<SEC-DOCUMENT>0000950103-17-002540.txt : 20170317
<SEC-HEADER>0000950103-17-002540.hdr.sgml : 20170317
<ACCEPTANCE-DATETIME>20170317063153
ACCESSION NUMBER:		0000950103-17-002540
CONFORMED SUBMISSION TYPE:	20-F
PUBLIC DOCUMENT COUNT:		37
CONFORMED PERIOD OF REPORT:	20161231
FILED AS OF DATE:		20170317
DATE AS OF CHANGE:		20170317

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AC Immune SA
		CENTRAL INDEX KEY:			0001651625
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		20-F
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37891
		FILM NUMBER:		17696301

	BUSINESS ADDRESS:	
		STREET 1:		EPFL INNOVATION PARK, BUILDING B
		CITY:			1015 LAUSANNE
		STATE:			V8
		ZIP:			00000
		BUSINESS PHONE:		41 21 345 91 21

	MAIL ADDRESS:	
		STREET 1:		EPFL INNOVATION PARK, BUILDING B
		CITY:			1015 LAUSANNE
		STATE:			V8
		ZIP:			00000
</SEC-HEADER>
<DOCUMENT>
<TYPE>20-F
<SEQUENCE>1
<FILENAME>dp74065_20f.htm
<DESCRIPTION>FORM 20-F
<TEXT>
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<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-weight: normal">UNITED
STATES</FONT><BR>
<FONT STYLE="font-weight: normal">SECURITIES AND EXCHANGE COMMISSION</FONT><BR>
<FONT STYLE="font-weight: normal">Washington, D.C. 20549</FONT><BR>
FORM 20-F</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(Mark One)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD><TD><B>REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"> <B>OR</B></P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></TD><TD><B>ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 </B><BR>
<B>for the fiscal year ended December 31, 2016</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"> <B>OR</B></P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD><TD><B>TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934</B><BR>
<B>For the transition period from ________________ to ________________</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"> <B>OR</B></P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD><TD><B>SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934</B><BR>
<B>Date of event requiring this shell company report</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Commission file number: &#9;001-37891</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">AC IMMUNE SA<BR>
<FONT STYLE="font-weight: normal"><I>(Exact name of Registrant as specified in its charter)</I></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Switzerland<BR>
<FONT STYLE="font-weight: normal"><I>(Jurisdiction of incorporation)</I></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">EPFL INNOVATION PARK<BR>
Building B<BR>
1015 Lausanne<BR>
Switzerland<BR>
<FONT STYLE="font-weight: normal"><I>(Address of principal executive offices)</I></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Andrea Pfeifer<BR>
Tel: +41 21 345 91 21<BR>
EPFL INNOVATION PARK<BR>
Building B<BR>
1015 Lausanne<BR>
Switzerland<BR>
<FONT STYLE="font-weight: normal"><I>(Name, Telephone, E-mail and/or Facsimile number and Address of Company Contact Person)</I></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><I>Copies to:</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 100%; text-align: center; font-size: 10pt"><B>Richard D. Truesdell, Jr.</B><BR>
<B>Derek J. Dostal</B><BR>
<B>Davis Polk &amp; Wardwell LLP</B><BR>
<B>450 Lexington Avenue</B><BR>
<B>New York, NY 10017</B><BR>
<B>(212) 450-4000</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities registered or to be registered
pursuant to Section 12(b) of the Act:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Title
of each class</P></TD>
    <TD STYLE="width: 50%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Name
of each exchange on which registered</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt; text-align: center">Common Shares, nominal value CHF 0.02 per share</TD>
    <TD STYLE="font-size: 10pt; text-align: center">The NASDAQ Global Market</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities registered or to be registered
pursuant to Section 12(g) of the Act:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">None</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Securities for which there is a reporting
obligation pursuant to Section 15(d) of the Act:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">None</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>



<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate the number of outstanding shares of each of the issuer&rsquo;s
classes of capital stock or common stock as of the close of the period covered by the annual report.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Common shares: 56,773,392</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark if the registrant is a well-known seasoned
issuer, as defined in Rule 405 of the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT>
Yes <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT> No</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If this report is an annual or transition report, indicate by
check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange Act&nbsp;of&nbsp;1934.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT>
Yes <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT> No</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant (1) has filed
all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12&nbsp;months
(or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements
for the past 90 days.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT>
Yes <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT> No</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant has submitted
electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and&nbsp;posted
pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required
to submit and post such files).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT>
Yes <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT> No</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, or a non-accelerated filer. See definition of &ldquo;accelerated filer and large accelerated filer&rdquo;
in Rule 12b-2 of the Exchange Act. (Check one):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 34%; text-align: center; font-size: 10pt">Large accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD>
    <TD STYLE="width: 33%; text-align: center; font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD>
    <TD STYLE="width: 33%; text-align: center; font-size: 10pt">Non-accelerated filer <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark which basis of accounting the registrant
has used to prepare the financial statements included in this filing:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 34%; text-align: center">US GAAP <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD>
    <TD STYLE="width: 33%; text-align: center">International Financial Reporting Standards as issued by the International Accounting Standards Board <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT></TD>
    <TD STYLE="width: 33%; text-align: center">Other <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If &ldquo;Other&rdquo; has been checked in response to the previous
question indicate by check mark which financial statement item the registrant has elected to follow.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT>
Item 17 <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT> Item 18</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If this is an annual report, indicate by check mark whether
the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif">&#9744;</FONT>
Yes <FONT STYLE="font-family: Times New Roman, Times, Serif">&#9746;</FONT> No</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>



<P STYLE="margin: 0"></P>

<P STYLE="margin: 0">&nbsp;</P>

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<P STYLE="margin: 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">AC IMMUNE SA</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>table
of contents</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B></B></FONT></P>

<!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 15%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><U>Page</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>



<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%">
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="width: 90%; text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">FORWARD-LOOKING STATEMENTS</TD>
    <TD STYLE="width: 10%; text-align: right; padding-top: 0in; padding-bottom: 0pt">1</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">PART I</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 1. IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERS</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Directors and senior management</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Advisers</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Auditors</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 2. OFFER STATISTICS AND EXPECTED TIMETABLE</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Offer statistics</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Method and expected timetable</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 3. KEY INFORMATION</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Selected Financial Data</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">3</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Capitalization and indebtedness</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">5</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Reasons for the offer and use of proceeds</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">5</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;Risk factors</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">5</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 4. INFORMATION ON THE COMPANY</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">44</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;History and development of the Company</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">44</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Business overview</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">44</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Organizational structure</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">97</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;Property, plant and equipment</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">97</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 4A. UNRESOLVED STAFF COMMENTS</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">98</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 5. OPERATING AND FINANCIAL REVIEW AND PROSPECTS</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">98</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Operating results</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">98</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Liquidity and capital resources</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">109</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Research and development, patents and licenses, etc.</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">111</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;Trend information</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">112</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">E.&nbsp;&nbsp;&nbsp;Off-balance sheet arrangements</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">112</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">F.&nbsp;&nbsp;&nbsp;Tabular disclosure of contractual obligations</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">112</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">G.&nbsp;&nbsp;&nbsp;Safe harbor</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">112</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 6. DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">112</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Directors and senior management</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">112</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Compensation</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">115</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Board practices</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">117</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;Employees</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">119</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">E.&nbsp;&nbsp;&nbsp;Share ownership</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">119</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 7. MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">119</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Major shareholders</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">119</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Related party transactions</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">121</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Interests of Experts and Counsel</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">122</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 8. FINANCIAL INFORMATION</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">122</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Consolidated statements and other financial information</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">122</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Significant changes</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">122</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 9. THE OFFER AND LISTING</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Offering and listing details</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Plan of distribution</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Markets</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;Selling shareholders</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">E.&nbsp;&nbsp;&nbsp;Dilution</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">F.&nbsp;&nbsp;&nbsp;Expenses of the issue</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 10. ADDITIONAL INFORMATION</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Share capital</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Memorandum and articles of association</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Material contracts</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">123</TD></TR>
</TABLE>

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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%">
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt; width: 90%">D.&nbsp;&nbsp;&nbsp;Exchange controls</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt; width: 10%">124</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">E.&nbsp;&nbsp;&nbsp;Taxation</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">124</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">F.&nbsp;&nbsp;&nbsp;Dividends and paying agents</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">129</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">G.&nbsp;&nbsp;&nbsp;Statement by experts</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">129</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">H.&nbsp;&nbsp;&nbsp;Documents on display</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">130</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">I.&nbsp;&nbsp;&nbsp;Subsidiary information</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">130</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 11. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">130</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 12. DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Debt securities</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Warrants and rights</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Other securities</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;American Depositary Shares</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">PART II</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 13. DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Defaults</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Arrears and delinquencies</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">131</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 14. MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY HOLDERS AND USE OF PROCEEDS</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">132</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 15. CONTROLS AND PROCEDURES</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">132</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">A.&nbsp;&nbsp;&nbsp;Disclosure Controls and Procedures</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">132</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">B.&nbsp;&nbsp;&nbsp;Management&rsquo;s Annual Report on Internal Control over Financial Reporting</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">132</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">C.&nbsp;&nbsp;&nbsp;Attestation Report of the Registered Public Accounting Firm</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">132</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 12.25pt">D.&nbsp;&nbsp;&nbsp;Changes in Internal Control over Financial Reporting</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16. [RESERVED]</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16A. Audit committee financial expert</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16B. Code of ethics</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16C. Principal accountant fees and services (in CHF and thousands)</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16D. Exemptions from the listing standards for audit committees</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16E. Purchases of equity securities by the issuer and affiliated purchasers</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16F. Change in registrant&rsquo;s certifying accountant</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">133</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16G. Corporate governance</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">134</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 16H. Mine safety disclosure</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">134</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">PART III</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">134</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 17. Financial statements</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">134</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: White">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 18. Financial statements</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">135</TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-top: 0in; padding-bottom: 0pt; padding-left: 0in">ITEM 19. Exhibits</TD>
    <TD STYLE="text-align: right; padding-top: 0in; padding-bottom: 0pt">135</TD></TR>
</TABLE>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">PRESENTATION OF FINANCIAL AND OTHER
INFORMATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Unless otherwise indicated or the context
otherwise requires, all references in this annual report on Form 20-F (the &ldquo;Annual Report&rdquo;) to &ldquo;AC Immune&rdquo;
or the &ldquo;Company,&rdquo; &ldquo;we,&rdquo; &ldquo;our,&rdquo; &ldquo;ours,&rdquo; &ldquo;us&rdquo; or similar terms refer
to AC Immune SA. The Company owns various trademark registrations and applications, and unregistered trademarks, including Morphomer&trade;,
SupraAntigen&trade; and its corporate logo. All other trademarks, trade names and service marks of other companies appearing in
this Annual Report are the property of their respective owners. Solely for convenience, the trademarks and trade names in this
Annual Report may be referred to without the &copy; and &trade; symbols, but such references should not be construed as any indicator
that their respective owners will not assert, to the fullest extent under applicable law, their rights thereto. The Company does
not intend to use or display other companies&rsquo; trademarks and trade names to imply a relationship with, or endorsement or
sponsorship of the Company by, any other companies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Financial Statements</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our financial statements are presented
in Swiss Francs and in accordance with International Financial Reporting Standards, or IFRS, as issued by the International Accounting
Standards Board, or IASB. None of the financial statements were prepared in accordance with generally accepted accounting principles
in the United States. The terms &ldquo;dollar,&rdquo; &ldquo;USD&rdquo; or &ldquo;$&rdquo; refer to U.S. dollars and the term &ldquo;Swiss
Franc&rdquo; and &ldquo;CHF&rdquo; refer to the legal currency of Switzerland, unless otherwise indicated. Unless otherwise indicated,
certain Swiss Franc amounts and certain U.S. dollar amounts have been translated into U.S. dollars and Swiss Francs, respectively,
at a rate of USD 1.0160 to CHF 1.00, the official exchange rate quoted as of December 31, 2016 by the U.S. Federal Reserve Bank.
Such Swiss Franc and U.S. dollar amounts are not necessarily indicative of the amounts of U.S. dollars and Swiss Francs, respectively,
that could actually have been purchased upon exchange of the other currency at the dates indicated or any other date, and such
translated amounts have been provided solely for the convenience of the reader. We have made rounding adjustments to some of the
figures included in this Annual Report. Accordingly, any numerical discrepancies in any table between totals and sums of the amounts
listed are due to rounding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">FORWARD-LOOKING
STATEMENTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">This Annual Report contains statements
that constitute forward-looking statements. All statements other than statements of historical facts contained in this Annual Report,
including statements regarding our future results of operations and financial position, business strategy, product candidates,
product pipeline, ongoing and planned clinical studies, including those of our collaboration partners, regulatory approvals, research
and development costs, timing and likelihood of success, as well as plans and objectives of management for future operations are
forward-looking statements. Many of the forward-looking statements contained in this Annual Report can be identified by the use
of forward-looking words such as &ldquo;anticipate,&rdquo; &ldquo;believe,&rdquo; &ldquo;could,&rdquo; &ldquo;expect,&rdquo; &ldquo;should,&rdquo;
&ldquo;plan,&rdquo; &ldquo;intend,&rdquo; &ldquo;estimate,&rdquo; &ldquo;will&rdquo; and &ldquo;potential,&rdquo; among others.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Forward-looking statements appear in a
number of places in this Annual Report and include, but are not limited to, statements regarding our intent, belief or current
expectations. Forward-looking statements are based on our management&rsquo;s beliefs and assumptions and on information currently
available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from
those expressed or implied in the forward-looking statements due to of various factors, including, but not limited to, those identified
under &ldquo;Item 3. Key Information &ndash; D. Risk Factors&rdquo; in this Annual Report. These risks and uncertainties include
factors relating to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The success of our and our collaboration partners&rsquo; clinical studies, and our and their ability to obtain regulatory approval
and to commercialize crenezumab, our anti-tau antibody candidate, ACI-24 for Alzheimer&rsquo;s disease, or AD and ACI-35;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The ability of our competitors to discover, develop or commercialize competing products before or more successfully than we
do;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Our Morphomer proprietary technology platform and its success in building additional product candidates for our pipeline;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The identification of serious adverse, undesirable or unacceptable side effects related to our product candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

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<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Our ability to maintain our current strategic relationships with our collaboration partners;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Failure to protect our, and not infringe on third parties&rsquo;, intellectual property rights throughout the world;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Our ability to raise capital when needed in order to continue our product development programs or commercialization efforts;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The Food and Drug Administration&rsquo;s and applicable foreign regulatory authorities&rsquo; acceptance of data from studies
we conduct outside the United States in the future;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Our foreign private issuer status, the loss of which would require us to comply with the Exchange Act&rsquo;s domestic reporting
regime and cause us to incur significant legal, accounting and other expenses;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Our incorporation in Switzerland, the laws of which govern our corporate affairs and may differ from those applicable to companies
incorporated in the United States; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-weight: normal; font-style: normal">&#183;</FONT></TD><TD><FONT STYLE="font-weight: normal; font-style: normal">Our failure to maintain an effective system of internal control over
financial reporting, given the material weakness identified in connection with the audit of our financial statements as of and
for the year ended December 31, 2014. This material weakness continued to exist as of December 31, 2016; and </FONT></TD></TR></TABLE>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The other risk factors discussed under &ldquo;Item 3. Key Information &ndash; D. Risk Factors.&rdquo;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">These forward-looking statements speak
only as of the date of this Annual Report and are subject to a number of risks, uncertainties and assumptions described under the
sections in this Annual Report entitled &ldquo;Item 3. Key Information&mdash;D. Risk Factors&rdquo; and &ldquo;Item 5. Operating
and Financial Review and Prospects&rdquo; and elsewhere in this Annual Report. Because forward-looking statements are inherently
subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond our control, you
should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in
our forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in
the forward-looking statements. Moreover, we operate in an evolving environment. New risk factors and uncertainties may emerge
from time to time, and it is not possible for management to predict all risk factors and uncertainties. Except as required by applicable
law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new
information, future events, changed circumstances or otherwise.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ENFORCEMENT OF JUDGMENTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are organized under the laws of Switzerland
and our registered office and domicile is located in Ecublens, Switzerland. Moreover, a number of our directors and executive officers
are not residents of the United States, and all or a substantial portion of the assets of such persons are located outside the
United States. As a result, it may not be possible for investors to effect service of process within the United States upon us
or upon such persons or to enforce against them judgments obtained in U.S. courts, including judgments in actions predicated upon
the civil liability provisions of the federal securities laws of the United States. We have been advised by our Swiss counsel that
there is doubt as to the enforceability in Switzerland of original actions, or in actions for enforcement of judgments of U.S.
courts, of civil liabilities to the extent solely predicated upon the federal and state securities laws of the United States. Original
actions against persons in Switzerland based solely upon the U.S. federal or state securities laws are governed, among other things,
by the principles set forth in the Swiss Federal Act on Private International Law. This statute provides that the application of
provisions of non-Swiss law by the courts in Switzerland shall be precluded if the result would be incompatible with Swiss public
policy. Also, mandatory provisions of Swiss law may be applicable regardless of any other law that would otherwise apply. Switzerland
and the United States do not have a treaty providing for reciprocal recognition of and enforcement of judgments in civil and commercial
matters. The recognition and enforcement of a judgment of the courts of the United States in Switzerland is governed by the principles
set forth in the Swiss Federal Act on Private International Law. This statute provides in principle that a judgment rendered by
a non-Swiss court may be enforced in Switzerland only if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the non-Swiss court had jurisdiction pursuant to the Swiss Federal Act on Private International Law;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the judgment of such non-Swiss court has become final and non-appealable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the judgment does not contravene Swiss public policy;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the court procedures and the service of documents leading to the judgment were in accordance with the due process of law; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>no proceeding involving the same position and the same subject matter was first brought in Switzerland, or adjudicated in Switzerland,
or was earlier adjudicated in a third state and this decision is recognizable in Switzerland.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">PART I</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 1. IDENTITY OF DIRECTORS, SENIOR MANAGEMENT AND ADVISERS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Directors and senior management</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Advisers</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Auditors</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 2. OFFER STATISTICS AND EXPECTED TIMETABLE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Offer statistics</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Method and expected timetable</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 3. KEY INFORMATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Selected Financial Data</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following tables summarize our financial
data as of the dates and for the periods indicated. The financial data for the years ended December&nbsp;31, 2016, 2015, and 2014
has been derived from our audited financial statements, which have been prepared in accordance with International Financial Reporting
Standards, or IFRS, as issued by the International Accounting Standards Board, or IASB, and audited in accordance with the standards
of the U.S. Public Company Accounting Oversight Board, and included elsewhere in this Annual Report.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our historical results are not necessarily
indicative of the results that may be expected in the future. The following summary financial data should be read in conjunction
with &ldquo;Item 5. Operating and Financial Review and Prospects&rdquo; and our financial statements included elsewhere in this
Annual Report.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We maintain our books and records and our
audited financial statements in Swiss Francs (CHF).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="11" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">(in CHF &lsquo;000 except for share and per share data)</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="font-weight: bold; text-align: left">Income Statement Data:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 67%">Revenue&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">23,214</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">39,090</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">30,269</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">Research and development expenses&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(25,774</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(17,049</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(16,116</TD><TD STYLE="text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt">General and administrative expenses&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(7,896</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(3,417</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(3,436</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">Operating income/(loss)&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(10,456</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">18,624</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,717</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Finance result&mdash;net&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,360</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,646</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">27</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD>&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Net income/(loss) before tax&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(7,096</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20,270</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,744</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left; padding-bottom: 1pt">Income taxes&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Net income/(loss) for the period&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,096</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">20,270</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">10,744</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="11" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">(in CHF &lsquo;000 except for share and per share data)</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD><TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="width: 67%">Earnings per share in CHF (basic)(1)(2)&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(0.14</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.47</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.25</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Earnings per share in CHF (fully diluted)(2)&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(0.14</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.44</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.24</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">Weighted-average number of shares used to compute earnings per share basic&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">50,096,859</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43,412,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">42,684,750</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Weighted-average number of shares used to compute earnings per share fully diluted&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">50,096,859</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">46,043,198</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">45,552,500</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.5in 0pt 0">_______________</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.5in 0pt 0; border-bottom: Black 0.5pt solid"></P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>For the periods prior to the closing of our initial public offering on September 23, 2016, earnings per share includes preferred
shares outstanding. These preferred shares were converted on a one-for-one basis upon closing of our initial public offering on
September 23, 2016. Amounts for fiscal years 2015 and 2014 have also been adjusted for the 250-for-1 stock split effective October
23, 2015.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>Earnings per share calculations do not give effect to the Series E Private Placement Extension or the CS AG Share Issuance.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="11" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of December 31,</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="11" STYLE="font-size: 8pt; font-weight: bold; text-align: center">(in CHF &lsquo;000)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="width: 67%; text-align: left">Cash and cash equivalents&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">152,210</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">76,522</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">3,306</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Total assets&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">156,100</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">79,931</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">30,296</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">Accumulated deficit&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(46,921</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(40,381</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(60,455</TD><TD STYLE="text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Total equity&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">142,380</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">71,043</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">23,467</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">Total equity and liabilities&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">156,100</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">79,931</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">30,296</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>Share capital&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,135</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">928</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">854</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Exchange Rate Information</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table sets forth, for the
periods indicated, the high, low, average and period-end exchange rates for the purchase of U.S. dollars expressed in CHF per U.S.
dollar. The average rate is calculated by using the average of the U.S. Federal Reserve Bank&rsquo;s reported exchange rates on
each day during a monthly period and on the last day of each month during an annual period. On March 10, 2017, the exchange rate
as reported by the U.S. Federal Reserve Bank was CHF&nbsp;1.0104 to $1.00. In this Annual Report, translations from CHF to U.S.
dollars were made at the rate of CHF 1.0160 to $1.00, the official exchange rate quoted as of December&nbsp;31, 2016 by the U.S.
