10-Q 1 xfor-10q_20190630.htm 10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)

☒ | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2019

or

☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 001-38295

X4 PHARMACEUTICALS, INC.

(Exact name of registrant as specified in its charter)

Delaware | 27-3181608
(State or other jurisdiction of incorporation or organization) | (I.R.S. Employer Identification No.)
955 Massachusetts Avenue, 4th Floor Cambridge, Massachusetts | 02139
(Address of principal executive offices) | (Zip Code)

(857) 529-8300

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class |  | Trading Symbol(s) |  | Name of each exchange on which registered
Common Stock |  | XFOR |  | The Nasdaq Capital Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer | ☐ |  | Accelerated filer | ☐
Non-accelerated filer | ☒ |  | Smaller reporting company | ☒
|  |  | Emerging growth company | ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☒

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

As of August 2, 2019, the registrant had 12,430,434 shares of common stock outstanding.

X4 Pharmaceuticals, Inc.

EXPLANATORY NOTE |  | 3
CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |  | 3
|  | PART I: FINANCIAL INFORMATION |  |
Item 1. |  | FINANCIAL STATEMENTS |  | 5
|  | Condensed Consolidated Balance Sheets (unaudited) as of June 30, 2019 and December 31, 2018 |  | 5
|  | Condensed Consolidated Statements of Operations (unaudited) for the Three and Six Months Ended June 30, 2019 and 2018 |  | 6
|  | Condensed Consolidated Statements of Comprehensive Loss (unaudited) for the Three and Six Months Ended June 30, 2019 and 2018 |  | 7
|  | Condensed Consolidated Statements of Convertible Preferred Stock, Redeemable Common Stock and Stockholders’ Equity (Deficit) (unaudited) for the Three and Six Months Ended June 30, 2019 and 2018 |  | 8
|  | Condensed Consolidated Statements of Cash Flows (unaudited) for the Six Months Ended June 30, 2019 and 2018 |  | 9
|  | Notes to Condensed Consolidated Financial Statements (unaudited) |  | 10
Item 2. |  | MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS |  | 41
Item 3. |  | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK |  | 54
Item 4. |  | CONTROLS AND PROCEDURES |  | 54
|  | PART II: OTHER INFORMATION |  |
Item 1. |  | LEGAL PROCEEDINGS |  | 56
Item 1A. |  | RISK FACTORS |  | 56
Item 2. |  | UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS |  | 56
Item 3. |  | DEFAULTS UPON SENIOR SECURITIES |  | 56
Item 4. |  | MINE SAFETY DISCLOSURES |  | 56
Item 5. |  | OTHER INFORMATION |  | 56
Item 6. |  | EXHIBITS |  | 57
SIGNATURES |  | 59

2

EXPLANATO RY NOTE

On March 13, 2019, X4 Pharmaceuticals, Inc. (formerly Arsanis, Inc), or the Company, completed its business combination in accordance with the terms of the Agreement and Plan of Merger, dated as of November 26, 2018, as amended on December 20, 2018 and March 8, 2019, or the Merger Agreement, by and among the Company, X4 Therapeutics, Inc. (formerly X4 Pharmaceuticals, Inc.) and Artemis AC Corp., a Delaware corporation and a wholly owned subsidiary of the Company, or the Merger Sub, pursuant to which, among other matters, Merger Sub merged with and into X4 Therapeutics, Inc., with X4 Therapeutics, Inc. continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger, or the Merger. Following the Merger, on March 13, 2019, the Company effected a 1-for-6 reverse stock split of its common stock, or the Reverse Stock Split, and changed its name to “X4 Pharmaceuticals, Inc.” Following the completion of the Merger, the business conducted by the Company became primarily the business conducted by X4 Therapeutics, Inc., which is a clinical-stage biopharmaceutical company focused on the research, development and commercialization of novel therapeutics for the treatment of rare diseases.

Unless otherwise noted, all references to common stock share and per share amounts in this Quarterly Report on Form 10-Q have been retroactively adjusted to reflect the conversion of shares in the Merger based on an exchange ratio of 0.5702 and, the Reverse Stock Split. As used herein, the words “the Company,” “we,” “us,” and “our” refer to, for periods following the Merger, X4 Pharmaceuticals, Inc. (formerly Arsanis, Inc.), together with is direct and indirect subsidiaries, and for periods prior to the Merger, X4 Therapeutics, Inc. (formerly X4 Pharmaceuticals, Inc.), and its direct and indirect subsidiaries, as applicable. In addition, the word “Arsanis” refers to the Company prior to the completion of the Merger, and we sometimes refer to X4 Therapeutics, Inc. as “X4.”

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This Quarterly Report includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act, that relate to future events or to our future operations or financial performance. Any forward-looking statement involves known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by such forward-looking statement. Forward-looking statements include statements, other than statements of historical fact, about, among other things:

| • | the progress, scope, cost, duration or results of our development activities, nonclinical studies and clinical trials of mavorixafor (X4P-001), X4P-002 and X4P-003 or any of our other product candidates or programs, such as the target indication(s) for development, the size, design, population, conduct, cost, objective or endpoints of any clinical trial, or the timing for initiation or completion of or availability of results from any clinical trial, including our planned trials for mavorixafor in WHIM syndrome, severe congenital neutropenia, or SCN, and Waldenström macroglobulinemia, or WM, for submission or approval of any regulatory filing or for meeting with regulatory authorities;

| • | the potential benefits that may be derived from any of our product candidates;

| • | the timing of and our ability to obtain and maintain regulatory approval of our existing product candidates, any product candidates that we may develop, and any related restrictions, limitations, or warnings in the label of any approved product candidates;

| • | our plans to research, develop, manufacture and commercialize our product candidates

| • | the timing of our regulatory filings for our product candidates, along with regulatory developments in the United States and other foreign countries;

| • | our commercialization, marketing and manufacturing capabilities and strategy;

| • | our ability to attract and retain qualified employees and key personnel;

| • | our competitive position;

| • | our expectations regarding our ability to obtain and maintain intellectual property protection;

| • | our estimates and expectations regarding future operations, financial position, revenues, costs, expenses, uses of cash, capital requirements or our need for additional financing;

3

| • | our ability to raise capital and

| • | our strategies, prospects, plans, expectations or objectives.

Words such as, but not limited to, “believe,” “expect,” “anticipate,” “estimate,” “forecast,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “targets,” “likely,” “will,” “would,” “could,” “should,” “continue,” “scheduled” and similar expressions or phrases, or the negative of those expressions or phrases, are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Although we believe that we have a reasonable basis for each forward-looking statement contained in this report, we caution you that these statements are based on our estimates or projections of the future that are subject to known and unknown risks and uncertainties and other important factors that may cause our actual results, level of activity, performance, experience or achievements to differ materially from those expressed or implied by any forward-looking statement. These risks, uncertainties and other factors are described in greater detail under the caption “Risk Factors” contained in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, as updated by our Current Report on Form 8-K filed on April 11, 2019 and our subsequent filings under the Exchange Act, and in other filings that we make with the Securities and Exchange Commission, or SEC. As a result of the risks and uncertainties, the results or events indicated by the forward-looking statements may not occur. We caution you not to place undue reliance on any forward-looking statement.

In addition, any forward-looking statement in this Quarterly Report represents our views only as of the date of this quarterly report and should not be relied upon as representing our views as of any subsequent date. We anticipate that subsequent events and developments may cause our views to change. Although we may elect to update these forward-looking statements publicly at some point in the future, we specifically disclaim any obligation to do so, except as required by applicable law. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures or investments we may make.

4

PART I: FINANCIA L INFORMATION

Item 1. | FINANCIAL STATEMENTS

X4 PHARMACEUTICALS, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands, except share and per share amounts)

(Unaudited)

|  | June 30, 2019 |  |  | December 31, 2018 |
Assets |  |  |  |  |  |  |  |
Current assets: |  |  |  |  |  |  |  |
Cash and cash equivalents |  | $ | 90,180 |  |  | $ | 8,134 |
Restricted cash |  |  | 3,163 |  |  |  | — |
Research and development incentive receivable |  |  | 1,708 |  |  |  | — |
Prepaid expenses and other current assets |  |  | 1,598 |  |  |  | 1,205 |
Total current assets |  |  | 96,649 |  |  |  | 9,339 |
Property and equipment, net |  |  | 258 |  |  |  | 241 |
Intangible assets |  |  | 4,900 |  |  |  | — |
Goodwill |  |  | 27,109 |  |  |  | — |
Right-of-use assets |  |  | 2,187 |  |  |  | — |
Restricted cash |  |  | 2,298 |  |  |  | 364 |
Other assets |  |  | 106 |  |  |  | — |
Total assets |  | $ | 133,507 |  |  | $ | 9,944 |
Liabilities, Convertible Preferred Stock, Redeemable Common Stock and Stockholders’ Equity (Deficit) |  |  |  |  |  |  |  |
Current liabilities: |  |  |  |  |  |  |  |
Accounts payable |  | $ | 3,099 |  |  | $ | 2,969 |
Accrued expenses |  |  | 5,094 |  |  |  | 3,251 |
Current portion of lease liability |  |  | 860 |  |  |  | — |
Current portion of long-term debt, net of discount |  |  | 4,151 |  |  |  | 1,687 |
Total current liabilities |  |  | 13,204 |  |  |  | 7,907 |
Preferred stock warrant liability |  |  | — |  |  |  | 4,947 |
Long-term debt, including accretion, net of discount and current portion |  |  | 21,748 |  |  |  | 8,145 |
Deferred rent |  |  | — |  |  |  | 417 |
Lease liability |  |  | 2,369 |  |  |  | — |
Other liabilities |  |  | 18 |  |  |  | 205 |
Total liabilities |  |  | 37,339 |  |  |  | 21,621 |
Commitments and contingencies (Note 9) |  |  |  |  |  |  |  |
Convertible preferred stock (Series Seed, A and B), $0.001 par value; 10,000,000 and 59,413,523 shares authorized as of June 30, 2019 and December 31, 2018, respectively; 0 and 40,079,567 shares issued and outstanding as of June 30, 2019 and December 31, 2018, respectively |  |  | — |  |  |  | 64,675 |
Redeemable common stock, $0.001 par value; 0 and 107,364 shares issued and outstanding as of June 30, 2019 and December 31, 2018, respectively |  |  | — |  |  |  | 734 |
Stockholders’ equity (deficit): |  |  |  |  |  |  |  |
Common stock, $0.001 par value. 33,333,333 and 11,070,776 shares authorized as of June 30, 2019 and December 31, 2018, respectively; 12,429,057 and 351,652 shares issued and outstanding as of June 30, 2019 and December 31, 2018, respectively |  |  | 13 |  |  |  | — |
Additional paid-in capital |  |  | 199,690 |  |  |  | 2,151 |
Accumulated other comprehensive income |  |  | (42 | ) |  |  | — |
Accumulated deficit |  |  | (103,493 | ) |  |  | (79,237 | )
Total stockholders’ equity (deficit) |  |  | 96,168 |  |  |  | (77,086 | )
Total liabilities, convertible preferred stock, redeemable common stock and stockholders’ equity (deficit) |  | $ | 133,507 |  |  | $ | 9,944 |

The accompanying unaudited notes are an integral part of these condensed consolidated financial statements.

5

X4 PHARMACEUTICALS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except share and per share amounts)

(Unaudited)

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  | $ | 8,854 |  |  | $ | 4,755 |  |  | $ | 14,509 |  |  | $ | 9,499 |
General and administrative |  |  | 4,560 |  |  |  | 1,621 |  |  |  | 9,343 |  |  |  | 2,987 |
Total operating expenses |  |  | 13,414 |  |  |  | 6,376 |  |  | $ | 23,852 |  |  |  | 12,486 |
Loss from operations |  |  | (13,414 | ) |  |  | (6,376 | ) |  | $ | (23,852 | ) |  |  | (12,486 | )
Other income (expense): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 394 |  |  |  | 67 |  |  |  | 463 |  |  |  | 136 |
Interest expense |  |  | (512 | ) |  |  | (167 | ) |  |  | (911 | ) |  |  | (336 | )
Change in fair value of preferred stock warrant liability |  |  | — |  |  |  | 283 |  |  |  | (288 | ) |  |  | (309 | )
Change in fair value of derivative liability |  |  | — |  |  |  | 159 |  |  |  | 183 |  |  |  | (406 | )
Other income (expense) |  |  | 149 |  |  |  | — |  |  |  | 149 |  |  |  | — |
Total other income (expense), net |  |  | 31 |  |  |  | 342 |  |  |  | (404 | ) |  |  | (915 | )
Net loss |  |  | (13,383 | ) |  |  | (6,034 | ) |  |  | (24,256 | ) |  |  | (13,401 | )
Accruing dividends on Series A convertible preferred stock |  |  | — |  |  |  | (748 | ) |  |  | (592 | ) |  |  | (1,488 | )
Adjustment to accumulated deficit in connection with repurchase of Series Seed convertible preferred stock |  |  | — |  |  |  | (22 | ) |  |  | — |  |  |  | (22 | )
Net loss attributable to common stockholders |  | $ | (13,383 | ) |  | $ | (6,804 | ) |  | $ | (24,848 | ) |  | $ | (14,911 | )
Net loss per share attributable to common stockholders—basic and diluted |  | $ | (1.02 | ) |  | $ | (14.83 | ) |  | $ | (3.32 | ) |  | $ | (32.53 | )
Weighted average common shares outstanding—basic and diluted |  |  | 13,177,235 |  |  |  | 458,718 |  |  |  | 7,479,178 |  |  |  | 458,346 |

The accompanying unaudited notes are an integral part of these condensed consolidated financial statements.

6

X4 PHARMACEUTICALS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(In thousands)

(Unaudited)

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Net loss |  | $ | (13,383 | ) |  | $ | (6,034 | ) |  | $ | (24,256 | ) |  | $ | (13,401 | )
Other comprehensive loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Currency translation adjustments |  |  | (65 | ) |  |  | — |  |  |  | (42 | ) |  |  | — |
Total comprehensive loss |  | $ | (13,448 | ) |  | $ | (6,034 | ) |  | $ | (24,298 | ) |  | $ | (13,401 | )

The accompanying unaudited notes are an integral part of these condensed consolidated financial statements

7

X4 PHARMACEUTICALS, INC

CONDENSED CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK, REDEEMABLE COMMON STOCK AND STOCKHOLDERS’ EQUITY (DEFICIT)

(In thousands, except share amounts)

(Unaudited)

|  | Series Seed, A and B Convertible Preferred |  |  | Redeemable Common Stock |  |  |  | Common Stock |  |  | Additional Paid-In |  |  | Accumulated Other Comprehensive |  |  | Accumulated |  |  | Total Stockholders’ (Deficit) |
|  | Shares |  |  | Amount |  |  | Shares |  |  | Amount |  |  |  | Shares |  |  | Amount |  |  | Capital |  |  | Income (Loss) |  |  | Deficit |  |  | Equity |
Balance at December 31, 2018 |  |  | 40,079,567 |  |  | $ | 64,675 |  |  |  | 107,364 |  |  | $ | 734 |  |  |  |  | 351,652 |  |  | $ | — |  |  | $ | 2,151 |  |  | $ | — |  |  | $ | (79,237 | ) |  | $ | (77,086 | )
Conversion of redeemable common stock into common stock |  |  | — |  |  |  | — |  |  |  | (107,364 | ) |  |  | (734 | ) |  |  |  | 107,364 |  |  |  | 1 |  |  |  | 733 |  |  |  | — |  |  |  | — |  |  |  | 734 |
Conversion of convertible preferred shares into common stock |  |  | (40,079,567 | ) |  |  | (64,675 | ) |  |  | — |  |  |  | — |  |  |  |  | 3,808,430 |  |  |  | 4 |  |  |  | 64,671 |  |  |  | — |  |  |  | — |  |  |  | 64,675 |
Exchange of common stock in connection with Merger |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,440,582 |  |  |  | 2 |  |  |  | 45,539 |  |  |  | — |  |  |  | — |  |  |  | 45,541 |
Fair value of replacement equity awards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 817 |  |  |  | — |  |  |  | — |  |  |  | 817 |
Reclassification of warrant liability to permanent equity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 5,235 |  |  |  | — |  |  |  | — |  |  |  | 5,235 |
Exercise of stock options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 16,483 |  |  |  | — |  |  |  | 113 |  |  |  | — |  |  |  | — |  |  |  | 113 |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 262 |  |  |  | — |  |  |  | — |  |  |  | 262 |
Currency translation adjustments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 23 |  |  |  |  |  |  |  | 23 |
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | — |  |  |  | (10,873 | ) |  |  | (10,873 | )
Balance at March 31, 2019 |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  |  | 6,724,511 |  |  |  | 7 |  |  |  | 119,521 |  |  |  | 23 |  |  |  | (90,110 | ) |  |  | 29,441 |
Issuance of common stock and prefunded warrants for the purchase of common stock, net of issuance costs of $931 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,670,000 |  |  |  | 6 |  |  |  | 79,291 |  |  |  |  |  |  |  |  |  |  |  | 79,297 |
Exercise of stock options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 700 |  |  |  |  |  |  |  | 5 |  |  |  |  |  |  |  |  |  |  |  | 5 |
Exercise of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 33,846 |  |  |  |  |  |  |  | 440 |  |  |  |  |  |  |  |  |  |  |  | 440 |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 433 |  |  |  |  |  |  |  |  |  |  |  | 433 |
Currency translation adjustments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (65 | ) |  |  |  |  |  |  | (65 | )
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (13,383 | ) |  |  | (13,383 | )
Balance at June 30, 2019 |  |  | — |  |  | $ | - |  |  |  | — |  |  | $ | - |  |  |  |  | 12,429,057 |  |  | $ | 13 |  |  | $ | 199,690 |  |  | $ | (42 | ) |  | $ | (103,493 | ) |  | $ | 96,168 |

|  | Series Seed, A and B Convertible Preferred |  |  | Redeemable Common Stock |  |  |  | Common Stock |  |  | Additional Paid-In |  |  | Accumulated Other Comprehensive |  |  | Accumulated |  |  | Total Stockholders’ (Deficit) |
|  | Shares |  |  | Amount |  |  | Shares |  |  | Amount |  |  |  | Shares |  |  | Amount |  |  | Capital |  |  | Income (Loss) |  |  | Deficit |  |  | Equity |
Balance at December 31, 2017 |  |  | 38,018,968 |  |  | $ | 60,903 |  |  |  | 107,364 |  |  | $ | 734 |  |  |  |  | 350,607 |  |  | $ | — |  |  | $ | 1,385 |  |  | $ | — |  |  | $ | (45,930 | ) |  | $ | (44,545 | )
Repurchase of Series Seed convertible preferred stock, net of issuance costs of $1 |  |  | (598,975 | ) |  |  | (517 | ) |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (22 | ) |  |  | (22 | )
Exercise of stock options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |
Stock-based compensation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 128 |  |  |  |  |  |  |  |  |  |  |  | 128 |
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (7,367 | ) |  |  | (7,367 | )
Balance at March 31, 2018 |  |  | 37,419,993 |  |  |  | 60,386 |  |  |  | 107,364 |  |  |  | 734 |  |  |  |  | 350,607 |  |  |  | — |  |  |  | 1,513 |  |  |  | — |  |  |  | (53,319 | ) |  |  | (51,806 | )
Exercise of stock options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,045 |  |  |  |  |  |  |  | 7 |  |  |  |  |  |  |  |  |  |  |  | 7 |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | — |  |  |  | 145 |  |  |  | — |  |  |  | — |  |  |  | 145 |
Net loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | (6,034 | ) |  |  | (6,034 | )
Balance at June 30, 2018 |  |  | 37,419,993 |  |  | $ | 60,386 |  |  |  | 107,364 |  |  | $ | 734 |  |  |  |  | 351,652 |  |  | $ | - |  |  | $ | 1,665 |  |  | $ | - |  |  | $ | (59,353 | ) |  | $ | (57,688 | )

The accompanying unaudited notes are an integral part of these condensed consolidated financial statements.

8

X4 PHARMACEUTICALS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

(Unaudited)

|  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |
Cash flows from operating activities: |  |  |  |  |  |  |  |
Net loss |  | $ | (24,256 | ) |  | $ | (13,401 | )
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  | 695 |  |  |  | 273 |
Depreciation expense |  |  | 44 |  |  |  | 51 |
Non-cash lease expense |  |  | 244 |  |  |  | — |
Non-cash interest expense |  |  | 369 |  |  |  | 59 |
Change in fair value of preferred stock warrant liability |  |  | 288 |  |  |  | 309 |
Change in fair value of derivative liability |  |  | (183 | ) |  |  | 406 |
Changes in operating assets and liabilities: |  |  |  |  |  |  |  |
Prepaid expenses and other current assets |  |  | 13 |  |  |  | 490 |
Accounts payable |  |  | (1,702 | ) |  |  | (605 | )
Accrued expenses |  |  | (1,157 | ) |  |  | 453 |
Lease liabilities |  |  | (397 | ) |  |  | — |
Net cash used in operating activities |  |  | (26,042 | ) |  |  | (11,965 | )
Cash flows from investing activities: |  |  |  |  |  |  |  |
Cash, cash equivalents and restricted cash acquired in connection with the Merger |  |  | 26,406 |  |  |  | — |
Acquisition of property, plant and equipment |  |  | (10 | ) |  |  | — |
Net cash provided by investing activities |  |  | 26,396 |  |  |  | — |
Cash flows from financing activities: |  |  |  |  |  |  |  |
Proceeds from exercise of stock options and warrants |  |  | 565 |  |  |  | 7 |
Proceeds from borrowings under loan and security agreements, net of issuance costs |  |  | 9,849 |  |  |  | — |
Repurchase of Series Seed convertible preferred stock |  |  | — |  |  |  | (1,160 | )
Repayments of borrowings under loan and security agreement |  |  | (2,914 | ) |  |  | (1,000 | )
Sale of common stock, pre-funded warrants and Class A warrants, net of issuance costs |  |  | 79,291 |  |  |  | — |
Net cash provided by (used in) financing activities |  |  | 86,791 |  |  |  | (2,153 | )
Effect of exchange rate changes on cash, cash equivalents and restricted cash |  |  | (2 | ) |  |  | — |
Net increase (decrease) in cash, cash equivalents and restricted cash |  |  | 87,143 |  |  |  | (14,118 | )
Cash, cash equivalents and restricted cash at beginning of period |  |  | 8,498 |  |  |  | 27,048 |
Cash, cash equivalents and restricted cash at end of period |  | $ | 95,641 |  |  | $ | 12,930 |
Supplemental disclosure of non-cash investing and financing activities: |  |  |  |  |  |  |  |
Issuance costs not yet paid |  | $ | 354 |  |  |  | — |
Conversion of convertible preferred stock into common stock |  | $ | 64,675 |  |  |  | — |
Conversion of redeemable common stock into common stock |  | $ | 734 |  |  |  | — |
Conversion of convertible preferred stock warrants into common stock warrants |  | $ | 5,235 |  |  |  | — |
Fair value of net assets acquired in the Merger |  | $ | 46,358 |  |  |  | — |

The accompanying unaudited notes are an integral part of these condensed consolidated financial statements.

9

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

1. | Nature of the Business and Basis of Presentation

X4 Pharmaceuticals, Inc. (formerly Arsanis, Inc.), together with its subsidiaries (the “Company”), is a clinical-stage biotechnology company focused on the research, development and commercialization of novel therapeutics for the treatment of rare diseases. The Company’s lead product candidate, mavorixafor (X4P-001), is a potential first-in-class, once-daily, oral inhibitor of CXCR4 and is currently in Phase 3 development for treatment of WHIM syndrome, a rare, inherited, primary immunodeficiency disease caused by genetic mutations in the CXCR4 receptor gene. The Company is headquartered in Cambridge, Massachusetts.

