the United Kingdom. We account for such relief received as other income.

Liquidity and Capital Resources

Sources of Liquidity

Since our inception, we have funded our operations primarily through private and public placements of our ordinary and preferred shares as well as from grants and research incentives, various agreements with public funding agencies, and most recently from an upfront payment from OUI in connection with the OUI License Agreement Amendment and the issuance of convertible loan notes. Through September 30, 2021, we had received gross proceeds of approximately $324.8 million from the issuance of our ordinary and preferred shares and convertible loan notes. As of September 30, 2021, we had cash and cash equivalents of $233.9 million. Key financing and corporate milestones include the following:

● | In March 2016, we raised gross proceeds of approximately $14.0 million from the issuance of our seed round of ordinary shares.

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● | Between November 2017 and December 2018, we raised gross proceeds of $33.9 million from the issuance of our Series A Shares.

● | Between July 2020 and November 2020, we raised gross proceeds of $41.2 million from the issuance of convertible loan notes.

● | In March 2021, we raised gross proceeds of $125.2 million from the issuance of our Series B shares.

● | In May 2021, we raised gross proceeds of $110.5 million from the initial public offering of our ordinary shares on NASDAQ.

We do not expect positive cash flows from operations in the foreseeable future, if at all. Historically, we have incurred operating losses as a result of ongoing efforts to develop our heterologous ChAdOx1-MVA prime-boost immunotherapy platform and our product candidates, including conducting ongoing research and development, preclinical studies, clinical trials, providing general and administrative support for these operations and developing our intellectual property portfolio. We expect to continue to incur net operating losses for at least the next few years as we progress clinical development, seek regulatory approval, prepare for and, if approved, proceed to manufacture and commercialization of our most advanced product candidates. Operating profits may arrive earlier if programs are licensed or sold to third parties before final approval, but this cannot be guaranteed.

Cash Flows

The following table sets forth a summary of the primary sources and uses of cash (in thousands) for each period presented:

​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Nine months | ​ | Nine months
​ | ​ | ended September | ​ | ended September
​ |  | 30, 2021 |  | 30, 2020
Net cash used in operating activities | ​ | $ | (24,611) | ​ | $ | (6,132)
Net cash used in investing activities | ​ |  | (722) | ​ |  | (98)
Net cash provided by financing activities | ​ |  | 222,733 | ​ |  | 24,954
Effect of exchange rates on cash and cash equivalents | ​ |  | (6,795) | ​ |  | (526)
Net increase (decrease) in cash and cash equivalents | ​ | $ | 190,605 | ​ |  | 18,198

​

Cash Used in Operating Activities

During the nine months ended September 30, 2021, net cash used in operating activities was $24.6 million, primarily resulting from our net loss of $35.9 million, adjusted by fair value gain on embedded derivatives of $6.0 million, loss on conversion of convertible loan notes of $13.8 million, share-based compensation of $12.9 million, non-cash interest expense of $0.8 million, depreciation and amortization of $0.3 million, foreign exchange gain on convertible loan notes of $0.2 million and changes in our operating assets and liabilities, net of $10.2 million. During the nine months ended September 30, 2020, net cash used in operating activities was $6.1 million, primarily resulting from our net loss of $7.4 million, adjusted by share-based compensation of $1.4 million, and changes in our operating assets and liabilities, net of $0.3 million.

Net Cash Used in Investing Activities

During the nine months ended September 30, 2021 and 2020, cash used in investing activities was $0.7 million and $0.1 million, respectively, which resulted from capital expenditures in connection with new labs, improvements to expand our laboratory space and purchases of property and equipment.

Net Cash Provided by Financing Activities

During the nine months ended September 30, 2021, cash provided by financing activities was $222.7 million consisting of $121.8 million of net proceeds from the issuance of Series B shares, $102.8 million of net proceeds from our initial public, offering costs of $2.2million and $0.3 million of proceeds from issuance of shares to noncontrolling interest. During the nine months ended September 30, 2020, cash provided by financing activities was $25.0 million consisting of net proceeds from the issuance of convertible loan notes.