Federal Reserve Bank.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Period-end</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Average for Period</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Low</TD><TD STYLE="font-size: 8pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">High</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 8pt; font-weight: bold; text-align: center">(CHF per U.S. dollar)</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-size: 8pt; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 8pt; font-weight: bold; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="font-weight: bold">Years Ended December 31:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 56%; text-align: left">2012&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.9155</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.9337</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.8949</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.9957</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">2013&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.8904</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9269</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.8856</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9814</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">2014&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9934</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9147</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.8712</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9934</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="text-align: left">2015&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0017</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9628</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.8488</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0305</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">2016&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0160</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9848</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9536</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0334</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD STYLE="font-weight: bold">Months Ended:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>September 30, 2016&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9694</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9732</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9655</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9804</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD>October 31, 2016&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9890</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9876</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9740</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9951</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>November 30, 2016&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0187</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9963</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9682</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0187</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD>December 31, 2016&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0160</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0194</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0065</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0334</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>January 31, 2017&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9888</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0075</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9888</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0266</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
    <TD>February 28, 2017&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0022</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0010</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.9894</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0083</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>March 2017 (through March 10, 2017)&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0104</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0117</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0072</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.0146</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Capitalization and indebtedness</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Reasons for the offer and use of proceeds</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Risk factors</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>You should carefully consider the risks
and uncertainties described below and the other information in this Annual Report before making an investment in our common shares.
Our business, financial condition or results of operations could be materially and adversely affected if any of these risks occurs,
and as a result, the market price of our common shares could decline and you could lose all or part of your investment. This Annual
Reports also contains forward-looking statements that involve risks and uncertainties. See &ldquo;Forward-Looking Statements.&rdquo;
Our actual results could differ materially and adversely from those anticipated in these forward-looking statements as a result
of certain factors.</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Risks Related to Our Business</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We depend heavily on the success of crenezumab,
and, to a lesser extent, our anti-tau antibody candidate, ACI-24 for AD and ACI-35, all of which are in clinical development. If
our clinical studies are unsuccessful, we or our collaboration partner do not obtain regulatory approval or we are unable to commercialize
crenezumab, our anti-tau antibody candidate, ACI-24 for AD and ACI-35, or we experience significant delays in doing so, our business,
financial condition and results of operations will be materially adversely affected.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We currently have no products approved
for sale and have invested a significant portion of our efforts and financial resources in the development of crenezumab, our anti-tau
antibody candidate, ACI-24 for AD and ACI-35, all of which are in clinical development. Our ability to generate product revenues,
which we do not expect will occur for at least the next several years, if ever, will depend heavily on successful clinical development,
obtaining regulatory approval and eventual commercialization of these product candidates. We currently generate no revenues from
sales of any drugs, and we may never be able to develop or commercialize a marketable drug. The success of our current and future
product candidates will depend on several factors, including the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>completing clinical studies that demonstrate the efficacy and safety of our product candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>receiving marketing approvals from applicable regulatory authorities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>establishing commercial manufacturing capabilities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>launching commercial sales, marketing and distribution operations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>acceptance of our product candidates by patients, the medical community and third-party payors;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>a continued acceptable safety profile following approval;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>competing effectively with other therapies; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>qualifying for, obtaining, maintaining, enforcing and defending our intellectual property rights and claims and not infringing
on third parties&rsquo; intellectual property rights.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If we or our collaboration partner do not
achieve one or more of these factors in a timely manner or at all, we could experience significant delays or an inability to successfully
commercialize our current or future product candidates, which would materially adversely affect our business, financial condition
and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Results of early clinical studies may
not be predictive of future study results.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Positive or timely results from preclinical
or early stage studies do not ensure positive or timely results in late stage clinical studies or product approval by the U.S.
Food and Drug Administration, or the FDA, the European</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Medicines Agency, or the EMA, or comparable
foreign regulatory authorities. Products that show positive preclinical or early clinical results may not show sufficient safety
or efficacy in later stage clinical studies and therefore may fail to obtain regulatory approvals. For example, our collaboration
partner Genentech may fail to achieve success in Phase 3 clinical studies of crenezumab. In addition, preclinical and clinical
data are often susceptible to varying interpretations and analyses. Many companies that believed their product candidates performed
satisfactorily in preclinical and clinical studies have nonetheless failed to obtain marketing approval for the product candidates.
The FDA, the EMA and comparable foreign regulatory authorities have substantial discretion in the approval process and in determining
when or whether regulatory approval will be obtained for any of our product candidates. Even if we believe the data collected from
clinical studies of our product candidates are promising, such data may not be sufficient to support approval by the FDA, the EMA
or any other regulatory authority.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In some instances, there can be significant
variability in safety and/or efficacy results between different studies of the same product candidate due to numerous factors,
including changes in study procedures set forth in protocols, differences in the size and type of the patient populations, adherence
to the dosing regimen and other study protocols and the rate of dropout among clinical study participants. In the case of our late
stage clinical product candidates, results may differ in general on the basis of the larger number of clinical study sites and
additional countries and languages involved in Phase 3 clinical studies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Clinical studies are, or will be, based
on patient reported outcomes, some of which are or will be captured daily by study participants with electronic diaries. We have
no assurance and cannot rely on past experience that the high frequency of questioning is not influencing the measured outcome.
In addition, low compliance with daily reporting requirements may impact the studies&rsquo; validity or statistical power. We cannot
assure you that any Phase 2, Phase 3 or other clinical studies that either we or our collaboration partners may conduct will demonstrate
consistent or adequate efficacy and safety to obtain regulatory approval to market our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If we or our collaboration partners are
required to conduct additional clinical studies or other testing of any of our current or future product candidates that we or
our collaboration partners develop beyond the studies and testing that we or our collaboration partners contemplate, if we or our
collaboration partners are unable to successfully complete clinical studies of our product candidates or other testing, if the
results of these studies or tests are unfavorable or are only modestly favorable or if there are safety concerns associated with
our current or future product candidates, we may:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>be delayed in obtaining marketing approval for our product candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>not obtain marketing approval;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>obtain approval for indications or patient populations that are not as broad as intended or desired;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>obtain approval with labeling that includes significant use or distribution restrictions or significant safety warnings, including
boxed warnings;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>be subject to additional post-marketing testing or other requirements; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>remove the product from the market after obtaining marketing approval.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our product development costs will also
increase if we experience delays in testing or marketing approvals and we may be required to obtain additional funds to complete
clinical studies. We cannot assure you that our clinical studies will begin as planned or be completed on schedule, if at all,
or that we will not need to restructure our studies after they have begun. Significant clinical study delays also could shorten
any periods during which we may have the exclusive right to commercialize our product candidates or allow our competitors to bring
products to market before we do or shorten any periods during which we have the exclusive right to commercialize our product candidates,
which may harm our business and results of operations. In addition, some of the factors that cause, or lead to, clinical study
delays may ultimately lead to the denial of regulatory approval of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Additional competitors could enter the
market with generic versions of our products, which may result in a material decline in sales of affected products.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the Drug Price Competition and Patent
Term Restoration Act of 1984, or the Hatch-Waxman Act, a pharmaceutical manufacturer may file an abbreviated new drug application,
or ANDA, seeking approval of a generic copy of an approved innovator product. Under the Hatch-Waxman Act, a manufacturer may also
submit a new drug application, or NDA, under section 505(b)(2) that references the FDA&rsquo;s prior approval of the innovator
product. A 505(b)(2) NDA product may be for a new or improved version of the original innovator product. Hatch-Waxman also provides
for certain periods of regulatory exclusivity, which preclude FDA approval (or in some circumstances, FDA filing and reviewing)
of an ANDA or 505(b)(2) NDA. These include, subject to certain exceptions, the period during which an FDA-approved drug is subject
to orphan drug exclusivity. In addition to the benefits of regulatory exclusivity, an innovator NDA holder may have patents claiming
the active ingredient, product formulation or an approved use of the drug, which would be listed with the product in the FDA publication,
&ldquo;Approved Drug Products with Therapeutic Equivalence Evaluations,&rdquo; known as the &ldquo;Orange Book.&rdquo; If there
are patents listed in the Orange Book, a generic or 505(b)(2) applicant that seeks to market its product before expiration of the
patents must include in the ANDA what is known as a &ldquo;Paragraph IV certification,&rdquo; challenging the validity or enforceability
of, or claiming non-infringement of, the listed patent or patents. Notice of the certification must be given to the innovator,
too, and if within 45 days of receiving notice the innovator sues to protect its patents, approval of the ANDA is stayed for 30
months, or as lengthened or shortened by the court.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Accordingly, if crenezumab, ACI-24, ACI-35
and our anti-tau antibody candidate are approved, competitors could file ANDAs for generic versions of crenezumab, ACI-24 and ACI-35,
or 505(b) (2)&nbsp;NDAs that reference crenezumab, ACI-24, ACI-35 or our anti-tau antibody candidate, respectively. If there are
patents listed for crenezumab, ACI-24 and ACI-35 in the Orange Book, those ANDAs and 505(b) (2) NDAs would be required to include
a certification as to each listed patent indicating whether the ANDA applicant does or does not intend to challenge the patent.
We cannot predict whether any patents issuing from our pending patent applications will be eligible for listing in the Orange Book,
how any generic competitor would address such patents, whether we would sue on any such patents, or the outcome of any such suit.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We may not be successful in securing or
maintaining proprietary patent protection for products and technologies we develop or license. Moreover, if any patents that are
granted and listed in the Orange Book are successfully challenged by way of a Paragraph IV certification and subsequent litigation,
the affected product could immediately face generic competition and its sales would likely decline rapidly and materially. Should
sales decline, we may have to write off a portion or all of the intangible assets associated with the affected product and our
results of operations and cash flows could be materially and adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">One of our collaboration partners is
evaluating a product candidate in the same indication as our lead product candidate crenezumab.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our collaboration partner Genentech is
a subsidiary of Roche, which is evaluating gantenerumab, a product candidate for the same indication as our lead product candidate
crenezumab, and Roche&rsquo;s collaboration partner MorphoSys AG announced in March 2017 that Roche plans to initiate a phase 3
program for gantenerumab in patients with prodromal to mild AD. Our collaboration agreement with Genentech for crenezumab provides
Genentech with control over, and responsibility for, the clinical development process, including obtaining regulatory and marketing
approvals, manufacturing costs and sales and marketing costs. In addition, the collaboration agreement provides that Genentech
may terminate the agreement at any time by providing three months&rsquo; notice to us. As a result, Roche may choose to devote
more time and resources to advancing gantenerumab instead of crenezumab, which could render crenezumab non-competitive and limit
or make it more difficult for us to achieve or maintain profitability with crenezumab. Should this occur, our business, financial
condition and results of operations could be materially impacted.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">The successful commercialization of our
product candidates will depend in part on the extent to which governmental authorities and health insurers establish adequate coverage
and reimbursement levels and pricing policies.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The successful commercialization of our
product candidates will depend, in part, on the extent to which coverage and reimbursement for our products will be available from
government and health administration authorities, private health insurers and other third-party payors. To manage healthcare costs,
many governments and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">third-party payors increasingly scrutinize
the pricing of new technologies and require greater levels of evidence of favorable clinical outcomes and cost-effectiveness before
extending coverage. In light of such challenges to prices and increasing levels of evidence of the benefits and clinical outcomes
of new technologies, we cannot be sure that coverage will be available for any of our current or future product candidates that
we commercialize and, if available, that the reimbursement rates will be adequate. If we are unable to obtain adequate levels of
coverage and reimbursement for our product candidates, their marketability will be negatively and materially impacted.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Third party payors may deny coverage and
reimbursement status altogether of a given drug product, or cover the product but may also establish prices at levels that are
too low to enable us to realize an appropriate return on our investment in product development. Because the rules and regulations
regarding coverage and reimbursement change frequently, in some cases at short notice, even when there is favorable coverage and
reimbursement, future changes may occur that adversely impact the favorable status. Further, the net reimbursement for drug products
may be subject to additional reductions if there are changes to laws that presently restrict imports of drugs from countries where
they may be sold at lower prices than in the United States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The unavailability or inadequacy of third-party
coverage and reimbursement could have a material adverse effect on the market acceptance of our product candidates and the future
revenues we may expect to receive from those products. In addition, we are unable to predict what additional legislation or regulation
relating to the healthcare industry or third-party coverage and reimbursement may be enacted in the future, or what effect such
legislation or regulation would have on our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our products may not gain market acceptance,
in which case we may not be able to generate product revenues, which will materially adversely affect our business, financial condition
and results of operations.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Even if the FDA, the EMA or other regulatory
authority approves the marketing of any product candidates that we develop, physicians, healthcare providers, patients or the medical
community may not accept or use them. Efforts to educate the medical community and third-party payors on the benefits of our product
candidates may require significant resources and may not be successful. If any of our current or future product candidates does
not achieve an adequate level of acceptance, we may not generate significant product revenues or any profits from operations. The
degree of market acceptance of our product candidates that are approved for commercial sale will depend on a variety of factors,
including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>how clinicians and potential patients perceive our novel products;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the timing of market introduction;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the number and clinical profile of competing products;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>our ability to provide acceptable evidence of safety and efficacy;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the prevalence and severity of any side effects;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>relative convenience and ease of administration;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>cost-effectiveness;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>patient diagnostics and screening infrastructure in each market;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>marketing and distribution support;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>availability of coverage, reimbursement and adequate payment from health maintenance organizations and other third-party payors,
both public and private; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>other potential advantages over alternative treatment methods.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If our product candidates fail to gain
market acceptance, this will have a material adverse impact on our ability to generate revenues to provide a satisfactory, or any,
return on our investments. Even if some products achieve market acceptance, the market may prove not to be large enough to allow
us to generate significant revenues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, the potential market opportunity
of our product candidates is difficult to precisely estimate. Our estimates of the potential market opportunity are predicated
on several key assumptions such as industry knowledge and publications, third-party research reports and other surveys. These assumptions
involve the exercise of significant judgment on the part of our management, are inherently uncertain and the reasonableness of
these assumptions could not have been assessed by an independent source in every detail. If any of the assumptions proves to be
inaccurate, then the actual market for our product candidates could be smaller than our estimates of the potential market opportunity.
If the actual market for our product candidates is smaller than we expect, or if any approved products fail to achieve an adequate
level of acceptance by physicians, health care payors and patients, our product revenue may be limited and it may be more difficult
for us to achieve or maintain profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We depend on enrollment of patients in
our clinical studies for our product candidates. If we are unable to enroll patients in our clinical studies, our research and
development efforts could be materially adversely affected.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Successful and timely completion of clinical
studies will require that we enroll a sufficient number of patient candidates. Studies may be subject to delays as a result of
patient enrollment taking longer than anticipated or patient withdrawal. Patient enrollment depends on many factors, including
the size and nature of the patient population, eligibility criteria for the study, the proximity of patients to clinical sites,
the design of the clinical protocol, the availability of competing clinical studies, the availability of new drugs approved for
the indication the clinical study is investigating, and clinicians&rsquo; and patients&rsquo; perceptions as to the potential advantages
of the drug being studied in relation to other available therapies. In the Phase 3 clinical studies of crenezumab, our collaboration
partner Genentech will seek to enroll patients in the early stages of AD and it may be unable to successfully identify an adequate
number of eligible patients.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The specific target population of patients
and therapeutic time windows may make it difficult for us to enroll enough patients to complete our clinical studies in a timely
and cost-effective manner. Delays in the completion of any clinical study of our product candidates will increase our costs, slow
down our product candidate development and approval process and delay or potentially jeopardize our ability to commence product
sales and generate revenue. In addition, many of the factors that cause, or lead to, a delay in the commencement or completion
of clinical studies may also ultimately lead to the denial of regulatory approval of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If serious adverse, undesirable or unacceptable
side effects are identified during the development of our product candidates or following approval, if any, we may need to abandon
our development of such product candidates, the commercial profile of any approved label may be limited, or we may be subject to
other significant negative consequences following marketing approval, if any.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If our product candidates are associated
with serious adverse, undesirable or unacceptable side effects, we may need to abandon their development or limit development to
certain uses or sub-populations in which such side effects are less prevalent, less severe or more acceptable from a risk-benefit
perspective. Many compounds that initially showed promise in preclinical or early stage testing have later been found to cause
side effects that restricted their use and prevented further development of the compound for larger indications.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Genentech has not disclosed detailed information
about serious adverse events associated with crenezumab either publicly or to us. However, at the 2014 Alzheimer&rsquo;s Association
International Conference, it was reported that in the combined Phase 2 study populations, serious adverse events occurred at similar
rates in patients treated with crenezumab (16.5%) and in patients given a placebo (11.9%). In addition, adverse events identified
in the clinical studies of crenezumab initiated to date have included inflammation of the throat and nasal passages, urinary tract
infections and upper respiratory infections. At the 2016 Clinical Trials on Alzheimer&rsquo;s Disease (CTAD) meeting it was reported
that in a Phase 1b study to evaluate higher doses of crenezumab, no investigator-assessed drug-related serious adverse events occurred.
<FONT STYLE="color: #1F497D">Serious adverse events occurring in three patients of the blinded study </FONT> include malignant
melanoma, an accidental overdose, pneumonia and subdural hematoma and atypical chest pain. In addition, five serious adverse events
were observed in three patients during clinical studies of ACI-35, although we believe that these serious adverse events were not
related to the treatment. Acute pyelonephritis, or kidney infection, and dizziness were observed in one patient and sick sinus
syndrome was reported for a second patient, and these were labeled as possibly related due to the close timing proximity with the
last administration of ACI-35. In the third patient, urosepsis, or blood poisoning, and pyelonephritis were described and classified
as unlikely related to the drug. A relationship between these serious adverse effects and ACI-35 cannot be ruled out, however.
Nine non-drug related serious adverse effects were observed during clinical studies of ACI-24. They were prolongation of</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">hospitalization after planned hip replacement
or removal of colon polyp, fall, acute chest pain, death due to Alzheimer&rsquo;s disease or myocardial infarction (heart attack),
colonic cancer, wound infections, pneumonia and pancreatitis related to gallstones.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Occurrence of serious procedure- or treatment-related
side effects could impede clinical study enrollment and receipt of marketing approval from the FDA, the EMA and comparable foreign
regulatory authorities. Adverse events could also adversely affect physician or patient acceptance of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Additionally if one or more of our product
candidates receives marketing approval, and we or others later identify undesirable side effects caused by such products, a number
of potentially significant negative consequences could result, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>regulatory authorities may withdraw approvals of such product and require us to take any approved products off the market;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>regulatory authorities may require the addition of labeling statements, specific warnings, a contraindication or field alerts
to physicians and pharmacies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we may be required to create a medication guide outlining the risks of such side effects for distribution to patients;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we may be required to change the way the product is administered, conduct additional studies or change the labeling of the
product;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we may be subject to limitations in how we promote the product;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>sales of the product may decrease significantly;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we could be sued and held liable for harm caused to patients; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>our reputation and physician or patient acceptance of our products may suffer.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any of these events could prevent us from
achieving or maintaining market acceptance of the particular product candidate, if approved, and could significantly harm our business,
results of operations and prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We operate in highly competitive and
rapidly changing industries, which may result in others discovering, developing or commercializing competing products before or
more successfully than we do.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The biopharmaceutical and pharmaceutical
industries are highly competitive and subject to significant and rapid technological change. Our success is highly dependent on
our ability to discover, develop and obtain marketing approval for new and innovative products on a cost-effective basis and to
market them successfully. In doing so, we face and will continue to face intense competition from a variety of businesses, including
large, fully integrated pharmaceutical companies, specialty pharmaceutical companies and biopharmaceutical companies, academic
institutions, government agencies and other private and public research institutions in Europe, the United States and other jurisdictions.