The Company is subject to risks and uncertainties common to early-stage companies in the biotechnology industry, including, but not limited to, development by competitors of new technological innovations, dependence on key personnel, protection of proprietary technology, compliance with governmental regulations and the ability to secure additional capital to fund operations. Drug candidates currently under development will require extensive preclinical and clinical testing and regulatory approval prior to commercialization. These efforts require significant amounts of additional capital, adequate personnel, and infrastructure and extensive compliance-reporting capabilities. Even if the Company’s drug development efforts are successful, it is uncertain when, if ever, the Company will realize significant revenue from product sales.

Merger with Arsanis

On November 26, 2018, Arsanis, Inc., a publicly held Delaware corporation (“Arsanis”), Artemis AC Corp., a Delaware corporation and a wholly owned subsidiary of Arsanis (“Merger Sub”), and X4 Therapeutics, Inc. (“X4”) entered into an Agreement and Plan of Merger, as amended on December 20, 2018 and March 8, 2019 (the “Merger Agreement”), pursuant to which the Merger Sub merged with and into X4, with X4 surviving the merger as a wholly owned subsidiary of Arsanis. The transactions described in the foregoing sentence may be referred to in these condensed consolidated financial statements as “the Merger.”

The transaction was accounted for as a reverse merger in accordance with GAAP. Under this method of accounting, X4 was deemed to be the accounting acquirer for financial reporting purposes. This determination was primarily based on the facts that, immediately following the Merger: (i) the Company’s stockholders own a substantial majority of the voting rights in the combined organization, (ii) the Company designated a majority of the members of the initial board of directors of the combined organization and (iii) the Company’s senior management hold all key positions in the senior management of the combined organization. Accordingly, for accounting purposes, the business combination was treated as the equivalent of X4 issuing stock to acquire the net assets of Arsanis. As a result, as of the closing date of the Merger, the net assets of Arsanis were recorded at their acquisition-date fair values in the financial statements of the Company and the reported operating results prior to the business combination will be those of the Company. In addition, transaction costs incurred by the Company in connection with the business combination will be expensed as incurred.

On March 13, 2019, Arsanis, X4 and Merger Sub completed the Merger pursuant to the terms of the Merger Agreement. Pursuant to the terms of the Merger Agreement, each outstanding share of X4’s common stock and preferred stock was exchanged for 0.5702 shares of Arsanis’s common stock (the “Exchange Ratio”). In addition, all outstanding options exercisable for common stock and warrants exercisable for convertible preferred stock of X4 became options and warrants exercisable for the same number of shares of common stock of Arsanis multiplied by the Exchange Ratio. In connection with the Merger, X4 changed its name to X4 Therapeutics, Inc. Following the closing of the Merger, X4 Therapeutics, Inc. became a wholly owned subsidiary of the Company, which changed its name to X4 Pharmaceuticals, Inc. As used herein, the words “the Company” refers to, for periods following the Merger, X4 Pharmaceuticals, Inc. (formerly Arsanis, Inc.), together with is direct and indirect subsidiaries, and for periods prior to the Merger, X4 Therapeutics, Inc. (formerly X4 Pharmaceuticals, Inc.), and its direct and indirect subsidiaries, as applicable.

Immediately following the Merger, stockholders of X4 owned approximately 63.7% of the combined organization’s outstanding common stock. On March 14, 2019, the combined organization’s common stock began trading on The Nasdaq Capital Market under the ticker symbol “XFOR.”

10

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Reverse Stock Split--- On March 13, 2019, immediately following the closing of the Merger, the Company effected a 1-for-6 reverse stock split of its common stock (the “Reverse Stock Split”). Accordingly, all share and per share amounts for all periods presented in the a ccompanying condensed consolidated financial statements and notes thereto have been adjusted retroactively, where applicable, to reflect the Reverse Stock Split. No fractional shares were issued in connection with the Reverse Stock Split. Unless otherwise noted, all references to common stock share and per share amounts have also been adjusted to reflect the exchange ratio of 0.5702.

Going Concern Assessment--- In accordance with Accounting Standards Update (“ASU”) No. 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern (Subtopic 205-40), the Company has evaluated whether there are certain conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that the consolidated financial statements are issued. As of August 6, 2019, the issuance date of these condensed consolidated financial statements, the Company expects that its cash and cash equivalents will be sufficient to fund its forecasted operating expenses, capital expenditure requirements and debt service payments for at least the next twelve months from the issuance of these financial statements. The future viability of the Company beyond that point is dependent on its ability to raise additional capital to finance its operations.

If the Company is unable to obtain funding, the Company will be forced to delay, reduce or eliminate some or all of its research and development programs, product portfolio expansion or pre-commercialization efforts, which could adversely affect its business prospects, or the Company may be unable to continue operations. Although management continues to pursue these plans, there is no assurance that the Company will be successful in obtaining sufficient funding on terms acceptable to the Company to fund continuing operations, if at all.

2. | Summary of Significant Accounting Policies

Unaudited Interim Financial Statements--- The condensed balance sheet at December 31, 2018 was derived from audited financial statements but does not include all disclosures required by GAAP. The accompanying condensed consolidated financial statements are unaudited. The accompanying unaudited interim consolidated financial statements have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim financial statements. Accordingly, certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. However, the Company believes that the disclosures are adequate to make the information presented not misleading. These unaudited condensed financial statements should be read in conjunction with the Company’s audited financial statements and the notes thereto for the year ended December 31, 2018. In the opinion of management, all adjustments, consisting only of normal recurring adjustments as necessary, for the fair statement of the Company’s condensed financial position, condensed results of its operations and cash flows have been made. The results of operations for the three and six months ended June 30, 2019 are not necessarily indicative of the results of operations that may be expected for the year ending December 31, 2019.

Use of Estimates--- The preparation of the Company’s condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, and the reported amounts of expenses during the reporting period. Significant estimates and assumptions reflected in these consolidated financial statements include, but are not limited to, the accrual of research and development expenses, the valuation of intangible assets acquired in business combinations, the valuations of common stock prior to the Merger, the valuation of stock options, preferred stock warrants (and the resulting preferred stock warrant liability), derivative instruments (and the resulting derivative liability), and the preferred stock repurchase liability, and valuation of lease liabilities. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. On an ongoing basis, management evaluates its estimates when there are changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. Actual results could differ from those estimates.

Principles of Consolidation--- The condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries, including X4 Pharmaceuticals (Austria) GmbH, which is incorporated in Vienna, Austria and was formerly named Arsanis Biosciences GmbH (“X4 GmbH”), and X4 Therapeutics, Inc. All significant intercompany accounts and transactions have been eliminated.

10

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Foreign Currency and Currency Translation--- Management has determined that the functional currency for the Company’s wholly owned foreign subsidiary, X4 GmbH, is the e uro. Management’s assessment considered the currency environment in which the entity operates, including inflows of cash from research and development incentive programs and outflows of cash for operating expenditure. Accordingly, the assets and liabilities of X4 GmbH are translated from the e uro into U.S. dollars at the exchange rate in effect on the balanc e sheet date and income and expenses are translated at the average exchange rate in effect during the period. Unrealized translation gains and losses are recorded as a cumulative translation adjustment, which is included in the consolidated balance sheet a s a component of accumulated other comprehensive income (loss). Adjustments that arise from exchange rate changes on transactions denominated in a currency other than the e uro are included in other income (expense), net in the consolidated statements of op erations as incurred.

Concentrations of Credit Risk and Significant Suppliers--- Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash and cash equivalents and research and development incentive receivables. The Company generally maintains cash balances in various operating accounts at financial institutions that management believes to be of high credit quality in amounts that may exceed federally insured limits. The Company has not experienced losses related to its cash and cash equivalents.

The Company is dependent on third-party manufacturers to supply products for research and development activities in its programs. The Company relies and expects to continue to rely on a small number of manufacturers to supply it with its requirements for the active pharmaceutical ingredients and formulated drugs related to these programs. These programs could be adversely affected by a significant interruption in these manufacturing services or in the supply of active pharmaceutical ingredients and formulated drugs.

Cash and Cash Equivalents--- The Company considers all highly liquid investments with maturities of three months or less at the date of purchase to be cash equivalents. Cash equivalents consisted of money market funds as of June 30, 2019 and December 31, 2018.

Restricted Cash and Compensating Balance Arrangements---

|  | As of June 30, 2019 |  |  | As of December 31, 2018 |
Letter of credit security: Cambridge Lease (a) |  | $ | 264 |  |  | $ | 264 |
Letter of credit security: Waltham Lease (b) |  |  | 250 |  |  |  | — |
Letter of credit security: Vienna Austria Lease (c) |  |  | 95 |  |  |  | — |
Corporate credit card collateral (d) |  |  | 150 |  |  |  | 100 |
Compensating balance arrangement (e) |  |  | 1,539 |  |  |  |  |
Total restricted cash (non-current) |  | $ | 2,298 |  |  | $ | 364 |

(a) | In connection with the Company’s lease agreement for its facility in Cambridge, Massachusetts, the Company maintains a letter of credit of $264, which is secured by restricted cash, for the benefit of the landlord.

(b) | The Company maintains a letter of credit, which is secured by a restricted cash amount of $250 as of June 30, 2019, for the benefit of the landlord in connection with a leased facility in Waltham, Massachusetts.

(c) | In connection with the Company’s lease agreement for its laboratory and office facility in Vienna, Austria, the Company maintains a letter of credit of $95, which is secured by restricted cash, for the benefit of the landlord.

(d) | As of June 30, 2019 and December 31, 2018, the Company was required to maintain a separate cash balance of $150 and $100, respectively, to collateralize corporate credit cards with a bank.

(e) | In accordance with the Company’s loan agreement with Österreichische Forschungsförderungsgesellschaft mbH (“FFG”), as amended (see Note 7), the Company must maintain a cash balance of at least 70% of the outstanding principal of the FFG loan in a local Austrian bank account. As of June 30, 2019, non-current restricted cash includes 70% of the non-current portion of the FFG loan. In addition, 70% of the current portion of the FFG loan, or $3,163, is classified as current restricted cash on the Company’s consolidated balance sheet as of June 30, 2019.

11

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

In accordance with the Company’s Amended and Restated Loan Agreement with Hercules Capital, Inc. (“Hercules”) as further described in Note 7, the Company is required to maintain cash in an account accessible by the lender in an amount not less than 125% of the outstanding loan balance, or if the Company’s consolidated cash is lo wer than this amount, all of the Company’s cash other than $2,500. As of June 30, 2019, the Company maintained $25,000 in an account accessible by the lender in accordance with the terms of Amended and Restated Loan Agreement. The underlying cash subject t o these compensating balance agreements is classified within cash and cash equivalents on the consolidated balance sheet.

The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the condensed consolidated balance sheets to the sum to the total of amounts shown in the Company’s condensed consolidated statement of cash flows as of June 30, 2019, December 31, 2018, June 30, 2018 and December 31, 2017:

|  | June 30, 2019 |  |  | December 31, 2018 |  |  | June 30, 2018 |  |  | December 31, 2017 |
Cash and cash equivalents |  | $ | 90,180 |  |  | $ | 8,134 |  |  | $ | 12,566 |  |  | $ | 26,684 |
Restricted cash, current portion |  |  | 3,163 |  |  |  | — |  |  |  | — |  |  |  | — |
Restricted cash, non-current portion |  |  | 2,298 |  |  |  | 364 |  |  |  | 364 |  |  |  | 364 |
Total cash, cash equivalents and restricted cash |  | $ | 95,641 |  |  | $ | 8,498 |  |  | $ | 12,930 |  |  | $ | 27,048 |

Property and Equipment--- Property and equipment are stated at cost less accumulated depreciation and amortization. Depreciation and amortization expense is recognized using the straight-line method over the estimated useful life of each asset, as follows:

|  | Estimated Useful Life
Office furniture |  | 3 years
Computer equipment |  | 3 years
Software |  | 3 years
Laboratory equipment |  | 3 to 10 years
Leasehold improvements |  | Shorter of lease term or 10 years

Estimated useful lives are periodically assessed to determine if changes are appropriate. Maintenance and repairs are charged to expense as incurred. When assets are retired or otherwise disposed of, the cost of these assets and related accumulated depreciation or amortization are eliminated from the consolidated balance sheet and any resulting gains or losses are included in the consolidated statements of operations and comprehensive loss in the period of disposal. Costs for capital assets not yet placed into service are capitalized as construction-in-progress and depreciated once placed into service.

Right-of-Use Assets and Leases--- Effective January 1, 2019, the Company adopted Accounting Standards Codification (“ASC”), Topic 842, Leases (“ASC 842”), using the modified retrospective approach through a cumulative-effect adjustment and utilizing the effective date as its date of initial application, with prior periods unchanged and presented in accordance with the guidance in Topic 840, Leases (“ASC 840”).

At the inception of an arrangement, the Company determines whether the arrangement contains a lease based on the unique facts and circumstances present. Leases with a non-cancellable term greater than one year are recognized on the balance sheet as right-of-use assets, lease liabilities and long-term lease liabilities. The Company has elected not to recognize on the balance sheet leases with terms of one year or less. Options to renew a lease are not included in the Company’s initial lease term assessment unless there is reasonable certainty that the Company will renew the lease. If a lease is cancellable without penalty, the Company excludes from the lease term periods following the cancellation notice period unless it is reasonably certain that the Company will not cancel the lease.

Operating lease liabilities and their corresponding right-of-use assets are recorded based on the present value of lease payments over the expected remaining lease term. Certain adjustments to the right-of-use operating asset may be required for items such as incentives received or accrued rent. The interest rate implicit in lease contracts is typically not readily determinable. As a result, the Company utilizes its incremental borrowing rates, which are the rates it incurs to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment.

12

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

In accordance with the g uidance in ASC 842, components of a lease are split into lease components and non-lease components. A policy election is available pursuant to which an entity may elect to not separate lease and non-lease components. Rather, each lease component and the re lated non-lease components are accounted for together as a single component. For new and amended leases beginning in 2019 and after, the Company has elected to account for the lease and non-lease components as a combined lease component for its office and laboratory building leases.

Impairment of Long-Lived Assets--- Long-lived assets consist of property and equipment. Long-lived assets to be held and used are tested for recoverability whenever events or changes in business circumstances indicate that the carrying amount of the assets may not be fully recoverable. Factors that the Company considers in deciding when to perform an impairment review include significant underperformance of the business in relation to expectations, significant negative industry or economic trends and significant changes or planned changes in the use of the assets. If an impairment review is performed to evaluate a long-lived asset group for recoverability, the Company compares forecasts of undiscounted cash flows expected to result from the use and eventual disposition of the long-lived asset group to its carrying value. An impairment loss would be recognized in loss from operations when estimated undiscounted future cash flows expected to result from the use of an asset group are less than its carrying amount. The impairment loss would be based on the excess of the carrying value of the impaired asset group over its fair value. To date, the Company has not recorded any impairment losses on long-lived assets.

Goodwill--- Business combinations are accounted for under the acquisition method. The total purchase price of an acquisition is allocated to the underlying identifiable net assets, based on their respective estimated fair values as of the acquisition date. Determining the fair value of assets acquired and liabilities assumed requires management’s judgment and often involves the use of significant estimates and assumptions, including assumptions with respect to future cash inflows and outflows, probabilities of success, discount rates, and asset lives, among other items. Assets acquired and liabilities assumed are recorded at their estimated fair values. The excess of the purchase price over the estimated fair values of the net assets acquired is recorded as goodwill.

Goodwill is tested for impairment at the reporting unit level annually in the fourth quarter, or more frequently when events or changes in circumstances indicate that the asset might be impaired. Examples of such events or circumstances include, but are not limited to, a significant adverse change in legal or business climate, an adverse regulatory action or unanticipated competition. The Company has determined that it operates in a single operating segment and has a single reporting unit.

The Company assesses qualitative factors to determine whether the existence of events or circumstances would indicate that it is more likely than not that the fair value of the reporting unit was less than its carrying amount. If after assessing the totality of events or circumstances, the Company were to determine that it is more likely than not that the fair value of the reporting unit is less than its carrying amount, then the Company would perform a quantitative impairment test.

The Company compares the fair value of the reporting unit to its carrying value. If the fair value of the reporting unit exceeds the carrying value of the net assets, goodwill is not impaired, and no further testing is required. If the fair value of the reporting unit is less than the carrying value, the Company measures the amount of impairment loss, if any, as the excess of the carrying value over the fair value of the reporting unit. The Company has determined there were no indicators of goodwill impairment as of June 30, 2019.

Intangible Assets--- The Company acquired certain in-process research and development assets (“IPR&D”), which are classified as indefinite-lived intangible assets. Acquired IPR&D represents the fair value assigned to research and development assets that the Company acquires and have not been completed at the acquisition date. The fair value of IPR&D acquired in a business combination is recorded on the Company’s consolidated balance sheets at the acquisition-date fair value and is determined by estimating the costs to develop the technology into commercially viable products, estimating the resulting revenue from the projects, and discounting the projected net cash flows to present value. IPR&D is not amortized, but rather is reviewed for impairment on an annual basis or more frequently if indicators of impairment are present, until the project is completed, abandoned or transferred to a third party. If the Company determines that IPR&D becomes impaired or is abandoned, the carrying value is written down to its fair value with the related impairment charge recognized in the Company’s consolidated statement of operations in the period in which the impairment occurs. Upon successful completion of each project and launch of the product, the Company would make a separate determination of the estimated useful life of the IPR&D intangible asset and the related amortization will be recorded as an expense prospectively over its estimated useful life.

13

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

The projected discounted cash flow models used to estimate the Company’s IPR&D refl ect significant assumptions regarding the estimates a market participant would make in order to evaluate a drug development asset, including the following:

| • | Probability of successfully completing clinical trials and obtaining regulatory approval;

| • | Market size, market growth projections, and market share;

| • | Estimates regarding the timing of and the expected costs to advance the Company’s clinical programs to commercialization;

| • | Estimates of future cash flows from potential product sales; and

| • | A discount rate.

Additionally, to the extent the Company acquires other indefinite-lived intangible assets through its business combinations, these assets are reviewed for impairment on an annual basis or more frequently if indicators of impairment are present. If the Company determines that the asset becomes impaired, the carrying value is written down to its fair value with the related impairment charge recognized in its consolidated statements of operations in the period in which the impairment occurs.

Deferred Rent--- The Company’s lease agreements include payment escalations and lease incentives (including a leasehold improvement tenant allowance). For periods prior to January 1, 2019, these payments were accrued or deferred as appropriate such that rent expense was recognized on a straight-line basis over the respective lease terms. Effective January 1, 2019, upon the adoption of ASC 842, deferred rent was reclassified as a reduction to the applicable right-of-use asset as further described in Note 8.

Fair Value Measurements--- Certain assets and liabilities of the Company are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy, of which the first two are considered observable and the last is considered unobservable:

| • | Level 1—Quoted prices in active markets for identical assets or liabilities.

| • | Level 2—Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable market data.

| • | Level 3—Unobservable inputs that are supported by little or no market activity that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques.

Prior to the Merger, the Company’s preferred stock warrant liability, derivative liability and preferred stock repurchase liability were carried at fair value, determined according to Level 3 inputs in the fair value hierarchy described above (See Note 4). The Company’s cash equivalents, consisting of money market funds invested in U.S. Treasury securities, are carried at fair value, determined based on Level 2 inputs in the fair value hierarchy described above (see Note 4). The carrying values of the Company’s accounts payable and accrued expenses approximate their fair values due to the short-term nature of these liabilities. The carrying value of the Company’s outstanding loan and security agreement (the “Hercules Loan Agreement”) with Hercules approximates its fair value at June 30, 2019 because the debt bears interest at a variable market rate and the Company’s credit risk has not materially changed since the inception of the agreement. The carrying value of the Company’s loans under the funding agreements with FFG were recorded at fair value on the opening balance sheet of Arsanis as of the date of the Merger and approximates the fair value of the loans at June 30, 2019. (See Note 3).

Segment Information--- The Company manages its operations as a single operating segment for the purposes of assessing performance and making operating decisions. The Company’s focus is on the research, development and commercialization of novel therapeutics for the treatment of rare diseases.

14

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Revenue Recognition--- Effective January 1, 2018, the Company adopted ASC Topic 606, Revenue from Contracts with Customers (“ASC 606”), using the modified retrospective tran sition method. The modified retrospective method requires that the cumulative effect of initially applying ASC 606 be recognized as an adjustment to the opening balance of retained earnings or accumulated deficit of the annual period that includes the date of initial application. The Company had no arrangements that were in the scope of ASC 606 on January 1, 2018 and thus there was no impact to the condensed consolidated financial statements as a result of the adoption. This standard applies to all contract s with customers, except for contracts that are within the scope of other standards, such as collaboration arrangements and leases. Prior to completion of the Merger, Arsanis entered into a single out-licensing agreement with Janssen Pharmaceuticals, Inc. (see Note 13) that was within the scope of ASC 606. The revenue associated with this arrangement is not reflected in the consolidated financial statements of the Company as it occurred prior to the Merger.

Research and Development Programs--- Proceeds under the research and development incentive program from the Austrian government are recognized as other income in an amount equal to the qualifying expenses incurred in each period multiplied by the applicable reimbursement percentage. Incentive income recognized upon incurring qualifying expenses in advance of receipt of proceeds from research and development incentives is recorded in the consolidated balance sheet as research and development incentive receivable.

Research and Development Costs--- Costs associated with internal research and development and external research and development services, including drug development and preclinical studies, are expensed as incurred. Research and development expenses include costs for salaries, employee benefits, subcontractors, facility-related expenses, depreciation and amortization, stock-based compensation, third-party license fees, laboratory supplies, and external costs of outside vendors engaged to conduct discovery, preclinical and clinical development activities and clinical trials as well as to manufacture clinical trial materials, and other costs. The Company recognizes external research and development costs based on an evaluation of the progress to completion of specific tasks using information provided to the Company by its service providers.

Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are recorded as prepaid expenses. Such prepaid expenses are recognized as an expense when the goods have been delivered or the related services have been performed, or when it is no longer expected that the goods will be delivered or the services rendered.

Upfront payments, milestone payments and annual maintenance fees under license agreements are expensed in the period in which they are incurred.

Patent Costs--- All patent-related costs incurred in connection with filing and prosecuting patent applications are expensed as incurred due to the uncertainty about the recovery of the expenditure. Amounts incurred are classified as general and administrative expenses.

Debt Issuance Costs--- Debt issuance costs consist of payments made to secure commitments under certain debt financing arrangements. These amounts are recognized as interest expense over the period of the financing arrangement using the effective interest method. If the financing arrangement is canceled or forfeited, or if the utility of the arrangement to the Company is otherwise compromised, these costs are recognized as interest expense immediately. The Company’s consolidated financial statements present debt issuance costs related to a recognized debt liability as a direct reduction from the carrying amount of that debt liability.

Stock-Based Compensation---The Company measures all stock-based awards granted to employees and directors based on the fair value on the date of the grant and recognizes compensation expense for those awards, net of estimated forfeitures, over the requisite service period, which is generally the vesting period of the respective award. The Company issues stock-based awards with only service-based vesting conditions and records the expense for these awards using the straight-line method. The Company has not issued any stock-based awards with performance-based vesting conditions.