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Effect of exchange rates on cash and cash equivalents

During the nine months ended September 30, 2021 and 2020, the effect of foreign exchange on cash and cash equivalents was $6.8 million and $0.5 million respectively, primarily as a result of fluctuations between the U.S dollar and pound sterling exchange rates.

Future Funding Requirements

To date, we have devoted substantially all of our resources to organizing and staffing our company, business planning, raising capital, undertaking preclinical studies and conducting clinical trials of our product candidates. As a result, we are not yet profitable and have incurred losses in each period since our inception in 2016. As of September 30, 2021, we had an accumulated deficit of $93.5 million. We expect to continue to incur significant losses for the foreseeable future. We anticipate that our expenses will increase substantially as we:

● | pursue the clinical and preclinical development of our current product candidates;

● | use our technologies to advance additional product candidates into preclinical and clinical development;

● | seek marketing authorizations for product candidates that successfully complete clinical trials, if any;

● | attract, hire and retain additional clinical, regulatory, quality control and other scientific personnel;

● | establish our manufacturing capabilities through third parties or by ourselves and scale-up manufacturing to provide adequate supply for clinical trials and commercialization, including any manufacturing finishing and logistics personnel;

● | expand our operational, financial and management systems and increase personnel appropriately, including personnel to support our manufacturing and commercialization efforts and our operations as a public company;

● | maintain, expand, enforce, and protect our intellectual property portfolio as appropriate;

● | establish sales, marketing, medical affairs and distribution teams and infrastructure to commercialize any products for which we may obtain marketing approval and intend to commercialize on our own or jointly;

● | acquire or in-license other companies, product candidates and technologies; and

● | incur additional legal, accounting and other expenses in operating our business, including office expansion and the additional costs associated with operating as a public company.

Even if we succeed in commercializing one or more of our product candidates, we will continue to incur substantial research and development and other expenditure to develop and market additional product candidates. We may encounter unforeseen expenses, difficulties, complications, delays and other factors that may adversely affect our business. The size of our future net losses will depend on the rate of future growth of our expenses combined with our ability to generate revenue. Our prior losses and expected future losses have had and will continue to have an adverse effect on our shareholders’ equity and working capital unless and until eliminated by revenue growth.

We may require substantial additional financing in the future to meet any such unanticipated factors and a failure to obtain this necessary capital could force us to delay, limit, reduce or terminate our product development programs, commercialization efforts or other operations.

Since our foundation, we have invested a significant portion of our efforts and financial resources in research and development activities for our ChAdOx1, ChAdOx2 and MVA technologies and our product candidates derived from these technologies. Preclinical studies and especially clinical trials and additional research and development activities will require substantial funds to complete. We believe that we will continue to expend substantial resources for the foreseeable future in connection with the development of our current product candidates and programs as well as any future product candidates we may elect to pursue, as well as the gradual gaining of control over our required manufacturing capabilities and other corporate functions. These expenditures will

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include costs associated with conducting preclinical studies and clinical trials, obtaining regulatory approvals, and potentially in-house manufacturing and supply, as well as marketing and selling any products approved for sale. In addition, other unanticipated costs may arise as outlined above. Because the outcome of any preclinical study or clinical trial is uncertain and the rate of change of third-party costs is also unpredictable, we cannot reasonably estimate now the actual amounts which will be necessary to complete the development and commercialization of our current or future product candidates successfully.

Our future capital requirements may depend on many factors, including:

● | the scope, progress, results and costs of researching and developing our current and future product candidates and programs, and of conducting preclinical studies and clinical trials;

● | the number and development requirements of other product candidates that we may pursue, and of other indications for our current product candidates that we may pursue;

● | the stability, scale and yield of future manufacturing processes as we scale-up production and formulation of our product candidates either internally or externally for later stages of development and commercialization;

● | the timing of, success achieved and the costs involved in obtaining regulatory and marketing approvals and developing our ability to establish license or sale transactions and/or sales and marketing capabilities, if any, for our current and future product candidates if clinical trials and approval processes are successful;

● | the success of our collaborations with CanSino, CRUK and the Ludwig Institute and any future collaboration partners;

● | the success of OUI’s licensed product candidate with AstraZeneca;

● | our ability to establish and maintain collaborations, strategic licensing or other arrangements and the financial terms of such agreements;

● | the cost to the company of commercialization activities for our current and future product candidates that we may take on, whether alone or with a collaborator;

● | the costs involved in preparing, filing, prosecuting, maintaining, expanding, defending and enforcing patent and other intellectual property claims, including litigation costs and the outcome of such litigation;

● | the timing, receipt and amount of sales of, or royalties or other income from, our future products, if any; and

● | the emergence and success or otherwise of competing oncology and infectious disease therapies and other market developments.