Many of our potential competitors, alone or with their strategic partners, have substantially greater financial, technical and
human resources than we do and significantly greater experience in the discovery and development of product candidates, obtaining
FDA and other regulatory approvals of treatments and the commercialization of those treatments. Mergers and acquisitions in the
biotechnology and pharmaceutical industries may result in even more resources being concentrated among a smaller number of our
competitors. Our commercial opportunity could be reduced or eliminated if our competitors develop and commercialize products that
are safer, more effective, have fewer or less severe side effects, are more convenient or are less expensive than any products
that we may develop. Our competitors also may obtain FDA or other regulatory approval for their products more rapidly than we may
obtain approval for ours, which could result in our competitors establishing a strong market position before we are able to enter
the market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We believe that our key competitor product
candidates are (i)&nbsp;aducanumab (Biogen) and gantenerumab (Roche) for crenezumab; (ii)&nbsp;CAD-106 (Novartis) and ABvac 40
(Araclon Biotech) for ACI-24; and (iii)&nbsp;AADVAC1 (Axon Neurosciences) for ACI-35, as described under &ldquo;Business&mdash;Competition.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The highly competitive nature of and rapid
technological changes in the biotechnology and pharmaceutical industries could render our product candidates or our technology
obsolete or non-competitive. Our competitors may, among other things:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>develop and commercialize products that are safer, more effective, less expensive, or more convenient or easier to administer;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>obtain quicker regulatory approval;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>establish superior intellectual property and proprietary positions;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>have access to more manufacturing capacity;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>implement more effective approaches to sales and marketing; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>form more advantageous strategic alliances.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Should any of these occur, our business,
financial condition and results of operations could be materially adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may not be successful in our efforts
to use and expand our Morphomer proprietary technology platform to build additional product candidates for our pipeline.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A key element of our strategy is to use
and expand our Morphomer proprietary technology platform to create unique drug therapies for conformational diseases, such as AD,
and progress these product candidates through clinical development. Although our research and development efforts to date have
resulted in a pipeline of product candidates, we may not be able to develop product candidates that are safe and effective. Even
if we are successful in continuing to build our pipelines, the potential product candidates that we identify may not be suitable
for clinical development, including as a result of being shown to have harmful side effects or other characteristics that indicate
that they are unlikely to be products that will receive marketing approval and achieve market acceptance. If we do not continue
to successfully develop and begin to commercialize product candidates, we will face difficulty in obtaining product revenues in
future periods, which could result in significant harm to our financial position and adversely affect the price of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our business is subject to economic,
political, regulatory and other risks associated with international operations.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our business is subject to risks associated
with conducting business internationally. We and a number of our suppliers and collaborative and clinical study relationships are
located outside the United States. Accordingly, our future results could be harmed by a variety of factors, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>economic weakness, including inflation, or political instability in particular non-U.S. economies and markets;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>differing regulatory requirements for drug approvals in non-U.S. countries;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>potentially reduced protection for intellectual property rights;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>difficulties in compliance with non-U.S. laws and regulations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>changes in non-U.S. regulations and customs, tariffs and trade barriers;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>changes in non-U.S. currency exchange rates and currency controls;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>changes in a specific country&rsquo;s or region&rsquo;s political or economic environment;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>trade protection measures, import or export licensing requirements or other restrictive actions by U.S. or non-U.S. governments;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>negative consequences from changes in tax laws;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>compliance with tax, employment, immigration and labor laws for employees living or traveling abroad;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>workforce uncertainty in countries where labor unrest is more common than in the United States;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>difficulties associated with staffing and managing international operations, including differing labor relations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>production shortages resulting from any events affecting raw material supply or manufacturing capabilities abroad; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>business interruptions resulting from geo-political actions, including war and terrorism, or natural disasters including earthquakes,
typhoons, floods and fires.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We have no history of commercializing
pharmaceutical products, which may make it difficult to evaluate the prospects for our future viability.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We began our operations in 2003. Our operations
to date have been limited to financing and staffing our company, developing our technology and developing crenezumab and our other
product candidates. We have not yet demonstrated an ability to successfully complete a large-scale, pivotal clinical study, obtain
marketing approval, manufacture a commercial scale product or conduct sales and marketing activities necessary for successful product
commercialization. Consequently, predictions about our future success or viability may not be as accurate as they could be if we
had a history of successfully developing and commercializing pharmaceutical products.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Business interruptions could delay us
in the process of developing our product candidates.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Loss of our laboratory facilities through
fire or other causes could have an adverse effect on our ability to continue to conduct our business. We currently have insurance
coverage to compensate us for such business interruptions; however, such coverage may prove insufficient to fully compensate us
for the damage to our business resulting from any significant property or casualty loss to our facilities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our future growth and ability to compete
depends on retaining our key personnel and recruiting additional qualified personnel.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our success depends upon the continued
contributions of our key management, scientific and technical personnel, many of whom have substantial experience with or been
instrumental for us and our projects. Members of our key management include Dr.&nbsp;Andrea Pfeifer, our Chief Executive Officer;
Dr.&nbsp;Andreas Muhs, our Chief Scientific Officer; Dr.&nbsp;Wolfgang Barth, our Director of Development; Joerg Hornstein, our
Chief Financial Officer (who is expected to join our team on April 1, 2017); and Jean-Fabien Monin, our Chief Administrative Officer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The loss of our key managers and senior
scientists could delay our research and development activities. Laws and regulations on executive compensation, including legislation
in our home country, Switzerland, may restrict our ability to attract, motivate and retain the required level of qualified personnel.
In Switzerland, new legislation affecting public companies has been passed that, among other things, (i)&nbsp;imposes an annual
binding shareholders&rsquo; &ldquo;say on pay&rdquo; vote with respect to the compensation of executive management, including executive
officers and the board of directors; (ii)&nbsp;prohibits severance, advances, transaction premiums and similar payments to executive
officers and directors; and (iii)&nbsp;requires companies to specify various compensation-related matters in their articles of
association, thus requiring them to be approved by a shareholders&rsquo; vote. In addition, the competition for qualified personnel
in the biopharmaceutical and pharmaceutical field is intense, and our future success depends upon our ability to attract, retain
and motivate highly-skilled scientific, technical and managerial employees. We face competition for personnel from other companies,
universities, public and private research institutions and other organizations. If our recruitment and retention efforts are unsuccessful
in the future, it may be difficult for us to implement business strategy, which could have a material adverse effect on our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We expect to expand our development,
and regulatory capabilities, and as a result, we may encounter difficulties in managing our growth, which could disrupt our operations.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We expect to experience growth in the number
of our employees and the scope of our operations. To manage our anticipated future growth, we must continue to implement and improve
our managerial, operational and financial systems, expand our facilities and continue to recruit and train additional qualified
personnel. Due to our limited financial resources, we may not be able to effectively manage the expansion of our operations or
recruit and train additional qualified personnel. The expansion of our operations may lead to significant costs and may divert
our management and business development resources. Any inability to manage growth could delay the execution of our business plans
or disrupt our operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may become exposed to costly and damaging
liability claims, either when testing our product candidates in the clinic or at the commercial stage; and our product liability
insurance may not cover all damages from such claims.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are exposed to potential product liability
and professional indemnity risks that are inherent in the research, development, manufacturing, marketing and use of pharmaceutical
products. Currently we have no products that have been approved for commercial sale; however, our current and future use of product
candidates in clinical studies, and the sale of any approved products in the future, may expose us to liability claims. These claims
might be made by patients that use the product, healthcare providers, pharmaceutical companies or others selling such products.
Any claims against us, regardless of their merit, could be difficult and costly to defend and could materially adversely affect
the market for our product candidates or any prospects for commercialization of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Although the clinical study process is
designed to identify and assess potential side effects, it is always possible that a drug, even after regulatory approval, may
exhibit unforeseen side effects. If any of our product candidates were to cause adverse side effects during clinical studies or
after approval of the product candidate, we may be exposed to substantial liabilities. Physicians and patients may not comply with
any warnings that identify known potential adverse effects and patients who should not use our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We purchase liability insurance in connection
with the clinical studies that we undertake in amounts that we consider to be consistent with industry norms. It is possible that
our liabilities could exceed our insurance coverage. We intend to expand our insurance coverage to include the sale of commercial
products if we obtain marketing approval for any of our product candidates. However, we may not be able to maintain insurance coverage
at a reasonable cost or obtain insurance coverage that will be adequate to satisfy any liability that may arise. If a successful
product liability claim or series of claims is brought against us for uninsured liabilities or in excess of insured liabilities,
our assets may not be sufficient to cover such claims and our business operations could be impaired.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Should any of the events described above
occur, this could have a material adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may seek to obtain orphan drug designation
for certain of our product candidates. Orphan drug designation may not ensure that we will enjoy market exclusivity in a particular
market, and if we fail to obtain or maintain orphan drug exclusivity for such product candidates, we may be subject to earlier
competition and our potential revenue will be reduced.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the Orphan Drug Act, the FDA may
designate a product as an orphan drug if it is intended to treat a rare disease or condition, defined as a patient population of
fewer than 200,000 in the United States, or a patient population greater than 200,000 in the United States where there is no reasonable
expectation that the cost of developing the drug will be recovered from sales in the United States. In the European Union, the
EMA&rsquo;s Committee for Orphan Medicinal Products, or COMP, grants orphan drug designation to promote the development of products
that are intended for the diagnosis, prevention, or treatment of a life-threatening or chronically debilitating condition affecting
not more than five in 10,000 persons in the European Union. Additionally, designation is granted for products intended for the
diagnosis, prevention, or treatment of a life-threatening, seriously debilitating or serious and chronic condition when, without
incentives, it is unlikely that sales of the drug in the European Union would be sufficient to justify the necessary investment
in developing the drug or biological</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">product or where there is no satisfactory
method of diagnosis, prevention, or treatment, or, if such a method exists, the medicine must be of significant benefit to those
affected by the condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the United States, orphan drug designation
entitles a party to financial incentives such as opportunities for grant funding towards clinical study costs, tax advantages and
user-fee waivers. In addition, if a product receives the first FDA approval for the indication for which it has orphan designation,
the product is entitled to orphan drug exclusivity, which means the FDA may not approve any other application to market the same
drug for the same indication for a period of seven years, except in limited circumstances, such as a showing of clinical superiority
over the product with orphan exclusivity or where the manufacturer is unable to assure sufficient product quantity. In the European
Union, orphan drug designation entitles a party to financial incentives such as reduction of fees or fee waivers and ten years
of market exclusivity following drug or biological product approval. This period may be reduced to six years if the orphan drug
designation criteria are no longer met, including where it is shown that the product is sufficiently profitable not to justify
maintenance of market exclusivity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We may not be able to obtain orphan drug
designation for any of our product candidates, and even if we do, we may not be the first to obtain marketing approval for any
particular orphan indication due to the uncertainties associated with developing pharmaceutical products. Further, even if we obtain
orphan drug designation for a product, that exclusivity may not effectively protect the product from competition because different
drugs with different active moieties can be approved for the same condition. Orphan drug designation neither shortens the development
time or regulatory review time of a drug nor gives the drug any advantage in the regulatory review or approval process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Due to our limited resources and access
to capital, we must prioritize development of certain product candidates.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Because we have limited resources and access
to capital to fund our operations, we must decide which product candidates to pursue and the amount of resources to allocate to
each. As such, we are currently primarily focused on the development of ACI-24 and ACI-35 for the treatment of AD. Our decisions
concerning the allocation of research, collaboration, management and financial resources toward particular compounds, product candidates
or therapeutic areas may not lead to the development of viable commercial products and may divert resources away from better opportunities.
Similarly, our potential decisions to delay, terminate or collaborate with third parties in respect of certain product development
programs may also prove not to be optimal and could cause us to miss valuable opportunities. If we make incorrect determinations
regarding the market potential of our product candidates or misread trends in the biopharmaceutical industry, in particular for
neurological disorders, our business, financial condition and results of operations could be materially adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our research and development activities
could be affected or delayed as a result of possible restrictions on animal testing.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Certain laws and regulations require us
to test our product candidates on animals before initiating clinical studies in humans. Animal testing activities have been the
subject of controversy and adverse publicity. Animal rights groups and other organizations and individuals have attempted to stop
animal testing activities by pressing for legislation and regulation in these areas and by disrupting these activities through
protests and other means. To the extent the activities of these groups are successful, our research and development activities
may be interrupted, delayed or become more expensive.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our information technology systems could
face serious disruptions that could adversely affect our business.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our information technology and other internal
infrastructure systems, including corporate firewalls, servers, leased lines and connection to the internet, face the risk of systemic
failure that could disrupt our operations. A significant disruption in the availability of our information technology and other
internal infrastructure systems could cause interruptions in our collaborations with our partners and delays in our research and
development work. The loss of product development or clinical study data could result in delays in our regulatory approval efforts
and significantly increase our costs. To the extent that any disruption or security breach were to result in a loss of, or damage
to, our data or applications, or inappropriate disclosure of confidential or proprietary information, we could incur liability
and our development programs and the development of our product candidates could be delayed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We have never commercialized a product
candidate before and may lack the necessary expertise, personnel and resources to successfully commercialize our products on our
own or together with suitable partners.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have never commercialized a product
candidate, and we currently have no sales force, marketing or distribution capabilities. To achieve commercial success for our
product candidates, we will have to develop our own sales, marketing and supply organization or outsource these activities to a
third party.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Factors that may affect our ability to
commercialize our product candidates on our own include recruiting and retaining adequate numbers of effective sales and marketing
personnel, obtaining access to or persuading adequate numbers of physicians to prescribe our drug candidates and other unforeseen
costs associated with creating an independent sales and marketing organization. Developing a sales and marketing organization requires
significant investment, is time-consuming and could delay the launch of our product candidates. We may not be able to build an
effective sales and marketing organization. If we are unable to build our own distribution and marketing capabilities or to find
suitable partners for the commercialization of our product candidates, we may not generate revenues from them or be able to reach
or sustain profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Risks Related to Our Relationships with Third Parties</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If we fail to maintain our current strategic
relationships with Genentech, Janssen, Piramal and other of our current or future strategic partners, our business, commercialization
prospects and financial condition may be materially adversely affected.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have two partnerships with
Genentech. In 2006, we granted Genentech an exclusive, worldwide license for crenezumab. In 2012, we entered into a second
partnership to commercialize our anti-tau antibodies for use as immunotherapies. We partner with  Janssen Pharmaceuticals,
Inc. (Janssen) to develop and commercialize therapeutic anti-tau vaccines for the treatment of AD and potentially other
tauopathies. We also have a diagnostic partnership with Piramal Imaging for a compound from our Morphomer chemical library
that binds pathogenic tau for use as a positron emission tomography, or PET, tracer. Genentech has the right to terminate its
agreements with us at any time and for any reason upon providing us with a certain notice period. After a specified amount of
time, Janssen and Piramal will also each have the right to terminate their agreements with us for any reason upon providing
us with a certain notice period. If Genentech, Janssen, Piramal or other of our current or future strategic partners
terminates its agreement with us at any time, it could delay or prevent development of our product candidates and materially
harm our business, financial condition, commercialization prospects and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Good relationships with Genentech, Janssen,
Piramal and other of our current or future strategic partners are important for our business prospects. If our relationships with
Genentech, Janssen, Piramal or other of our current or future strategic partners were to deteriorate substantially or Genentech,
Janssen, Piramal or other of our current or future strategic partners were to challenge our use of their intellectual property
or our calculations of the payments we owe under our agreements, our business, financial condition, commercialization prospects
and results of operations could be materially adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Lastly, our collaboration agreement with
Genentech for crenezumab provides Genentech with control over, and responsibility for, the clinical development process, including
obtaining regulatory and marketing approvals, manufacturing costs and sales and marketing costs. Our other existing collaboration
agreements provide our collaboration partners with similar control over the clinical development process and future collaboration
agreements may also relinquish development control to our partners. Genentech or our other current or future collaboration partners
may separately pursue competing products, therapeutic approaches or technologies to develop treatments for the diseases targeted
by us or our collaborative efforts. Even if our partners continue their contributions to the collaborative agreements to which
we are a party, they may nevertheless determine not to actively pursue the development or commercialization of any resulting products.
Our partners may also fail to perform their obligations under the collaboration agreements or may be slow in performing their obligations.
Any of these circumstances could result in a material adverse impact on our business, financial condition, commercialization prospectus
or results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may seek to form additional strategic
alliances in the future with respect to our product candidates, and if we do not realize the benefits of such alliances, our business,
financial condition, commercialization prospects and results of operations may be materially adversely affected.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our product development programs and the
potential commercialization of our product candidates will require substantial additional cash to fund expenses and may require
expertise, such as sales and marketing expertise, which we do not currently possess. Therefore, in addition to our relationships
with Genentech, Janssen and Piramal, we may decide to enter into strategic alliances, or create joint ventures or collaborations
with pharmaceutical or biopharmaceutical companies for the further development and potential commercialization of those and other
of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We face significant competition in seeking
appropriate collaborators. Collaborations are complex and time-consuming to negotiate and document. Any delays in entering into
new strategic partnership agreements related to our product candidates could delay the development and commercialization of our
product candidates and reduce their competitiveness even if they reach the market. We may also be restricted under existing and
future collaboration agreements from entering into strategic partnerships or collaboration agreements on certain terms with other
potential collaborators. We may not be able to negotiate collaborations on acceptable terms, or at all, for any of our existing
or future product candidates and programs because the potential partner may consider that our research and development pipeline
is insufficiently developed to justify a collaborative effort, or that our product candidates and programs do not have the requisite
potential to demonstrate safety and efficacy in the target population. If we are unsuccessful in establishing and maintaining a
collaboration with respect to a particular product candidate, we may have to curtail the development of that product candidate,
reduce the scope of or delay its development program or one or more of our other development programs, delay its potential commercialization
or reduce the scope of our sales or marketing activities, or increase our expenditures and undertake development or commercialization
activities at our own expense for which we have not budgeted. If we elect to increase our expenditures to fund development or commercialization
activities on our own, we may need to obtain additional capital, which may not be available to us on acceptable terms or at all.
If we do not have sufficient funds, we will not be able to bring our product candidates to market and generate product revenue.
Even if we are successful in establishing a new strategic partnership or entering into a collaboration agreement, we cannot be
certain that, following such a strategic transaction or license, we will be able to progress the development and commercialization
of the applicable product candidates as envisaged, or that we will achieve the revenues that would justify such transaction, and
we could be subject to the following risks, each of which may materially harm our business, commercialization prospects and financial
condition:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we may not be able to control the amount and timing of resources that the collaboration partner devotes to the product development
program;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the collaboration partner may experience financial difficulties;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we may be required to grant or otherwise relinquish important rights such as marketing, distribution and intellectual property
rights;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>a collaboration partner could move forward with a competing product developed either independently or in collaboration with
third parties, including our competitors; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>business combinations or significant changes in a collaboration partner&rsquo;s business strategy may adversely affect our
willingness to complete our obligations under any arrangement.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We rely on third parties to conduct our
nonclinical and clinical studies and perform other tasks for us. If these third parties do not successfully carry out their contractual
duties, meet expected deadlines, or comply with regulatory requirements, we may not be able to obtain regulatory approval for or
commercialize our product candidates and our business could be substantially harmed.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have relied upon and plan to continue
to rely upon third-party clinical research organizations, or CROs, to monitor and manage data for our ongoing nonclinical and clinical
programs, including the clinical studies of our product candidates. We rely on these parties for execution of our nonclinical and
clinical studies and control only certain aspects of their activities. Nevertheless, we are responsible for ensuring that each
of our studies is conducted in accordance with the applicable protocol, legal, regulatory and scientific standards and our reliance
on the CROs</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">does not relieve us of our regulatory responsibilities.
We and our CROs and other vendors are required to comply with current good manufacturing practices, or cGMP, current good clinical
practice, or cGCP, and Good Laboratory Practice, or GLP, which are regulations and guidelines enforced by the FDA, the Competent
Authorities of the Member States of the European Union and comparable foreign regulatory authorities for all of our product candidates
in nonclinical and clinical development. Regulatory authorities enforce these regulations through periodic inspections of study
sponsors, principal investigators, study sites and other contractors. If we or any of our CROs or vendors fail to comply with applicable
regulations, the data generated in our nonclinical and clinical studies may be deemed unreliable and the EMA, FDA, other regulatory
authorities may require us to perform additional nonclinical and clinical studies before approving our marketing applications.