Effective January 1, 2019, the Company adopted ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting (“ASU 2018-07”), which expands the scope of Topic 718 to include share-based payment awards to nonemployees. As a result, stock-based awards granted to consultants and non-employees are accounted for in the same manner as awards granted to employees and directors as described above. The impact of adoption this new guidance did not have a material impact on the Company’s consolidated financial statements. Prior to the adoption of ASU 2018-07, for stock-based awards granted to non-employee consultants, compensation expense was recognized over the period during which services were rendered by such non-employee consultants until completed. At the end of each financial reporting period prior to completion of the service, the fair value of these awards was remeasured using the then-current fair value of the Company’s common stock and updated assumption inputs in the Black-Scholes option-pricing model.

15

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

The Company classifies stock-based compensation expense in its consolidated statement of operations in the same manner in which the award recipient’s payroll costs are cla ssified or in which the award recipient’s service payments are classified.

The Company recognizes compensation expense for only the portion of awards that are expected to vest. In developing a forfeiture rate estimate, the Company has considered its historical experience to estimate pre-vesting forfeitures for service-based awards. The impact of a forfeiture rate adjustment will be recognized in full in the period of adjustment, and if the actual forfeiture rate is materially different from the Company’s estimate, the Company may be required to record adjustments to stock-based compensation expense in future periods.

The fair value of each stock option grant is estimated on the date of grant using the Black-Scholes option-pricing model. Prior to March 13, 2019, the Company had been a private company and lacked company-specific historical and implied volatility information for its common stock. Therefore, the Company estimates its expected common stock price volatility based on the historical volatility of publicly traded peer companies and expects to continue to do so until it has adequate historical data regarding the volatility of its own traded stock price. The expected term of the Company’s stock options has been determined utilizing the “simplified” method for awards that qualify as “plain-vanilla” options. The expected term of stock options granted to non-employee consultants is equal to the contractual term of the option award. The risk-free interest rate is determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award for time periods approximately equal to the expected term of the award. Expected dividend yield considers the fact that the Company has never paid cash dividends on common stock and does not expect to pay any cash dividends in the foreseeable future.

Preferred Stock Warrant Liability--- Prior to the Merger with Arsanis, the Company classified warrants for the purchase of shares of its convertible preferred stock (see Note 10) as a liability on its consolidated balance sheets as these warrants are freestanding financial instruments that may have required the Company to transfer assets upon exercise. The warrant liability, which consisted of warrants for the purchase of Series A and Series B convertible preferred stock, was initially recorded at fair value upon the date of issuance of each warrant and was subsequently remeasured to fair value at each reporting date. Changes in the fair value of the warrant liability are recognized as a component of other income (expense), net in the consolidated statement of operations. Concurrent with the closing of the Merger, all X4 preferred stock was converted to common stock and the X4 preferred stock warrants converted to warrants for the purchase of Arsanis common stock. The Company assessed the features of the warrants and determined that they qualify for classification as permanent equity. Accordingly, the Company remeasured the warrants to fair value upon the closing of the Merger and reclassified the resulting warrant liability to additional paid-in capital (see Note 10).

Derivative Liabilities: Genzyme Continent Payment---The Company’s license agreement with Genzyme Corporation (“Genzyme”) (see Note 13) contains a contingent payment obligation that required the Company to make a cash payment to Genzyme upon a change of control event of the Company. The contingent payment obligation met the definition of a derivative instrument as the contingent payment obligation was not clearly and closely related to its host instrument and was a cash-settled liability. Accordingly, the Company classified this derivative as a liability within other liabilities (non-current) on its condensed consolidated balance sheet. The derivative liability was initially recorded at fair value on the date of entering into the license agreement and was subsequently remeasured to fair value at each reporting date. Changes in the fair value of this derivative liability were recognized as a component of other income (expense), net in the condensed consolidated statement of operations. The Merger with Arsanis (see Note 1) qualified as a change of control event, as defined in the license agreement, but resulted in no payment being due to Genzyme under the license agreement. As a result, on March 13, 2019, the closing date of the Merger with Arsanis, the derivative liability was remeasured to fair value, which was $0, and subsequent changes in fair value will no longer be recognized in the consolidated statements of operations because the contingent payment obligation to Genzyme expired at that time.

Derivative Liabilities: Hercules Loan Redemption Feature---The Company’s Hercules loan (see Note 7) contains a redemption feature that, upon an event of default, provides Hercules the option to accelerate and demand repayment of the debt, including a prepayment premium. The redemption feature meets the definition of a derivative instrument as the repayment of the debt contains a substantial premium, resulting in the redemption feature not being clearly and closely related to its host instrument. Accordingly, the Company classifies this derivative as a liability within other liabilities (non-current) on its condensed consolidated balance sheet. The derivative liability was initially recorded at fair value on the date of entering into the Hercules Loan Agreement and is subsequently remeasured to fair value at each reporting date. Changes in the fair value of this derivative liability are recognized as a component of other income (expense), net in the condensed consolidated statement of operations and comprehensive loss. Changes in the fair value of this derivative liability will continue to be recognized until all amounts outstanding under the Hercules Loan Agreement are repaid or until the Hercules Loan Agreement is terminated.

16

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Comprehensive Loss--- Comprehensive loss includes net loss as well as foreign currency translation adjustments. For the three and six months ended June 30, 2019, comprehensive loss include s $65 and $42 of foreign currency translation adjustments, respectively.

Income Taxes---The Company accounts for income taxes using the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been recognized in the consolidated financial statements or in the Company’s tax returns. Deferred tax assets and liabilities are determined based on the difference between the financial statement and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. Changes in deferred tax assets and liabilities are recorded in the provision for income taxes. The Company assesses the likelihood that its deferred tax assets will be recovered from future taxable income and, to the extent it believes, based upon the weight of available evidence, that it is more likely than not that all or a portion of the deferred tax assets will not be realized, a valuation allowance is established through a charge to income tax expense. Potential for recovery of deferred tax assets is evaluated by estimating the future taxable profits expected and considering prudent and feasible tax planning strategies.

The Company accounts for uncertainty in income taxes recognized in the consolidated financial statements by applying a two-step process to determine the amount of tax benefit to be recognized. First, the tax position must be evaluated to determine the likelihood that it will be sustained upon external examination by the taxing authorities. If the tax position is deemed more-likely-than-not to be sustained, the tax position is then assessed to determine the amount of benefit to recognize in the consolidated financial statements. The amount of the benefit that may be recognized is the largest amount that has a greater than 50% likelihood of being realized upon ultimate settlement. The provision for income taxes includes the effects of any resulting tax reserves, or unrecognized tax benefits, that are considered appropriate as well as the related net interest and penalties.

Net Income (Loss) per Share---For periods prior to the Merger with Arsanis on March 13, 2019, the Company follows the two-class method when computing net income (loss) per share as the Company had issued shares that met the definition of participating securities. The two-class method determines net income (loss) per share for each class of common and participating securities according to dividends declared or accumulated and participation rights in undistributed earnings. The two-class method requires income available to common stockholders for the period to be allocated between common and participating securities based upon their respective rights to receive dividends as if all income for the period had been distributed.

Basic net income (loss) per share attributable to common stockholders is computed by dividing the net income (loss) attributable to common stockholders by the weighted average number of shares of common stock outstanding for the period. Basic shares outstanding includes the weighted average effect of the Company’s pre-funded warrants issued in April 2019, the exercise of which requires little or no consideration for the delivery of shares of common stock. Diluted net income (loss) attributable to common stockholders is computed by adjusting net income (loss) attributable to common stockholders to reallocate undistributed earnings based on the potential impact of dilutive securities. Diluted net income (loss) per share attributable to common stockholders is computed by dividing the diluted net income (loss) attributable to common stockholders by the weighted average number of common shares outstanding for the period, including potential dilutive common shares. For purpose of this calculation, outstanding stock options, convertible preferred stock and warrants to purchase shares of convertible preferred stock are considered potential dilutive common shares.

The Company’s convertible preferred stock contractually entitled the holders of such shares to participate in dividends but did not contractually require the holders of such shares to participate in losses of the Company. Accordingly, in periods in which the Company reports a net loss attributable to common stockholders, such losses are not allocated to such participating securities. In periods in which the Company reports a net loss attributable to common stockholders, diluted net loss per share attributable to common stockholders is the same as basic net loss per share attributable to common stockholders, since dilutive common shares are not assumed to have been issued if their effect is anti-dilutive. The Company reported a net loss attributable to common stockholders for the three and six months ended June 30, 2019 and 2018.

17

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Recently Adopted Accounting Pronouncements

In February 2016, the FASB issued ASU No. 2016-02, Leases (Topic 842) (“ASU 2016-02” or “ASC 842”)), which sets out the principles for the recognition, measurement, presentation and disclosure of leases for both parties to a contract (i.e., lessees and lessors). The new standard requires lessees to apply a dual approach, classifying leases as either finance or operating leases based on the principle of whether or not the lease is effectively a financed purchase by the lessee. This classification will determine whether lease expense is recognized based on an effective interest method or on a straight-line basis over the term of the lease. A lessee is also required to record a right-of-use asset and a lease liability for all leases with a term of greater than 12 months regardless of their classification. Leases with a term of 12 months or less may be accounted for similar to prior guidance for operating leases. The Company adopted the new leasing standard as of the required effective date of January 1, 2019 using a modified retrospective transition approach to be applied to leases existing as of, or entered into after, January 1, 2019. The adoption had no impact on accumulated deficit. The new lease standard provides a number of optional practical expedients in transition. The Company applied the package of practical expedients to leases that commenced prior to the effective date, whereby it will elect to not reassess the following: (i) whether any expired or existing contracts contain leases; (ii) the lease classification for any expired or existing leases; and (iii) initial direct costs for any existing leases. The Company also elected the short-term lease recognition exemption for all leases that qualify, where a right-of-use asset or lease liability will not be recognized for short-term leases. Upon the adoption of ASC 842, the Company recorded $2.5 million of operating lease liabilities and $2.0 million of operating lease right-of-use assets on its consolidated balance. The adoption did not have a material impact on the Company’s statement of operations, statement of comprehensive loss or statement of cash flows.

In January 2017, the FASB issued ASU No. 2017-04, Intangibles-Goodwill and Other (Topic 350): Simplifying the Test for Goodwill Impairment. The new standard simplifies the subsequent measurement of goodwill by eliminating the second step of the goodwill impairment test. This ASU will be applied prospectively and is effective for annual or interim goodwill impairment tests in fiscal years beginning after December 15, 2019 with early adoption permitted. The Company has adopted this guidance on January 1, 2019 and will apply it to its annual impairment test, and any interim impairment tests during the year ending December 31, 2019.

In April 2017, the FASB issued ASU 2017-08, Receivables – Nonrefundable Fees and Other Costs (“Subtopic 310-20”). The new standard amends the amortization period for certain purchased callable debt securities held at a premium by shortening the amortization period for the premium to the earliest call date. Subtopic 310-20 calls for a modified retrospective application under which a cumulative-effect adjustment will be made to retained earnings as of the beginning of the first reporting period in which the guidance is adopted. The Company adopted this guidance, effective January 1, 2019, and its adoption had no impact on the Company’s financial position, results of operations or cash flows.

In July 2017, the FASB issued ASU No. 2017-11, Earnings Per Share (Topic 260), Distinguishing Liabilities from Equity (Topic 480), Derivatives and Hedging (Topic 815) (Part I) Accounting for Certain Financial Instruments with Down Round Features (Part II) Replacement of the Indefinite Deferral for Mandatorily Redeemable Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception (“ASU 2017-11”). Part I applies to entities that issue financial instruments such as warrants, convertible debt or convertible preferred stock that contain down-round features. Part II replaces the indefinite deferral for certain mandatorily redeemable noncontrolling interests and mandatorily redeemable financial instruments of nonpublic entities contained within ASC Topic 480 with a scope exception and does not impact the accounting for these mandatorily redeemable instruments. For public entities, ASU 2017-11 is effective for annual reporting periods beginning after December 15, 2018, including interim periods within those fiscal years. The Company adopted ASU 2017-11 as of the required effective date of January 1, 2019. The adoption of ASU 2017-11 had no impact on the Company’s financial position, results of operations or cash flows.

In June 2018, the FASB issued ASU 2018-07, which superseded Subtopic 505-50, Equity—Equity-Based Payments to Non-Employees and amends ASC 718 to include share-based payments issued to non-employees for goods or services. Consequently, the accounting for share-based payments to non-employees and employees will be substantially aligned. The Company adopted ASU 2018-07 on January 1, 2019 and the adoption of this standard had no impact on the Company’s financial position, results of operations or cash flows.

18

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Recently Issued Accounting Pronouncements

In June 2016, the FASB issued ASU 2016-13, Credit Losses (Topic 326) ("ASU 2016-13"). ASU 2016-13 requires that financial assets measured at amortized cost, such as trade receivables, be presented net of expected credit losses, which may be estimated based on relevant information such as historical experience, current conditions, and future expectation for each pool of similar financial asset. The new guidance requires enhanced disclosures related to trade receivables and associated credit losses. The guidance is effective beginning January 1, 2020. The Company does not expect the adoption of this standard to have a material impact on its consolidated financial statements and related disclosures.

In August 2018, the FASB issued ASU No. 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework—Changes to the Disclosure Requirements for Fair Value Measurement (“ASU 2018-13”), which removes, adds and modifies certain disclosure requirements for fair value measurements in Topic 820. The Company will no longer be required to disclose the amount of and reasons for transfers between Level 1 and Level 2 of the fair value hierarchy as well as the valuation processes of Level 3 fair value measurements. However, the Company will be required to additionally disclose the changes in unrealized gains and losses included in other comprehensive income for recurring Level 3 fair value measurements and the range and weighted average of assumptions used to develop significant unobservable inputs for Level 3 fair value measurements. ASU 2018-13 is effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2019. The amendments relating to additional disclosure requirements will be applied prospectively for only the most recent interim or annual period presented in the initial year of adoption. All other amendments will be applied retrospectively to all periods presented upon their effective date. The Company does not believe that the adoption of ASU 2018-13 will have a material impact on its consolidated financial statements.

In August 2018, the FASB issued ASU 2018-15, Intangibles-Goodwill and Other-Internal-Use Software (Subtopic 350-40): Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract, (“ASU 2018-15”). The amendments in this update align the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software (and hosting arrangements that include an internal-use software license). The accounting for the service element of a hosting arrangement that is a service contract is not affected by the amendments in this update. The new standard will be effective beginning January 1, 2020 and early adoption is permitted. The amendments in this update should be applied either retrospectively or prospectively to all implementation costs incurred after the date of adoption. The Company is currently evaluating the impact that the adoption of ASU 2018-15 will have on its consolidated financial statements.

In November 2018, the FASB issued ASU 2018-18, Clarifying the Interaction between Topic 808 and Topic 606 (“ASU 2018-18”). ASU 2018-18 clarifies the interaction between the accounting guidance for collaborative arrangements and revenue from contracts with customers. The amendments become effective January 1, 2020. Early adoption, including adoption in any period, is permitted. The new guidance is required to be applied retrospectively as of the date of adoption of the new revenue guidance under ASC 606. The Company is evaluating the impact, if any, of this guidance on its consolidated financial statements and related disclosures and the timing of adoption.

In April 2019, the FASB issued ASU 2019-04, Codification Improvements to Topic 326 Financial Instruments- Credit Losses, Topic 815, Derivatives and Hedging, and Topic 825 (“ASU 2019-04”). ASU 2014-04 clarifies the accounting treatment for the measurement of credit losses under ASC 236 and provides further clarification of ASU 2017-12, Derivative and Hedging (Topic 815): Targeted Improvements to Accounting for Hedging Activities and ASU 2016-01, Financial Instruments—Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities. ASU 2019-04 is effective for fiscal years beginning after December 15, 2019, including interim periods within those fiscal years. The Company is evaluating the impact, if any, of this new standard but does not anticipate that it will have a material impact on its consolidated financial statements and related disclosures.

3. | Merger Accounting

On March 13, 2019, the Company completed its merger with Arsanis. Based on the Exchange Ratio of 0.5702, immediately following the Merger, former Arsanis stockholders, Arsanis option holders and other persons holding securities or other rights directly or indirectly convertible, exercisable or exchangeable for Arsanis common stock owned approximately 31.3% of the outstanding capital stock of the combined organization on a fully diluted basis, and former X4 stockholders, holders of options or warrants to acquire X4 capital stock and other persons holding securities and other rights directly or indirectly convertible, exercisable or exchangeable for X4 capital stock owned approximately 68.7% of the outstanding capital stock of the combined organization on a fully diluted basis. At the closing of the Merger, all shares of X4 common stock and X4 preferred stock then outstanding were exchanged for Arsanis common stock.

19

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

In addition, pursuant to the terms of the Merger Agreement, the Company, for accounting purposes, assumed all outstanding stock options to purchase shares of Arsanis common stock at the closing of the Merger. At the closing of the Mer ger, such stock options became options to purchase an aggregate of 271,230 shares of the Company’s common stock after giving effect to the Reverse Stock Split.

The total purchase price paid in the Merger has been allocated to the tangible and intangible assets acquired and liabilities assumed of Arsanis based on their fair values as of the completion of the Merger, with the excess allocated to goodwill. The following summarizes the preliminary estimate of the purchase price paid in the Merger:

Number of shares of the combined organization owned by Arsanis stockholders (1) |  |  | 2,440,582 |
Multiplied by the fair value per share of Arsanis common stock (2) |  | $ | 18.66 |
Fair value of consideration issued it effect the Merger |  | $ | 45,541 |
Fair value of replacement awards held by former employees, board of directors and consultants of Arsanis that were vested as of the Merger. |  | $ | 817 |
Purchase price: |  | $ | 46,358 |

(1) | The number of shares of 2,440,582 represents the historical 14,643,737 shares of Arsanis common stock outstanding immediately prior to the closing of the Merger, adjusted for the Reverse Stock Split.

(2) | Based on the last reported sale price of Arsanis common stock on the Nasdaq Global Market on March 13, 2019, the closing date of the Merger, and gives effect to the Reverse Stock Split.

The following summarizes the allocation of the purchase price to the net tangible and intangible assets acquired:

Cash, cash equivalents and restricted cash |  | $ | 26,406 |
Other current assets |  |  | 2,147 |
Property and equipment, net |  |  | 68 |
IPR&D indefinite-lived intangible assets |  |  | 4,900 |
Other assets, non-current |  |  | 486 |
Current liabilities |  |  | (5,205 | )
Loans payable |  |  | (8,713 | )
Other liabilities, non-current |  |  | (840 | )
Goodwill |  |  | 27,109 |
Purchase price |  | $ | 46,358 |

The goodwill of $27,109 is not tax deductible and represents the excess of the consideration paid over the fair value of assets acquired and liabilities assumed. Goodwill is mainly attributable to the enhanced value of the combined company, as reflected in the increase in market value of the Arsanis common shares following the announcement of the Merger with X4. During the quarter ended June 30, 2019, goodwill was adjusted by $298 to reflect a change in the allocation of purchase price to the fair value of an acquired operating lease as of March 13, 2019. There have been no other changes in the value of goodwill from the acquisition date to June 30, 2019, and there were no indicators of impairment as of June 30, 2019.

The Company incurred costs directly related to the Merger of approximately $1 million for the six months ended June 30, 2019.

20

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

The in-process research and development intangible assets represent the acquisition-date fair value of three development programs acquired from Arsanis, which the Company refers to as the ASN 200, ASN300 and ASN500 programs. The fair value of the IPR&D intangible assets was based on assumptions that market participants would use in pricing the assets, based on the most advantageous market for the asset s assuming highest and best use. T he fair value was determined by estimating the costs to develop the project into commercially viable products, estimating the resulting revenue from the projects, and discounting the projected net cash flows to present value using a weighted average discount rate of 19.5%. These IPR&D intangible assets are not amortized, but rather are reviewed for impairment on an annual basis or more frequently if indicators of impairment are present, until the project is completed, abandoned or transferred to a third party. As f urther described in Note 16, in July 2019, the Company entered into outlicensing arrangements with two third parties and, as a result, transferred the rights to develop and commercialize the programs underlying the IPR&D intangible assets. Accordingly, the Company considered whether these subsequent transactions indicated that the fair value of the IPR&D intangible assets was lower than their carrying amounts and thus impaired. The Company concluded that the carrying amount continued to reflect the fair val ue of the IPR&D assets based on assumptions that market participants would use in pricing the assets and assuming the highest and best use of the assets.

The preliminary allocation of the purchase price for the Merger was based on estimates of the fair value of the net assets acquired and is subject to adjustment upon finalization of the valuation of the acquired intangible assets, property, plant and equipment, right-of-use assets, lease obligations, fair value of debt and any related deferred taxes. Measurements of these items inherently require significant estimates and assumptions.

The following supplemental unaudited pro forma information presents the Company’s financial results as if the acquisition of Arsanis had occurred on January 1, 2018:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  |  |  |  |  |  |  |  |  | 2019 |  |  | 2018 |
|  |  |  |  |  |  |  |  |  | (unaudited) |
Revenue |  | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |
Net loss |  | $ | (12,904 | ) |  | $ | (18,616 | ) |  | $ | (29,162 | ) |  | $ | (38,851 | )

The above unaudited pro forma information was determined based on the historical GAAP results of the Company and Arsanis. The unaudited pro forma consolidated results are not necessarily indicative of what the Company’s consolidated results of operations would have been if the acquisition was completed on January 1, 2018. The unaudited pro forma consolidated net loss includes pro forma adjustments primarily relating to the reclassification of transaction costs and severance payments directly related to the closing of the Merger of $2,663 from the six months ended June 30, 2019 to the six months ended June 30, 2018. There were no material pro forma adjustments for the three month periods ended June 30, 2019 or June 30, 2018.

4. | Fair Value of Financial Assets and Liabilities

The following tables present information about the Company’s financial assets and liabilities measured at fair value on a recurring basis and indicate the level of the fair value hierarchy used to determine such fair values:

|  | Fair Value Measurements as of June 30, 2019 Using: |
|  | Level 1 |  |  | Level 2 |  |  | Level 3 |  |  | Total |
Assets: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents—money market funds |  | $ | — |  |  | $ | 89,545 |  |  | $ | — |  |  | $ | 89,545 |
|  | $ | — |  |  | $ | 89,545 |  |  | $ | — |  |  | $ | 89,545 |
Liabilities: None |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

21

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

|  | Fair Value Measurements as of December 31, 2018 Using: |
|  | Level 1 |  |  | Level 2 |  |  | Level 3 |  |  | Total |
Assets: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents—money market fund |  | $ | — |  |  | $ | 8,134 |  |  | $ | — |  |  | $ | 8,134 |
|  | $ | — |  |  | $ | 8,134 |  |  | $ | — |  |  | $ | 8,134 |
Liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock warrant liability |  | $ | — |  |  | $ | — |  |  | $ | 4,947 |  |  | $ | 4,947 |
Derivative liability |  |  | — |  |  |  | — |  |  |  | 201 |  |  | $ | 201 |
|  | $ | — |  |  | $ | — |  |  | $ | 5,148 |  |  | $ | 5,148 |

As of June 30, 2019 and December 31, 2018, there were no transfers between Level 1, Level 2 and Level 3.

The Company’s cash equivalents consisted of a money market fund invested in U.S. Treasury securities. The money market fund was valued using inputs observable in active markets for similar securities, which represents a Level 2 measurement in the fair value hierarchy.

