EX-32.1 8 a4q24krysex321.htm EX-32.1
Exhibit 32.1
CERTIFICATION OF CHIEF EXECUTIVE OFFICER AND CHIEF ACCOUNTING OFFICER
PURSUANT TO
18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
I, Krish S. Krishnan, Chief Executive Officer, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:
1.the Annual Report on Form 10-K for the fiscal year ended December 31, 2024, (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2.information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Krystal Biotech, Inc.

Date: February 19, 2025 | By: |  | /s/ Krish S. Krishnan
|  |  | Krish S. Krishnan
|  |  | President and Chief Executive Officer

I, Kathryn A. Romano, Chief Accounting Officer, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:
1.the Annual Report on Form 10-K for the fiscal year ended December 31, 2024, (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
2.information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Krystal Biotech, Inc.

Date: February 19, 2025 | By: |  | /s/ Kathryn A. Romano
|  |  | Kathryn A. Romano
|  |  | Chief Accounting Officer