We cannot assure you that upon inspection by a given regulatory authority, such regulatory authority will determine that all of
our clinical studies comply with cGCP regulations. In addition, our clinical studies must be conducted with products produced under
cGMP regulations. Our failure to comply with these regulations may require us to repeat clinical studies, which would delay the
regulatory approval process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If any of our relationships with these
third-party CROs terminates, we may not be able to enter into arrangements with alternative CROs or do so on commercially reasonable
terms. In addition, our CROs are not our employees, and except for remedies available to us under our agreements with such CROs,
we cannot control whether or not they devote sufficient time and resources to our on-going nonclinical and clinical programs. If
CROs do not successfully carry out their contractual duties or obligations or meet expected deadlines, if they need to be replaced
or if the quality or accuracy of the data they obtain is compromised due to the failure to adhere to our protocols, regulatory
requirements, or for other reasons, our clinical studies may be extended, delayed, or terminated and we may not be able to obtain
regulatory approval for or successfully commercialize our product candidates. CROs may also generate higher costs than anticipated.
As a result, our results of operations and the commercial prospects for our product candidates would be harmed, our costs could
increase, and our ability to generate revenue could be delayed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Switching or adding additional CROs involves
additional cost and requires management time and focus. In addition, there is a natural transition period when a new CRO commences
work. As a result, delays occur, which can materially impact our ability to meet our desired clinical development timelines. Though
we carefully manage our relationships with our CROs, there can be no assurance that we will not encounter similar challenges or
delays in the future or that these delays or challenges will not have a material adverse impact on our business, financial condition
and prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We currently rely on third-party suppliers
and other third parties for production of our product candidates and our dependence on these third parties may impair the advancement
of our research and development programs and the development of our product candidates.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We currently rely on and expect to continue
to rely on third parties, for the manufacturing and supply of chemical compounds for the clinical studies of our current and future
product candidates. For the foreseeable future, we expect to continue to rely on such third parties for the manufacture of any
of our product candidates on a clinical or commercial scale, if any of our product candidates receives regulatory approval. Reliance
on third-party providers may expose us to different risks than if we were to manufacture product candidates ourselves. The facilities
used by our contract manufacturers to manufacture our product candidates must be approved by the FDA or other regulatory authorities
pursuant to inspections that will be conducted after we submit our NDA or comparable marketing application to the FDA or other
regulatory authority. We do not have control over a supplier&rsquo;s or manufacturer&rsquo;s compliance with these laws, regulations
and applicable cGMP standards and other laws and regulations, such as those related to environmental health and safety matters.
If our contract manufacturers cannot successfully manufacture material that conforms to our specifications and the strict regulatory
requirements of the FDA or others, they will not be able to secure and/or maintain regulatory approval for their manufacturing
facilities. In addition, we have no control over the ability of our contract manufacturers to maintain adequate quality control,
quality assurance and qualified personnel. If the FDA or a comparable foreign regulatory authority does not approve these facilities
for the manufacture of our product candidates or if it withdraws any such approval in the future, we may need to find alternative
manufacturing facilities, which would significantly impact our ability to develop, obtain regulatory approval for or market our
product candidates, if approved. Any failure to achieve and maintain compliance with these laws, regulations and standards could
subject us to the risk that we may have to suspend the manufacturing of our product candidates or that obtained approvals could
be revoked, which would adversely affect our business and reputation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Third-party providers may breach agreements
they have with us because of factors beyond our control. Contract manufacturers often encounter difficulties involving production
yields, quality control and quality assurance, as well as shortages of qualified personnel. They may also terminate or refuse to
renew their agreements because of their own financial difficulties or business priorities, potentially at a time that is costly
or otherwise inconvenient for us. If we were unable to find adequate replacement or another acceptable solution in time, our clinical
studies could be delayed or our commercial activities could be harmed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, the fact that we are dependent
on our suppliers and other third parties for the manufacture, storage and distribution of our product candidates means that we
are subject to the risk that our product candidates and, if approved, commercial products may have manufacturing defects that we
have limited ability to prevent or control. The sale of products containing such defects could result in recalls or regulatory
enforcement action that could adversely affect our business, financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Growth in the costs and expenses of components
or raw materials may also adversely influence our business, financial condition and results of operations. Supply sources could
be interrupted from time to time and, if interrupted, we cannot be certain that supplies could be resumed (whether in part or in
whole) within a reasonable timeframe and at an acceptable cost or at all. Our current and anticipated future dependence upon others
for the manufacturing of our current and future product candidates may adversely affect our future profit margins and our ability
to commercialize any products that receive marketing approval on a timely and competitive basis.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our collaboration arrangements with our
strategic partners may make us an attractive target for potential acquisitions under certain circumstances.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under certain circumstances, due to the
structure of our collaboration arrangements with our strategic partners, our strategic partners may prefer to acquire us rather
than paying the milestone payments or royalties under the collaboration arrangements, which may bring additional uncertainties
to our business development and prospects. For example, under our collaboration arrangements with Genentech and Janssen, we may
become entitled to substantial milestone payments and royalties. As a result, rather than paying the milestone payments or royalties,
Genentech or Janssen, or one of their affiliates including Roche or Johnson&nbsp;&amp; Johnson, may choose to acquire us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Risks Related to Intellectual Property</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may not have sufficient patent terms
to effectively protect our products and business.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Patents have a limited lifespan. In the
United States, the natural expiration of a patent is generally 20 years after it is filed. Although various extensions or adjustments
may be available, such as adjustments based on certain delays caused by the United States Patent and Trademark Office, or the USPTO,
the life of a patent, and the protection it affords, is limited. Given the amount of time required for the development, testing
and regulatory review of new product candidates, patents protecting such candidates might expire before or shortly after such candidates
are commercialized. As a result, our owned, co-owned and licensed patent portfolios may not provide us with sufficient rights to
exclude others from commercializing products similar or identical to ours or otherwise provide us with a competitive advantage.
Even if patents covering our product candidates are obtained and unchallenged, once the patent life has expired for a product,
we may be open to competition from generic medications.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">While patent term extensions under the
Hatch-Waxman Act, in the United States and under supplementary protection certificates in Europe may be available to extend the
patent exclusivity term for our products, we cannot provide any assurances that any such patent term extension will be obtained
and, if so, for how long. The Hatch-Waxman Act permits a patent extension term of up to five years as compensation for patent term
lost during the FDA regulatory review process. A patent term extension cannot extend the remaining term of a patent beyond a total
of 14 years from the date of product approval, only one patent may be extended and only those claims covering the approved drug,
a method for using it or a method for manufacturing it may be extended. However, we may not be granted any extension because of,
for example, failing to exercise due diligence during the testing phase or regulatory review process, failing to apply within applicable
deadlines, failing to apply prior to expiration of relevant patents or otherwise failing to satisfy applicable requirements. Moreover,
the applicable time period or the scope of patent protection afforded could be less than we request. If we are unable to obtain
patent term extension or the term of any such extension is less than we request, such result could have a material adverse effect
on our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We or our licensing or collaboration
partners may become subject to intellectual property-related litigation or other proceedings to protect or enforce our patents
or the patents of our licensors or collaborators, any of which could be expensive, time consuming, and unsuccessful, and may ultimately
result in our loss of ownership of intellectual property.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Competitors may infringe our patents or
the patents of our licensors or collaborators. To counter such infringement, we may be required to file claims against those competitors,
which can be expensive and time-consuming. If we or one of our licensing or collaboration partners were to initiate legal proceedings
against a third party to enforce a patent covering one of our product candidates, the defendant could counterclaim that the patent
covering our product candidate is invalid or unenforceable, or that we infringe the defendant&rsquo;s patents. In patent litigation
in the United States, defendant counterclaims alleging invalidity or unenforceability are commonplace. Grounds for a validity challenge
could be an alleged failure to meet any of several statutory requirements, including lack of novelty, obviousness, obviousness-type
double patenting, lack of written description, or non-enablement. Grounds for an unenforceability assertion could be an allegation
that someone connected with prosecution of the patent withheld relevant information from the USPTO, or made a misleading statement,
during prosecution. In addition, third parties may raise similar claims before administrative bodies in the United States or abroad,
even outside the context of litigation. Such mechanisms include re-examination, post grant review<I>, inter partes</I> review,
interference and derivation proceedings as well as equivalent proceedings in foreign jurisdictions. The outcome following legal
assertions of invalidity and unenforceability is unpredictable. Such proceedings or patent litigations could result in the revocation
or cancellation of or amendment to our patents in such a way that they no longer cover our product candidates or otherwise provide
any competitive advantage. With respect to the validity question, for example, we cannot be certain that there is no invalidating
prior art, of which the patent examiner and we or our licensing or collaboration partners were unaware during prosecution. A court
may also refuse to stop a third party from using the technology in question on the grounds that our patents do not cover that technology.
An adverse result in any proceeding could put one or more of our patents at risk of being invalidated or interpreted narrowly,
which could have a material adverse effect on our business and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Interference proceedings provoked by third
parties or brought by us or declared by the USPTO may be necessary to determine the priority of inventions with respect to our
patents or patent applications or those of our licensors or collaborators. An unfavorable outcome could require us or our licensing
or collaboration partners to cease using the related technology or to attempt to license rights to it from the prevailing party.
Our business could be materially harmed if the prevailing party does not offer us or our licensing or collaboration partners a
license on commercially reasonable terms or at all. If we or our licensing or collaboration partners are unsuccessful in any interference
proceedings, we may lose our ownership of intellectual property or our patents may be narrowed or invalidated. There can be no
assurance as to the outcome of the interference and opposition proceedings, and any of the foregoing could result in a material
adverse effect on our business, financial condition, results of operations or prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our defense of litigation, interference
proceedings or other intellectual property-related proceedings may fail and, even if successful, may result in substantial costs
and distract our management and other employees from their normal responsibilities. Such litigation or proceedings could substantially
increase our operating losses and could substantially reduce the funds necessary to continue our clinical studies, continue our
research programs, license necessary technology from third parties, or enter into development partnerships that would help us bring
our product candidates to market. We may not be able to prevent, alone or with our licensing or collaboration partners, misappropriation
of our intellectual property rights, particularly in countries where the laws may not protect those rights as fully as in the United
States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Furthermore, because of the substantial
amount of discovery required in connection with intellectual property litigation, there is a risk that some of our confidential
information could be compromised by disclosure during this type of litigation. There could also be public announcements of the
results of hearings, motions, decisions or other interim proceedings or developments. If securities analysts or investors perceive
these results to be negative, it could have a material adverse effect on the price of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If we or our licensing or collaboration
partners are unable to obtain and maintain effective patent rights for our technologies, product candidates or any future product
candidates, or if the scope of the patent rights obtained is not sufficiently broad, our competitors could develop and commercialize
products and technology similar or identical to ours, and our ability to successfully commercialize our products and technology
may be adversely affected.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We rely upon a combination of patents,
trade secret protection, and confidentiality agreements to protect the intellectual property related to our technologies and product
candidates. Our success depends in large part on our and our licensing or collaboration partners&rsquo; ability to obtain and maintain
patent and other intellectual property protection in the United States and in other countries with respect to our proprietary technologies
and product candidates. In particular, Genentech or our other licensing or collaboration partners may be dependent on a license
with a third party for the development and commercialization of crenezumab or our other product candidates. If such license is
terminated, Genentech or such other licensing or collaboration partners may be required to cease development and commercialization
of crenezumab or our other product candidates, any of which could have a material adverse effect on our business, financial condition,
results of operations or prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have sought to protect our proprietary
position by filing patent applications in the United States and abroad related to any of our novel technologies and products that
are important to our business. This process is expensive, time consuming, and complex, and we may not be able to file and prosecute
all necessary or desirable patent applications at a reasonable cost, in a timely manner or in all jurisdictions. It is also possible
that we will fail to identify patentable aspects of our or our licensing or collaboration partners&rsquo; research and development
output before it is too late to obtain patent protection. Moreover, in some circumstances, we do not have the right to control
the preparation, filing and prosecution of patent applications, or to maintain the patents, covering technology that we license
to or from third parties. Therefore, these patents and applications may not be prosecuted and enforced in a manner consistent with
the best interests of our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The patent position of biotechnology and
pharmaceutical companies generally is highly uncertain and involves complex legal and factual questions for which legal principles
remain unsolved. As a result, the inventorship, issuance, scope, validity, enforceability and commercial value of our patent rights
are highly uncertain. The pending or future patent applications that we own, co-own or in-license may fail to issue, fail to result
in issued patents with claims that cover our product candidates in the United States or in other foreign countries, or fail to
effectively prevent others from commercializing competitive technologies and product candidates. Changes in either the patent laws
or interpretation of the patent laws in the United States and other countries may diminish the value of our patents or narrow the
scope of our patent protection.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We may not be aware of all third-party
intellectual property rights potentially relating to our technologies or product candidates. Publications of discoveries in the
scientific literature often lag behind the actual discoveries, and patent applications in the United States and other jurisdictions
remain confidential for a period of time after filing, and some remain so until issued. Therefore, we cannot be certain that we
were the first to file any patent application related to our product candidates or technologies, or whether we were the first to
make the inventions claimed in our owned or co-owned patents or pending patent applications, nor can we know whether those from
whom we license patents were the first to make the inventions claimed or were the first to file.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">There is no assurance that all potentially
relevant prior art relating to our patents and patent applications has been found, which can invalidate a patent or prevent a patent
from issuing from a pending patent application. Even if patents do successfully issue, and even if such patents cover our product
candidates, third parties may challenge their validity, enforceability, or scope, which may result in such patents being narrowed,
found unenforceable or invalidated, which could allow third parties to commercialize our technology or products and compete directly
with us, without payment to us, or result in our inability to manufacture or commercialize products without infringing third party
patent rights. Furthermore, even if they are unchallenged, our patents and patent applications may not adequately protect our intellectual
property, provide exclusivity for our product candidates, prevent others from designing around our claims or provide us with a
competitive advantage. Any of these outcomes could impair our ability to prevent competition from third parties, which may have
a material adverse effect on our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may be subject to claims challenging
the inventorship of our patents and other intellectual property.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We may be subject to claims that former
employees, collaborators or other third parties have an interest in our patents or other intellectual property as an inventor or
co-inventor. For example, we may have inventorship disputes</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">arise from conflicting obligations of consultants
or others who are involved in developing our product candidates. Litigation may be necessary to defend against these and other
claims challenging inventorship or our ownership of our patents or other intellectual property. If we fail in defending any such
claims, in addition to paying monetary damages, we may lose valuable intellectual property rights, such as exclusive ownership
of, or the right to use, valuable intellectual property. Such an outcome could have a material adverse effect on our business.
Even if we are successful in defending against such claims, litigation could result in substantial costs and be a distraction to
management and other employees.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Patent policy and rule changes could
increase the uncertainties and costs surrounding the prosecution of our patent applications and the enforcement or defense of our
issued patents, thereby impairing our ability to protect our technologies and products.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Changes in either the patent laws or interpretation
of the patent laws in the United States could increase the uncertainties and costs surrounding the prosecution of patent applications
and the enforcement or defense of issued patents. Assuming the other requirements for patentability are met, in the United States
prior to March 15, 2013, the first to make the claimed invention is entitled to the patent, while outside the United States, the
first to file a patent application is entitled to the patent. After March 15, 2013, under the Leahy-Smith America Invents Act,
or the Leahy-Smith Act, enacted on September 16, 2011, the United States has moved to a first-to-file system. Under a first-to-file
system, assuming the other requirements for patentability are met, the first inventor to file a patent application generally will
be entitled to the patent on an invention regardless of whether a third party was the first to invent the invention. The Leahy-Smith
Act also includes a number of significant changes that affect the way patent applications will be prosecuted and may also affect
patent litigation. These include allowing third-party submission of prior art to the USPTO during patent prosecution and additional
procedures to attack the validity of a patent by the USPTO administered post grant proceedings, including reexamination proceedings,
<I>inter partes </I>review, post-grant review and derivation proceedings. The effects of these changes on the operation of our
business are currently unclear as, among other reasons, the USPTO must still implement various regulations and courts must interpret
these changes. However, the Leahy-Smith Act and its implementation could increase the uncertainties and costs surrounding the prosecution
of our patent applications and the enforcement or defense of our issued patents, all of which could have a material adverse effect
on our business, financial condition, results of operations and prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, the patent positions of companies
in the development and commercialization of biologics and pharmaceuticals are particularly uncertain. Recent U.S. Supreme Court
rulings have narrowed the scope of patent protection available in certain circumstances and weakened the rights of patent owners
in certain situations. This combination of events has created uncertainty with respect to the validity and enforceability of patents,
once obtained. Depending on future actions by the U.S. Congress, the federal courts, and the USPTO, the laws and regulations governing
patents could change in unpredictable ways that could have a material adverse effect on our existing patent portfolio and our ability
to protect and enforce our intellectual property in the future.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If we are unable to maintain effective
proprietary rights for our technologies, product candidates or any future product candidates, we may not be able to compete effectively
in our markets.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition to the protection afforded
by patents, we rely on trade secret protection and confidentiality agreements to protect proprietary know-how that is not patentable
or that we elect not to patent, processes for which patents are difficult to enforce and any other elements of our product candidate
discovery and development processes that involve proprietary know-how, information or technology that is not covered by patents.