Valuation of Preferred Stock Warrant Liabilities

The preferred stock warrant liability in the table above consists of the fair values of (i) warrants to purchase shares of Series A convertible preferred stock that were issued in 2015 and shares of Series B convertible preferred stock that were issued in 2017 and 2018 in connection with the Company’s Series A and Series B convertible preferred stock financings, respectively (see Notes 10), (ii) warrants to purchase shares of Series A convertible preferred stock that were issued in 2016 in connection with the Company’s entering into a loan and security agreement with Silicon Valley Bank (see Note 7) and (iii) warrants to purchase shares of Series B convertible preferred stock that were issued or were issuable in 2018 in connection with the Company’s entering into the Hercules Loan Agreement (see Note 7). The liability associated with the warrants was recorded at fair value on the dates the warrants were issued and exercisable and was subsequently remeasured to fair value at each reporting date through December 31, 2018. Upon the closing of the Merger on March 13, 2019, all X4 preferred stock warrants were converted to warrants for Company’s common stock and, as a result, the warrants were adjusted to fair value and reclassified to permanent equity. The aggregate fair value of the warrant liability was determined based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy.

The Company used various valuation methods, including the Monte Carlo method, the option-pricing method and the hybrid method (which is a combination of an option-pricing method and a probability-weighted expected return method), all of which incorporate assumptions and estimates, to value the preferred stock warrants. Estimates and assumptions impacting the fair value measurement include the fair value per share of the underlying shares of the Company’s Series A and Series B convertible preferred stock, risk free interest rate, expected dividend yield, expected volatility of the price of the underlying preferred stock, and either the remaining contractual term of the warrants (except for warrants that would be automatically exercised upon an initial public offering, in which case the remaining estimated term to automatic exercise was used). The most significant assumption in the Monte Carlo method, the option-pricing method and the hybrid method impacting the fair value of the preferred stock warrants is the fair value of the Company’s convertible preferred stock as of each remeasurement date. The Company determines the fair value per share of the underlying preferred stock by taking into consideration the most recent sales of its convertible preferred stock, results obtained from third-party valuations and additional factors that are deemed relevant. As of December 31, 2018, the fair value of the Series A convertible preferred stock was $1.70 per share the fair value of the Series B convertible preferred stock was $1.86 per share. There were no warrants for the purchase of convertible preferred shares as of June 30, 2019 as all such warrants were converted to warrants for the purchase of common stock upon the Merger. The Company had been a private company prior to the Merger and lacked company-specific historical and implied volatility information of its stock. Therefore, it estimated its expected stock volatility based on the historical volatility of publicly traded peer companies for a term equal to the estimated remaining term of the warrants. The risk-free interest rate is determined by reference to the U.S. Treasury yield curve for time periods approximately equal to the estimated remaining term of the warrants. The Company estimated a 0% expected dividend yield as the Company has never paid or declared dividends and does not intend to do so in the foreseeable future.

22

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Valuation of Derivative Liability

The fair value of the derivative liability recognized in connection with the Company’s July 2014 license agreement with Genzyme (see Note 13) was determined based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy. The fair value of this derivative liability is reported within other liabilities on the consolidated balance sheets. The fair value of this derivative liability was estimated by the Company at each reporting date based, in part, on the results of third-party valuations, which were prepared using the option-pricing method or the hybrid method, each of which considered as inputs the type, timing and probability of occurrence of a change of control event, the potential amount of the payment under potential exit scenarios, the fair value per share of the underlying common stock and the risk-adjusted discount rate. As of December 31, 2018, the fair value of this derivative liability was $183. The Merger with Arsanis (see Note 1) qualified as a change of control event, as defined in the license agreement, but results in no payment being due to Genzyme under the license agreement. As a result, on March 13, 2019, the closing date of the Merger with Arsanis, this derivative liability was remeasured to fair value, which was $0, and subsequent changes in fair value will no longer be recognized in the consolidated statements of operations and comprehensive loss because the contingent payment obligation to Genzyme expired at that time.

The fair value of the derivative liability recognized in connection with the Hercules Loan Agreement (see Note 7) was determined based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy. The fair value of this derivative liability is reported within other liabilities on the consolidated balance sheets. The fair value of this derivative liability was estimated by the Company at each reporting date based, in part, on the results of third-party valuations, which were prepared based on a discounted cash flow model that considered the timing and probability of occurrence of a redemption upon an event of default, the potential amount of prepayment upon an event of default and the risk-adjusted discount rate. As of June 30, 2019 and December 31, 2018, the fair value of this derivative liability was immaterial.

The following table provides a roll-forward of the aggregate fair values of the Company’s warrant liability and derivative liability, for which fair values are determined using Level 3 inputs:

|  | Preferred Stock Warrant Liability |  |  | Derivative Liability |
Balance as of December 31, 2018 |  | $ | 4,947 |  |  | $ | 201 |
Change in fair value |  |  | 288 |  |  |  | (183 | )
Conversion of convertible preferred stock warrant into common stock warrant in connection with Merger |  |  | (5,235 | ) |  |  |  |
Balance as of June 30, 2019 |  | $ | — |  |  | $ | 18 |

5. | Property and Equipment, Net

Property and equipment, net consisted of the following:

|  | June 30, 2019 |  |  | December 31, 2018 |
Leasehold improvements |  | $ | 336 |  |  | $ | 299 |
Furniture and fixtures |  |  | 105 |  |  |  | 53 |
Computer equipment |  |  | 52 |  |  |  | 56 |
Software |  |  | 9 |  |  |  | 9 |
Lab equipment |  |  | 61 |  |  |  | — |
|  |  | 563 |  |  |  | 417 |
Less: Accumulated depreciation and amortization |  |  | (305 | ) |  |  | (176 | )
|  | $ | 258 |  |  | $ | 241 |

23

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Depreciation and amortization expense related to property and equipment was $44 and $51 for the six months ended June 30, 2019 and 2018, respectively.

6.Accrued Expenses

Accrued expenses consisted of the following:

|  | June 30, 2019 |  |  | December 31, 2018 |
Accrued employee compensation and benefits |  | $ | 1,374 |  |  |  | 924 |
Accrued external research and development expenses |  |  | 2,561 |  |  |  | 754 |
Accrued professional fees |  |  | 879 |  |  |  | 1,324 |
Other |  |  | 280 |  |  |  | 249 |
|  | $ | 5,094 |  |  | $ | 3,251 |

7. | Long-Term Debt

Long-term debt consisted of the following:

|  | June 30, 2019 |  |  | December 31, 2018 |
Principal amount of long-term debt |  | $ | 26,717 |  |  | $ | 10,000 |
Less: Current portion of long-term debt |  |  | (4,519 | ) |  |  | (1,687 | )
Long-term debt, net of current portion |  |  | 22,198 |  |  |  | 8,313 |
Debt discount, net of accretion |  |  | (672 | ) |  |  | (226 | )
Cumulative accretion of final payment due at maturity |  |  | 222 |  |  |  | 58 |
Long-term debt, including accretion, net of current portion |  | $ | 21,748 |  |  | $ | 8,145 |

SVB Loan Agreement

In October 2016, the Company entered into a loan and security agreement with Silicon Valley Bank (“SVB”), which the Company refers to as the SVB Loan Agreement, pursuant to which SVB made certain term loans available to the Company. The SVB Loan Agreement provided for a term loan of up to $6,000, which was borrowed by the Company in June 2017. Borrowings under the SVB Loan Agreement bore interest at a variable rate equal to 5.5% plus the greater of (i) 3.5% or (ii) The Wall Street Journal prime rate. In October 2018, in connection with entering into the Hercules Loan Agreement, the Company terminated the SVB Loan Agreement and repaid all amounts due under the SVB Loan Agreement, including unpaid principal of $4,333, a final payment of $270, a prepayment premium of $87 and accrued interest of $23. As of October 19, 2018, the date of repayment of all borrowings under the SVB Loan Agreement, the interest rate applicable to borrowings under the SVB Loan Agreement was 10.75%.

Hercules Loan Agreements

Hercules Loan Agreement and First Amendment

In October 2018, the Company entered into the Hercules Loan Agreement. The Hercules Loan Agreement provided for aggregate borrowings of up to $13,000, consisting of (i) a term loan of up to $8,000, which was available upon entering into the agreement, (ii) subject to specified financing conditions, an additional term loan of up to $2,000, available for borrowing from January 1, 2019 to March 31, 2019, and (iii) subject to specified financing conditions and the receipt of the second tranche term loan in the amount of $2,000 described above, an additional term loan of up to $3,000, available for borrowing until March 31, 2019. In October 2018, the Company borrowed $8,000 under the Hercules Loan Agreement. In December 2018, the Company entered into the First Amendment to the Hercules Loan Agreement (the “First Amendment”), which amended the available borrowing dates of the second tranche from between January 1, 2019 and March 31, 2019 to between December 11, 2018 and December 14, 2018 and amended the term loan maturity date to November 1, 2021. In December 2018, the Company borrowed the additional $2,000 provided under the Hercules Loan Agreement, as amended by the First Amendment. In March 2019, the conditions necessary for borrowing the remaining $3,000

24

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

under the Hercules Loan Agreement, as amended by the First Amendment, were not met and the borrowing capacity expired at that time.

In connection with entering into the Hercules Loan Agreement in October 2018, the Company issued to Hercules warrants for the purchase of 210,638 shares of Series B convertible preferred stock at an exercise price of $1.88 per share (which were subsequently converted to warrants for the purchase of 20,016 shares of common stock at an exercise price of $19.78 per share following the Merger). These warrants were immediately exercisable and expire in October 2028. In addition, in connection with entering into the First Amendment in December 2018, the Company agreed to issue to Hercules warrants for the purchase of a specified number of shares of convertible preferred stock at an aggregate exercise price of $99. On March 18, 2019, as a result of the closing of the Merger with Arsanis on March 13, 2019, the Company issued to Hercules warrants for the purchase of 5,000 shares of common stock of the combined organization at an exercise price of $19.80 per share, each of which reflected the share Exchange Ratio of 1-for-0.5702 applied in the Merger as well as the Reverse Stock Split effected by the combined organization on March 13, 2019. On October 19, 2018 and December 11, 2018, the dates the Company entered into the Hercules Loan Agreement and the First Amendment, respectively, the Company recorded the aggregate initial fair value of the warrants of $132 as a preferred stock warrant liability, with a corresponding amount recorded as a debt discount on the Company’s consolidated balance sheet. As of March 13, 2019, and December 31, 2018, the fair value of the warrants were $326 and $282, respectively. Upon the closing of the Merger, the warrants were converted to warrants for common stock and are no longer adjusted to fair value.

Amended and Restated Loan Agreement

In June 2019, the Company refinanced the Hercules Loan Agreement, as amended, and entered into an Amended and Restated Loan and Security Agreement (the “June 2019 Loan Agreement”) with Hercules. The June 2019 Loan Agreement provides for aggregate maximum borrowings of $35,000, of which $10,000 was previously outstanding. The Company agreed to borrow $20,000 as of the closing date on June 27, 2019, including $10,000 in new borrowings and $10,000 rolled over from the previous agreement. An additional $5,000 is available for borrowing through December 15, 2020 and, subject to approval by Hercules, an additional term loan of $10,000 is available through June 15, 2022. Borrowings under the June 2019 Loan Agreement bear interest at a variable rate equal to the greater of (i) 8.75% or (ii) 8.75% plus The Wall Street Journal prime rate minus 6.0%. In an event of default, as defined in the June 2019 Loan Agreement, and until such event is no longer continuing, the interest rate applicable to borrowings under the June 2019 Loan Agreement would be increased by 4.0%.

Borrowings under the June 2019 Loan Agreement are repayable in monthly interest-only payments through January 1, 2022, and in equal monthly payments of principal and accrued interest from February 1, 2022 until the maturity date of the loan, which is July 1, 2023. At the Company’s option, the Company may prepay all, but not less than all, of the outstanding borrowings, subject to a prepayment premium of up to 2.0% of the principal amount outstanding as of the date of repayment. In addition, the June 2019 Loan Agreement provides for payments by the Company to Hercules of (i) $795,000 payable upon the earlier of November 1, 2021 or the repayment in full of all obligations under the June 2019 Loan Agreement, and (ii) 4.0% of the aggregate principal drawn under the June 2019 Loan Agreement payable upon the earlier of maturity or the repayment in full of all obligations under such agreement.

Borrowings under the June 2019 Loan Agreement are collateralized by substantially all of the Company’s personal property and other assets except for the Company’s intellectual property (but including rights to payment and proceeds from the sale, licensing or disposition of the intellectual property). Under the 2019 Loan Agreement, the Company has agreed to affirmative and negative covenants to which it will remain subject until maturity or repayment of the loan in full. The covenants include (a) maintaining a minimum liquidity amount of the lesser of (i) 125% of the aggregate principal amount of outstanding borrowings under the June 2019 Loan Agreement and (ii) 100% of the Company and its consolidated subsidiaries’ cash and cash equivalents (other than up to $2.5 million which may be held by an excluded subsidiary, as defined) in an account in which Hercules has a first priority security interest, as well as (b) restrictions on the Company’s ability to incur additional indebtedness, pay dividends, encumber its intellectual property, or engage in certain fundamental business transactions, such as mergers or acquisitions of other businesses. The June 2019 Loan Agreement also contains a covenant that requires the Company to repay its FFG Loan Agreement on or prior to December 31, 2019. The FFG Loan Agreement was not modified as a result of this covenant. The Company was in compliance with all covenants under the June 2019 Loan Agreement as of June 30, 2019 and the FFG principal amounts are classified on the consolidated balance sheet in accordance with their contractual maturity dates.

The Company’s obligations under the June 2019 Loan Agreement are subject to acceleration upon occurrence of specified events of default, including payment default, insolvency and a material adverse change in the Company’s business, operations or financial or other conditions. The Company concluded that the redemption feature meets the definition of an embedded derivative instrument as the repayment of the debt contains a substantial premium, resulting in the redemption feature not being clearly and closely related to

25

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

the host instrument. The Company recorded the issuance-date fair value of the derivative liability of $1 8 as a component of debt issuance costs.

In connection with entering into the Hercules Loan Agreement and the First Amendment, the Company had deferred $180 associated with upfront (1) fees associated with entering into the agreement, (2) the fair value of the warrants issued and (3) the fair value of an embedded derivative associated with the accelerated redemption feature. The $180 is classified as a debt discount, which is reflected as a reduction of the carrying value of long-term debt on the Company’s consolidated balance sheet and is being amortized to interest expense over the term of the loan using the effective interest method. As a result of the June 2019 refinancing and entering into the June 2019 Loan Agreement, the Company considered whether the previous debt was either extinguished or modified based on the difference in the cash flows of the previous and new debt. The Company determined that Hercules Loan Agreement, as amended by the First Amendment, was modified. Accordingly, the unamortized debt discount of the previous debt and newly incurred fees paid to the lender related to the June 2019 Loan Agreement will be amortized to interest expense over the life of the new debt arrangement using the effective interest method.

The Company recognized aggregate interest expense under the Hercules Loan Agreement, as amended by the First Amendment, and the June 2019 Loan Agreement of $382 and $0 during the three months ended June 30, 2019 and 2018, respectively, and $739 and $0 during six months ended June 30, 2019 and 2018, respectively. Interest expense includes $101 and $215 for the three and six months ended June 30, 2019, respectively, related to the accretion of the debt discount and the final payment. As of June 30, 2019 the unamortized debt discount was $104. The annual effective interest rate on the 2019 June Loan Agreement as of June 30, 2019 is 11.0%. There were no principal payments due or paid under the Hercules Loan Agreement, as amended by the First Amendment, during the six months ended June 30, 2019. Principal payments begin in January 2022.

FFG Loan Agreement

Between September 2011 and March 2017, Arsanis GmbH entered into a series of funding agreements with Österreichische Forschungsförderungsgesellschaft mbH (“FFG”) that provided for loans and grants to fund qualifying research and development expenditures of X4 GmbH on a project-by-project basis, as approved by FFG. Amounts due under the FFG loans bear interest at rates ranging from 0.75% to 2.0% per annum. Giving effect to the Settlement Agreement (as defined below), the loans matured at various dates between March 31, 2019 and March 2021. Interest on amounts due under the loans is payable semi-annually in arrears, with all principal and remaining accrued interest due upon maturity.

On March 8, 2019, Arsanis, Merger Sub, X4 and Arsanis GmbH entered into a Settlement Agreement with FFG (the “Settlement Agreement”) in respect to allegations by FFG in February 2019 that Arsanis and Arsanis GmbH breached certain reporting, performance and other obligations in connection with grants and loans made by FFG to Arsanis GmbH between September 2011 and March 2017 to fund qualifying research and development expenditures. Pursuant to the terms of the Settlement Agreement, in exchange for FFG’s waiver of all claims against Arsanis and Arsanis GmbH (except for its claims for repayment of the loans and regular interest but including its waiver of claims for repayment of grants and interest exceeding regular interest), subject to compliance by Arsanis and Arsanis GmbH with the terms of the Settlement Agreement, Arsanis GmbH agreed to repay the outstanding loan principal (plus regular interest accrued thereon) on an accelerated payment schedule of three years instead of five years, with the final accelerated installment due and payable on June 30, 2021. The parties also agreed, among other things, that (i) the portion of such loans to be repaid in 2019 will be $2,914 on the first business day following March 31, 2019, and such amount was paid on April 1, 2019, and (ii) until all of the loans have been repaid and subject to other terms specified in the Settlement Agreement, commencing April 30, 2019, a minimum cash balance equal to 70% of the then-outstanding principal amount of the loans will be maintained at X4 Pharmaceuticals (Austria) GmbH in an account held with an Austrian bank. The Company was in compliance with all covenants under the FFG Loan Agreement as of June 30, 2019 and the principal amounts of the FFG loans are classified as either current of non-current on the consolidated balance sheet in accordance with the contractual maturity dates within the FFG Loan Agreement. As noted above, the June 2019 Loan Agreement with Hercules includes a covenant that requires the Company to repay the FFG loans in full on or prior to June 30, 2019.

26

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

As of June 30, 2019, future principal payments and the final payment due under the Company’s loan agr eements were as follows:

Year Ending December 31, |  | Hercules |  |  | FFG |  |  | Total |
2019 |  | $ | — |  |  | $ | — |  |  | $ | — |
2020 |  |  | — |  |  |  | 4,519 |  |  |  | 4,519 |
2021 |  |  | — |  |  |  | 2,198 |  |  |  | 2,198 |
2022 |  |  | 11,897 |  |  |  | — |  |  |  | 11,897 |
2023 |  |  | 8,103 |  |  |  | — |  |  |  | 8,103 |
Long-term debt |  | $ | 20,000 |  |  | $ | 6,717 |  |  | $ | 26,717 |

8. | Leases

Effective January 1, 2019, the Company adopted ASC 842 using the modified retrospective approach through a cumulative-effect adjustment and utilizing the effective date as its date of initial application, with prior periods unchanged and presented in accordance with the previous lease accounting guidance. Upon adoption, the Company recorded right-of-use assets of $2,026 and lease liabilities of $2,538, of which $1,925 was classified as non-current and $613 as current. The difference between the value of the right-of-use asset and the lease liabilities related to $512 of net deferred, accrued and prepaid rent that was reclassified against the right-of-use asset upon adoption of ASC 842 on January 1, 2019. The Company has lease agreements for its facilities in Cambridge, Massachusetts, which is the Company’s global headquarters, Vienna, Austria, which is the Company’s research and development center, and Waltham, Massachusetts, which is the former headquarters of Arsanis. The Company plans to sublease its Waltham, Massachusetts facility. There are no restrictions or financial covenants associated with any of the lease agreements.

Cambridge Lease

In August 2017, the Company entered into a non-cancellable operating lease agreement for office space of approximately thirteen thousand square feet in Cambridge, Massachusetts (“Cambridge Lease”) which expires on July 31, 2022. The Cambridge lease includes an annual rent escalation clause and the Company has the option to extend the lease for one period of five additional years. Base rent is approximately $816 annually and the monthly rent expense is being recognized on a straight-line basis over the term of the lease as the Company amortizes the associated operating lease right-of-use asset. In addition to the base rent, the Company is also responsible for its share of operating expenses, electricity and real estate taxes, in accordance with the terms of lease. These costs are not included in the determination of the leases’ right-of-use operating assets or lease operating liabilities.

Waltham Lease

On March 13, 2019, as part of its Merger with Arsanis, the Company acquired a non-cancellable operating lease for approximately six thousand square feet of office space in Waltham, Massachusetts (“Waltham Lease”). The Waltham lease, as amended, commenced on January 1, 2019, and expires approximately 5 years from the commencement date. The base rent is approximately $262 annually. In addition to the base rent, the Company is also responsible for its share of operating expenses, electricity and real estate taxes, which costs are not included in the determination of the leases’ right-of-use assets or lease liabilities. The Company has ceased using the leased space and is actively seeking to obtain a subtenant. As a result, the Company has adjusted the value of the right-of-use asset to its estimated fair value, which represents management’s best estimate of sublease income that could be obtained for the space, less costs to obtain a sublease. The right-of-use asset is being amortized to rent expense over the 5 year term of the lease.

Vienna Austria Lease

On March 13, 2019, as part of its Merger with Arsanis, the Company acquired an operating lease for approximately four hundred square meters of laboratory and office space in Vienna, Austria, (the “Vienna Austria Lease”) which commenced on March 1, 2019, as amended, for a term of two years. The lease is cancellable by the Company upon three months’ notice with no penalty. The annual base rent is approximately $155. The Company has classified this lease as a short-term lease as it is not reasonably certain that the Company with not terminate the lease within one year and, accordingly, has not recorded a right-of-use asset. Accordingly, rent expense is recorded on a straight-line basis as incurred over the term of the lease.

27

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

As the Company’s leases do not provide an implicit rate, the Company estimated the incremental borrowing rate in calculating the present value of the lease payments. The Company utilizes its incremental borrowing rates, which are the rates incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment.

The components of lease expense for the three and six months ended June 30, 2019 were as follows:

Lease Cost |  | For the Three months ended June 30, 2019 |  |  | For the Six months ended June 30, 2019 |
Fixed operating lease cost |  | $ | 198 |  |  | $ | 385 |
Short-term lease costs |  |  | 38 |  |  |  | 46 |
Total lease expense |  | $ | 236 |  |  | $ | 431 |
Other information |  |  |  |  |  |  |  |
Cash paid for amounts included in the measurement of lease liabilities: |  |  |  |  |  |  |  |
Operating cash flows from operating leases |  | $ | 266 |  |  | $ | 467 |
Leased assets obtained in exchange for new operating lease liabilities (1) |  |  |  |  |  | $ | 388 |
Weighted-average remaining lease term—operating leases |  |  |  |  |  | 3.5 years |
Weighted-average discount rate—operating leases |  |  |  |  |  |  | 9.0 | %

(1) | Acquired in Merger with Arsanis

Maturities of lease liabilities due under these lease agreements as of June 30, 2019 are as follows:

Maturity of lease liabilities |  | Operating Leases |
2019 (remainder of 2019) |  | $ | 551 |
2020 |  |  | 1,085 |
2021 |  |  | 1,098 |
2022 |  |  | 754 |
2023 |  |  | 263 |
Thereafter |  |  | — |
Total lease payments |  |  | 3,751 |
Less: interest |  |  | (522 | )
Total operating lease liabilities as of June 30, 2019 |  | $ | 3,229 |

The Company adopted ASU 2016-02 on January 1, 2019 as noted above, and as required, the following disclosure is provided for periods prior to adoption. Future annual minimum lease payments due under the Company’s operating leases as of December 31, 2018 were as follows:

Year Ending December 31, |  | Operating Leases |
2019 |  | $ | 810 |
2020 |  |  | 823 |
2021 |  |  | 835 |
2022 |  |  | 492 |
Total |  | $ | 2,960 |

28

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

9. | Commitment and Contingencies

Sponsored Research Agreement Commitments

In April 2017, the Company entered into a sponsored research agreement with a university pursuant to which the Company and the university are conducting a research program related to understanding the mechanisms of failed long-term adaptive immunity in WHIM patients. Under the terms of the agreement, the Company agreed to provide funding for the research program of up to $499 over a three-year period. The agreement will remain in effect for three years, unless earlier terminated. The Company may terminate the agreement at any time upon at least 60 days’ prior written notice. For the three and six months ended June 30, 2019, the Company incurred $41 and $83, respectively, of research and development expenses related to its payment obligations to the university under the agreement. As of June 30, 2019, the Company had non-cancelable purchase commitments under this agreement totaling $139, with $83 committed in 2019 and $56 committed in 2020.