A change in the outcome of any of these or other variables with respect to the development of any of our current and future product candidates could significantly change the costs and timing associated with the development of that product candidate, in either direction. Furthermore, our operating plans may change in the future owing to research outcomes or other opportunities, and we may need additional funds to meet operational needs and capital requirements associated with such altered operating plans.

Based on our research and development plans, we expect that the net proceeds from our IPO, together with our existing cash and cash equivalents, will enable us to fund our operating expenses and capital expenditure requirements into 2024. These estimates are based on assumptions that may prove to be wrong, and we could use our available capital resources more quickly than we expect.

Emerging Growth Company Status

We are an emerging growth company under the Jumpstart Our Business Startups Act of 2012, as amended, or the JOBS Act. As an emerging growth company, we may delay the adoption of certain accounting standards until those standards would otherwise apply to private companies.

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We will remain an emerging growth company until the earliest of (1) the last day of the fiscal year (a) following the fifth anniversary of the date of the closing of our IPO, (b) in which we have total annual gross revenue of at least $1.07 billion, or (c) in which we are deemed to be a “large accelerated filer” as defined in Rule 12b-2 under the Exchange Act, which would occur if the market value of our ADSs held by non-affiliates exceeded $700.0 million as of the prior September 30th, and (2) the date on which we have issued more than $1.0 billion in non-convertible debt securities during the prior three-year period.

Off-Balance Sheet Arrangements

We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements as defined in the rules and regulations of the SEC.

Recent Accounting Pronouncements

A description of recently issued accounting pronouncement that may potentially impact our financial position and results of operations is disclosed in Note 2 to our condensed consolidated financial statements.

Item 3. Quantitative and Qualitative Disclosure About Market Risk

Foreign Currency and Currency Translation

We are subject to the risk of fluctuations in foreign currency exchange rates, specifically with respect to the euro, pound sterling and Australian dollar. Our reporting currency is the U.S. dollar, our functional currency is the pound sterling and the functional currency of our wholly owned foreign subsidiary, Vaccitech Australia Pty, is the Australian dollar. Our cash and cash equivalents as of September 30, 2021 consisted primarily of cash balances held by Vaccitech (UK) Limited in U.S. dollars.

Assets and liabilities are translated into U.S. dollars at the exchange rate in effect on the balance sheet date. Revenue and expenses are translated at the average exchange rate in effect during the period. Translation adjustments are included in the consolidated Balance Sheet as a component of accumulated other comprehensive loss. Adjustments that arise from exchange rate changes on transactions denominated in a currency other than the local currency are included in operating expenses, net in the consolidated Statements of Operations and Comprehensive Loss as incurred.

Interest Rate Sensitivity

We are not currently exposed significantly to market risk related to changes in interest rates, as we have no significant interest-bearing liabilities. We had cash and cash equivalents of $233.9 million as of September 30, 2021, which were primarily held as account balances with banks in the United Kingdom, United States and Australia. A hypothetical 10% relative change in interest rates during any of the periods presented would not have had a material impact on our financial statements.

Item 4. Controls and Procedures

Our management, with the participation of our Chief Executive Officer and Chief Financial Officer, evaluated the effectiveness of our disclosure controls and procedures (as defined in Rule 13a-15(e) of the Securities Exchange Act of 1934, as amended, or the Exchange Act) as of the end of the period covered by this report. Based on that evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures as of the end of the period covered by this report were not effective for the reasons set forth below.