However, trade secrets can be difficult to protect and some courts inside and outside the United States are less willing or unwilling
to protect trade secrets. Because we rely on our advisors, employees and third-party contractors and consultants to research and
develop and to manufacture our product candidates, we must, at times, share our intellectual property with them. We seek to protect
our intellectual property and other proprietary technology in part by entering into confidentiality agreements and, if applicable,
material transfer agreements, consulting agreements or other similar agreements with our advisors, employees, contractors, consultants,
licensing and collaboration partners, and other third parties. These agreements typically limit the rights of these third parties
to use or disclose our confidential information, including our intellectual property and trade secrets. These agreements also typically
restrict the ability of third parties to publish data potentially relating to our intellectual property, although our agreements
may contain certain limited publication rights. For example, any academic institution that we may collaborate with in the future
may expect to be granted rights to publish data arising out of such collaboration, provided that we may have the right to be notified
in advance and given the opportunity to delay publication for a limited time period in order for us to secure patent protection
of intellectual property rights arising from the</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">collaboration, in addition to the opportunity
to remove confidential or trade secret information from any such publication. In the future, we may also conduct joint research
and development programs that may require us to share intellectual property under the terms of our research and development or
similar agreements. However, we cannot guarantee that we have entered into such agreements with each party that may have or have
had access to our trade secrets or other confidential information or proprietary technology and processes or that such agreements
will not be breached or that our trade secrets or other confidential information will not otherwise be disclosed. Despite the contractual
provisions employed when working with these advisors, employees and third party contractors and consultants, the need to share
intellectual property and other confidential information increases the risk that such confidential information becomes known by
our competitors, is inadvertently incorporated into the product development of others or is disclosed or used in violation of these
agreements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We also seek to preserve the integrity
and confidentiality of our data and trade secrets by maintaining physical security of our premises and physical and electronic
security of our information technology systems. Despite our efforts to protect our intellectual property, our competitors may discover
our trade secrets through breach of our agreements with third parties, where we may not have adequate remedies for any breach,
independent development or publication of information by any of our licensing or collaboration partners. Additionally, if the steps
taken to maintain our trade secrets are deemed inadequate, we may have insufficient recourse against third parties for misappropriating
such trade secrets. Misappropriation or unauthorized disclosure of our trade secrets could impair our competitive position and
may have a material adverse effect on our business. Moreover, if any of our trade secrets were to be lawfully obtained or independently
developed by a competitor or other third party, we would have no right to prevent such competitor or other third party from using
that technology or information to compete with us. A competitor&rsquo;s or other third party&rsquo;s discovery of our intellectual
property would impair our competitive position and have a material adverse effect on our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Further, the laws of some foreign countries
do not protect proprietary rights to the same extent or in the same manner as the laws of the United States. As a result, we may
encounter significant problems in protecting and defending our intellectual property both in the United States and abroad. If we
are unable to prevent material disclosure of the intellectual property related to our technologies to third parties, we will not
be able to establish or maintain a competitive advantage in our market, which could materially adversely affect our business, financial
condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Obtaining and maintaining our patent
protection depends on compliance with various procedural, document submission, fee payment and other requirements imposed by governmental
patent agencies, and our patent protection could be reduced or eliminated for non-compliance with these requirements.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Periodic maintenance fees, renewal fees,
annuity fees and various other government fees on a patent and patent application are due to be paid to the USPTO and foreign patent
agencies in several stages over the lifetime of the patent and patent application. The USPTO and various foreign governmental patent
agencies require compliance with a number of procedural, documentary, fee payment and other similar provisions during the patent
application process. We employ reputable law firms and other professionals to help us comply with these requirements and we are
also dependent on our licensors or collaboration partners to take the necessary action to comply with these requirements with respect
to certain of our intellectual property. While an inadvertent lapse can in many cases be cured by payment of a late fee or by other
means in accordance with the applicable rules, there are situations in which noncompliance can result in abandonment or lapse of
the patent or patent application, resulting in partial or complete loss of patent rights in the relevant jurisdiction. Non-compliance
events that could result in abandonment or lapse of a patent or patent application include, but are not limited to, failure to
respond to official actions within prescribed time limits, non-payment of fees and failure to properly legalize and submit formal
documents. In such an event, our competitors might be able to enter the market, which would have a material adverse effect on our
business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">The patent protection and patent prosecution
for some of our product candidates is dependent on third parties.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">While we normally seek to obtain the right
to control prosecution, maintenance and enforcement of the patents relating to our product candidates, there may be times when
the filing and prosecution activities for patents relating to our product candidates are controlled by our licensors or collaboration
partners. If any of our current or future licensing or collaboration partners fail to prosecute, maintain and enforce such patents
and patent applications in a manner consistent with the best interests of our business, including by payment of all applicable
fees for patents covering our product candidates, we could lose our rights to the intellectual property or our exclusivity with
respect</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">to those rights, our ability to develop and
commercialize those product candidates may be adversely affected and we may not be able to prevent competitors from making, using,
and selling competing products. In addition, even where we have the right to control patent prosecution of patents and patent applications
we have licensed to and from third parties, we may still be adversely affected or prejudiced by actions or inactions of our licensees,
our licensors and their counsel that took place prior to the date upon which we assumed control over patent prosecution.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If we fail to comply with the obligations
in our intellectual property agreements, including those under which we license intellectual property and other rights to or from
third parties, or otherwise experience disruptions to our business relationships with our licensees, our licensors and partners,
we could lose intellectual property rights that are important to our business.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a party to a number of intellectual
property license and co-ownership agreements that are important to our business and expect to enter into additional such agreements
in the future. Under certain circumstances, the royalties payable to us under these agreements are subject to certain reductions,
which may have a materially adverse effect on our business, financial condition, results of operations and prospects. In addition,
our existing agreements impose, and we expect that future agreements will impose, various diligence, commercialization, milestone
payment, royalty and other obligations on us. If we fail to comply with our obligations under these agreements, or we are subject
to a bankruptcy, we may be required to make certain payments to the licensor, we may lose the exclusivity of our license, or the
licensor may have the right to terminate the license, in which event we would not be able to develop or market products covered
by the license.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Licensing of intellectual property is of
critical importance to our business and involves complex legal, business, and scientific issues. Disputes may arise regarding intellectual
property subject to a licensing or co-ownership agreement, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the scope of rights granted under the agreement and other interpretation-related issues;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the extent to which our technology and processes infringe or otherwise violate intellectual property of the licensor, the licensee
or partner that is not subject to the agreement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the sublicensing of patent and other rights;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the diligence, development and commercialization obligations under the agreement and what activities satisfy those obligations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the ownership of inventions and know-how resulting from the joint creation or use of intellectual property by our licensors
or collaboration partners and us; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the priority of invention of patented technology.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If disputes over intellectual property
and other rights that we have licensed or co-own prevent or impair our ability to maintain our current licensing or exclusivity
arrangements on acceptable terms, we may be unable to successfully develop and commercialize the affected product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, certain provisions in the
agreements under which we currently license intellectual property or technology to and from third parties may be susceptible to
multiple interpretations. The resolution of any contract interpretation disagreement that may arise could narrow what we believe
to be the scope of our rights to the relevant intellectual property or technology, increase what we believe to be our financial
or other obligations under the relevant agreement, or decrease the third party&rsquo;s financial or other obligations under the
relevant agreement, any of which could have a material adverse effect on our business, financial condition, results of operations
and prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may not be successful in obtaining
or maintaining necessary rights to our product candidates through acquisitions and in-licenses.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our programs may in the future require
the use of proprietary rights held by third parties, the growth of our business will likely depend in part on our ability to acquire,
in-license, maintain or use these proprietary rights. In addition, our product candidates may require specific formulations to
work effectively and efficiently and the rights to these formulations may be held by others. We may be unable to acquire or in-license
any compositions, methods of use, processes, or other third-party intellectual property rights from third parties that we identify
as necessary for</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">our product candidates. The licensing and
acquisition of third-party intellectual property rights is a competitive area, and a number of more established companies may pursue
strategies to license or acquire third-party intellectual property rights that we may consider attractive or necessary. These established
companies may have a competitive advantage over us due to their size, cash resources, and greater clinical development and commercialization
capabilities. In addition, companies that perceive us to be a competitor may be unwilling to assign or license rights to us. We
also may be unable to license or acquire third-party intellectual property rights on terms that would allow us to make an appropriate
return on our investment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For example, we sometimes collaborate with
U.S. and foreign academic institutions to accelerate our preclinical research or development under written agreements with these
institutions. Typically, these institutions provide us with an option to negotiate a license to any of the institution&rsquo;s
rights in technology resulting from the collaboration. Regardless of such option, we may be unable to negotiate a license within
the specified timeframe or under terms that are acceptable to us. If we are unable to do so, the institution may offer the intellectual
property rights to other parties, potentially blocking our ability to pursue our applicable product candidate or program.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If we are unable to successfully obtain
a license to third-party intellectual property rights necessary for the development of a product candidate or program, we may have
to abandon development of that product candidate or program and our business and financial condition could suffer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Third-party claims of intellectual property
infringement may expose us to substantial liability or prevent or delay our development and commercialization efforts.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our commercial success depends on our ability
and the ability of our licensees or collaborators to develop, manufacture, market and sell our product candidates and use our proprietary
technology without infringing, misappropriating, or otherwise violating the proprietary rights and intellectual property of third
parties. The biotechnology and pharmaceutical industries are characterized by extensive and complex litigation regarding patents
and other intellectual property rights. We may in the future become party to, or be threatened with, adversarial proceedings or
litigation regarding intellectual property rights with respect to our product candidates and technology, including patent infringement
lawsuits, interferences, oppositions, reexamination proceedings, <I>inter partes</I> review, derivation proceedings and post grant
review before the USPTO and corresponding foreign patent offices.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Numerous U.S. and foreign issued patents
and pending patent applications, which are owned by third parties, exist in the fields in which we are developing product candidates.
For example, we are aware of third party patents that may be construed to cover one or more of our product candidates. If these
patents are asserted against us or our licensing or collaboration partners and either we or our licensing or collaboration partners
are found to infringe any of these patents, and are unsuccessful in demonstrating that such patents are invalid or unenforceable,
then we and our licensing or collaboration partners could be required to pay substantial monetary damages or cease further development
or commercialization of one or more of our product candidates. There may also be other third-party patents or patent applications
with claims to materials, formulations, methods of manufacture, or methods of treatment related to the use or manufacture of our
product candidates and technology. Although we generally conduct a freedom to operate search and review with respect to our product
candidates, we cannot guarantee that our search and review is complete and thorough, nor can we be sure that we have identified
each and every patent and pending application in the United States and abroad that is relevant or necessary to the commercialization
of our product candidates or use of our technology. Because patent applications can take many years to issue, there may be currently
pending patent applications that may later result in issued patents that our product candidates may infringe. In addition, third
parties may obtain patents in the future and claim that use of our technologies infringes upon these patents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Third parties may assert infringement claims
against us based on existing patents or patents that may be granted in the future, regardless of merit. Even if we believe such
claims are without merit, a court of competent jurisdiction could hold that these third party patents are valid, enforceable and
infringed, which could materially and adversely affect our ability to commercialize our product candidates or technologies covered
by the asserted third party patents. If we are found to infringe a third party&rsquo;s valid and enforceable intellectual property
rights, we could be required to obtain a license from such third party to continue developing, manufacturing and marketing our
product candidates and technology. However, we may not be able to obtain any required license on commercially reasonable terms
or at all. Even if we were able to obtain a license, it could be non-exclusive, thereby giving our competitors</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">and other third parties access to the same
technologies licensed to us and it could require us to make substantial payments to the licensor.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Parties making claims against us may also
obtain injunctive or other equitable relief, which could effectively block our ability to further develop and commercialize one
or more of our product candidates. Defense of these claims, regardless of their merit, would involve substantial litigation expense
and would be a substantial diversion of management and employee resources from our business. In the event of a successful claim
of infringement against us, we may have to pay substantial damages, including treble damages and attorneys&rsquo; fees for willful
infringement, pay royalties, redesign our infringing products or obtain one or more licenses from third parties, which may be impossible
or require substantial time and monetary expenditure. Any of the foregoing could have a material and adverse effect on our business,
financial conditions, results of operations and prospects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, claims that we have misappropriated
the confidential information or trade secrets of third parties could have a similar negative impact on our business, financial
condition, results of operations and prospects. There could also be public announcements of the results of hearings, motions, decisions,
or other interim proceedings or developments. If securities analysts or investors perceive these results to be negative, it could
have a material adverse effect on the price of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Some of our competitors may have substantially
greater resources and more mature and developed intellectual property portfolios than we do and may be able to sustain the costs
of complex intellectual property litigation to a greater degree and for longer periods of time than we could. In addition, patent
holding companies that focus solely on extracting royalties and settlements by enforcing patent rights may target us. As the biotechnology
and pharmaceutical industries expand and more patents are issued, the risk increases that our product candidates may be subject
to claims of infringement of the patent rights of third parties. The uncertainties resulting from the initiation and continuation
of patent litigation or other proceedings could have a material adverse effect on our ability to compete in the marketplace.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may be subject to claims that our
employees, consultants, or independent contractors have wrongfully used or disclosed confidential information of third parties
or that our employees have wrongfully used or disclosed alleged trade secrets of their former employers.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We employ and utilize the services of individuals
who were previously employed or provided services to universities or other biotechnology or pharmaceutical companies, including
our competitors or potential competitors. Although we try to ensure that our employees, consultants, and independent contractors
do not use the proprietary information or know-how of others in their work for us, we may be subject to claims that we or our employees,
consultants, or independent contractors have inadvertently or otherwise used or disclosed intellectual property, including trade
secrets or other proprietary information, of any of our employee&rsquo;s, consultant&rsquo;s or independent contractor&rsquo;s
former employer or other third parties. Litigation may be necessary to defend against these claims. If we fail in defending any
such claims, in addition to paying monetary damages, we may lose valuable intellectual property rights or personnel, which could
adversely impact our business. Even if we are successful in defending against such claims, litigation could result in substantial
costs and be a distraction to management and other employees.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, while it is our policy to
require our employees, consultants and independent contractors who may be involved in the conception or development of intellectual
property to execute agreements assigning such intellectual property to us, we may be unsuccessful in executing such an agreement
with each party who, in fact, conceives or develops intellectual property that we regard as our own. The assignment of intellectual
property rights may not be self-executing or the assignment agreements may be breached, and we may be forced to bring claims against
third parties, or defend claims that they may bring against us, to determine the ownership of what we regard as our intellectual
property.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may not be able to protect our intellectual
property rights throughout the world.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Filing, prosecuting and defending patents
on product candidates in all countries throughout the world would be prohibitively expensive, and our intellectual property rights
in some countries outside the United States can be less extensive than those in the United States. In addition, the laws of some
foreign countries do not protect intellectual property rights to the same extent as the laws in the United States. Consequently,
we may not be able to prevent third parties from practicing our inventions in all countries outside the United States, or from
selling or importing</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">products made using our inventions in and
into the United States or other jurisdictions. In the ordinary course of prosecution and maintenance activities, we determine whether
to seek patent protection outside the U.S. and in which countries. This also applies to patents we have acquired or in-licensed
from third parties. In some cases, we, or our predecessors in interest or licensors of patents within our portfolio, have sought
patent protection in a limited number of countries for patents covering our product candidates. Competitors may use our technologies
in jurisdictions where we have not obtained or are unable to adequately enforce patent protection to develop their own products
and further, may export otherwise infringing products to territories where we have patent protection, but enforcement is not as
strong as that in the United States. These products may compete with our products and our patents or other intellectual property
rights may not be effective or sufficient to prevent them from competing, which would have a material adverse effect on our business
and financial positions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Many companies have encountered significant
problems in protecting and defending intellectual property rights in foreign jurisdictions. The legal systems of certain countries,
particularly certain developing countries, do not favor the enforcement of patents, trade secrets, and other intellectual property
protection, particularly those relating to biotechnology products, which could make it difficult for us to stop the infringement,
misappropriation or other violations of our intellectual property and proprietary rights. Proceedings to enforce our patent rights
in foreign jurisdictions, whether or not successful, could result in substantial costs and divert our efforts and attention from
other aspects of our business, could put our patents at risk of being invalidated or interpreted narrowly and our patent applications
at risk of not issuing and could provoke third parties to assert claims against us. We may not prevail in any lawsuits that we
initiate and the damages or other remedies awarded, if any, may not be commercially meaningful. Accordingly, our efforts to enforce
our intellectual property rights around the world may be inadequate to obtain a significant commercial advantage from the intellectual
property that we develop or license.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Risks Related to Our Financial Condition and Capital Requirements</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We are a clinical-stage company and have
a history of operating losses. We anticipate that we will continue to incur losses for the foreseeable future.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a clinical-stage biopharmaceutical
company. Since 2003, while we have received upfront and milestone payments from our collaboration partners and certain other revenue,
we have also incurred significant operating losses. For example, we incurred net losses (defined as net loss attributable to owners
of the company) of CHF 7.1 million for the year ended December&nbsp;31, 2016.&nbsp;In addition, we had accumulated losses of CHF&nbsp;47.0
million as of December&nbsp;31, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our losses have resulted principally from
research and development expenses and from general business and administrative expenses. We expect to continue to incur significant
operating losses in the future as we continue our research and development efforts for our current and future product candidates
and seek to obtain regulatory approval and commercialization of such product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, we have financed our operations
through proceeds from our initial public offering (&ldquo;IPO&rdquo;) in September 2016, private placements of preferred securities,
and upfront and milestone payments from our collaboration partners and certain other revenue. We have no products approved for
commercialization and have never generated any revenues from product sales. Biopharmaceutical product development is a highly speculative
undertaking and involves a substantial degree of risk. It may be several years, if ever, before we or our collaboration partners
complete pivotal clinical studies and have a product candidate approved for commercialization and we begin to generate revenue
or royalties from product sales.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">While we have generated revenues from
upfront and milestone payments related to our collaboration agreements, we have never generated any revenue from product sales
and may never be profitable.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">While we have generated revenue from upfront
and milestone payments related to our collaboration agreements, we have no products approved for commercialization and have never
generated any revenue from product sales. Our ability to generate revenue and achieve profitability depends on our ability to successfully
complete the development of, and obtain the marketing approvals necessary to commercialize, one or more of our product candidates.
We do not anticipate generating revenue from product sales unless and until we or our collaboration partners obtain regulatory
approval for, and commercialize, our product candidates. Our ability to generate future revenue from product sales depends heavily
on our success in many areas, including but not limited to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>completing research and clinical development of our product candidates, including us or our collaboration partners, as the
case may be, successfully completing a Phase 3 clinical study of crenezumab, a Phase 1/2a clinical study of ACI-24 for AD, a Phase
1 clinical study of ACI-24 in Down syndrome, a Phase 1b clinical study of ACI-35 and a Phase 1 clinical study of our anti-tau antibody
candidate;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>obtaining marketing approvals for our product candidates, including crenezumab, ACI-24 for AD or ACI-35 or our anti-tau antibody
candidate, for which we complete clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>developing a sustainable and scalable manufacturing process for any approved product candidates and maintaining supply and
manufacturing relationships with third parties that can conduct the process and provide adequate (in amount and quality) products
to support clinical development and the market demand for our product candidates, if approved;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>launching and commercializing product candidates for which we obtain marketing approval, either directly or with a collaborator
or distributor;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>obtaining market acceptance of our product candidates as viable treatment options;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>addressing any competing technological and market developments;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>identifying, assessing, acquiring and/or developing new product candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>negotiating favorable terms in any collaboration, licensing, or other similar arrangements into which we may enter;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>maintaining, protecting, and expanding our portfolio of intellectual property rights, including patents, trade secrets and
know-how; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>attracting, hiring and retaining qualified personnel.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Even if one or more of the product candidates
that we develop is approved for commercial sale, we anticipate incurring significant costs associated with commercializing any
approved product candidate. Because of the numerous risks and uncertainties with pharmaceutical product development, we are unable
to accurately predict the timing or amount of increased expenses or when, or if, we will be able to achieve profitability. Our
expenses could increase beyond expectations if we are required by the FDA, the EMA, or other regulatory agencies, domestic or foreign,
to change our manufacturing processes, or to perform clinical, nonclinical, or other types of studies in addition to those that
we currently anticipate. In cases where we are successful in obtaining regulatory approvals to market one or more of our product
candidates, our revenue will be dependent, in part, upon the size of the markets in the territories for which we gain regulatory
approval, the accepted price for the product, the ability to obtain coverage and reimbursement at any price, and whether we own
the commercial rights for that territory. If the number of our addressable patients is not as significant as we estimate, the indication
approved by regulatory authorities is narrower than we expect, or the treatment population is narrowed by competition, physician
choice or treatment guidelines, we may not generate significant revenue from sales of such products, even if approved. Accordingly,
we may not be profitable in the future from the sale of any approved products.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We may be unable to develop and commercialize
any of our current or future product candidates and, even if we do, may not achieve profitability in the future. Even if we do
achieve profitability in the future, we may not be able to sustain or increase profitability on a quarterly or annual basis. Our
failure to be profitable in the future would decrease the value of our company and could impair our ability to raise capital, expand
our business or continue our operations. A decline in the value of our company could cause you to lose all or part of your investment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We expect that we will need substantial
additional funding before we can expect to become profitable from sales of our products. If we are unable to raise capital when
needed, we could be forced to delay, reduce or eliminate our product development programs or commercialization efforts.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are currently advancing our product
candidates through clinical development, either together with a collaboration partner (crenezumab, ACI-35 and our anti-tau antibody
candidate) or independently (ACI-24 for AD and Down syndrome). We expect our research and development expenses to continue to increase
in connection with</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">our ongoing activities, particularly as we
and/or our collaboration partners continue our ongoing studies and initiate new studies of crenezumab, ACI-24 for AD, ACI-35 and
our anti-tau antibody candidate and initiate preclinical and clinical development of our other product candidates. As of December&nbsp;31,
2016, we had cash and cash equivalents of CHF 152.2&nbsp;million. We currently believe that our existing capital resources, not
including potential milestone payments, will be sufficient to meet our projected operating requirements for at least through the
fourth quarter of fiscal year 2018. We have based this estimate on assumptions that may prove to be wrong, and we could exhaust
our capital resources sooner than we currently expect. Our future funding requirements will depend on many factors, including but
not limited to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the scope, rate of progress, results and cost of our pre-clinical and clinical studies and other related activities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the cost of manufacturing clinical supplies and establishing commercial supplies of our existing product candidates and any
other products we may develop;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the cost, timing, and outcomes of regulatory approvals;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the cost and timing of establishing sales, marketing and distribution capabilities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the terms and timing of any collaborative, licensing, and other arrangements that currently exist or that we may establish
in the future, including any required milestone and royalty payments thereunder;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the emergence of competing technologies or other adverse market developments; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the potential cost and timing of managing and protecting our portfolio of intellectual property.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We expect that we will require additional
capital to commercialize our product candidates. If we receive regulatory approval for our current and future product candidates,
and if we have not already licensed such product candidate to a collaboration partner and choose to commercialize such product
candidate independently, we expect to incur significant commercialization expenses related to product manufacturing, sales, marketing
and distribution, depending on where we choose to commercialize. We also expect to incur additional costs associated with operating
as a public company as a result of our IPO. Additional funds may not be available on a timely basis, on favorable terms, or at
all, and such funds, if raised, may not be sufficient to enable us to continue to implement our long-term business strategy. If
we are not able to raise capital when needed, we could be forced to delay, reduce or eliminate our product development programs
or commercialization efforts.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Raising additional capital may cause
dilution to our shareholders, restrict our operations or require us to relinquish rights to our intellectual property or future
revenue streams.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Until such time, if ever, as we can generate
substantial product revenue, we expect to finance our cash needs through a combination of equity offerings, debt financings, grants
and license and development agreements in connection with collaborations. We do not have any committed external source of funds.