In May 2019, the Company amended its agreement with a clinical research organization (“CRO”) pursuant to which the Company and the CRO are conducting a global Phase 3 clinical trial of mavorixafor for the treatment of WHIM syndrome. The Company may terminate the agreement by providing 30 days’ notice and if such termination occurred, the Company would incur early termination fees of up to $1,000 based on a percentage of committed resources of the CRO as of the termination.

Indemnification Agreements

In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors and its executive officers that will require the Company to, among other things, indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnification obligations. The Company is not currently aware of any indemnification claims and has not accrued any liabilities related to such obligations in its consolidated financial statements as of June 30, 2019 or December 31, 2018.

License Agreements

In February 2017, Arsanis entered into an option and license agreement with Adimab, LLC (“Adimab”), under which the Company is obligated to make contingent and non-contingent payments should the Company exercise its option to obtain rights to certain RSV antibodies, which are being utilized in what the Company refers to as the “ASN500” program. The option fee includes an up-front payment of approximately $250 and potential milestone payments of up to approximately $25,000, as well as royalty payments on a product-by-product and country-by-country basis of a mid-single-digit percentage based on net sales by the Company, its affiliates, licensees or sublicensees of products based on certain RSV antibodies during the applicable term for such product in that country. In July 2019, as further described in Note 16, the Company entered into an outlicensing arrangement (the “ASN500 Agreement”) with a third party whereby the Company transferred intellectual property related to the ASN500 program through an exclusive, worldwide license. In accordance with the ASN500 Agreement, the third party agreed to fund the exercise of the Adimab license agreement and is required to honor any future payments due to Adimab.

Legal Proceedings

The Company is not a party to any litigation and does not have contingency reserves established for any litigation liabilities. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses as incurred the costs related to such legal proceedings.

29

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

10. | Preferred and Common Stock Warrants

Prior to the Merger with Arsanis (see Note 1), the Company had issued warrants for the purchase of its preferred stock and had classified its preferred stock warrants as a liability on its consolidated balance sheet as the warrants were deemed to be freestanding financial instruments that may have required the Company to transfer assets upon exercise. The liability associated with each of these warrants was initially recorded at fair value upon the issuance date of each warrant and was subsequently remeasured to fair value as a component of other income (expense), net in the consolidated statement of operations. Upon the closing of the Merger, pursuant to the Merger Agreement, all of the outstanding X4 preferred stock was converted to Arsanis common stock and the X4 preferred stock warrants converted to warrants for the purchase of Arsanis common stock. The Company assessed the features of the warrants and determined that they qualify for classification as permanent equity upon the closing of the Merger. Accordingly, the Company remeasured the warrants to fair value upon the closing of the Merger, which was $5,235 at March 13, 2019, with $288 of expense recorded during the three months ended March 31, 2019. Upon the closing of the Merger, the warrant liability was reclassified to additional paid-in capital.

In connection with its issuance of common stock in a public offering that closed on April 16, 2019, the Company issued 3,900,000 Class A warrants, which have an exercise price of $13.20 per warrant and are convertible into shares of the Company’s common stock. These warrants expire on April 15, 2024 and were immediately exercisable. In addition, the Company issued 2,130,000 pre- funded warrants for proceeds of $10.999 per share. Each of the pre-funded warrants is convertible into one common share, has a remaining exercise price of $0.001 per share and was immediately exercisable upon issuance.

The following table provides a roll forward of outstanding warrants:

|  | Number of warrants |  |  | Weighted Average Exercise Price |  |  | Weighted Average Contractual Term (Years) |
Outstanding and exercisable warrants to purchase preferred shares as of December 31, 2018 |  |  | 5,146,400 |  |  | $ | 1.94 |  |  |  | 4.23 |
Converted to warrants for the purchase of common stock and adjusted for the Exchange Ratio and Reverse Stock Split |  |  | (4,657,350 | ) |  |  |  |  |  |  |  |
Issued |  |  | 6,035,000 |  |  |  | 12.43 |  |  |  |  |
Exercised |  |  | (33,846 | ) |  |  | 13.20 |  |  |  |  |
Cancelled |  |  | — |  |  |  | — |  |  |  |  |
Outstanding and exercisable as of June 30, 2019 |  |  | 6,490,204 |  |  | $ | 13.03 |  |  |  | 3.15 |

30

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

As of June 30, 2019, the Company’s outstanding warrants to purchase shares of common stock consisted of the following:

Issuance Date |  | Number of Shares of Common Stock Issuable |  |  | Exercise Price |  |  | Classification |  | Expiration Date
August 14, 2015 |  |  | 81,228 |  |  | $ | 21.78 |  |  | Equity |  | August 14, 2020
August 21, 2015 |  |  | 69,603 |  |  | $ | 21.78 |  |  | Equity |  | August 21, 2020
October 25, 2016 |  |  | 5,155 |  |  | $ | 19.78 |  |  | Equity |  | October 24, 2026
November 1, 2017 |  |  | 130,609 |  |  | $ | 19.78 |  |  | Equity |  | October 31, 2020
November 17, 2017 |  |  | 8,442 |  |  | $ | 19.78 |  |  | Equity |  | November 16, 2020
December 4, 2017 |  |  | 5,661 |  |  | $ | 19.78 |  |  | Equity |  | December 3, 2020
December 28, 2017 |  |  | 6,925 |  |  | $ | 19.78 |  |  | Equity |  | December 27, 2020
December 28, 2017 |  |  | 115,916 |  |  | $ | 19.78 |  |  | Equity |  | December 28, 2027
September 12, 2018 |  |  | 25,275 |  |  | $ | 19.78 |  |  | Equity |  | September 12, 2021
September 12, 2018 |  |  | 20,220 |  |  | $ | 19.78 |  |  | Equity |  | September 12, 2028
October 19, 2018 |  |  | 20,016 |  |  | $ | 19.78 |  |  | Equity |  | October 19, 2028
March 13, 2019 |  |  | 5,000 |  |  | $ | 19.80 |  |  | Equity |  | March 12, 2029
April 16, 2019 |  |  | 3,866,154 |  |  | $ | 13.20 |  |  | Equity |  | April 15, 2024
April 16, 2019 |  |  | 2,130,000 |  |  | $ | 11.00 |  |  | Equity |  | n/a
|  |  | 6,490,204 |  |  |  |  |  |  |  |  |

As of December 31, 2018, the Company’s outstanding warrants to purchase shares of preferred stock (which converted into warrants to purchase common stock upon close of the Merger) consisted of the following (not adjusted for the Reverse Stock Split or Exchange Ratio):

December 31, 2018
Warrant Name |  | Issuance Date |  | Number of Shares of Preferred Stock Issuable |  |  | Exercise Price |  |  | Exercisable for |  | Classification |  | Expiration Date
Series A warrants |  | August 14, 2015 |  |  | 854,785 |  |  | $ | 2.07 |  |  | Series A |  | Liability |  | August 14, 2020
Series A warrants |  | August 21, 2015 |  |  | 732,453 |  |  | $ | 2.07 |  |  | Series A |  | Liability |  | August 21, 2020
SVB warrants |  | October 25, 2016 |  |  | 54,256 |  |  | $ | 1.88 |  |  | Series A |  | Liability |  | October 24, 2026
Series B warrants |  | November 1, 2017 |  |  | 1,374,435 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | October 31, 2020
Series B warrants |  | November 17, 2017 |  |  | 88,845 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | November 16, 2020
Series B warrants |  | December 4, 2017 |  |  | 59,576 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | December 3, 2020
Series B warrants |  | December 28, 2017 |  |  | 72,875 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | December 27, 2020
Series B warrants |  | December 28, 2017 |  |  | 1,219,815 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | December 28, 2027
Series B warrants |  | September 12, 2018 |  |  | 265,957 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | September 12, 2021
Series B warrants |  | September 12, 2018 |  |  | 212,765 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | September 12, 2028
Series B warrants |  | October 19, 2018 |  |  | 210,638 |  |  | $ | 1.88 |  |  | Series B |  | Liability |  | October 19, 2028
|  |  |  |  | 5,146,400 |  |  |  |  |  |  |  |  |  |  |

31

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

11. | Common Stock, Redeemable Common Stock, and Convertible Preferred Stock (converted to Common Stock)

Common Stock

As of June 30, 2019 and December 31, 2018, the Company’s certificate of incorporation, as amended and restated, authorized the Company to issue 33,333,333 shares and 11,070,776, shares, respectively, of $0.001 par value common stock. The voting, dividend and liquidation rights of the holders of the Company’s common stock are subject to and qualified by the rights, powers and preferences of the holders of the preferred stock. Each share of common stock entitles the holder to one vote on all matters submitted to a vote of the Company’s stockholders. Common stockholders are entitled to receive dividends, as may be declared by the board of directors, if any. No cash dividends have been declared or paid to date.

On April 12, 2019, the Company entered into an underwriting agreement with Cowen and Company, LLC and Stifel, Nicolaus & Company, Incorporated, as representatives of the several underwriters named therein pursuant to which it sold 5,670,000 shares of common stock and, in lieu of common stock, pre-funded warrants to purchase 2,130,000 shares of common stock, and accompanying Class A warrants to purchase 3,900,000 shares of its common stock. The common stock was issued at a price to the public of $11.00 per share and accompanying Class A warrants and the pre-funded warrants were issued at a price of $10.999 per pre-funded warrant and accompanying Class A warrants. The Class A warrants have an exercise price of $13.20, will expire five years from the date of issuance, and are immediately exercisable with certain restrictions. The gross proceeds from the offering were $85.8 million before deducting underwriting discounts and offering expenses. The offering closed on April 16, 2019.

The Company evaluated the Class A and pre-funded warrants for liability or equity classification in accordance with the provisions of ASC 480, Distinguishing Liabilities from Equity, and ASC 815-40, Derivatives and Hedging, and determined that equity treatment was appropriate because neither the Class A warrants nor pre-funded warrants meet the definition of a liability instrument. Neither the Class A warrants nor the pre-funded warrants are mandatorily redeemable and they do not embody an obligation for the Company to repurchase them in circumstances that are outside of the Company’s control that could require the transfer of assets. The funds received in the equity offering related to these warrants has been classified as permanent equity as the warrants are freestanding financial instruments that are legally detachable and separately exercisable from the common stock with which they were issued, are immediately exercisable, do not embody an obligation for the Company to repurchase its shares and permit the holders to receive a fixed number of common stock upon exercise. Furthermore, the delivery of common stock to the warrant holder upon exercise of the warrant is within the Company’s control.

Redeemable Common Stock

Pursuant to the requirements of the July 2014 license agreement with Genzyme (see Note 13), in August 2015, the Company issued to Genzyme for no additional consideration 107,371, as adjusted for the Reverse Stock Split and Exchange Ratio, shares of common stock, which had an aggregate fair value of $734 on the date of issuance. Genzyme had the right to require the Company to repurchase all, but not less than all, of these shares of common stock at any time during the term of the license agreement for a price of $0.01 per share. Because of this redemption feature, the shares of common stock issued to Genzyme were classified outside of stockholders’ deficit on the consolidated balance sheets. As a result of the Merger, these shares were exchanged for common stock.

Convertible Preferred Stock (converted to Common Stock)

The Company has issued Series Seed convertible preferred stock (the “Series Seed preferred stock”), Series A convertible preferred stock (the “Series A preferred stock”) and Series B convertible preferred stock (the “Series B preferred stock”). As of June 30, 2019 and December 31, 2018, the Company’s certificate of incorporation, as amended and restated, authorized the Company to issue a total of 10,000,000 shares and 59,413,523 shares, respectively, of preferred stock, with a par value of $0.001 per share.

The holders of Preferred Stock have liquidation rights in the event of a deemed liquidation that, in certain situations, are not solely within the control of the Company. Therefore, the Preferred Stock is classified outside of stockholders’ deficit on the consolidated balance sheet.

32

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

A s of June 30, 2019, there was no preferred stock outstanding. As of December 31, 2018, the p referred s tock consisted of the following:

|  | December 31, 2018 |
|  | Preferred Stock Designated |  |  | Preferred Stock Issued and Outstanding |  |  | Carrying Value |  |  | Liquidation Preference |  |  | Common Stock Issuable Upon Conversion (1) |
Series Seed preferred stock |  |  | 2,313,523 |  |  |  | 1,516,136 |  |  | $ | 1,310 |  |  | $ | 1,444 |  |  |  | 143,630 |
Series A preferred stock |  |  | 22,000,000 |  |  |  | 19,946,862 |  |  |  | 32,480 |  |  |  | 47,624 |  |  |  | 1,895,610 |
Series B preferred stock |  |  | 25,100,000 |  |  |  | 18,616,569 |  |  |  | 30,885 |  |  |  | 34,999 |  |  |  | 1,769,190 |
|  |  | 49,413,523 |  |  |  | 40,079,567 |  |  | $ | 64,675 |  |  | $ | 84,067 |  |  |  | 3,808,430 |

(1) | Adjusted to reflect Reverse Stock Split and Exchange Ratio.

12. | Stock-Based Compensation

Summary of Plans

Upon completion of the Merger with Arsanis on March 13, 2019, X4’s 2015 Employee, Director and Consultant Equity Incentive Plan, as amended (the “2015 Plan”), Arsanis’ 2017 Equity Incentive Plan (the “2017 Plan”) and Arsanis’ 2017 Employee Stock Purchase Plan (the “2017 ESPP”) were assumed by the Company. In June 2019, the Company adopted the 2019 Inducement Equity Incentive Plan (the “2019 Plan”). These plans are administered by the Board of Directors or, at the discretion of the Board of Directors, by a committee of the Board of Directors. The exercise prices, vesting and other restrictions are determined at the discretion of the Board of Directors, or its committee if so delegated, except that the exercise price per share of stock options may not be less than 100% of the fair market value of the share of common stock on the date of grant and the term of the stock option may not be greater than ten years. Incentive stock options granted to employees and restricted stock awards granted to employees, officers, members of the board of directors, advisors, and consultants of the Company typically vest over four years. Non-statutory options granted to employees, officers, members of the board of directors, advisors, and consultants of the Company typically vest over three or four years. Shares that are expired, terminated, surrendered or canceled under the Plans without having been fully exercised will be available for future awards. In addition, shares of common stock that are tendered to the Company by a participant to exercise an award are added to the number of shares of common stock available for the grant of awards.

2015 Employee, Director and Consultant Equity Incentive Plan

In 2015, the board of directors and shareholders of X4 adopted the 2015 Plan, which provided for the Company to grant incentive stock options or nonqualified stock options, restricted stock awards and other stock-based awards to employees, directors and consultants of the Company. Each stock option outstanding under the 2015 Plan at the effective time of the Merger was automatically converted into a stock option exercisable for a number of shares of the Company’s common stock calculated based on the Exchange Ratio and the exercise price per share of such outstanding stock option.

As of June 30, 2019, the total number of shares of common stock that may be issued under the 2015 Plan is 969,340 shares, adjusted for the Exchange Ratio and Reverse Stock Split. Shares that are expired, forfeited, canceled or otherwise terminated without having been fully exercised will be available for future grant under the 2015 Plan. In addition, shares of common stock that are tendered to the Company by a participant to exercise an award are added to the number of shares of common stock available for future grants.

33

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

2017 Equity Incentive Plan

In 2017, the board of directors and shareholders of Arsanis adopted the 2017 Plan, which provided for the Company to grant incentive stock options, non-qualified options, stock appreciation rights, restricted stock awards, restricted stock units and other stock-based awards. Incentive stock options may be granted only to the Company’s employees, including officers and directors who are also employees. Awards other than incentive stock options may be granted to employees, officers, members of the board of directors, advisors and consultants of the Company. The number of shares of common stock reserved for issuance under this plan will automatically increase on January 1 of each year, through January 1, 2027, in an amount equal to the lowest of 170,915 shares of the Company’s common stock (as adjusted for the Reverse Stock Split), 4% of the number of shares of the Company’s common stock outstanding on January 1 of each year and an amount determined by the Company’s board of directors.

2017 Employee Stock Purchase Plan

In 2017, the board of directors and shareholders of Arsanis adopted the 2017 ESPP. The 2017 ESPP provides participating employees with the opportunity to purchase shares of the Company’s common stock at defined purchase prices over six-month offering periods. For the six months ended June 30, 2019, no shares of common stock were issued under the 2017 ESPP.

2019 Inducement Equity Incentive Plan

On June 17, 2019, the board of directors approved the adoption of the 2019 Plan, which provides for the Company to grant nonqualified stock options, restricted stock awards and other stock-based awards to new employees of the Company. Awards issued from the 2019 Plan are intended to be material inducements to each employee’s acceptance of employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4). As of June 30, 2019, the total number of shares of common stock that may be issued under the 2019 Plan is 150,000 shares. Shares that are expired, forfeited, canceled or otherwise terminated without having been fully exercised will be available for future grant under the 2019 Plan. In addition, shares of common stock that are tendered to the Company by a participant to exercise an award are added to the number of shares of common stock available for future grants.

Stock Option Valuation

The following table presents, on a weighted average basis, the assumptions used in the Black-Scholes option-pricing model to determine the grant-date fair value of stock options granted to employees, directors and non- employees:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Risk-free interest rate |  |  | 2.0 | % |  |  | 2.6 | % |  |  | 2.1 | % |  |  | 2.6 | %
Expected term (in years) |  |  | 6.05 |  |  |  | 5.67 |  |  |  | 6.00 |  |  | 5.74 |
Expected volatility |  |  | 88.0 | % |  |  | 87.4 | % |  |  | 88.9 | % |  |  | 86.7 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %

34

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Stock Options

The following table summarizes the Company’s stock option activity for the six months ended June 30, 2019:

|  | Number of Shares |  |  | Weighted Average Exercise Price |  |  | Weighted Average Contractual Term (Years) |  |  | Aggregate Intrinsic Value |
Outstanding as of December 31, 2018 |  |  | 797,931 |  |  | $ | 8.29 |  |  |  | 8.42 |  |  | $ | 6,486 |
Assumed as part of Merger with Arsanis |  |  | 271,230 |  |  |  | 62.60 |  |  |  |  |  |  |  |  |
Granted |  |  | 377,906 |  |  |  | 16.21 |  |  |  |  |  |  |  |  |
Exercised |  |  | (17,183 | ) |  |  | 6.68 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (156,352 | ) |  |  | 51.98 |  |  |  |  |  |  |  |  |
Outstanding as of June 30, 2019 |  |  | 1,273,532 |  |  | $ | 21.97 |  |  |  | 7.65 |  |  | $ | 7,168 |
Exercisable as of June 30, 2019 |  |  | 489,033 |  |  | $ | 21.62 |  |  | 7.02 |  |  |  |  |
Vested and expected to vest as of June 30, 2019 |  |  | 1,097,545 |  |  | $ | 17.69 |  |  | 8.34 |  |  |  |  |

The aggregate intrinsic value of options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock for those options that had exercise prices lower than the fair value of the Company’s common stock. The aggregate intrinsic value of stock options exercised during the six months ended June 30, 2019 was $130. The weighted average grant-date fair value per share of stock options granted during the six months ended June 30, 2019 was $11.92.

Restricted Stock Units

During the three months ended June 30, 2019, the Company granted 116,689 restricted stock units to employees. The restricted stock units vest 25% annually on the grant anniversary over four years and had a grant date fair value of $1,721, which will be recognized as stock-based compensation expense, net of estimated forfeitures, over the vesting period.

Stock-Based Compensation

Effective January 1, 2019, the Company adopted ASU 2018-07 and no longer remeasures the fair value of equity awards granted to non-employees at each reporting period end (see Note 2).

As of June 30, 2019, total unrecognized compensation expense related to unvested stock options and restricted stock units was $6,529, which is expected to be recognized over a weighted average period of 3.4 years.

Stock-based compensation expense was classified in the consolidated statements of operations as follows:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Research and development expense |  | $ | 214 |  |  | $ | 51 |  |  | $ | 298 |  |  | $ | 89 |
General and administrative expense |  |  | 219 |  |  |  | 94 |  |  |  | 397 |  |  |  | 184 |
Total stock-based compensation |  |  | 433 |  |  |  | 145 |  |  |  | 695 |  |  |  | 273 |

35

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

13. | License, Collaboration, and Funding Agreements

Genzyme Agreement

In July 2014, the Company entered into a license agreement (the “Genzyme Agreement”) with Genzyme pursuant to which the Company was granted an exclusive license to certain patents and intellectual property owned or controlled by Genzyme related to the CXCR4 receptor to develop and commercialize products containing licensed compounds (including but not limited to X4P-001) for all therapeutic, prophylactic and diagnostic uses, with the exception of autologous and allogenic human stem cell therapy. Under the terms of the Genzyme Agreement, the Company is obligated to use commercially reasonable efforts to develop and commercialize licensed products for use in the field in the United States and at least one other major market country. The Company has the right to grant sublicenses of the licensed rights that cover X4P-001 to third parties.

In exchange for these rights, in August 2014, the Company made an upfront payment of $50 to Genzyme. The Company accounted for the acquisition of technology as an asset acquisition because it did not meet the definition of a business. The Company recorded the upfront payment as research and development expense in the consolidated statement of operations because the acquired technology represented in-process research and development and had no alternative future use. In August 2015, as a result of the closing of the Company’s Series A preferred stock financing, the Company made an additional cash payment of $300 to Genzyme and issued to Genzyme 107,371 shares of its common stock, as adjusted for the 1 for 6 Reverse Stock Split and Exchange Ratio (see Note 11), each as required by the Genzyme Agreement. The $300 payment and the $734 fair value of the 107,371 shares of common stock issued to Genzyme were recorded as research and development expense in the consolidated statements of operations and comprehensive loss for the year ended December 31, 2015. Prior to the Merger with Arsanis, Genzyme had the right to require the Company to repurchase all, but not less than all, of these shares of common stock at any time during the term of the Genzyme Agreement for a price of $0.01 per share. Due to this redemption feature, the shares of common stock issued to Genzyme were classified outside of stockholders’ deficit on the consolidated balance sheets as of December 31, 2018. On March 13, 2019, the closing date of the Merger with Arsanis, these redeemable common shares were exchanged for common shares and, as a result, the fair value of the shares was reclassified to permanent equity.

Under the Genzyme Agreement, the Company is obligated to pay Genzyme milestone payments in the aggregate amount of up to $25,000, contingent upon the achievement by the Company of certain late-stage regulatory and sales milestones with respect to licensed products. In addition, the Company may be required to make a one-time milestone payment to Genzyme upon the consummation by the Company of a change of control transaction, in an amount equal to 5.5% of the consideration paid to equity holders of the Company, other than Genzyme, in connection with such change of control transaction, after deducting outstanding debt obligations of the Company and the aggregate cash investments made by equity holders into the Company prior to the closing of the change of control transaction. The Merger with Arsanis qualifies as a change of control transaction, as defined in the license agreement, but resulted in no payment being due to Genzyme under the license agreement.