In connection with the reviews and audits of our consolidated financial statements for each of the periods ended December 31, 2019 and 2020, September 30, 2020, and March 31, 2020 and 2021, our management and independent registered public accounting firm identified material weaknesses in our internal control over financial reporting. The material weaknesses related to: (i) our lack of a sufficient number of personnel with an appropriate level of knowledge and experience in the application of U.S. generally accepted accounting principles, or U.S. GAAP, commensurate with our financial reporting requirements; (ii) our IT general control environment has not been sufficiently designed to include appropriate user access rights and (iii) policies and procedures with respect to the review, supervision and monitoring of our accounting and reporting functions were either not designed and in place or not operating effectively. As a result, a number of adjustments to our consolidated financial statements for each of the years ended December 31, 2019 and 2020 were identified and made during the course of the audit process. In addition, our condensed consolidated

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financial statements for the three months ended March 31, 2021 include the correction of an error related to the year ended December 31, 2019.

We are continuing to implement measures designed to improve our internal control over financial reporting to remediate the material weaknesses, including having hired a Chief Financial Officer and Head of Financial Reporting. The additional personnel will oversee the implementation of improved processes and internal controls, build our financial management and reporting infrastructure and further develop and document our accounting policies and financial reporting procedures, including review and supervision. We have also taken measures to address the IT general control environment and expect to implement a new enterprise resource planning system before the year ended December 31, 2021.

Changes in Internal Control over Financial Reporting

Other than the changes intended to remediate the material weaknesses noted above, no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) occurred during the three months ended September 30, 2021 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

PART II - OTHER INFORMATION

Item 1. Legal Proceedings.

From time to time, we may become subject to various legal proceedings and claims that arise in the ordinary course of our business activities. Although the results of litigation and claims cannot be predicted with certainty, as of September 30, 2021, we do not believe we are party to any claim or litigation the outcome of which, if determined adversely to us, would individually or in the aggregate be reasonably expected to have a material adverse effect on our business. Regardless of the outcome, litigation can have an adverse impact on us because of defense and settlement costs, diversion of management resources and other factors.

Item 1A Risk Factors.

There have been no material changes from the risk factors previously disclosed in the Company’s most recent Quarterly Report on Form 10-Q as filed with the SEC on August 12, 2021.

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

This quarterly report contains express or implied forward-looking statements that involve substantial risks and uncertainties. In some cases, you can identify forward-looking statements by the words “may,” “might,” “will,” “could,” “would,” “should,” “expect,” “intend,” “plan,” “objective,” “anticipate,” “believe,” “estimate,” “predict,” “potential,” “continue,” “ongoing,” or the negative of these terms, or other comparable terminology intended to identify statements about the future. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, levels of activity, performance or achievements to be materially different from the information expressed or implied by these forward-looking statements. The forward-looking statements and opinions contained in this quarterly report are based upon information available to our management as of the date of this quarterly report and, while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available relevant information. Forward-looking statements contained in this quarterly report include, but are not limited to, statements about:

● | the success, cost and timing of our product development activities and clinical trials;

● | the timing, scope or likelihood of regulatory filings and approvals, including timing of Investigational New Drug Application and Biological License Application filings for our current and future product candidates, and final U.S. Food and Drug Administration, European Medicines Agency, United Kingdom Medicines and Healthcare products Regulatory Agency or other foreign regulatory authority approval of our current and future product candidates;

● | our ability to develop and advance our current and future product candidates and programs into, and successfully complete, clinical trials;

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● | our ability to establish future or maintain current collaborations or strategic relationships or obtain additional funding;

● | the rate and degree of market acceptance and clinical utility of our current and future product candidates;

● | the ability and willingness of our third-party collaborators to continue research and development activities relating to our product candidates;

● | our and our collaborators’ ability to obtain, maintain, defend and enforce our intellectual property protection for our product candidates, and the scope of such protection;

● | our manufacturing, commercialization and marketing capabilities and strategy;

● | future agreements with third parties in connection with the commercialization of our product candidates and any other approved products;

● | regulatory developments in the United States and foreign countries;

● | competitive companies, technologies and our industry and the success of competing therapies that are or may become available;

● | our ability to attract and retain key scientific or management personnel;

● | our ability to obtain funding for our operations, including funding necessary to complete further development and commercialization of our product candidates;

● | the accuracy of our estimates of our annual total addressable markets, future revenue, expenses, capital requirements and needs for additional financing;

● | our expectations about market trends;

● | our ability to overcome the challenges posed by the COVID-19 pandemic to the conduct of our business; and

● | our expectations regarding the period during which we qualify as an emerging growth company under the Jumpstart Our Business Startups Act of 2012, as amended.