In the event we need to seek additional funds, we may raise additional capital through the sale of equity, convertible debt or
other securities. In such an event, your ownership interest will be diluted, and the terms of these securities may include liquidation
or other preferences that adversely affect your rights as a holder of our common shares. Debt financing, if available, may involve
agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt,
making capital expenditures or proposing dividends to our shareholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If we raise additional funds through collaborations,
strategic alliances or marketing, distribution or licensing arrangements with third parties, we may have to grant or otherwise
relinquish valuable rights to our intellectual property or future revenue streams. If we are unable to raise additional funds when
needed, we may be required to delay, limit, reduce or terminate our product development or future commercialization efforts or
grant rights to develop and market product candidates that we would otherwise prefer to develop and market ourselves.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our ability to use tax loss carryforwards
in Switzerland may be limited.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December 31, 2016, we reported tax
loss carryforwards from financial years 2010 until 2016 for purposes of Swiss corporate income tax in the aggregate amount of CHF
36.7 million that could be available to offset future taxable income. If not used, these tax losses will expire seven years after
the year in which they were incurred. Due</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">to our limited income, there is a high risk
that the tax loss carryforwards will expire partly or entirely and cannot be used to offset future taxable income thereafter for
Swiss corporate income tax purposes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Exchange rate fluctuations or abandonment
of the euro currency may materially affect our results of operations and financial condition.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under our existing agreements, we receive
and make a significant amount of payments in USD, Swiss Francs and Euro. As a result, changes and fluctuations in currency exchange
rates between the Swiss Franc and other currencies, especially the USD and euro could have a materially adverse effect on our operating
results. Since our reporting currency is the Swiss Franc, financial line items are converted into Swiss Francs at the applicable
exchange rates. We also expect that in the future, a significant portion of our revenues and expenses will be denominated in Swiss
Franc, USD and Euro. Therefore, unfavorable developments in the value of the Swiss Franc as compared to the Euro or any other currency
could have a material adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Risks Related to the Regulatory Environment</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We cannot give any assurance that any
of our product candidates will receive regulatory approval, which is necessary before they can be commercialized.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our future success is dependent on our
ability to successfully develop, obtain regulatory approval for, and then successfully commercialize one or more product candidates.
We currently have one product candidate that has completed Phase 2 clinical studies. Enrollment in Phase 3 clinical studies of
crenezumab initiated by our collaboration partner Genentech started in the first quarter of 2016. We are not permitted to market
or promote any of our product candidates before we receive regulatory approval from the FDA, EMA or comparable foreign regulatory
authorities, and we may never receive such regulatory approval for any of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We cannot be certain that any of our product
candidates will be successful in clinical studies or receive regulatory approval. Applications for our product candidates could
fail to receive regulatory approval for many reasons, including but not limited to the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the FDA, EMA or comparable foreign regulatory authorities may disagree with the design or implementation of our clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the population studied in the clinical program may not be sufficiently broad or representative to assure safety in the full
population for which we seek approval;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the FDA, EMA or comparable foreign regulatory authorities may disagree with our interpretation of data from nonclinical or
clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the data collected from clinical studies of our product candidates may not be sufficient to support the submission of an NDA
or other submission or to obtain regulatory approval in the United States or elsewhere;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>we may be unable to demonstrate to the FDA, EMA or comparable foreign regulatory authorities that a product candidate&rsquo;s
risk-benefit ratio for its proposed indication is acceptable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the FDA, EMA or other regulatory authorities may fail to approve the manufacturing processes, test procedures and specifications,
or facilities of third-party manufacturers with which we contract for clinical and commercial supplies; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the approval policies or regulations of the FDA, EMA or comparable foreign regulatory authorities may significantly change
in a manner rendering our clinical data insufficient for approval.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We generally plan to seek regulatory approval
to commercialize our product candidates in the United States, the European Union and in additional foreign countries where we have
commercial rights. To obtain regulatory approval in other countries, we must comply with numerous and varying regulatory requirements
of such other countries regarding safety, efficacy, chemistry, manufacturing and controls, clinical studies, commercial sales,
pricing, and distribution of our product candidates. Even if we are successful in obtaining approval in one</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">jurisdiction, we cannot ensure that we will
obtain approval in any other jurisdictions. Failure to obtain marketing authorization for our product candidates will result in
our being unable to market and sell such products, which would materially adversely affect our business, financial conditional
and results of operation. If we fail to obtain approval in any jurisdiction, the geographic market for our product candidates could
be limited. Similarly, regulatory agencies may not approve the labeling claims that are necessary or desirable for the successful
commercialization of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Clinical drug development involves a
lengthy and expensive process with uncertain timelines and uncertain outcomes. If clinical studies of our product candidates are
prolonged or delayed, we may be unable to obtain required regulatory approvals, and therefore be unable to commercialize our product
candidates on a timely basis or at all.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To obtain the requisite regulatory approvals
to market and sell any of our product candidates, we must demonstrate through extensive preclinical and clinical studies that our
products are safe and effective in humans. Clinical testing is expensive and can take many years to complete, and its outcome is
inherently uncertain. Failure can occur at any time during the clinical study process. The results of preclinical and early clinical
studies of our product candidates may not be predictive of the results of later-stage clinical studies. For example, the positive
results generated to date in clinical studies for our product candidates do not ensure that later clinical studies will demonstrate
similar results. Product candidates in later stages of clinical studies may fail to show the desired safety and efficacy traits
despite having progressed through preclinical studies and initial clinical studies. A number of companies in the biopharmaceutical
industry have suffered significant setbacks in advanced clinical studies due to lack of efficacy or adverse safety profiles, notwithstanding
promising results in earlier studies. Our future clinical study results may not be successful.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Clinical studies must be conducted in accordance
with FDA, EMA and comparable foreign regulatory authorities&rsquo; legal requirements, regulations or guidelines, and are subject
to oversight by these governmental agencies and Institutional Review Boards, or IRBs, at the medical institutions where the clinical
studies are conducted. In addition, clinical studies must be conducted with supplies of our product candidates produced under cGMP
and other requirements. We depend on medical institutions and CROs, to conduct our clinical studies in compliance with cGCP standards.
To the extent the CROs fail to enroll participants for our clinical studies, fail to conduct the study to cGCP standards or are
delayed for a significant time in the execution of studies, including achieving full enrollment, we may be affected by increased
costs, program delays or both, which may harm our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, neither we nor our collaboration
partners have completed all clinical studies required for the approval of any of our product candidates. Crenezumab has completed
Phase 2 clinical testing and is currently in a Phase 3 clinical study, ACI-24 for AD is in a combined Phase 1/2a clinical study,
ACI-24 for Down syndrome is in a Phase 1 clinical study, ACI-35 is in Phase 1b clinical studies, our anti-tau antibody candidate
in a Phase 1 clinical study and our tau-PET imaging program has started clinical development. The development of our other product
candidates is less advanced and studies have not yet started.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The completion of clinical studies for
our clinical product candidates may be delayed, suspended or terminated as a result of many factors, including but not limited
to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the delay or refusal of regulators or IRBs to authorize us to commence a clinical study at a prospective study site or changes
in regulatory requirements, policies and guidelines;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>delays or failure to reach agreement on acceptable terms with prospective CROs and clinical study sites, the terms of which
can be subject to extensive negotiation and may vary significantly among different CROs and study sites;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>delays in patient enrollment and variability in the number and types of patients available for clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the inability to enroll a sufficient number of patients in studies to ensure adequate statistical power to detect statistically
significant treatment effects;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>negative or inconclusive results, which may require
us to conduct additional preclinical or clinical studies or to abandon projects that we expected to be promising;</TD>
</TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>safety or tolerability concerns, which could cause
us to suspend or terminate a study if we find that the participants are being exposed to unacceptable health risks;</TD>
</TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>regulators or IRBs requiring that we or our investigators
suspend or terminate clinical research for various reasons, including noncompliance with regulatory requirements or safety concerns,
among others;</TD>
</TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>lower than anticipated retention rates of patients and volunteers in clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>our CROs or clinical study sites failing to comply with regulatory requirements or meet their contractual obligations to us
in a timely manner, or at all, deviating from the protocol or dropping out of a study;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>delays relating to adding new clinical study sites;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>difficulty in maintaining contact with patients after treatment, resulting in incomplete data;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>delays in establishing the appropriate dosage levels;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the quality or stability of the product candidate falling below acceptable standards;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the inability to produce or obtain sufficient quantities of the product candidate to complete clinical studies; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>exceeding budgeted costs due to difficulty in accurately predicting costs associated with clinical studies.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any delays in completing our clinical studies
will increase our costs, slow our product candidate development and approval process and jeopardize our ability to commence product
sales and generate revenues. Any of these occurrences may harm our business, financial condition and prospects significantly. In
addition, many of the factors that cause, or lead to, a delay in the commencement or completion of clinical studies may also ultimately
lead to the denial of regulatory approval of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Even if we obtain and maintain approval
for our drug candidates from one jurisdiction, we may never obtain approval for our drug candidates in other jurisdictions, which
would limit our market opportunities and adversely affect our business.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Sales of our approved drugs will be subject
to U.S. and non-U.S. regulatory requirements governing clinical studies and regulatory approval, and we plan to seek regulatory
approval to commercialize our drug candidates in the United States, the European Economic Area, and other countries. Clinical studies
conducted in one country may not be accepted by regulatory authorities in other countries and regulatory approval in one country
does not ensure approval in any other country, while a failure or delay in obtaining regulatory approval in one country may have
a negative effect on the regulatory approval process in others. For example, approval in the United States by the FDA does not
ensure approval by the regulatory authorities in other countries or jurisdictions, and similarly approval by a non-U.S. regulatory
authority, such as the EMA, does not ensure approval by regulatory authorities in other countries, including by the FDA. However,
the failure to obtain approval in one jurisdiction may have a negative impact on our ability to obtain approval elsewhere. Approval
processes and regulatory requirements vary among countries and can involve additional drug testing and validation and additional
administrative review periods. Even if a drug is approved, the FDA or EMA, as the case may be, may limit the indications for which
the drug may be marketed, require extensive warnings on the drug labeling or require expensive and time-consuming clinical studies
or reporting as conditions of approval. In many countries outside the United States, a drug candidate must be approved for reimbursement
before it can be approved for sale in that country. In some cases, the price that we intend to charge for a drug is also subject
to approval. Regulatory authorities in other countries also have their own requirements for approval of drug candidates with which
we must comply prior to marketing in those countries. Obtaining non-U.S. regulatory approvals and compliance with such non-U.S.
regulatory requirements could result in significant delays, difficulties and costs for us and could delay or prevent the introduction
of our current and any future drugs, in certain countries. If we fail to comply with regulatory requirements in international markets
or to</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">obtain and maintain required approvals, or
if regulatory approvals in international markets are delayed, our target market will be reduced and our ability to realize the
full market potential of our drug candidates will be unrealized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Even if our product candidates obtain
regulatory approval, we will be subject to ongoing obligations and continued regulatory review, which may result in significant
additional expense. Additionally, our product candidates, if approved, could be subject to labeling and other restrictions and
market withdrawal and we may be subject to penalties if we fail to comply with regulatory requirements or experience unanticipated
problems with our products.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If marketing authorization is obtained
for any of our product candidates, the product will remain subject to continual regulatory review and therefore authorization could
be subsequently withdrawn or restricted. Any regulatory approvals that we receive for our product candidates may also be subject
to limitations on the approved indicated uses for which the product may be marketed or to the conditions of approval, or contain
requirements for potentially costly post-marketing testing, including Phase 4 clinical studies and surveillance to monitor the
safety and efficacy of the product candidate. In addition, if the FDA or a comparable foreign regulatory authority approves any
of our product candidates, we will be subject to ongoing regulatory obligations and oversight by regulatory authorities, including
with respect to the manufacturing processes, labeling, packing, distribution, adverse event reporting, storage, advertising and
marketing restrictions, and recordkeeping and, potentially, other post-marketing obligations, all of which may result in significant
expense and limit our ability to commercialize such products. These requirements include submissions of safety and other post-marketing
information and reports, registration, as well as continued compliance with cGMPs and cGCPs for any clinical studies that we conduct
post-approval. Later discovery of previously unknown problems with a product, including adverse events of unanticipated severity
or frequency, or with our third-party manufacturers or manufacturing processes, or failure to comply with regulatory requirements,
may result in, among other things:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>restrictions on the marketing or manufacturing of the product, withdrawal of the product from the market, or voluntary or mandatory
product recalls;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>fines, warning letters or holds on clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>refusal by the FDA to approve pending applications or supplements to approved applications filed by us, or suspension or revocation
of product license approvals;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>product seizure or detention, or refusal to permit the import or export of products; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>injunctions or the imposition of civil or criminal penalties.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If any of these events occurs, our ability
to sell such product may be impaired, and we may incur substantial additional expense to comply with regulatory requirements, which
could materially adversely affect our business, financial condition and results of operations. The FDA&rsquo;s policies may change
and additional government regulations may be enacted that could prevent, limit or delay regulatory approval of our product candidates.
If we are slow or unable to adapt to changes in existing requirements or the adoption of new requirements or policies, or if we
are not able to maintain regulatory compliance, we may lose any marketing approval that we may have obtained, which would adversely
affect our business, prospects and ability to achieve or sustain profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We have conducted and may in the future
conduct clinical studies for our drug candidates outside the United States, and the FDA and applicable foreign regulatory authorities
may not accept data from such studies.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have conducted and may in the future
choose to conduct one or more of our clinical studies outside the United States, including in Germany, Austria, Denmark, Sweden
and Finland. The acceptance of study data from clinical studies conducted outside the United States or another jurisdiction by
the FDA or applicable foreign regulatory authority may be subject to certain conditions. In cases where data from foreign clinical
studies are intended to serve as the basis for marketing approval in the United States, the FDA will not approve the application
on the basis of foreign data alone unless the following are true: the data are applicable to the United States population and United
States medical practice; the studies were performed by clinical investigators of recognized competence; and the data are considered
valid without the need for an on-site inspection by the FDA or, if the FDA considers such an inspection to be necessary, the FDA
is able to validate the data through an on- site inspection or other appropriate means. Additionally, the FDA&rsquo;s clinical
study requirements, including sufficient size of patient</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">populations and statistical powering, must
be met. Many foreign regulatory bodies have similar requirements. In addition, such foreign studies would be subject to the applicable
local laws of the foreign jurisdictions where the studies are conducted. There can be no assurance that the FDA or any applicable
foreign regulatory authority will accept data from studies conducted outside of the United States or the applicable jurisdiction.
If the FDA or any applicable foreign regulatory authority does not accept such data, it would result in the need for additional
studies, which would be costly and time-consuming and delay aspects of our business plan, and which may result in our drugs or
drug candidates not receiving approval or clearance for commercialization in the applicable jurisdiction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Enacted and future legislation may increase
the difficulty and cost for us to obtain marketing approval of and commercialize our product candidates and may affect the prices
we may set.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the United States and the European Union,
there have been a number of legislative and regulatory changes and proposed changes regarding the healthcare system. These changes
could prevent or delay marketing approval of our product candidates, restrict or regulate post-approval activities and affect our
ability to profitably sell any products for which we obtain marketing approval.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the United States, the Medicare Prescription
Drug, Improvement, and Modernization Act of 2003, or the Medicare Modernization Act, changed the way Medicare covers and pays for
pharmaceutical products. The legislation expanded Medicare coverage for drug purchases by the elderly and introduced a new reimbursement
methodology based on average sale prices for physician-administered drugs. In addition, this legislation provided authority for
limiting the number of drugs that will be covered in any therapeutic class. Cost-reduction initiatives and other provisions of
this legislation could decrease the coverage and price that we receive for any approved products. While the Medicare Modernization
Act applies only to drug benefits for Medicare beneficiaries, private payors often follow Medicare coverage policy and payment
limitations in setting their own reimbursement rates. Therefore, any reduction in reimbursement that results from the Medicare
Modernization Act may result in a similar reduction in payments from private payors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">More recently, in March 2010, former President
Obama signed into law the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation
Act, or collectively, the Health Care Reform Law, a sweeping law intended to broaden access to health insurance, reduce or constrain
the growth of healthcare spending, enhance remedies against fraud and abuse, add new transparency requirements for health care
and health insurance industries, impose new taxes and fees on the health industry and impose additional health policy reforms.
The Health Care Reform Law, among other things, increased rebates a manufacturer must pay to the Medicaid program, addressed a
new methodology by which rebates owed by manufacturers under the Medicaid Drug Rebate Program are calculated for drugs that are
inhaled, infused, instilled, implanted or injected, established a new Medicare Part D coverage gap discount program, in which manufacturers
must provide 50% point-of-sale discounts on products covered under Part D and implemented payment system reforms including a national
pilot program on payment bundling to encourage hospitals, physicians and other providers to improve the coordination, quality and
efficiency of certain healthcare services through bundled payment models. Further, the new law imposed a significant annual fee
on companies that manufacture or import branded prescription drug products. Substantial new provisions affecting compliance were
enacted, which may affect our business practices with health care practitioners.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2017, we may face uncertainties because
there likely will be U.S. federal legislative and administrative efforts to repeal, substantially modify or invalidate some or
all of the provisions of the Health Care Reform Law. In January 2017, Congress voted to adopt a budget resolution for fiscal year
2017, or the Budget Resolution, that authorizes the implementation of legislation that would repeal portions of the Health Care
Reform Law. Further, on January 20, 2017, President Trump signed an Executive Order directing federal agencies with authorities
and responsibilities under Health Care Reform Law to waive, defer, grant exemptions from, or delay the implementation of any provision
of Health Care Reform Law that would impose a fiscal or regulatory burden on states, individuals, healthcare providers, health
insurers, or manufacturers of pharmaceuticals or medical devices. Congress also could consider subsequent legislation to replace
elements of the Health Care Reform Law that are repealed. There is no assurance that the Health Care Reform Law, as currently enacted
or as amended in the future, will not adversely affect our business and financial results, and we cannot predict how future federal
or state legislative or administrative changes relating to healthcare reform will affect our business<FONT STYLE="font-size: 10pt; color: blue">.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Moreover, other legislative changes have
also been proposed and adopted in the United States since the Health Care Reform Law was enacted. On August&nbsp;2, 2011, the Budget
Control Act of 2011, among other things, created</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt; text-indent: 0pt">measures for spending reductions by Congress.
A Joint Select Committee on Deficit Reduction, tasked with recommending a targeted deficit reduction of at least $1.2 trillion
for the years 2013 through 2021, was unable to reach required goals, thereby triggering the legislation&rsquo;s automatic reduction
to several government programs. This includes aggregate reductions to Medicare payments to providers of 2%&nbsp;per fiscal year,
which went into effect on April&nbsp;1, 2013. On January&nbsp;2, 2013, former President Obama signed into law the American Taxpayer
Relief Act of 2012, or the ATRA, which, among other things, further reduced Medicare payments to several providers, including hospitals,
imaging centers and cancer treatment centers, and increased the statute of limitations period for the government to recover overpayments
to providers from three to five years. These new laws may result in additional reductions in Medicare and other health care funding,
which could have a material adverse effect on our customers and accordingly, our financial operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the European Union, proposed new clinical
study regulations will centralize clinical study approval, which eliminates redundancy, but in some cases this may extend timelines
for clinical study approvals due to potentially longer wait times. Proposals to require specific consents for use of data in research,
among other measures, may increase the costs and timelines for our product development efforts. Austerity measures in certain European
nations may also affect the prices we are able to seek if our products are approved, as discussed below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Both in the United States and in the European
Union, legislative and regulatory proposals have been made to expand post-approval requirements and restrict sales and promotional
activities for pharmaceutical products. We do not know whether additional legislative changes will be enacted, or whether the regulations,
guidance or interpretations will be changed, or what the impact of such changes on the marketing approvals of our product candidates,
if any, may be.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We could be subject to liabilities under
environmental, health and safety laws or regulations, or fines, penalties or other sanctions, if we fail to comply with such laws
or regulations or otherwise incur costs that could have a material adverse effect on the success of our business.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are subject to numerous environmental,
health and safety laws, regulations, and permitting requirements, including those governing laboratory procedures, decontamination
activities and the handling, transportation, use, remediation, storage, treatment and disposal of hazardous materials and wastes.
Our operations involve the use of hazardous and flammable materials, including chemicals and biological materials and produce hazardous
waste products. We generally contract with third parties for the disposal of these materials and wastes. We cannot eliminate the
risk of contamination or injury from these materials or wastes either at our sites or at third party disposal sites. In the event
of such contamination or injury, we could be held liable for any resulting damages, and any liability could exceed our resources.
We also could incur significant costs associated with civil or criminal fines and penalties. Although we maintain workers&rsquo;
compensation insurance to cover us for costs and expenses we may incur due to injuries to our employees resulting from the use
of hazardous materials or other work-related injuries, this insurance may not provide adequate coverage against potential liabilities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, we may incur substantial costs
in order to comply with current or future environmental, health and safety laws, regulations or permitting requirements. Such laws,
regulations and requirements are becoming increasingly more stringent and may impair our research, development or production efforts.