The Company concluded that this contingent payment obligation meets the definition of a derivative instrument as the contingent payment obligation is not clearly and closely related to its host instrument and is a cash-settled liability (see Note 2). Accordingly, the Company classifies this derivative as a liability within other liabilities (non-current) on its consolidated balance sheet (see Note 2), and changes in the fair value of the derivative liability are recognized as a component of other income (expense), net in the consolidated statement of operations and comprehensive loss (see Note 4). On March 13, 2019, the closing date of the Merger with Arsanis, this derivative liability was remeasured to fair value, which was $0, and subsequent changes in fair value will no longer be recognized in the consolidated statements of operations and comprehensive loss because the contingent payment obligation expired at that time.

Under the Genzyme Agreement, the Company is obligated to pay Genzyme tiered royalties based on net sales of licensed products that the Company commercializes under the agreement. The obligation to pay royalties for each licensed product expires on a country-by-country basis on the latest of (i) the expiration of licensed patent rights that cover that licensed product in that country, (ii) the expiration of regulatory exclusivity in that country and (iii) ten years after the first commercial sale of such licensed product in that country. Royalty rates are subject to reduction under the agreement in specified circumstances, including in any country if the Company is required to obtain a license from any third party to the extent the Company’s patent rights might infringe the third party’s patent rights, if a licensed product is not covered by a valid claim in that country or if sales of generic products reach certain thresholds in that country. If the Company enters into a sublicense under the agreement, the Company will be obligated to pay Genzyme a percentage of certain upfront fees, maintenance fees, milestone payments and royalty payments paid to the Company by the sublicensee.

36

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

Under the Genzyme Agreement, the Company will itself manufacture and supply, or enter into manufacturing or supply agreements with Genzyme o r third parties to manufacture and supply, clinical and commercial supplies of licensed compounds and each licensed product. During the six months ended June 30, 2019, the Company did not enter into any third-party manufacturing or supply agreements in con nection with the Genzyme Agreement. The Company is also responsible for all costs related to the filing, prosecution and maintenance of the licensed patent rights.

The Genzyme Agreement will remain in effect until the expiration of the royalty term in all countries for all licensed products. The agreement may be terminated by either party with at least 90 days’ notice in the event of material breach by the other party that remains uncured for 90 days, by either party for insolvency or bankruptcy of the other party, immediately by Genzyme if the Company challenges the licensed patents, or immediately by the Company if a material safety issue arises.

During the six months ended June 30, 2019, the Company did not incur any payment obligations to Genzyme under the Genzyme Agreement.

Georgetown Agreement

In December 2016, the Company entered into a license agreement (the “Georgetown Agreement”) with Georgetown University (“Georgetown”) pursuant to which the Company obtained an exclusive, worldwide license to make, have made, use, sell, offer for sale and import of products covered by patent rights co-owned by Georgetown. The rights licensed to the Company are for all therapeutic, prophylactic and diagnostic uses in all disease indications in humans and animals.

Under the terms of the Georgetown Agreement, the Company paid a one-time only, upfront fee of $50 and the Company may be required to make milestone payments of up to an aggregate of $800 related to commercial sales of a product. The Company recorded the upfront payment as research and development expense in the consolidated statement of operations because the acquired technology represented in-process research and development and had no alternative future use.

Under the Georgetown Agreement, the Company is solely responsible for all development and commercialization activities and costs in its respective territories. The Company is also responsible for all costs related to the filing, prosecution and maintenance of the licensed patent rights.

The term of the Georgetown Agreement will continue until the expiration of the last valid claim within the patent rights covering the product. Georgetown may terminate the agreement in the event (i) the Company fails to pay any amount and fails to cure such failure within 30 days after receipt of notice, (ii) the Company defaults in its obligation to obtain and maintain insurance and fails to remedy such breach within 45 days after receipt of notice, or (iii) the Company declares insolvency or bankruptcy. The Company may terminate the agreement at any time upon at least 60 days’ written notice.

During the six months ended June 30, 2019, the Company did not incur any payment obligations to Georgetown under the Georgetown Agreement and no milestone payments were made or due under the Georgetown Agreement.

Beth Israel Deaconess Medical Center Agreement

In December 2016, the Company entered into a license agreement (the “BIDMC Agreement”) with Beth Israel Deaconess Medical Center (“BIDMC”), pursuant to which the Company obtained an exclusive, worldwide license to make, have made, use, sell, offer for sale and import products covered by patent rights co-owned by BIDMC. The rights licensed to the Company are for all fields of use.

Under the terms of the BIDMC Agreement, the Company paid a one-time, upfront fee of $20 and the Company is responsible for all future patent prosecution costs. The Company recorded the upfront payment as research and development expense in the consolidated statement of operations because the acquired technology represented in-process research and development and had no alternative future use.

37

X4 PHARMACEUTICALS, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

The term of the BIDMC Agreement will continue until the expiration of the last valid claim within the patent rights covering the licensed products. BIDMC may terminate the agreement in the event (i) the Company fails to pay any amount and fail s to cure such failure within 15 days after receipt of notice, (ii) the Company is in material breach of any material provision of the agreement and fails to remedy such breach within 60 days after receipt of notice, or (iii) the Company declares insolvenc y or bankruptcy. The Company may terminate the agreement at any time upon at least 90 days’ written notice.

The Company did not incur any payment obligations under the BIDMC Agreement during the six months ended June 30, 2019.

Research and Development Incentive Program

The Company participates in a research and development incentive program provided by the Austrian government whereby the Company is entitled to reimbursement by the Austrian government for a percentage of qualifying research and development expenses incurred by the Company’s subsidiary in Austria. Under the program, the reimbursement rate for qualifying research and development expenses incurred by the Company through its subsidiary in Austria is 14% for the current year.

The Company recognizes incentive income from Austrian research and development incentives when qualifying expenses have been incurred, there is reasonable assurance that the payment will be received, and the consideration can be reliably measured. Management has assessed the Company’s research and development activities and expenditures to determine which activities and expenditures are likely to be eligible under the research and development incentive program described above. At each reporting date, management estimates the reimbursable incentive income available to the Company based on available information at the time.

As of June 30, 2019, the amount due under the program is $1.7 million, which amounts were included in grant and incentive receivables in the consolidated balance sheet. During the three and six months ended June 30, 2019, the Company recorded $136 of income related to the program within the condensed consolidated statement of operations as “other income (expense)”.

Janssen License and Option Agreement

On December 12, 2018, Arsanis entered into a patent license and option agreement with Janssen Pharmaceuticals, Inc. (“Janssen”), (the “Janssen License and Option Agreement”). Pursuant to the Janssen License and Option Agreement, Arsanis granted to Janssen (i) a non-exclusive license to specified patents in Arsanis’s portfolio related to the ASN200 program, and (ii) an option for Janssen to acquire these patents in the future if specified conditions are met. Janssen agreed to pay Arsanis $3.5 million within 15 business days after the December 12, 2018 effective date of the Janssen License and Option Agreement, in addition to a future $0.5 million payment in the event Janssen exercises its option to acquire the relevant patents. Arsanis received the $3.5 million and recognized this amount as revenue. Such revenue is not reflected in the consolidated financial statements of the Company as it occurred prior to the Merger. Janssen’s option to the relevant patents will be recognized as revenue in full in the period in which the option exercise occurs.

14. | Income Taxes

The Company did not record a federal or state income tax benefit for its losses for the three and six months ended June 30, 2019 and 2018 due to the conclusion that a full valuation allowance is required against the Company’s deferred tax assets.

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NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

15. | Net Loss per Share

Basic and diluted net loss per share attributable to common stockholders was calculated as follow:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Numerator: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  | $ | (13,383 | ) |  | $ | (6,034 | ) |  | $ | (24,256 | ) |  | $ | (13,401 | )
Accruing dividends on Series A convertible preferred stock |  |  | — |  |  |  | (748 | ) |  |  | (592 | ) |  |  | (1,488 | )
Adjustment to accumulated deficit in connection with repurchase of Series Seed convertible preferred stock |  |  | — |  |  |  | (22 | ) |  |  | — |  |  |  | (22 | )
Net loss attributable to common stockholders |  | $ | (13,383 | ) |  | $ | (6,804 | ) |  | $ | (24,848 | ) |  | $ | (14,911 | )
Denominator: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Weighted average common shares outstanding—basic and diluted |  |  | 13,177,235 |  |  |  | 458,718 |  |  |  | 7,479,178 |  |  |  | 458,346 |
Net loss per share attributable to common stockholders— basic and diluted |  | $ | (1.02 | ) |  | $ | (14.83 | ) |  | $ | (3.32 | ) |  | $ | (32.53 | )

The Company has included 107,371 shares of redeemable common stock in its computation of basic and diluted weighted average common shares outstanding for the six months ended June 30, 2019 and the three and six months ended June 30, 2018 as this class of stock participates in losses similarly to other common stockholders. Basic and diluted weighted average common shares outstanding for the three and six months ended June 30, 2019 also includes the weighted average effect of 2,130,000 pre-funded warrants for the purchase of common shares, which were issued in April 2019 and for which the remaining unfunded exercise price is less than $0.01 per share.

The Company’s potentially dilutive securities included outstanding stock options, convertible preferred stock, and warrants to purchase shares of convertible preferred stock for the three and six months ended June 30, 2018 and included outstanding stock options and warrants to purchase common stock for the three and six months ended June 30, 2019. These potentially dilutive securities have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share, and thus they are considered “anti-dilutive.” Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same. The Company excluded the following potential common shares, presented based on amounts outstanding at each period end and adjusted for the Exchange Ratio and Reverse Stock Split, from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Options to purchase common stock |  |  | 1,273,532 |  |  |  | 532,081 |  |  |  | 1,273,532 |  |  |  | 532,081 |
Convertible preferred stock (as converted to common stock) |  |  | — |  |  |  | 3,556,147 |  |  |  | — |  |  |  | 3,556,147 |
Warrants to purchase common stock (excluding prefunded warrants, which are included in basic shares outstanding) |  |  | 4,360,204 |  |  |  | 423,539 |  |  |  | 4,360,204 |  |  |  | 423,539 |
|  |  | 5,633,736 |  |  |  | 4,511,767 |  |  |  | 5,633,736 |  |  |  | 4,511,767 |

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NOTES TO CONDENSED CONSOLIDATED FINANCIALS STATEMENTS

(Amounts in thousands, except share and per share amounts)

(Unaudited)

16. | Subsequent Events

On July 17, 2019, the Company announced that it has entered into an agreement with Abbisko Therapeutics (“Abbisko”) to develop and commercialize the Company’s product candidate, mavorixafor, in combination with checkpoint inhibitors or other agents in Greater China for oncology indications. The agreement provides Abbisko with the exclusive rights in China, Taiwan, Hong Kong and Macau to develop and commercialize mavorixafor in combination with checkpoint inhibitors or other agents in oncology indications. Pancreatic cancer, ovarian cancer and triple negative breast cancer will be explored initially. The Company retains the full rest-of-world rights to develop and commercialize mavorixafor outside of Greater China for all indications and the ability to utilize and data generated pursuant to the Abbisko collaboration for rest-of-world development. The Company is assessing the financial impact of this arrangement and will account for this arrangement beginning in the third quarter of 2019.

In July 2019, the Company entered into an outlicensing arrangement with Evotec International GmbH (“Evotec”) whereby the Company transferred intellectual property and other rights related to its ASN500 program through an exclusive, worldwide license in return for an upfront fee, future payments based on achievement of clinical and regulatory milestones, and royalties based on net sales of the resulting licensed product. In addition, in July 2019, Bravos Bioscience LLC (“Bravos”), an entity that had entered into option agreements with Arsanis in 2018 to license certain intellectual property and other rights related to two preclinical stage programs that Arsanis referred to as the ASN200 and ASN300 programs, exercised amended versions of the option agreements. In accordance with the amended option agreements, Bravos obtained exclusive, sublicensable, rights to the ASN200 and ASN300 programs in return for an upfront fee and future payments to the Company, which are based on a percentage of future transaction fees, as defined, obtained by Bravos related to the programs. The Company is assessing the financial impact of these arrangements will account for these arrangements beginning in the third quarter of 2019.

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Item 2. | MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

You should read the following discussion and analysis of our financial condition and results of operations together with our consolidated financial statements and the related notes included elsewhere in this Quarterly Report on Form 10-Q. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report on Form 10-Q, including information with respect to our plans and strategy for our business and related financing, includes forward-looking statements that involve risks, uncertainties and assumptions. Our actual results, performance or experience could differ materially from what is indicated by any forward-looking statement due to various important factors, risks and uncertainties, including, but not limited to, those set forth under “Cautionary Note Regarding Forward-Looking Statements” included elsewhere in this Quarterly Report on Form 10-Q or under “Risk Factors” in Item 1A of Part I of our Annual Report on Form 10-K for the fiscal year ended December 31, 2018, as updated by our Current Report on Form 8-K filed on April 11, 2019 and our subsequent filings under the Exchange Act.

Overview

We are a clinical-stage biopharmaceutical company focused on the research, development and commercialization of novel therapeutics for the treatment of rare diseases. Our pipeline is comprised of potentially first-in-class, oral, small molecule antagonists of chemokine receptor CXCR4, which have the potential to treat a broad range of rare diseases, including primary immunodeficiencies (“PIs”) and certain types of cancer. PIs are a group of more than 250 rare, chronic disorders in which flaws in the immune system cause increased susceptibility to infections and, in some cases, increased risk of cancers. Within this broad disease classification, a number of PIs are attributed to the improper trafficking of immune cells related to the CXCR4 receptor and its ligand CXCL12. CXCR4 is stimulated by its only chemokine ligand, CXCL12, and plays a key role in enabling the trafficking of immune cells and effectively monitoring the function of the immune system, or immunosurveillance. Overstimulation of the CXCL12/CXCR4 pathway leads to inhibition of the immune response, or immunosuppression.

Our lead product candidate, mavorixafor (X4P-001), is a potentially first-in-class, oral, allosteric antagonist of the CXCR4 receptor designed to correct the abnormal signaling caused by the receptor/ligand interaction and enable mobilization and trafficking of immune cells. Mavorixafor has completed a Phase 2 clinical trial in patients with Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (“WHIM”) syndrome, which is a rare, inherited primary immunodeficiency disease. On June 26, 2019, we announced the initiation of 4WHIM, a pivotal, 52-week Phase 3 global clinical trial of mavorixafor for the treatment of patients with WHIM syndrome. We plan to report top-line data from this trial in 2021. Beyond WHIM syndrome, we plan to initiate a Phase 1 clinical trial of mavorixafor in another PI, severe congenital neutropenia (“SCN”), and a Phase 1/2 clinical trial of mavorixafor in Waldenström macroglobulinemia (“WM”) in 2019. We expect to report data from the SCN trial in the middle of 2020 and data from the WM trial in the second half of 2020.

We are also developing X4P-002, a CXCR4 antagonist that has unique properties that we believe will enable it to penetrate the blood-brain barrier and provide appropriate therapeutic exposures to treat brain cancers, including glioblastoma multiforme (“GBM”), and X4P-003, a second -generation molecule designed to have an enhanced pharmacokinetic profile relative to mavorixafor, potentially enabling improved patient compliance and ease of use to better serve patients suffering from chronic rare diseases. Both of these programs are in preclinical development.

Recent Developments

Abbisko Collaboration. On July 17, 2019, we announced that we had entered into an agreement with Abbisko to develop and commercialize mavorixafor in combination with checkpoint inhibitors or other agents in Greater China for oncology indications. The agreement provides Abbisko with the exclusive rights in China, Taiwan, Hong Kong and Macau to develop and commercialize mavorixafor in combination with checkpoint inhibitors or other agents in oncology indications. Pancreatic cancer, ovarian cancer and triple negative breast cancer will be explored initially. We retain the full rest-of-world rights to develop and commercialize mavorixafor outside of Greater China for all indications and the ability to utilize and data generated pursuant to the Abbisko collaboration for rest-of-world development.

Global 4WHIM Trial. On June 26, 2019, we announced the initiation of 4WHIM, a pivotal Phase 3 global clinical trial of mavorixafor for the treatment of WHIM syndrome. The global 4WHIM trial is a 52-week, randomized, double-blind, placebo-controlled, multicenter trial designed to evaluate the safety and efficacy of mavorixafor in genetically confirmed WHIM patients. The trial is designed to enroll a minimum of 18 and up to 28 subjects in approximately 20 countries, followed by an open-label extension trial. The primary efficacy endpoint for the trial will compare the level of circulating neutrophils relative to a clinically meaningful threshold (500 cells/µL), in response to mavorixafor versus placebo measured during multiple 24-hour periods over the course of 52 weeks. Secondary endpoints include infection rates, wart burden, and assessments of immune system function and quality of life. We plan to report top-line data from this trial in 2021.

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Debt Refinancing. In June 2019, we refinanced our prior loan agreement with Hercules Capital, Inc. (“Hercules”) and entered into an a mended and r estated l oan and s ecurity a greement (the “June 2019 Loan A greement”) with Hercules. The June 2019 Loan Agreement provides for aggregate maximum borrowings of $35.0 million of which $10.0 million was previously outstanding. We agreed to borrow $20.0 million as of the closing date o f June 27, 2019, including $10.0 million in new borrowings and $10.0 million rolled over from the p rior loan agreement. An additional $5.0 million is available for borrowing through December 15, 2020 and, subject to approval by Hercules, an additional term loan of $10.0 million is available through June 15, 2022. Borrowings under the June 2019 Loan Agreement bear interest at a variable rate equal to the greater of (i) 8.7 5% or (ii) 8.7 5% plus T he Wall Street Journal prime rate minus 6.0%. Interest-only payme nts are due monthly and amortization payments begin in November 2021, and the agreement matures in July 2023.

Equity Financing. On April 16, 2019, we sold to the public 5,670,000 shares of our common stock at a price to the public of $11.00 per share and, in lieu of common stock, pre-funded warrants to purchase 2,130,000 shares of common stock at a price of $10.999 per pre-funded warrant, and accompanying Class A warrants to purchase 3,900,000 shares of our common stock. The Class A warrants have an exercise price of $13.20, will expire five years from the date of issuance, and are immediately exercisable with certain restrictions. The net proceeds from the offering were $79.3million after deducting underwriting discounts and offering expenses.

Reverse Merger. On March 13, 2019, X4 Pharmaceuticals, Inc., formerly Arsanis, Inc. (the “Company”), completed a business combination with X4 Therapeutics, Inc., formerly X4 Pharmaceuticals, Inc. (“X4”), in accordance with the terms of the Agreement and Plan of Merger, dated as of November 26, 2018, as amended on December 20, 2018 and March 8, 2019 (the “Merger Agreement”), by and among the Company, X4 and Artemis AC Corp., a Delaware corporation and a wholly owned subsidiary of the Company (“Merger Sub”), pursuant to which, among other matters, Merger Sub merged with and into X4 with X4 continuing as a wholly owned subsidiary of the Company and the surviving corporation of the merger (the “Merger”). Following the completion of the Merger on March 13, 2019, the Company effected a 1-for-6 reverse stock split of its common stock (the “Reverse Stock Split”) and changed its name to “X4 Pharmaceuticals, Inc.” Following the completion of the Merger, the business conducted by the combined organization became primarily the business conducted by X4. Unless noted otherwise, all references to common stock share and per share amounts reflect the Reverse Stock Split.

Under the terms of the Merger Agreement, at the closing of the Merger, the Company issued an aggregate of approximately 25.7 million shares of its common stock to X4 stockholders, based on a common stock exchange ratio of 0.5702 shares of the Company’s common stock for each share of X4’s common stock outstanding immediately prior to the Merger and a preferred stock exchange ratio of 0.5702 shares of the Company’s common stock for each share of X4 preferred stock outstanding prior to the Merger, in each case before taking into account the Reverse Stock Split (each such exchange ratio, the “Exchange Ratio”). The Company also assumed all of the outstanding and unexercised stock options and warrants to purchase shares of X4 capital stock, with the number of shares subject to such options or warrants representing the right to purchase a number of shares of the Company’s common stock equal to 0.5702 multiplied by the number of shares of X4 capital stock previously represented by such options or warrants, before taking into account the Reverse Stock Split. The exercise prices of such options and warrants were also appropriately adjusted to reflect the Exchange Ratio of 0.5702, before taking into account the Reverse Stock Split. As a result of the Reverse Stock Split, the number of shares subject to such options and warrants and the exercise prices of such options and warrants were further adjusted by decreasing the number of shares subject to such options and warrants and increasing the exercise price of such options and warrants on a 1-for-6 Reverse Stock Split basis. The assumed options continue to be governed by the terms of the X4 Therapeutics, Inc. 2015 Employee, Director and Consultant Equity Incentive Plan, as amended, under which the options were originally granted (the “X4 Therapeutics Plan”). Upon the closing of the Merger, X4 Pharmaceuticals, Inc. also assumed the X4 Therapeutics Plan.

Immediately following the Merger and the Reverse Stock Split, there were approximately 6.7 million shares of X4 Pharmaceuticals, Inc. common stock outstanding, and the former X4 Therapeutics, Inc. stockholders owned approximately 4.3 million shares, or 63.7%, of the combined organization’s common stock outstanding. In addition, immediately following the Merger and the Reverse Stock Split, the former X4 Pharmaceuticals, Inc. option-holders held options to purchase approximately 0.8 million shares of the combined organization’s common stock, and the former X4 Pharmaceuticals, Inc. warrant-holders held warrants to purchase approximately 0.5 million shares of the combined organization’s common stock. Approximately 24.3% of our common stock outstanding immediately after the Merger was held by stockholders subject to lock-up restrictions, pursuant to which such stockholders have agreed, except in limited circumstances, not to sell or transfer, or engage in swap or similar transactions with respect to, shares of the combined organization’s common stock, including, as applicable, shares received in the Merger and issuable upon exercise of certain warrants and options, for a period of 180 days following the closing of the Merger.

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The business c ombination has been accounted for as a “reverse merger” in accordance with GAAP. Under this method of accounting, X4 Therapeutics, Inc. is deemed to be the accounting acquirer for financial reporting purposes. This determination was primarily based on the facts that, immediately following the Merger: (i) the stockholders of X4 own a substantial majority of the voting rights in the combined organization, (ii) X4 designated a majority of the members of the initial board of directors of the combined organizati on and (iii) X4’s senior management hold all key positions in the senior management of the combined organization. Accordingly, for accounting purposes, the business combination has been treated as the equivalent of X4 issuing stock to acquire the net asset s of Arsanis. As a result, as of the closing date of the Merger, the net assets of Arsanis have been recorded at their acquisition-date fair values in the financial statements of the combined entity and the reported operating results prior to the business combination will be those of X4. Subsequent to the closing of the Merger, the reported operating results will reflect those of the combined organization. In addition, transaction costs incurred by X4 in connection with the business combination have been ex pensed as incurred.

Our common stock remained listed on the Nasdaq Stock Market, with trading having commenced on a post-Reverse Stock Split basis and under the new name as of March 14, 2019. The trading symbol also changed on that date from “ASNS” to “XFOR.”

Operating History

Since our inception in 2012, we have devoted substantially all our efforts and financial resources to business planning; raising capital; acquiring or discovering product candidates and securing related intellectual property rights; and conducting discovery, and research and development activities for our product candidates. We do not have any products approved for sale and have not generated any revenue from product sales. Through December 31, 2018, we have funded our operations primarily with proceeds from sales of preferred stock, proceeds from the issuance of convertible debt and borrowings under loan and security agreements. Through December 31, 2018, we had received net proceeds of $73.7 million from sales of our preferred stock (including proceeds from convertible debt, which converted into preferred stock) and gross proceeds of $16.0 million from borrowings under loan and security agreements, net of amounts used to repay prior loan and security agreements. On March 13, 2019, as a result of our Merger with Arsanis, we acquired $26.4 million of cash, cash equivalents and restricted cash. In April 2019, as noted above, we raised $79.3 million of net proceeds from the sale of our common stock, pre-funded warrants and accompanying Class A warrants.