If our forward-looking statements prove to be inaccurate, the inaccuracy may be material. In light of the significant uncertainties in these forward-looking statements, you should not regard these statements as a representation or warranty by us or any other person that we will achieve our objectives and plans in any specified time frame, or at all. We undertake no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. You should read this quarterly report and the documents that we reference in this quarterly report with the understanding that our actual future results may be materially different from what we expect. We qualify all of our forward-looking statements in this quarterly report by these cautionary statements.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

Set forth below is information regarding shares of equity securities sold, and options granted, by us during the three months ended September 30, 2021 that were not registered under the Securities Act.

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Recent Sales of Unregistered Equity Securities

During the period between July 1, 2021 and September 30, 2021, we issued to certain of our employees and advisors, options to purchase an aggregate of 30,900 ordinary shares at an average exercise price of $14.96 per share. We deemed these issuances to be exempt from registration under the Securities Act either in reliance on Rule 701 of the Securities Act as sales and offers under compensatory benefit.

Use of Proceeds from Initial Public Offering

On May 4, 2021, we completed our initial public offering (“IPO”) of 6,500,000 ADSs at a price of $17.00 per ADS for an aggregate offering price of approximately $110.5 million. Morgan Stanley & Co., Jefferies LLC, Barclays Capital Inc., William Blair & Company, L.L.C. and H.C. Wainwright & Co., LLC served as the underwriters of the IPO. The offer and sale of all of the ADSs in the offering were registered under the Securities Act pursuant to a registration statement on Form S-1 (File No. 333-255158), which became effective on April 29, 2021.

We received aggregate net proceeds from the offering of approximately $99.9 million, after deducting underwriting discounts and commissions, as well as other offering expenses. No offering expenses were paid directly or indirectly to any of our directors or officers (or their associates) or persons owning ten percent or more of any class of our equity securities or to any other affiliates.

There has been no material change in our planned use of the net proceeds from the IPO as described in the final prospectus filed with the SEC pursuant to Rule 424(b) under the Securities Act.

Item 3. Defaults Upon Senior Securities.

Not Applicable.

Item 4. Mine Safety Disclosures.

Not Applicable.

Item 5. Other Information.

None.

​

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Item 6. Exhibits.

​

Exhibit Number | Description
3.1 | Articles of Association of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K (File No. 001-40367) filed on May 10, 2021).
10.1* | Lease Agreement dated September 3, 2021 by and among The Harwell Science and Innovation Campus General Partner Limited, The Harwell Science and Innovation Campus Nominee Limited, The Harwell Science and Innovation Campus Limited Partnership and Vaccitech (UK) Limited.
31.1* | Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
31.2* | Certification of Principal Financial Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
32.1** | Certification of Principal Executive Officer and Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
101.INS | XBRL Instance Document
101.SCH | XBRL Taxonomy Extension Schema Document
101.CAL | XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF | XBRL Taxonomy Extension Definition Linkbase Document
101.LAB | XBRL Taxonomy Extension Label Linkbase Document
101.PRE | XBRL Taxonomy Extension Presentation Linkbase Document
104 | Cover Page Data File (the cover page XBRL tags are embedded within the iXBRL document).

* | Filed herewith.

** | This certification will not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liability of that section. Such certification will not be deemed to be incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act, except to the extent specifically incorporated by reference into such filing.

​

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

​

​ | VACCITECH PLC
​ | ​ | ​
Date: November 12, 2021 | By: | /s/ William Enright
​ | ​ | William Enright
​ | ​ | Chief Executive Officer (Principal Executive Officer)
​ | ​ | ​
Date: November 12, 2021 | By: | /s/ Georgy Egorov
​ | ​ | Georgy Egorov
​ | ​ | Chief Financial Officer (Principal Financial
​ | ​ | and Accounting Officer)

​

​

​

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