Failure to comply with these laws, regulations and permitting requirements also may result in substantial fines, penalties or other
sanctions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our relationships with customers and
payors will be subject to applicable anti-kickback, fraud and abuse and other healthcare laws and regulations, which, if violated,
could expose us to criminal sanctions, civil penalties, exclusion from government healthcare programs, contractual damages, reputational
harm and diminished profits and future earnings.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Healthcare providers, physicians and others
play a primary role in the recommendation and prescription of any products for which we obtain marketing approval. Our future arrangements
with third-party payors and customers may expose us to broadly applicable fraud and abuse and other healthcare laws and regulations,
primarily in the United States, that may constrain the business or financial arrangements and relationships through which we market,
sell and distribute our products for which we obtain marketing approval. Restrictions under applicable healthcare laws and regulations,
include the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the U.S. healthcare anti-kickback statute prohibits, among other things, persons from knowingly and willfully soliciting, offering,
receiving or providing remuneration, directly or indirectly, in cash or in kind,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">to induce or reward either the referral
of an individual for, or the purchase, order or recommendation of, any good or service, for which payment may be made under U.S.
government healthcare programs such as Medicare and Medicaid;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the U.S. False Claims Act imposes criminal and civil penalties, including civil whistleblower or qui tam actions, against individuals
or entities for knowingly presenting, or causing to be presented, to the U.S. government, claims for payment that are false or
fraudulent or making a false statement to avoid, decrease or conceal an obligation to pay money to the federal government;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the U.S. Health Insurance Portability and Accountability Act of 1996, or HIPAA, imposes criminal and civil liability for executing
a scheme to defraud any healthcare benefit program or making false statements relating to healthcare matters;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>HIPAA, as amended by the Health Information Technology for Economic and Clinical Health Act, imposes obligations, including
mandatory contractual terms, with respect to safeguarding the privacy, security and transmission of individually identifiable health
information;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the transparency requirements under the Health Care Reform Law require manufacturers of drugs, devices, biologics and medical
supplies to report to the U.S. Department of Health and Human Services information related to payments and other transfers of value
made by such manufacturers to physicians and teaching hospitals, and ownership and investment interests held by physicians or their
immediate family members; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>analogous laws and regulations, such as state anti-kickback and false claims laws, may apply to sales or marketing arrangements
and claims involving healthcare items or services reimbursed by non-governmental third-party payors, including private insurers,
and some state laws require pharmaceutical companies to comply with the pharmaceutical industry&rsquo;s voluntary compliance guidelines
and the relevant compliance guidance promulgated by the federal government in addition to requiring manufacturers to report information
related to payments to physicians and other health care providers or marketing expenditures.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Because of the breadth of these laws and
the narrowness of the statutory exceptions and safe harbors available under the U.S. federal Anti-Kickback Statute, it is possible
that some of our future business activities could be subject to challenge under one or more of such laws. In addition, recent health
care reform legislation has strengthened these laws. For example, the Health Care Reform Law, among other things, amends the intent
requirement of the federal anti-kickback and criminal healthcare fraud statutes. A person or entity no longer needs to have actual
knowledge of this statute or specific intent to violate it. Moreover, the Health Care Reform Law provides that the government may
assert that a claim including items or services resulting from a violation of the federal anti-kickback statute constitutes a false
or fraudulent claim for purposes of the False Claims Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Efforts to ensure that our business arrangements
with third parties will comply with applicable healthcare laws and regulations will involve substantial costs. It is possible that
governmental authorities will conclude that our business practices may not comply with current or future statutes, regulations
or case law involving applicable fraud and abuse or other healthcare laws and regulations. If our operations are found to be in
violation of any of these laws or any other governmental regulations that may apply to us, we may be subject to significant civil,
criminal and administrative penalties, damages, fines, exclusion from U.S. government funded healthcare programs, such as Medicare
and Medicaid, and the curtailment or restructuring of our operations. If any of the physicians or other providers or entities with
whom we expect to do business with are found to be not in compliance with applicable laws, they may be subject to criminal, civil
or administrative sanctions, including exclusions from government funded healthcare programs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Risks from the improper conduct of employees,
agents, contractors, or collaborators could adversely affect our reputation and our business, prospects, operating results, and
financial condition.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We cannot ensure that our compliance controls,
policies, and procedures will in every instance protect us from acts committed by our employees, agents, contractors, or collaborators
that would violate the laws or regulations of the jurisdictions in which we operate, including, without limitation, healthcare,
employment, foreign corrupt practices, environmental, competition, and patient privacy and other privacy laws and regulations.
Such improper</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">actions could subject us to civil or criminal
investigations, and monetary and injunctive penalties, and could adversely impact our operating results, ability to conduct business,
and reputation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are exposed to the risk of employee
fraud or other misconduct. Misconduct by employees could include intentional failures to comply with FDA or EMA regulations, to
provide accurate information to the FDA or the EMA or intentional failures to report financial information or data accurately or
to disclose unauthorized activities to us. Employee misconduct could also involve the improper use of information obtained in the
course of clinical studies, which could result in regulatory sanctions and serious harm to our reputation. In October 2015, we
adopted a code of conduct, but it is not always possible to identify and deter employee misconduct, and the precautions we take
to detect and prevent this activity may not be effective in controlling unknown or unmanaged risks or losses or in protecting us
from governmental investigations or other actions or lawsuits stemming from a failure to comply with these laws or regulations.
If any such actions are instituted against us, and we are not successful in defending ourselves or asserting our rights, those
actions could have a significant impact on our business, including the imposition of significant fines or other sanctions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our business activities may be subject
to the Foreign Corrupt Practices Act, or FCPA, and similar anti-bribery and anti-corruption laws.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our business activities may be subject
to the FCPA and similar anti-bribery or anti-corruption laws, regulations or rules of other countries in which we operate, including
the U.K. Bribery Act. The FCPA generally prohibits offering, promising, giving, or authorizing others to give anything of value,
either directly or indirectly, to a non-U.S. government official in order to influence official action, or otherwise obtain or
retain business. The FCPA also requires public companies to make and keep books and records that accurately and fairly reflect
the transactions of the corporation and to devise and maintain an adequate system of internal accounting controls. Our business
is heavily regulated and therefore involves significant interaction with public officials, including officials of non-U.S. governments.
Additionally, in many other countries, the health care providers who prescribe pharmaceuticals are employed by their government,
and the purchasers of pharmaceuticals are government entities; therefore, our dealings with these prescribers and purchasers are
subject to regulation under the FCPA. Recently the Securities and Exchange Commission, or SEC, and Department of Justice have increased
their FCPA enforcement activities with respect to pharmaceutical companies. There is no certainty that all of our employees, agents,
contractors, or collaborators, or those of our affiliates, will comply with all applicable laws and regulations, particularly given
the high level of complexity of these laws. Violations of these laws and regulations could result in fines, criminal sanctions
against us, our officers, or our employees, the closing down of our facilities, requirements to obtain export licenses, cessation
of business activities in sanctioned countries, implementation of compliance programs, and prohibitions on the conduct of our business.
Any such violations could include prohibitions on our ability to offer our products in one or more countries and could materially
damage our reputation, our brand, our international expansion efforts, our ability to attract and retain employees, and our business,
prospects, operating results, and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Risks Related to Our Common Shares</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">The price of our common shares may be
volatile and may fluctuate due to factors beyond our control.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The share prices of publicly traded emerging
biopharmaceutical and drug discovery and development companies have been highly volatile and are likely to remain highly volatile
in the future. The market price of our common shares may fluctuate significantly due to a variety of factors, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>positive or negative results of testing and clinical studies by us, strategic partners, or competitors;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>delays in entering into strategic relationships with respect to development and/or commercialization of our product candidates
or entry into strategic relationships on terms that are not deemed to be favorable to us;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>technological innovations or commercial product introductions by us or competitors;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>changes in government regulations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>developments concerning proprietary rights, including patents and litigation matters;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>public concern relating to the commercial value or safety of any of our product candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>financing or other corporate transactions;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>publication of research reports or comments by securities or industry analysts;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>general market conditions in the pharmaceutical industry or in the economy as a whole; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>other events and factors beyond our control.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, the stock market in general
has recently experienced extreme price and volume fluctuations that have often been unrelated or disproportionate to the operating
performance of individual companies. Broad market and industry factors may materially affect the market price of companies&rsquo;
stock, including ours, regardless of actual operating performance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Certain of our existing shareholders
exercise significant control over us, and your interests may conflict with the interests of our existing shareholders.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Certain principal shareholders as well
as our executive officers and directors together beneficially own approximately 62.5% of our common shares. Depending on the level
of attendance at our general meetings of shareholders, these shareholders may be in a position to determine the outcome of decisions
taken at any such general meeting. To the extent that the interests of these shareholders may differ from the interests of the
company&rsquo;s other shareholders, the latter may be disadvantaged by any action that these shareholders may seek to pursue. Among
other consequences, this concentration of ownership may have the effect of delaying or preventing a change in control and might
therefore negatively affect the market price of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Future sales, or the possibility of future
sales, of a substantial number of our common shares could adversely affect the price of our common shares.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Future sales of a substantial number of
our common shares, or the perception that such sales will occur, could cause a decline in the market price of our common shares.
If certain of our shareholders sell substantial amounts of common shares in the public market, or the market perceives that such
sales may occur, the market price of our common shares and our ability to raise capital through an issue of equity securities in
the future could be adversely affected. We also entered into a registration rights agreement in connection with the Series E Private
Placement with certain investors in the Series E Private Placement pursuant to which we agreed under certain circumstances to file
a registration statement to register the resale of the common shares held by certain of our existing shareholders, as well as to
cooperate in certain public offerings of such common shares. In addition, we have adopted a new omnibus equity incentive plan under
which we have the discretion to grant a broad range of equity-based awards to eligible participants. These shares were registered
pursuant to the registration statement on Form S-8 that we filed with SEC and, therefore, can be freely sold in the public market
upon issuance, subject to volume limitations applicable to affiliates. If a large number of our common shares or securities convertible
into our common shares are sold in the public market after they become eligible for sale, the sales could reduce the trading price
of our common shares and impede our ability to raise future capital.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We have broad discretion in the use of
our cash and cash equivalents and may not use them effectively.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our management will have broad discretion
in the application of our cash and cash equivalents and could spend the proceeds in ways that do not improve our results of operations
or enhance the value of our common shares. The failure by our management to apply these funds effectively could result in financial
losses that could have a material adverse effect on our business, cause the price of our common shares to decline and delay the
development of our product candidates. Pending their use, we may invest our cash and cash equivalents in a manner that does not
produce income or that loses value.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We do not expect to pay dividends in
the foreseeable future.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have not paid any dividends since our
incorporation. Even if future operations lead to significant levels of distributable profits, we currently intend that any earnings
will be reinvested in our business and that dividends will not be paid until we have an established revenue stream to support continuing
dividends. The proposal to pay future dividends to shareholders will in addition effectively be at the discretion of our board
of directors after taking into</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">account various factors including our business
prospects, cash requirements, financial performance and new product development. In addition, payment of future dividends is subject
to certain limitation pursuant to Swiss law or by our articles of association. Accordingly, investors cannot rely on dividend income
from our common shares and any returns on an investment in our common shares will likely depend entirely upon any future appreciation
in the price of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We are a Swiss corporation. The rights
of our shareholders may be different from the rights of shareholders in companies governed by the laws of U.S. jurisdictions.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a Swiss corporation. Our corporate
affairs are governed by our articles of association and by the laws governing companies, including listed companies, incorporated
in Switzerland. The rights of our shareholders and the responsibilities of members of our board of directors may be different from
the rights and obligations of shareholders and directors of companies governed by the laws of U.S. jurisdictions. In the performance
of its duties, our board of directors is required by Swiss law to consider the interests of our company, our shareholders, our
employees and other stakeholders, in all cases with due observation of the principles of reasonableness and fairness. It is possible
that some of these parties will have interests that are different from, or in addition to, your interests as a shareholder. Swiss
corporate law limits the ability of our shareholders to challenge resolutions made or other actions taken by our board of directors
in court. Our shareholders generally are not permitted to file a suit to reverse a decision or an action taken by our board of
directors but are instead only permitted to seek damages for breaches of fiduciary duty. As a matter of Swiss law, shareholder
claims against a member of our board of directors for breach of fiduciary duty would have to be brought in Lausanne, Switzerland,
or where the relevant member of our board of directors is domiciled. In addition, under Swiss law, any claims by our shareholders
against us must be brought exclusively in Lausanne, Switzerland.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our common shares are issued under the
laws of Switzerland, which may not protect investors in a similar fashion afforded by incorporation in a U.S. state.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are organized under the laws of Switzerland.
There can be no assurance that Swiss law will not change in the future or that it will serve to protect investors in a similar
fashion afforded under corporate law principles in the U.S., which could adversely affect the rights of investors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our status as a Swiss corporation may
limit our flexibility with respect to certain aspects of capital management and may cause us to be unable to make distributions
without subjecting our shareholders to Swiss withholding tax.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Swiss law allows our shareholders to authorize
share capital that can be issued by the board of directors without additional shareholder approval. This authorization is limited
to 50% of the existing registered share capital and must be renewed by the shareholders every two years. Additionally, subject
to specified exceptions, Swiss law grants pre-emptive subscription rights to existing shareholders to subscribe to any new issuance
of shares. Swiss law also does not provide as much flexibility in the various terms that can attach to different classes of shares
as the laws of some other jurisdictions. Swiss law also reserves for approval by shareholders certain corporate actions over which
a board of directors would have authority in some other jurisdictions. For example, dividends must be approved by shareholders.
These Swiss law requirements relating to our capital management may limit our flexibility, and situations may arise where greater
flexibility would have provided substantial benefits to our shareholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under Swiss law, a Swiss corporation may
pay dividends only if the corporation has sufficient distributable profits from previous fiscal years, or if the corporation has
distributable reserves, each as evidenced by its audited statutory balance sheet. Freely distributable reserves are generally booked
either as &ldquo;free reserves&rdquo; or as &ldquo;capital contributions&rdquo; (<I>apports de capital</I>, contributions received
from shareholders) in the &ldquo;reserve from capital contributions.&rdquo; Distributions may be made out of issued share capital&mdash;the
aggregate nominal value of a company&rsquo;s issued shares&mdash;only by way of a capital reduction. As of December 31, 2016, the
Company has CHF 179.2 million of qualifying capital contributions and CHF 1,135,468 of registered share capital (consisting of
56,773,392 common shares each with a nominal value of CHF 0.02 and no preferred shares) on its audited statutory balance sheet.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We expect the aggregate of these amounts
(less the lowest legally possible issued share capital and legal reserve of together CHF 150,000) to represent the amount available
for future dividends or capital reductions on a Swiss withholding tax-free basis. We will not be able to pay dividends or make
other distributions to shareholders on a</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Swiss withholding tax-free basis in excess
of that amount unless the Company increases its share capital or its reserves from capital contributions. We would also be able
to pay dividends out of distributable profits or freely distributable reserves but such dividends would be subject to Swiss withholding
taxes. There can be no assurance that we will have sufficient distributable profits, free reserves, reserves from capital contributions
or registered share capital to pay a dividend or effect a capital reduction, that our shareholders will approve dividends or capital
reductions proposed by us, or that we will be able to meet the other legal requirements for dividend payments or distributions
as a result of capital reductions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Generally, Swiss withholding tax of 35%
is due on dividends and similar distributions to our shareholders, regardless of the place of residency of the shareholder, unless
the distribution is made to shareholders out of (i)&nbsp;a reduction of nominal value or (ii)&nbsp;assuming certain conditions
are met, qualifying capital contributions accumulated on or after January&nbsp;1, 1997. A U.S. holder that qualifies for benefits
under the Convention between the United States of America and the Swiss Confederation for the Avoidance of Double Taxation with
Respect to Taxes on Income, which we refer to as the &ldquo;U.S.-Swiss Treaty,&rdquo; may apply for a refund of the tax withheld
in excess of the 15% treaty rate (or in excess of the 5% reduced treaty rate for qualifying corporate shareholders with at least
10% participation in our voting stock, or for a full refund in the case of qualified pension funds). There can be no assurance
that we will have sufficient qualifying capital contributions to pay dividends free from Swiss withholding tax, or that Swiss withholding
rules will not be changed in the future. In addition, we cannot provide assurance that the current Swiss law with respect to distributions
out of qualifying capital contributions will not be changed or that a change in Swiss law will not adversely affect us or our shareholders,
in particular as a result of distributions out of qualifying capital contributions becoming subject to additional corporate law
or other restrictions. There are currently motions pending in the Swiss Parliament that purport to limit the distribution of qualifying
capital contributions. In addition, over the long term, the amount of par value available to us for nominal value reductions or
qualifying capital contributions available to us to pay out as distributions is limited. If we are unable to make a distribution
through a reduction in nominal value or out of qualifying capital contributions, we may not be able to make distributions without
subjecting our shareholders to Swiss withholding taxes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under present Swiss tax laws, repurchases
of shares for the purposes of cancellation are treated as a partial liquidation subject to 35% Swiss withholding tax on the difference
between the repurchase price and the nominal value except, since January&nbsp;1, 2011, to the extent attributable to qualifying
capital contributions (<I>apports de capital</I>) if any, and to the extent that, the repurchase of shares is out of retained earnings
or other taxable reserves. No partial liquidation treatment applies and no withholding tax is triggered if the shares are not repurchased
for cancellation but held by the Company as treasury shares. However, should Company not resell such treasury shares within six
years, the withholding tax becomes due at the end of the six year period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">U.S. shareholders may not be able to
obtain judgments or enforce civil liabilities against us or our executive officers or members of our board of directors.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are organized under the laws of Switzerland
and our registered office and domicile is located in Ecublens, near Lausanne, Switzerland. Moreover, a number of our directors
and executive officers and a number of directors of each of our subsidiaries are not residents of the United States, and all or
a substantial portion of the assets of such persons are located outside the United States. As a result, it may not be possible
for investors to effect service of process within the United States upon us or upon such persons or to enforce against them judgments
obtained in U.S. courts, including judgments in actions predicated upon the civil liability provisions of the federal securities
laws of the United States. We have been advised by our Swiss counsel that there is doubt as to the enforceability in Switzerland
of original actions, or in actions for enforcement of judgments of U.S. courts, of civil liabilities to the extent solely predicated
upon the federal and state securities laws of the United States. Original actions against persons in Switzerland based solely upon
the U.S. federal or state securities laws are governed, among other things, by the principles set forth in the Swiss Federal Act
on Private International Law. This statute provides that the application of provisions of non-Swiss law by the courts in Switzerland
shall be precluded if the result is incompatible with Swiss public policy. Also, certain mandatory provisions of Swiss law may
be applicable regardless of any other law that would otherwise apply.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Switzerland and the United States do not
have a treaty providing for reciprocal recognition and enforcement of judgments in civil and commercial matters. The recognition
and enforcement of a judgment of the courts of the United States in Switzerland is governed by the principles set forth in the
Swiss Federal Act on Private International Law. This statute provides in principle that a judgment rendered by a non-Swiss court
may be enforced in Switzerland only if:</P>

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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the non-Swiss court had jurisdiction pursuant to the Swiss Federal Act on Private International Law;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the judgment of such non-Swiss court has become final and non-appealable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the judgment does not contravene Swiss public policy;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the court procedures and the service of documents leading to the judgment were in accordance with the due process of law; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>no proceeding involving the same position and the same subject matter was first brought in Switzerland, or adjudicated in Switzerland,
or was earlier adjudicated in a third state and this decision is recognizable in Switzerland.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our status as a Swiss corporation means
that our shareholders enjoy certain rights that may limit our flexibility to raise capital, issue dividends and otherwise manage
ongoing capital needs.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Swiss law reserves for approval by shareholders
certain corporate actions over which a board of directors would have authority in some other jurisdictions. For example, the payment
of dividends and cancellation of treasury shares must be approved by shareholders. Swiss law also requires that our shareholders
themselves resolve to, or authorize our board of directors to, increase our share capital. While our shareholders may authorize
share capital that can be issued by our board of directors without additional shareholder approval, Swiss law limits this authorization
to 50% of the issued share capital at the time of the authorization. The authorization, furthermore, has a limited duration of
up to two years and must be renewed by the shareholders from time to time thereafter in order to be available for raising capital.