We have incurred significant operating losses since inception. Our ability to generate product revenue sufficient to achieve profitability will depend heavily on the successful development and eventual commercialization of one or more of our current or future product candidates. Our net losses were $24.3 million and $13.4 million for the six months ended June 30, 2019 and 2018, respectively. As of June 30, 2019, we had an accumulated deficit of $103.5 million. We expect to continue to incur significant expenses and increasing operating losses for at least the next several years. We expect that our expenses and capital requirements will increase substantially in connection with our ongoing activities, particularly if and as we:

| • | conduct additional clinical trials for our product candidates;

| • | continue to discover and develop additional product candidates;

| • | acquire or in-license other product candidates and technologies;

| • | maintain, expand and protect our intellectual property portfolio;

| • | hire additional clinical, scientific and commercial personnel;

| • | establish a commercial manufacturing source and secure supply chain capacity sufficient to provide commercial quantities of any product candidates for which we may obtain regulatory approval;

| • | seek regulatory approvals for any product candidates that successfully complete clinical trials;

| • | establish a sales, marketing and distribution infrastructure to commercialize any products for which we may obtain regulatory approval; and

| • | add operational, financial and management information systems and personnel, including personnel to support our product development and planned future commercialization efforts, as well as additional expenses to support our operations as a public company.

We will not generate revenue from product sales unless and until we successfully complete clinical development and obtain regulatory approval for our product candidates. If we obtain regulatory approval for any of our product candidates and do not enter into a commercialization partnership, we expect to incur significant expenses related to developing our internal commercialization capability to support product sales, marketing and distribution. Further, we expect to incur additional costs as we operate as a public company that we did not incur as a private company.

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As a result, we will need substantial additional funding to support our continuing operations and pursue our growth strategy. Until we can generate significant revenue from product sales, if eve r, we expect to finance our operations through the sale of equity, debt financings or other capital sources, which may include collaborations with other companies or other strategic transactions. We may not be able to raise additional funds or enter into s uch other agreements or arrangements when needed on favorable terms, or at all. If we fail to raise capital or enter into such agreements as and when needed, we may have to significantly delay, reduce or eliminate the development and commercialization of o ne or more of our product candidates or delay our pursuit of potential in-licenses or acquisitions.

Because of the numerous risks and uncertainties associated with product development, we are unable to predict the timing or amount of increased expenses or when or if we will be able to achieve or maintain profitability. Even if we are able to generate product sales, we may not become profitable. If we fail to become profitable or are unable to sustain profitability on a continuing basis, then we may be unable to continue our operations at planned levels and be forced to reduce or terminate our operations.

We expect that our existing cash and cash equivalents of $90.2 million as of June 30, 2019 will be sufficient to fund our operating expenses, capital expenditure requirements and debt service payments for at least the next 12 months. See “Liquidity and Capital Resources.” We will need to raise additional capital in the future to finance our operations. The source, timing and availability of any future financing will depend principally upon market conditions and the status of our clinical programs. Funding may not be available when needed, at all, or on terms acceptable to us. See Note 1 of our consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q for additional information on our assessment.

Components of Results of Operations

Revenue

To date, we have not generated any revenue from product sales and do not expect to generate significant revenue from the sale of our products in the foreseeable future. If our development efforts for our product candidates are successful and result in regulatory approval, we may generate revenue in the future from product sales. We cannot predict if, when, or to what extent we will generate revenue from the commercialization and sale of our product candidates. We may never succeed in obtaining regulatory approval for any of our product candidates.

Operating Expenses

Research and Development Expenses

Research and development expenses consist primarily of costs incurred in connection with the discovery and development of our product candidates. We expense research and development costs as incurred. These expenses include:

| • | employee-related expenses, including salaries, related benefits and stock-based compensation expense, for employees engaged in research and development functions;

| • | expenses incurred in connection with the preclinical and clinical development of our product candidates, including under agreements with third parties, such as consultants and contract research organizations (“CROs”);

| • | the cost of manufacturing drug products for use in our preclinical studies and clinical trials, including under agreements with third parties, such as consultants and contract manufacturing organizations (“CMOs”);

| • | facilities, depreciation and other expenses, which include direct or allocated expenses for rent and maintenance of facilities and insurance;

| • | costs related to compliance with regulatory requirements; and

| • | payments made under third-party licensing agreements.

We recognize external development costs based on an evaluation of the progress to completion of specific tasks using information provided to us by our service providers. This process involves reviewing open contracts and purchase orders, communicating with our personnel to identify services that have been performed on our behalf, and estimating the level of service performed and the associated cost incurred for the service when we have not yet been invoiced or otherwise notified of actual costs. Nonrefundable advance payments for goods or services to be received in the future for use in research and development activities are recorded as prepaid expenses. Such amounts are recognized as an expense when the goods have been delivered or the services have been performed, or when it is no longer expected that the goods will be delivered or the services rendered. Upfront payments, milestone payments and annual maintenance fees under license agreements are expensed in the period in which they are incurred.

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Our direct research and development expenses are tracked by product candidate and consist primarily of external costs, such as fees paid to outside consultants, CROs, CMOs and research laboratories in connecti on with our preclinical development, process development, manufacturing and clinical development activities. Our direct research and development expenses by product candidate also include fees incurred under third-party license agreements. We do not alloca te employee costs and costs associated with our discovery efforts, laboratory supplies and facilities, including depreciation or other indirect costs, to specific product candidates because these costs are deployed across multiple programs and, as such, ar e not separately classified. We use internal resources primarily to conduct our research and discovery as well as for managing our preclinical development, process development, manufacturing and clinical development activities. These employees work across multiple programs and, therefore, we do not track our costs by product candidate.

The table below summarizes our research and development expenses incurred by product candidate:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | 2019 |  |  | 2018 |
Mavorixafor |  | $ | 5,419 |  |  | $ | 2,276 |  |  | $ | 8,270 |  |  | $ | 5,286 |
X4P-002 |  |  | 57 |  |  |  | — |  |  |  | 141 |  |  |  | — |
X4P-003 |  |  | 210 |  |  |  | — |  |  |  | 218 |  |  |  | — |
Unallocated research and development expenses |  |  | 3,168 |  |  |  | 2,479 |  |  |  | 5,880 |  |  |  | 4,213 |
Total research and development expenses |  | $ | 8,854 |  |  | $ | 4,755 |  |  | $ | 14,509 |  |  | $ | 9,499 |

Research and development activities are central to our business model. Product candidates in later stages of clinical development generally have higher development costs than those in earlier stages of clinical development, primarily due to the increased size and duration of later-stage clinical trials. As a result, we expect that our research and development expenses will increase over the next several years as a result of the Phase 3 pivotal clinical trial of mavorixafor (X4P-001) for the treatment of patients with WHIM syndrome that we initiated in the second quarter of 2019 and as we plan to initiate a Phase 1 clinical trial of mavorixafor in SCN and a Phase 1/2 clinical trial of mavorixafor in WM in 2019. In addition, we expect research and development expenses to increase related to conducting preclinical development and pursuing initial clinical stages of our product candidates X4P-002 and X4P-003.

The successful development and commercialization of our product candidates is highly uncertain. At this time, we cannot reasonably estimate or know the nature, timing and costs of the efforts that will be necessary to complete the preclinical and clinical development of any of our product candidates. This is due to the numerous risks and uncertainties associated with product development and commercialization, including the following:

| • | the timing and progress of preclinical and clinical development activities;

| • | the number and scope of preclinical and clinical programs that we decide to pursue;

| • | our ability to maintain our current research and development programs and to establish new ones;

| • | establishing an appropriate safety profile with Investigational New Drug (“IND”)-enabling studies;

| • | successful patient enrollment in, and the initiation and completion of, clinical trials;

| • | the receipt of regulatory approvals from applicable regulatory authorities;

| • | the successful completion of clinical trials with safety, tolerability and efficacy profiles that are satisfactory to the U.S Food and Drug Administration (“FDA”) or any comparable foreign regulatory authority;

| • | the timing, receipt and terms of any marketing approvals from applicable regulatory authorities;

| • | our ability to establish new licensing or collaboration arrangements;

| • | establishing agreements with third-party manufacturers for clinical supply for our clinical trials and commercial manufacturing, if any of our product candidates is approved;

| • | development and timely delivery of clinical-grade and commercial-grade drug formulations that can be used in our clinical trials and for commercial launch;

| • | obtaining, maintaining, defending and enforcing patent claims and other intellectual property rights;

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| • | launching commercial sales of our product candidates, if approved, whether alone or in collaboration with others; and

| • | maintaining a continued acceptable safety profile of the product candidates following approval.

A change in the outcome of any of these variables with respect to the development of our product candidates could significantly change the costs and timing associated with the development of that product candidate. We may never succeed in obtaining regulatory approval for any of our product candidates.

General and Administrative Expenses General and administrative expenses consist primarily of salaries and related costs, including stock-based compensation, for personnel in executive, finance and administrative functions. General and administrative expenses also include direct and allocated facility-related costs as well as professional fees for legal, patent, consulting, investor and public relations, accounting, and audit services.

We anticipate that our general and administrative expenses will increase in the future as we increase our headcount to support our continued research activities and the clinical development of our product candidates. We also expect to continue to incur increased accounting, audit, legal, regulatory, compliance and director and officer insurance costs as well as investor and public relations expenses as a public company.

Other Income (Expense), Net

Interest Income

Interest income consists of interest earned on our cash equivalents, which consist of money market funds. Our interest income has not been significant due to low interest rates earned on invested balances.

Interest Expense

For the three and six months ended June 30, 2019, interest expense primarily consists of interest on outstanding borrowings under our Hercules Loan Agreement, which was entered into with Hercules in October 2018, and interest expense on loans acquired from Arsanis. For the three and six months ended June 30, 2018, interest expense consisted of interest on outstanding borrowing under the 2016 loan and security agreement with Silicon Valley Bank, or SVB, which we refer to as the SVB Loan Agreement, as well as amortization of debt issuance costs and accretion of a final payment payable upon the maturity or the repayment in full of all obligations under the SVB Loan Agreement. In October 2018, in connection with entering into the Hercules Loan Agreement, all amounts due under the SVB Loan Agreement were repaid with proceeds from the Hercules Loan Agreement, and the SVB Loan Agreement was terminated. We expect that our interest expense will increase in 2019 as compared to 2018 due to the Hercules Loan Agreement, under which we borrowed an aggregate of $10.0 million in the fourth quarter of 2018, and which we refinanced in June 2019 to borrow an additional $10.0 million; and the FFG loan agreement acquired in March 2019, under which borrowings were $6.7 million as of June 30, 2019.

Change in Fair Value of Preferred Stock Warrant and Derivative Liabilities

Preferred Stock Warrants. In connection with our preferred stock financings prior to our merger with Arsanis, we issued warrants to purchase shares of our preferred stock. Due to the liquidation requirements of these preferred shares, we classified these warrants as a liability on our consolidated balance sheet, which was remeasured to fair value at each reporting date with changes in the fair value reported as a component of other income (expense), net in our consolidated statements of operations and comprehensive loss. Upon the closing of the Merger on March 13, 2019, all outstanding preferred stock warrants become exercisable for Arsanis common stock; accordingly, the liability as of March 13, 2019 for these warrants was remeasured to fair value and reclassified to additional paid-in capital. As a result, following the closing of the Merger, we will no longer recognize changes in the fair value of these warrants as other income (expense), net in our consolidated statements of operations.

Fair Value of Derivative Liability. Our license agreement with Genzyme contains a contingent payment obligation that required us to make a cash payment to Genzyme upon a change of control event. The contingent payment obligation met the definition of a derivative instrument as the contingent payment obligation was not clearly and closely related to its host instrument and was a cash-settled liability. Accordingly, we classified this derivative as a liability within other liabilities (non-current) on our condensed consolidated balance sheet. The derivative liability was initially recorded at fair value on the date of entry into the license agreement and was subsequently remeasured to fair value at each reporting date. Changes in the fair value of this derivative liability were recognized as a component of other income (expense), net in the condensed consolidated statement of operations. The Merger with Arsanis qualified as a change of control event, as defined in the license agreement, but resulted in no payment being due to Genzyme under the license agreement. As a result, on March 13, 2019, the closing date of the Merger with Arsanis, the derivative liability was remeasured to fair value, which was zero, and subsequent changes in fair value will no longer be recognized in our consolidated statements of operations because the contingent payment obligation to Genzyme expired at that time.

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Income Taxes Since our inception, we have not recorded any income tax benefit for the net losses we have incurred in each year or for our earned research and development tax credits, as we believe, based upon the weight of available evidence, that it i s more likely than not that all of our net operating loss carryforwards and tax credits will not be realized. Accordingly, we have recorded a full valuation allowance against our net deferred tax assets at each balance sheet date.

Results of Operations

Comparison of the Three and Six Months Ended June 30, 2019 and 2018

The following table summarizes the results of our operations for the periods indicated, in thousands:

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | Change |  |  | 2019 |  |  | 2018 |  |  | Change |
|  | (in thousands) |  |  | (in thousands) |
Operating expenses: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  | $ | 8,854 |  |  | $ | 4,755 |  |  | $ | 4,099 |  |  | $ | 14,509 |  |  | $ | 9,499 |  |  | $ | 5,010 |
General and administrative |  |  | 4,560 |  |  |  | 1,621 |  |  |  | 2,939 |  |  |  | 9,343 |  |  |  | 2,987 |  |  |  | 6,356 |
Total operating expenses |  |  | 13,414 |  |  |  | 6,376 |  |  |  | 7,038 |  |  |  | 23,852 |  |  |  | 12,486 |  |  |  | 11,366 |
Loss from operations |  |  | (13,414 | ) |  |  | (6,376 | ) |  |  | (7,038 | ) |  |  | (23,852 | ) |  |  | (12,486 | ) |  |  | (11,366 | )
Other income (expense): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest income |  |  | 394 |  |  |  | 67 |  |  |  | 327 |  |  |  | 463 |  |  |  | 136 |  |  |  | 327 |
Interest expense |  |  | (512 | ) |  |  | (167 | ) |  |  | (345 | ) |  |  | (911 | ) |  |  | (336 | ) |  |  | (575 | )
Change in fair value of preferred stock warrant and derivative liabilities |  |  | — |  |  |  | 442 |  |  |  | (442 | ) |  |  | (105 | ) |  |  | (715 | ) |  |  | 610 |
Other income (expense) |  |  | 149 |  |  |  | — |  |  |  | 149 |  |  |  | 149 |  |  |  | — |  |  |  | 149 |
Total other income (expense), net |  |  | 31 |  |  |  | 342 |  |  |  | (311 | ) |  |  | (404 | ) |  |  | (915 | ) |  |  | 511 |
Net loss |  | $ | (13,383 | ) |  | $ | (6,034 | ) |  | $ | (7,349 | ) |  | $ | (24,256 | ) |  | $ | (13,401 | ) |  | $ | (10,855 | )

Research and Development Expenses

|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |  |  | Change |  |  | 2019 |  |  | 2018 |  |  | Change |
|  | (in thousands) |  |  | (in thousands) |
Direct research and development expenses by product candidate: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Mavorixafor (X4P-001) |  | $ | 5,419 |  |  | $ | 2,276 |  |  | $ | 3,143 |  |  | $ | 8,270 |  |  | $ | 5,286 |  |  | $ | 2,984 |
X4P-002 |  |  | 57 |  |  |  | — |  |  |  | 57 |  |  |  | 141 |  |  |  | — |  |  |  | 141 |
X4P-003 |  |  | 210 |  |  |  | — |  |  |  | 210 |  |  |  | 218 |  |  |  | — |  |  |  | 218 |
Unallocated research and development expenses: |
Personnel related (including stock-based compensation) |  |  | 2,214 |  |  |  | 1,145 |  |  |  | 1,069 |  |  |  | 4,414 |  |  |  | 2,179 |  |  |  | 2,235 |
Other |  |  | 954 |  |  |  | 1,334 |  |  |  | (380 | ) |  |  | 1,466 |  |  |  | 2,034 |  |  |  | (568 | )
Total research and development expenses |  | $ | 8,854 |  |  | $ | 4,755 |  |  | $ | 4,099 |  |  | $ | 14,509 |  |  | $ | 9,499 |  |  | $ | 5,010 |

Research and development expenses were $8.9 million for the three months ended June 30, 2019, compared to $4.8 million for the three months ended June 30, 2018. Research and development expenses were $14.5 million for the six months ended June 30, 2019 compared to $9.5 million for the six months ended June 30, 2019. The increase in research and development expenses in each period was primarily due to an increase in direct expenses related to our mavorixafor development program as we prepared for entering the product candidate into the Phase 3 clinical development stage, and increased unallocated research and development costs, primarily associated with personnel and other costs associated with our research and development site in Vienna, Austria, acquired in the Merger with Arsanis. We expect that our research and development expenses for mavorixafor will increase over the next several years due to the initiation of our Phase 3 pivotal clinical trial of mavorixafor for the treatment of patients with WHIM syndrome in the second quarter of 2019 and our plans to initiate a Phase 1 clinical trial of mavorixafor in SCN and a Phase 1/2 clinical trial of mavorixafor in WM in the second half of 2019. Direct expenses related to our X4P-002 and X4P-003 product candidates have been relatively low as we paused the development of these candidates in favor of focusing our resources on the development of

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mavorixafor. We expect that our research and development expenses for X4P-002 and X4P-003 will inc rease over the next several years as we resume work on X4P-002’s preclinical development and initial clinical stage activities.

General and Administrative Expenses General and administrative expenses were $4.6 million for the three months ended June 30, 2019, compared to $1.6 million for the three months ended June 30, 2018. General and administrative expenses were $9.3 million for the six months ended June 30, 2019 compared to $3.0 million for the six months ended June 30, 2018. The increase in both periods was primarily due to a significant increase in professional fees, which increased due to higher audit, legal and market research expenses particularly related to the Merger, as well as increased legal costs incurred in connection with maintaining and registering worldwide patents and costs associated with our ongoing business operations. General and administrative expenses also increased due to an increase in personnel-related costs as we have added personnel to our general and administrative functions to support the growth of our business and the compliance-related requirements of becoming a public company. Personnel-related costs for the three months ended June 30, 2019 and 2018 included stock-based compensation of $0.2 million and $0.1 million, respectively. Personnel-related costs for the six months ended June 30, 2019 and 2018 included stock-based compensation of $0.4 million and $0.2 million, respectively.

Other Income (Expense), Net Other income (expense), net was approximately zero during the three months ended June 30, 2019 as interest income and other income offset our interest expense, compared to $0.3 million of income for the three months ended June 30, 2018. The decrease in other income (expense) was primarily due to a $0.4 million decrease in the other income generated from the change in the fair value of our preferred stock warrant and derivative liabilities in the three months ended June 30, 2018 as compared to the current period and a $0.3 million increase in interest expense in the current period, partially offset by an increase in interest income in the current period.

Other income (expense), net was $0.4 million of expense during the six months ended June 30, 2019, compared to $0.9 million of expense for the six months ended June 30, 2018. The increase in other income (expense) was primarily due to a $0.6 million decrease in other expense generated from the change in the fair value of our preferred stock warrant and derivative liabilities in the six months ended June 30, 2019 and an $0.3 million increase in investment income on our money market funds, partially offset by a $0.6 million increase in interest expense.

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Liquidity and Capital Resources

Since our inception, we have not generated revenue from any sources, including from product sales, and have incurred significant operating losses and negative cash flows from our operations. We expect that our research and development and general and administrative expenses will continue to increase and, as a result, we will need additional capital to fund our operations, which we may raise through a combination of equity offerings, debt financings, other third-party funding, marketing and distribution arrangements and other collaborations, strategic alliances and licensing arrangements.

We have funded our operations to date primarily with proceeds from sales of common stock, warrants and pre-funded warrants for the purchase of our preferred stock and our common stock, sales of preferred stock, proceeds from the issuance of convertible debt and borrowings under loan and security agreements. In March 2019, we completed a merger with Arsanis and acquired $26.4 million of cash, cash equivalents and restricted cash owned by Arsanis. In April 2019, we raised $79.3 million, net of offering costs, through a public offering of common stock, pre-funded warrants to purchase shares of common stock, and accompanying Class A warrants to purchase shares of common stock. In June 2019, we received $9.8 million in net proceeds as a result of refinancing our Hercules loan agreement and entering into the June 2019 Loan Agreement as described further below.

Cash Flows

The following table summarizes our cash flow activities for each of the periods presented:

|  | Six Months Ended June 30, |
|  | 2019 |  |  | 2018 |
|  | (in thousands) |
Net loss |  | $ | (24,256 | ) |  | $ | (13,401 | )
Adjustments to reconcile net loss to net cash used in operating activities |  |  | 1,457 |  |  |  | 1,098 |
Changes in operating assets and liabilities |  |  | (3,243 | ) |  |  | 338 |
Net cash used in operating activities |  |  | (26,042 | ) |  |  | (11,965 | )
Net cash provided by investing activities |  |  | 26,396 |  |  |  | — |
Net cash provided by (used in) financing activities |  |  | 86,791 |  |  |  | (2,153 | )
Impact of foreign exchange on cash and restricted cash |  |  | (2 | ) |  |  | — |
Net increase (decrease) in cash, cash equivalents and restricted cash |  | $ | 87,143 |  |  | $ | (14,118 | )

Operating Activities During the six months ended June 30, 2019, net cash used in operating activities was $26.0 million, primarily resulting from our net loss of $24.3 million, adjusted for net cash used in changes in our operating assets and liabilities of $3.2 million and by noncash expenses of $1.5 million. Net cash used in changes in our operating assets and liabilities for the six months ended June 30, 2019 primarily consisted of a $2.9 million decrease in accounts payable and accrued expenses as a result of the settlement of accounts payable and accrued expense acquired from Arsanis.

Investing Activities During the six months ended June 30, 2019, net cash provided by investing activities consisted primarily of $26.4 million of cash and restricted cash acquired in connection with the Merger. There was no comparable net cash provided by or used in investing activities during the six months ended June 30, 2018.

Financing Activities During the six months ended June 30, 2019, net cash provided by financing activities was $86.8 million, consisting primarily of $79.3 million of net proceeds for the sale in April 2019 of our common stock, pre-funded warrants, and Class A warrants, and net proceeds of $9.8 million received in our June 2019 Loan Agreement with Hercules, which closed in June 2019. During the six months ended June 30, 2018, net cash used in financing activities was $2.2 million, consisting primarily of $1.1 million for the repurchase of Series Seed convertible preferred stock and principal repayments of $1.0 million under the SVB Loan Agreement.

Loan and Security Agreements

Loan and Security Agreement with Silicon Valley Bank

In October 2016, we entered into the SVB Loan Agreement, which provided for aggregate maximum borrowings of up to $10.0 million, consisting of a term loan of up to $6.0 million, which we borrowed in June 2017, and, subject to specified conditions, an additional term loan of up to $4.0 million available for borrowing until December 31, 2017. In October 2018, in connection with entering into the Hercules Loan Agreement as described below, we terminated the SVB Loan Agreement and repaid all amounts due

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under the SVB Loan Agreement, including unpaid principal of $4.3 million, a final payment of $0.3 million, a prepayment premium of $87 thousand and accrued interest of $23 thousand. Our annual effective intere st rate of the SVB Loan Agreement was approximately 11.8% the period from January 1, 2018 through the date of repayment of all borrowings under the SVB Loan Agreement.

Loan and Security Agreement with Hercules Capital, Inc.

In October 2018, we entered into the Hercules Loan Agreement, which provided for aggregate borrowings of up to $13.0 million, consisting of (i) a term loan of up to $8.0 million, which was available upon entering into the agreement, (ii) subject to specified financing conditions, an additional term loan of up to $2.0 million, available for borrowing from January 1, 2019 to March 31, 2019, and (iii) subject to specified financing conditions and the receipt of the second tranche $2.0 million term loan described above, an additional term loan of up to $3.0 million, available for borrowing until March 31, 2019. In October 2018, we borrowed $8.0 million under the Hercules Loan Agreement.

In December 2018, we entered into the First Amendment to the Hercules Loan Agreement (the “First Amendment”), which amended the available borrowing dates of the second tranche from between January 1, 2019 and March 31, 2019 to between December 11, 2018 and December 14, 2018 and amended the term loan maturity date to November 1, 2021. In December 2018, we borrowed the additional $2.0 million provided under the Hercules Loan Agreement, as amended. In March 2019, the conditions necessary for borrowing the remaining $3.0 million under the Hercules Loan Agreement were not met and the borrowing capacity expired at that time.

In June 2019, we refinanced the prior Hercules Loan Agreement. The June 2019 Loan Agreement provides for aggregate maximum borrowings of $35.0 million of which $10.0 million was previously outstanding. We agreed to borrow $20.0 million as of the closing date on June 27, 2019, including $10.0 million in new borrowings and $10.0 million rolled over from the previous agreement. An additional $5.0 million is available for borrowing through December 15, 2020 and, subject to approval by Hercules, an additional term loan of $10.0 is available through June 15, 2022.

Borrowings under the June 2019 Loan Agreement bear interest at a variable rate equal to the greater of (i) 8.75% or (ii) 8.75% plus The Wall Street Journal prime rate minus 6.0%. In an event of default, as defined in the June 2019 Loan Agreement, and until such event is no longer continuing, the interest rate applicable to borrowings under the June 2019 Loan Agreement would be increased by 4.0%. As of June 30, 2019, the interest rate applicable to borrowings under the June 2019 Loan Agreement was 8.75%.

Borrowings under the June 2019 Loan Agreement are repayable in monthly interest-only payments through January 1, 2022, and in equal monthly payments of principal and accrued interest from February 1, 2022 until the maturity date of the loan, which is July 1, 2023. At our option, we may prepay all, but not less than all, of the outstanding borrowings, subject to a prepayment premium of up to 2.0% of the principal amount outstanding as of the date of repayment. In addition, the June 2019 Loan Agreement provides for payments of (i) $0.8 million payable upon the earlier of November 1, 2021 or the repayment in full of all obligations under the June 2019 Loan Agreement, and (ii) 4.0% of the aggregate principal amount of advances drawn under the June 2019 Loan Agreement payable upon the earlier of maturity or the repayment in full of all obligations under the agreement.

Borrowings under the June 2019 Loan Agreement are collateralized by substantially all of our personal property and other assets except for our intellectual property (but including rights to payment and proceeds from the sale, licensing or disposition of the intellectual property). Under the 2019 Loan Agreement, we have agreed to affirmative and negative covenants to which we will remain subject until maturity or repayment of the loan in full. The covenants include (a) maintaining a minimum liquidity amount of the lesser of (i) 125% of the aggregate principal amount of outstanding borrowings under the June 2019 Loan Agreement and (ii) 100% of our cash and cash equivalents (other than up to $2.5 million which may be held by an excluded subsidiary, as defined) in an account in which Hercules has a first priority security interest, as well as (b) restrictions on our ability to incur additional indebtedness, pay dividends, encumber our intellectual property, or engage in certain fundamental business transactions, such as mergers or acquisitions of other businesses. The June 2019 Loan Agreement also contains a covenant that requires us to repay its FFG Loan Agreement on or prior to December 31, 2019. The FFG Loan Agreement was not modified as a result of this covenant. We were in compliance with all covenants under the June 2019 Loan Agreement as of June 30, 2019 and the FFG principal amounts are classified on the consolidated balance sheet in accordance with their contractual maturity dates.

Our obligations under the June 2019 Loan Agreement are subject to acceleration upon occurrence of specified events of default, including payment default, insolvency and a material adverse change in our business, operations or financial or other conditions.

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FFG Borrowings

Between September 2011 and March 2017, Arsanis GmbH, a subsidiary of Arsanis, entered into a series of funding agreements with Österreichische Forschungsförderungsgesellschaft mbH (“FFG”) that provided for loans and grants to fund qualifying research and development expenditures of Arsanis GmbH on a project-by-project basis, as approved by FFG. On March 8, 2019, Arsanis entered into a settlement agreement (“Settlement Agreement”), with FFG in respect of allegations that Arsanis breached certain reporting, performance and other obligations. Pursuant to the terms of the Settlement Agreement, in exchange for FFG’s waiver of all claims against Arsanis and Arsanis GmbH except for its claims for repayment of the loans and regular interest, including its waiver of claims for repayment of grants and interest exceeding regular interest, Arsanis GmbH agreed to repay the outstanding loan principal (plus regular interest accrued thereon) on an accelerated payment schedule of three years instead of the original five years, with the final accelerated installment due and payable on June 30, 2021. The Settlement Agreement also contains certain other restrictive covenants, including a requirement to maintain, as of April 30, 2019, a minimum cash balance equal to 70% of the outstanding principal amount of the loans in an account held with an Austrian bank, until all of the loans have been repaid and subject to other terms specified in the Settlement Agreement.

We were in compliance with all covenants under the FFG Loan Agreement as of June 30, 2019 and the principal amounts of the FFG loans are classified as either current of non-current on the consolidated balance sheet in accordance with the contractual maturity dates within the FFG Loan Agreement. As noted above, the June 2019 Loan Agreement with Hercules includes a covenant that requires us to repay the FFG loans in full on or prior to June 30, 2019

Amounts due under the FFG loans bear interest at varying fixed rates ranging from 0.75% to 2.0% per annum. Interest is payable semi-annually in arrears, with all accrued interest and principal due upon maturity. After giving effect to the Settlement Agreement, the FFG loans mature at varying dates between June 2019 and June 2021. The FFG loans are not secured by any of our assets. We may be required to return all or a portion of the FFG loans and/or grants if we do not comply with the terms of the related FFG funding agreements and related guidelines, including specified requirements as to continued operations with respect to certain locations and funded projects, or if we fail to comply with the terms of the Settlement Agreement. As of June 30, 2019, the outstanding principal amount under loans from FFG was $6.7 million.

Funding Requirements

We expect our expenses to increase substantially in connection with our ongoing activities, particularly as we advance the preclinical activities and clinical trials of our product candidates in development. In addition, we expect to continue to incur additional costs as a public company. The timing and amount of our operating expenditures will depend largely on:

| • | the scope, number, initiation, progress, timing, costs, design, duration, any potential delays, and results of clinical trials and nonclinical studies for our current or future product candidates, particularly our Phase 3 pivotal clinical trial of mavorixafor for the treatment of patients with WHIM syndrome, our Phase 1 clinical trial of mavorixafor in SCN and our Phase 1/2 clinical trial of mavorixafor in WM;

| • | the clinical development plans we establish for these product candidates;

| • | the number and characteristics of product candidates and programs that we develop or may in-license;

| • | the outcome, timing and cost of regulatory reviews, approvals or other actions to meet regulatory requirements established by the FDA and comparable foreign regulatory authorities, including the potential for the FDA or comparable foreign regulatory authorities to require that we perform more studies for our product candidates than those that we currently expect;

| • | our ability to obtain marketing approval for our product candidates;

| • | the cost of filing, prosecuting, defending and enforcing our patent claims and other intellectual property rights covering our product candidates, including any such patent claims and intellectual property rights that we have licensed from Genzyme pursuant to the terms of our license agreement with Genzyme;

| • | our ability to maintain, expand and defend the scope of our intellectual property portfolio, including the cost of defending intellectual property disputes, including patent infringement actions brought by third parties against us or our product candidates;

| • | the cost and timing of completion of commercial-scale outsourced manufacturing activities with respect to our product candidates;

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| • | our ability to establish and maintain licensing, collaboration or similar arrangements on favorable terms and whether and to what extent we retain development or commercialization r esponsibilities under any new licensing, collaboration or similar arrangement;

| • | the cost of establishing sales, marketing and distribution capabilities for any product candidates for which we may receive regulatory approval in regions where we choose to commercialize our products on our own;

| • | the success of any other business, product or technology that we acquire or in which we invest;

| • | the costs of acquiring, licensing or investing in businesses, product candidates and technologies;

| • | our need and ability to hire additional management and scientific and medical personnel;

| • | the costs to continue to operate as a public company, including the need to implement additional financial and reporting systems and other internal systems and infrastructure for our business;

| • | market acceptance of our product candidates, to the extent any are approved for commercial sale; and

| • | the effect of competing technological and market developments.

We expect that our existing cash and cash equivalents will be sufficient to fund our operating expenses, capital expenditure requirements and debt service payments for at least the next 12 months.

Until such time, if ever, as we can generate substantial product revenue, we expect to finance our cash needs through a combination of equity offerings, debt financings, collaborations, strategic alliances, and marketing, distribution or licensing arrangements with third parties. In January 2019, Arsanis filed a universal shelf registration statement on Form S-3 with the SEC, which was declared effective in February 2019, and pursuant to which Arsanis registered for sale up to $150 million of any combination of our common stock, preferred stock, debt securities, warrants and/or units from time to time and at prices and on terms that we may determine. Subsequently, in April 2019, we raised $79.3 million, net of offering costs, for the sale of common stock, pre-funded warrants to purchase shares of common stock, and accompanying Class A warrants to purchase shares of our common stock. As of August 6, 2019, approximately $12 million of securities remain available for issuance under this shelf registration statement.

To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest of our stockholders may be materially diluted, and the terms of such securities could include liquidation or other preferences that adversely affect the rights of our stockholders. Debt financing and preferred equity financing, if available, may involve agreements that include restrictive covenants that limit our ability to take specified actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we raise funds through collaborations, strategic alliances or marketing, distribution or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds through equity or debt financings or other arrangements when needed, we may be required to delay, reduce or eliminate our product development or future commercialization efforts, or grant rights to develop and market product candidates that we would otherwise prefer to develop and market ourselves.

Critical Accounting Policies and Significant Judgments and Estimates

Our consolidated financial statements are prepared in accordance with generally accepted accounting principles in the United States. The preparation of our consolidated financial statements and related disclosures requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, costs and expenses, and the disclosure of contingent assets and liabilities in our financial statements. We base our estimates on historical experience, known trends and events and various other factors that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. We evaluate our estimates and assumptions on an ongoing basis. Our actual results may differ from these estimates under different assumptions or conditions.

While our significant accounting policies are described in more detail in Note 2 to our consolidated financial statements included elsewhere in this Quarterly Report, we believe that the following accounting policies are those most critical to the judgments and estimates used in the preparation of our consolidated financial statements.

Accrued Research and Development Expenses. As part of the process of preparing our consolidated financial statements, we are required to estimate our accrued research and development expenses. This process involves reviewing open contracts and purchase orders, communicating with our applicable personnel to identify services that have been performed on our behalf and estimating the level of service performed and the associated cost incurred for the service when we have not yet been invoiced or otherwise notified of

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actual costs. The majority of our service providers invoice us in arrears for services performed, on a pre-determined schedul e or when contractual milestones are met; however, some require advance payments. We make estimates of our accrued expenses as of each balance sheet date in the consolidated financial statements based on facts and circumstances known to them at that time. We periodically confirm the accuracy of these estimates with the service providers and make adjustments, if necessary. Examples of estimated accrued research and development expenses include fees paid to:

| • | vendors in connection with preclinical development activities;

| • | CROs and investigative sites in connection with preclinical studies and clinical trials; and

| • | CMOs in connection with the production of preclinical and clinical trial materials.

We base the expense recorded related to external research and development on our estimates of the services received and efforts expended pursuant to quotes and contracts with multiple CMOs and CROs that supply, conduct and manage preclinical studies and clinical trials on our behalf. The financial terms of these agreements are subject to negotiation, vary from contract to contract and may result in uneven payment flows. There may be instances in which payments made to our vendors will exceed the level of services provided and result in a prepayment of the expense. Payments under some of these contracts depend on factors such as the successful enrollment of patients and the completion of clinical trial milestones. In accruing service fees, we estimate the time period over which services will be performed and the level of effort to be expended in each period. If the actual timing of the performance of services or the level of effort varies from the estimate, we adjust the accrual or the amount of prepaid expenses accordingly.

Although we do not expect our estimates to be materially different from amounts actually incurred, our understanding of the status and timing of services performed relative to the actual status and timing of services performed may vary and may result in reporting amounts that are too high or too low in any particular period. To date, there have not been any material adjustments to our prior estimates of accrued research and development expenses.

Stock-Based Compensation. We measure all stock-based awards granted to employees, directors and consultants based on the grant-date fair value of the award and recognized compensation expense, net of estimated forfeitures, over the requisite service period, which is generally the vesting period of the respective award. The stock-based awards that we have issued to date include a service-based vesting condition and the expense for these awards is recognized using the straight-line method. To date, we have not issued stock-based awards with performance-based vesting conditions.

The fair value of stock option grants is estimated on the date of grant using the Black-Scholes option-pricing model, which uses as inputs the fair value of our common stock and assumptions we make for the volatility of our common stock, the expected term of the stock options, the risk-free interest rate for a period that approximates the expected term of our stock options and their expected dividend yield. Prior to the closing of the Merger and the listing of our common stock on the Nasdaq Capital Market, our board of directors historically determined, as of the date of each option grant and with input from our management, the assistance of a third-party valuation specialist the estimated fair value of our common stock on the date of grant based on a number of objectives and subjective factors. Since the Merger and the listing of our common stock on the Nasdaq Capital Market, we have relied on the market price of our common stock to determine the fair value on the date of grant. As our common stock does not have a sufficient history of trading, we estimate our volatility based on the historical volatility of publicly traded peer companies. We estimate the expected term of our stock awards by utilizing the “simplified” method, which calculates the expected term based on weighted average midpoint of the award’s vesting and expiration dates. We determine the risk-free interest rate by reference to the U.S. Treasury yield curve in effect at the time of grant of the award for time periods approximately equal to the expected term of the award. We estimate that no dividends will be paid as we do not expect to pay cash dividends in the foreseeable future.

The assumptions underlying these valuations represent the best estimates of our management, which involve inherent uncertainties and the application of our judgment. As a result, if factors or expected outcomes change and we use significantly different assumptions or estimates, the resulting share-based compensation expense could be materially different.

Valuation of Preferred Stock Warrant Liability. In connection with our preferred stock financings prior to our merger with Arsanis in March 2019, we issued warrants to purchase shares of our preferred stock. We classified these warrants as liabilities on our consolidated balance sheet because they were deemed to be freestanding financial instruments that may have required us to transfer assets upon exercise. The warrant liability was initially recorded at fair value upon the date of issuance of each warrant and is subsequently remeasured to fair value at each reporting date as a component of other income (expense), net in our consolidated statements of operations. Upon the closing of the Merger on March 13, 2019, all outstanding preferred stock warrants become exercisable for Arsanis common stock and, accordingly, the warrant liability as of March 13, 2019 was remeasured to fair value and

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reclassified to additional paid-in capital. As a result, following the closing of the M erger, we no longer recognize changes in the fair value of the warrant liability as other income (expense), net in our consolidated statement of operations.

To value the preferred stock warrants, we used various valuation methods, including the Monte Carlo method, the option-pricing method and the hybrid method, all of which incorporated assumptions and estimates. We assessed these assumptions and estimates on a quarterly basis as additional information impacting the assumptions is obtained. Estimates and assumptions impacting the fair value measurement included the fair value per share of the underlying shares of our Series A and Series B preferred stock, risk-free interest rate, expected dividend yield, expected volatility of the price of the underlying preferred stock, and the remaining contractual term of the warrants (except for the warrants that would be automatically exercised upon an initial public offering, in which case the remaining estimated term to automatic exercise was used). The most significant assumption in the Monte Carlo method, the option-pricing method and the hybrid method impacting the fair value of the preferred stock warrants was the fair value of our preferred stock as of each remeasurement date. We determined the fair value per share of the underlying preferred stock by taking into consideration the most recent sales of our preferred stock, results obtained from third-party valuations and additional factors that are deemed relevant.

Emerging Growth Company Status

We are an “emerging growth company,” or EGC, as defined in the Jumpstart Our Business Startups Act of 2012, or the JOBS Act, We will remain an EGC until the earlier of (1) the last day of the fiscal year following the fifth anniversary of the completion of Arsanis’ initial public offering (December 31, 2022), (2) the last day of the fiscal year in which we have total annual gross revenue of at least $1.07 billion, (3) the last day of the fiscal year in which we are deemed to be a “large accelerated filer” as defined in Rule 12b-2 under the Exchange Act, which would occur if the market value of our common stock held by non-affiliates exceeded $700.0 million as of the last business day of the second fiscal quarter of such fiscal year or (4) the date on which we have issued more than $1.0 billion in non-convertible debt securities during the prior three-year period. The JOBS Act permits an EGC to take advantage of an extended transition period to comply with new or revised accounting standards applicable to public companies until those standards would otherwise apply to private companies. We have irrevocably elected to “opt out” of this provision and, as a result, we will comply with new or revised accounting standards when they are required to be adopted by public companies that are not EGCs.

Off-Balance Sheet Arrangements

We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements, as defined in the rules and regulations of the SEC.

Recently Issued Accounting Pronouncements

A description of recently issued accounting pronouncements that may potentially impact our financial position and results of operations is disclosed in Note 2 to our consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q.

Item 3. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

As a smaller reporting company, as defined by Rule 12b-2 of the Exchange Act and in Item 10(f)(1) of Regulation S-K, we are electing scaled disclosure reporting obligations and therefore are not required to provide the information requested by this Item.

Item 4. | CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our principal executive officer and principal financial officer, evaluated the effectiveness of our disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) as of the end of the period covered by this Form 10-Q, and have concluded that, based on such evaluation, our disclosure controls and procedures were effective as of June 30, 2019 at the reasonable assurance level to ensure that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and is accumulated and communicated to our management, including our principal executive and principal financial officers, or persons performing similar functions, as appropriate, to allow timely decisions regarding required disclosure.

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Changes in Internal Contr ols

There were no changes in our internal control over financial reporting that occurred during the three months ended June 30, 2019 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II: OTHER INFORMATION

Item 1. | LEGAL PROCEEDINGS

From time to time, we may become involved in legal proceedings or be subject to claims arising in the ordinary course of our business. We are not currently a party to any material legal proceedings and we are not aware of any pending or threatened legal proceedings against us that we believe could have a material adverse effect on our business, operating results or financial condition.

Item 1A. | RISK FACTORS

There have been no material changes to the risk factors described in our Annual Report on Form 10-K for the year ended December 31, 2018 filed with the SEC on March 11, 2019, as updated by the risk factors described in our Current Report on Form 8-K, filed with the SEC on April 11, 2019.

Item 2. | UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

Item 3. | DEFAULTS UPON SENIOR SECURITIES

Not applicable.

Item 4. | MINE SAFETY DISCLOSURES

Not applicable.

Item 5. | OTHER INFORMATION

None.

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Item 6.EXHIBITS

Exhibit No. |  | Exhibit Description |  | Filed Herewith |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/Reg. Number
2.1 |  | Second Amendment to Agreement and Plan of Merger, dated March 8, 2019, by and among the Company, Artemis AC Corp. and X4 Therapeutics, Inc. (formerly X4 Pharmaceuticals Inc.). |  |  |  | 8-K (Exhibit 2.1) |  | 3/8/2019 |  | 001-38295
3.1 |  | Restated Certificate of Incorporation of the Company |  |  |  | 8-K (Exhibit 3.1) |  | 11/20/2017 |  | 001-38295
3.2 |  | Certificate of Amendment (Reverse Stock Split) to the Restated Certificate of Incorporation of the Company |  |  |  | 8-K (Exhibit 3.1) |  | 3/13/2019 |  | 001-38295
3.3 |  | Certificate of Amendment (Name Change) to the Restated Certificate of Incorporation of the Company |  |  |  | 8-K (Exhibit 3.2) |  | 3/13/2019 |  | 001-38295
10.1 |  | 2019 Inducement Equity Incentive Plan |  |  |  | 8-K (Exhibit 10.1) |  | 6/17/2019 |  | 001-38295
10.2 |  | Form of Stock Option Agreement under the 2019 Inducement Equity Incentive Plan |  |  |  | 8-K (Exhibit 10.2) |  | 6/17/2019 |  | 001-38295
10.3 |  | Form of Restricted Stock Agreement under the 2019 Inducement Equity Incentive Plan |  |  |  | 8-K (Exhibit 10.3) |  | 6/17/2019 |  | 001-38295
10.4 |  | Form of Restricted Stock Unit Agreement under the 2019 Inducement Equity Incentive Plan |  |  |  | 8-K (Exhibit 10.4) |  | 6/17/2019 |  | 001-38295
10.5 |  | Form of Restricted Stock Unit under the Company’s 2017 Equity Incentive Plan |  |  |  | 8-K (Exhibit 10.5) |  | 6/17/2019 |  | 001-38295
10.6 |  | Form of Restricted Stock Unit Agreement under the Company’s 2015 Employee, Director and Consultant Equity Incentive Plan, as amended |  |  |  | 8-K (Exhibit 10.6) |  | 6/17/2019 |  | 001-38295
10.7 |  | Amended and Restated Loan and Security Agreement, dated as of June 27, 2019, by and among X4 Pharmaceuticals, Inc., X4 Therapeutics, Inc., Hercules Capital, Inc. and Hercules Capital Funding Trust 2019-1. |  |  |  | 8-K (Exhibit 10.1) |  | 6/28/2019 |  | 001-38295
31.1 |  | Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |  | X |  |  |  |  |  |
31.2 |  | Certification of Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |  | X |  |  |  |  |  |
32.1* |  | Certification of Principal Executive Officer and Principal Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |  | X |  |  |  |  |  |

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Exhibit No. |  | Exhibit Description |  | Filed Herewith |  | Incorporated by Reference herein from Form or Schedule |  | Filing Date |  | SEC File/Reg. Number
101 |  | The following materials from the Registrant’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2019, formatted in XBRL (eXtensible Business Reporting Language): (i) Condensed Consolidated Balance Sheets (unaudited) as of June 30, 2019 and December 31, 2018, (ii) Condensed Consolidated Statements of Operations (unaudited) for the Three and Six months ended June 30, 2019 and 2018, (iii) Condensed Consolidated Statements of Comprehensive Loss (unaudited) for the Three and Six Months Ended June 30, 2019 and 2018, (iv) Condensed Consolidated Statements of Convertible Preferred Stock, Redeemable Common Stock and Stockholders’ Equity (Deficit) (unaudited) for the Three and Six Months Ended June 30, 2019 and 2018, and (v) Condensed Consol idated Statements of Cash Flows (unaudited) for the Six Months Ended June 3 0, 2019 and 2018. |  | X |  |  |  |  |  |
* | The certification attached as Exhibit 32.1 accompanying this Quarterly Report on Form 10-Q is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company. under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date of this Quarterly Report on Form 10-Q, irrespective of any general incorporation language contained in such filing. |  |  |  |

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SIGNAT URES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

| X4 PHARMACEUTICALS, INC.
Date: August 6, 2019 | By: | /s/ Paula Ragan, Ph.D.
|  | Paula Ragan, Ph.D. President, Chief Executive Officer and Secretary

Date: August 6, 2019 | By: | /s/ Adam S. Mostafa
|  | Adam S. Mostafa Chief Financial Officer and Treasurer

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