Additionally, subject to specified exceptions, including exceptions explicitly described in our articles of association, Swiss
law grants pre-emptive subscription rights to existing shareholders to subscribe for new issuances of shares. Swiss law also does
not provide as much flexibility in the various rights and regulations that can attach to different categories of shares as do the
laws of some other jurisdictions. These Swiss law requirements relating to our capital management may limit our flexibility, and
situations may arise where greater flexibility would have provided benefits to our shareholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Swiss law restricts our ability to pay
dividends.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The proposal to pay future dividends to
shareholders will effectively be at the discretion of our board of directors and subject to approval by, in their discretion, our
shareholders after taking into account various factors including our business prospects, cash requirements, financial performance
and new product development. In addition, payment of future dividends is subject to certain limitation pursuant to Swiss law or
by our articles of association. Accordingly, investors cannot rely on dividend income from our common shares and any returns on
an investment in our common shares will likely depend entirely upon any future appreciation in the price of our common shares.
Dividends paid on our common shares are subject to Swiss federal withholding tax, except if paid out of reserves from capital contributions
(<I>apports de capital</I>). See &ldquo;Item 10. Additional Information- E. Taxation&mdash;Swiss Tax Considerations&rdquo; for
a summary of certain Swiss tax consequences regarding dividends distributed to holders of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We are a foreign private issuer and,
as a result, we are not be subject to U.S. proxy rules and are subject to Exchange Act reporting obligations that, to some extent,
are more lenient and less frequent than those of a U.S. domestic public company.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are reporting under the Exchange Act
as a non-U.S. company with foreign private issuer status. Because we qualify as a foreign private issuer under the Exchange Act
and although we are subject to Swiss laws and regulations with regard to such matters and intend to furnish quarterly financial
information to the SEC, we are exempt from certain provisions of the Exchange Act that are applicable to U.S. domestic public companies,
including (i)&nbsp;the sections of the Exchange Act regulating the solicitation of proxies, consents or authorizations in respect
of a security registered under the Exchange Act; (ii)&nbsp;the sections of the Exchange Act requiring insiders to file public reports
of their stock ownership and trading activities and liability for insiders who profit from trades made in a short period of time;
and (iii)&nbsp;the rules under the Exchange Act requiring the filing with the SEC of quarterly reports on Form 10-Q containing
unaudited financial and other specified information, or current reports on Form 8-K, upon the occurrence of specified significant
events. In addition, foreign private issuers are not required to file their annual report on Form 20-F until four months after
the end of each financial year, while U.S. domestic issuers that are accelerated filers are</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">required to file their annual report on Form
10-K within 75 days after the end of each fiscal year. Foreign private issuers are also exempt from the Regulation Fair Disclosure,
aimed at preventing issuers from making selective disclosures of material information. As a result of the above, you may not have
the same protections afforded to shareholders of companies that are not foreign private issuers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">As a foreign private issuer and as permitted
by the listing requirements of NASDAQ, we rely on certain home country governance practices rather than the corporate governance
requirements of NASDAQ.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a foreign private issuer. As a result,
in accordance with NASDAQ Listing Rule 5615(a)(3), we comply with home country governance requirements and certain exemptions thereunder
rather than complying with certain of the corporate governance requirements of NASDAQ. Swiss law does not require that a majority
of our board of directors consist of independent directors. Our board of directors therefore may include fewer independent directors
than would be required if we were subject to NASDAQ Listing Rule 5605(b)(1). In addition, we are not be subject to NASDAQ Listing
Rule 5605(b)(2), which requires that independent directors must regularly have scheduled meetings at which only independent directors
are present.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Although Swiss law also requires that we
adopt a compensation committee, we follow home country requirements with respect to such committee and our compensation, nomination
and governance committee is tasked with certain director nomination and governance responsibilities as described under &ldquo;Item
6. Directors, Senior Management and Employees.&rdquo; As a result, our practice varies from the requirements of NASDAQ Listing
Rule 5605(d), which sets forth certain requirements as to the responsibilities, composition and independence of compensation committees,
and from the independent director oversight of director nominations requirements of NASDAQ Listing Rule 5605(e).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Furthermore, in accordance with Swiss law
and generally accepted business practices, our articles of association do not provide quorum requirements generally applicable
to general meetings of shareholders. Our practice thus varies from the requirement of NASDAQ Listing Rule 5620(c), which requires
an issuer to provide in its bylaws for a generally applicable quorum, and that such quorum may not be less than one-third of the
outstanding voting stock. Our articles of association provide for an independent proxy holder elected by our shareholders, who
may represent our shareholders at a general meeting of shareholders, and we must provide shareholders with an agenda and other
relevant documents for the general meeting of shareholders. However, Swiss law does not have a regulatory regime for the solicitation
of proxies and company solicitation of proxies is prohibited for public companies in Switzerland, thus our practice varies from
the requirement of NASDAQ Listing Rule 5620(b), which sets forth certain requirements regarding the solicitation of proxies. In
addition, we have opted out of shareholder approval requirements for the issuance of securities in connection with certain events
such as the acquisition of stock or assets of another company, the establishment of or amendments to equity-based compensation
plans for employees, a change of control of us and certain private placements. To this extent, our practice varies from the requirements
of NASDAQ Listing Rule 5635, which generally requires an issuer to obtain shareholder approval for the issuance of securities in
connection with such events.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For an overview of our corporate governance
principles, see &ldquo;Item 16G. Corporate governance&rdquo;. As a result of the above, you may not have the same protections afforded
to shareholders of companies that are not foreign private issuers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We may lose our foreign private issuer
status, which would then require us to comply with the Exchange Act&rsquo;s domestic reporting regime and cause us to incur significant
legal, accounting and other expenses.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a foreign private issuer and therefore
we are not required to comply with all of the periodic disclosure and current reporting requirements of the Exchange Act applicable
to U.S. domestic issuers. We may no longer be a foreign private issuer as of June&nbsp;30, 2017 (or the end of our second fiscal
quarter in any subsequent fiscal year), which would require us to comply with all of the periodic disclosure and current reporting
requirements of the Exchange Act applicable to U.S. domestic issuers as of January&nbsp;1, 2018 (or the first day of the fiscal
year immediately succeeding the end of such second quarter). In order to maintain our current status as a foreign private issuer,
either (a)&nbsp;a majority of our common shares must be either directly or indirectly owned of record by non-residents of the United
States or (b)(i) a majority of our executive officers or directors may not be United States citizens or residents, (ii)&nbsp;more
than 50 percent of our assets cannot be located in the United States and (iii)&nbsp;our business must be administered principally
outside the United States. If we lost this status, we would be required to comply with the Exchange Act reporting and other requirements
applicable to U.S. domestic issuers, which are more</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">detailed and extensive than the requirements
for foreign private issuers. We may also be required to make changes in our corporate governance practices in accordance with various
SEC and stock exchange rules. The regulatory and compliance costs to us under U.S. securities laws if we are required to comply
with the reporting requirements applicable to a U.S. domestic issuer may be significantly higher than the cost we would incur as
a foreign private issuer. As a result, we expect that a loss of foreign private issuer status would increase our legal and financial
compliance costs and would make some activities highly time consuming and costly. We also expect that if we were required to comply
with the rules and regulations applicable to U.S. domestic issuers, it would make it more difficult and expensive for us to obtain
director and officer liability insurance, and we may be required to accept reduced coverage or incur substantially higher costs
to obtain coverage. These rules and regulations could also make it more difficult for us to attract and retain qualified members
of our board of directors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">We are an &ldquo;emerging growth company,&rdquo;
and we cannot be certain if the reduced reporting requirements applicable to &ldquo;emerging growth companies&rdquo; will make
our common shares less attractive to investors.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are an &ldquo;emerging growth company,&rdquo;
as defined in the Jumpstart our Business Startups Act of 2012, or the JOBS Act. For as long as we continue to be an &ldquo;emerging
growth company,&rdquo; we may take advantage of exemptions from various reporting requirements that are applicable to other public
companies that are not &ldquo;emerging growth companies,&rdquo; including not being required to comply with the auditor attestation
requirements of Section&nbsp;404 of the Sarbanes-Oxley Act of 2002, exemptions from the requirements of holding a nonbinding advisory
vote on executive compensation and shareholder approval of any golden parachute payments not previously approved. We could be an
&ldquo;emerging growth company&rdquo; until the end of our fiscal year 2021, although circumstances could cause us to lose that
status earlier, including if the market value of our common shares held by non-affiliates exceeds $700 million as of any June&nbsp;30
(the end of our second fiscal quarter) before the end of our fiscal year 2021, in which case we would no longer be an &ldquo;emerging
growth company&rdquo; as of the following December&nbsp;31 (our fiscal year end). We cannot predict if investors will find our
common shares less attractive because we may rely on these exemptions. If some investors find our common shares less attractive
as a result, there may be a less active trading market for our common shares and the price of our common shares may be more volatile.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">As a result of being a public company
we incur additional costs and we may not manage to comply with our internal control procedures and corporate governance structures.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As a public company, we incur additional
legal, insurance, accounting and other expenses that we did not incur as a private company. For example, as a public company, we
needed to adopt additional internal controls and disclosure controls and procedures and bear all of the internal and external costs
of preparing and distributing periodic public reports in compliance with our obligation under the securities laws. However, if
our efforts to comply with evolving laws, regulations and standards differ from the activities intended by regulatory or governing
bodies due to ambiguities related to practice, regulatory authorities may initiate legal proceedings against us. This could have
a material adverse impact on our business, financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"></P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt"><B><I>In connection with the audit
of our financial statements as at and for the year ended December 31, 2014, we and our independent registered public
accounting firm identified a material weakness in our internal control over financial reporting. This material weakness
continued to exist as  of December 31, 2016. If we fail to maintain an effective system of internal control over financial
reporting, we may be unable to accurately report our financial results or prevent fraud, and investor confidence in our
company and the market price of our shares may be adversely affected. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 12.2pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">Prior to our IPO, we were a private company
with limited accounting personnel and other resources with which to address our internal control over financial reporting. Further,
our reporting obligations as a public company will continue to place a significant strain on our management, operational and financial
resources and systems for the foreseeable future. In connection with our preparation and the audit of our financial statements
as of and for the year ended December 31, 2014, we and our independent registered public accounting firm identified a material
weakness as defined under the Exchange Act and by the U.S. Public Company Accounting Oversight Board, or PCAOB, in our internal
control over financial reporting, and this material weakness was not remediated as of December 31, 2016. A material weakness is
a deficiency, or a combination of deficiencies, in internal control over financial reporting, such that there is a reasonable possibility
that a material misstatement of the company&rsquo;s annual financial statements will not be prevented or detected on a timely basis.
The material weakness identified relates specifically to the accounting for and disclosure of non-routine and complex accounting
transactions and the related internal controls and processes supporting these areas. In light of the material weakness that was
identified, we believe it is possible that, had we performed a formal assessment of our internal control over financial reporting
or had our independent registered public accounting firm performed an audit of our internal control over financial reporting in
accordance with PCAOB standards, additional control deficiencies may have been identified.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">As a result of reporting obligations under
U.S. securities laws and the Sarbanes-Oxley Act of 2002, Section 404 of the Sarbanes-Oxley Act will require that we include a report
from management on the effectiveness of our internal control over financial reporting in our annual report on Form 20-F beginning
with our annual report for the fiscal year ending December 31, 2017. If we fail to remediate the material weakness identified above,
our management may conclude that our internal control over financial reporting is not effective. This conclusion could adversely
impact the market price of our shares due to a loss of investor confidence in the reliability of our reporting processes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">We are taking measures and plan to continue
to take measures to remediate this material weakness. However, the implementation of these measures may not fully address this
material weakness in our internal control over financial reporting, and therefore we would not be able to conclude that it has
been fully remedied. Our failure to correct this material weakness or our failure to discover and address any other control deficiencies
could result in inaccuracies in our financial statements and could also impair our ability to comply with applicable financial
reporting requirements and make related regulatory filings on a timely basis. As a result, our business, financial condition, results
of operations and prospects, as well as the trading price of our shares, may be materially and adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If in the future we fail to maintain
an effective system of internal control over financial reporting, we may not be able to accurately report our financial results
or prevent fraud. As a result, shareholders could lose confidence in our financial and other public reporting, which would harm
our business and the trading price of our common shares.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Effective internal controls over financial
reporting are necessary for us to provide reliable financial reports and, together with adequate disclosure controls and procedures,
are designed to prevent fraud. Any failure to implement required new or improved controls, or difficulties encountered in their
implementation could cause us to fail to meet our reporting obligations. As discussed above, in connection with the audit of our
financial statements as and for the year ended December 31, 2014, we identified a material weakness in our internal control over
financial reporting, which was not remediated as at December 31, 2016. In addition, any testing by us conducted in connection with
Section&nbsp;404 of the Sarbanes-Oxley Act of 2002, or any subsequent testing by our independent registered public accounting firm,
may reveal deficiencies in our internal controls over financial reporting that are deemed to be material weaknesses or that may
require prospective or retroactive changes to our financial statements or identify other areas for further attention or improvement.
Inferior internal controls could also subject us to regulatory scrutiny and sanctions, impair our ability to raise revenue and
cause investors to lose confidence in our reported financial information, which could have a negative effect on the trading price
of our common shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are required to disclose changes made
in our internal controls and procedures and our management will be required to assess the effectiveness of these controls annually.
However, for as long as we are an &ldquo;emerging growth company&rdquo; under the JOBS Act, our independent registered public accounting
firm will not be required to attest to the effectiveness of our internal controls over financial reporting pursuant to Section&nbsp;404.
We could be an &ldquo;emerging growth company&rdquo; until the end of our fiscal year 2021. An independent assessment of the effectiveness
of our internal controls could detect problems that our management&rsquo;s assessment might not. Undetected material weaknesses
in our internal controls could lead to financial statement restatements and require us to incur the expense of remediation.</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">If securities or industry analysts do
not publish research, or publish inaccurate or unfavorable research, about our business, the price of our common shares and our
trading volume could decline.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The trading market for our common shares
will depend in part on the research and reports that securities or industry analysts publish about us or our business. If no or
too few securities or industry analysts cover our company, the trading price for our common shares would likely be negatively affected.
In addition, if one or more of the analysts who cover us downgrade our common shares or publish inaccurate or unfavorable research
about our business, the price of our common shares would likely decline. If one or more of these analysts cease coverage of our
company or fail to publish reports on us regularly, demand for our common shares could decrease, which might cause the price of
our common shares and trading volume to decline.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">An increase in our tax rate could occur,
which could adversely affect our financial results</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Swiss Federal government has recently
proposed changes to align Swiss corporate taxation with international recommendations but voters in Switzerland voted against such
proposals in a national referendum on February 12, 2017. As a result, uncertainty will continue about the future level of Swiss
corporate income taxes that may apply to us until revised proposals are put forward and gain acceptance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For further discussion, see &ldquo;Item
10. Additional Information&mdash;E. Taxation.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Although we believe that we were not
a &ldquo;passive foreign investment company,&rdquo; or PFIC, for U.S. federal income tax purposes in 2016, and we do not expect
to be a PFIC in the immediately foreseeable future, if we were a PFIC U.S. shareholders may be subject to adverse U.S. federal
income tax consequences.</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the Internal Revenue Code of 1986,
as amended, or the Code, we will be a PFIC for any taxable year in which, after the application of certain look-through rules with
respect to subsidiaries, either (i)&nbsp;75% or more of our gross income consists of passive income or (ii)&nbsp;50% or more of
the average quarterly value of our assets consists of assets that produce, or are held for the production of, passive income. Passive
income generally includes dividends, interest, certain non-active rents and royalties, and capital gains. Based on our business
plan and certain estimates and projections, including as to the relative values of our assets, we do not believe that we were a
PFIC for our 2016 taxable year and do not expect to be a PFIC in the immediately foreseeable future. However, there can be no assurance
that the IRS will agree with our conclusion. In addition, whether we will be a PFIC in 2017 or any future years is uncertain because,
among other things, (i)&nbsp;we currently own, a substantial amount of passive assets, including cash, and (ii)&nbsp;the valuation
of our assets that generate non-passive income for PFIC purposes, including our intangible assets, is uncertain and may vary substantially
over time. Accordingly, there can be no assurance that we will not be a PFIC for any taxable year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If we are a PFIC for any taxable year during
which a U.S. investor holds common shares, we generally would continue to be treated as a PFIC with respect to that U.S. investor
for all succeeding years during which the U.S. investor holds common shares, even if we ceased to meet the threshold requirements
for PFIC status. Such a U.S.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">investor may be subject to adverse U.S. federal
income tax consequences, including (i)&nbsp;the treatment of all or a portion of any gain on disposition as ordinary income, (ii)&nbsp;the
application of a deferred interest charge on such gain and the receipt of certain dividends and (iii)&nbsp;compliance with certain
reporting requirements. We do not intend to provide the information that would enable investors to take a qualified electing fund
election that could mitigate the adverse U.S. federal income tax consequences should we be classified as a PFIC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For further discussion, see &ldquo;Item
10. Additional Information&mdash;Section E. Taxation.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 4. INFORMATION ON THE COMPANY</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>History and development of the Company</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a Swiss stock corporation (<I>soci&eacute;t&eacute;
anonyme</I>) organized under the laws of Switzerland. We were formed as a Swiss limited liability company (<I>soci&eacute;t&eacute;
&agrave; responsabilit&eacute; limit&eacute;e</I>) on February&nbsp;13, 2003 with our registered office and domicile in Basel,
Switzerland. We converted to a Swiss stock corporation (<I>soci&eacute;t&eacute; anonyme</I>) under the laws of Switzerland on
August&nbsp;25, 2003. Our domicile and registered office is in Ecublens, near Lausanne, Canton of Vaud, Switzerland. Our ordinary
shares were admitted to trading on NASDAQ Global Market on September&nbsp;23, 2016. Our shares are traded under the symbol ACIU.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our registered and principal executive
offices are located at EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland, our general telephone number is (41) 21 345
91 21 and our internet address is www.acimmune.com. Our website and the information contained on or accessible through our website
are not part of this document.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Business overview</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a clinical stage biopharmaceutical
company leveraging our two proprietary technology platforms to discover, design and develop novel, proprietary medicines for prevention,
diagnosis and treatment of neurodegenerative diseases associated with protein misfolding. Misfolded proteins are generally recognized
as the leading cause of neurodegenerative diseases, such as Alzheimer&rsquo;s disease, or AD, and Parkinson&rsquo;s disease, or
PD, with common mechanisms and drug targets, such as Abeta, tau and alpha-synuclein. We believe that our large and diverse pipeline
of seven therapeutic candidates and three diagnostic candidates has the potential to drive a paradigm shift in the treatment of
a broad spectrum of neurodegenerative and other diseases related to protein misfolding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our lead product candidate is crenezumab,
a humanized, monoclonal, conformation-specific anti-Abeta antibody that we developed using our SupraAntigen platform. Crenezumab
commenced Phase 3 clinical studies in the first quarter of 2016. Genentech, Inc., a wholly owned subsidiary of Roche, or Genentech,
is advancing crenezumab under a collaboration agreement with us for the treatment of AD, a progressive neurodegenerative disease
that affected an estimated 9.0&nbsp;million people in the United States, the United Kingdom, Western Europe, Japan, China and India
in 2013. Under this collaboration agreement, Genentech is responsible for the clinical development of crenezumab, including the
costs associated with seeking and obtaining regulatory and marketing approvals, manufacturing costs and sales and marketing costs.
We believe our collaboration with Genentech validates our technology and crenezumab&rsquo;s potential to become a best-in-class
disease-modifying treatment for AD. We are eligible to receive up to $340 million in total payments from Genentech, as well as
sales royalties. Crenezumab has received Fast Track designation from the U.S. Food and Drug Administration, or FDA. The Fast Track
program is intended to expedite or facilitate the process for reviewing new drugs that are designed to treat a serious or life-threatening
condition and demonstrate the potential to address unmet medical needs, as further described under &ldquo;&mdash;Government Regulation
and Our Regulatory Department&mdash;Product Approval Process.&rdquo; In 2012, crenezumab was independently selected by the National
Institute of Health, or NIH, the Banner Alzheimer&rsquo;s Institute and Genentech for use in the first-ever AD prevention study,
which serves as the cornerstone of the global Alzheimer&rsquo;s Prevention Initiative.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If approved, crenezumab has the potential
to treat the underlying cause of the disease and intervene at an earlier stage of AD progression, prior to irreversible neuronal
damage. We believe that crenezumab is ideally positioned to be at the forefront of disease-modifying and preventive medicine. We
believe the key advantages of crenezumab include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Unique mechanism of action:</I></B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Recognizes and binds to multiple forms of misfolded Abeta, a protein commonly associated with AD.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Helps to protect against neurotoxicity due to high affinity for the multiple forms of misfolded Abeta, with high affinity for
oligomers (the form hypothesized to mediate neurotoxicity)</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Promotes disaggregation of existing Abeta aggregates and disrupts their assembly to prevent amyloid plaque formation, which
is associated with AD.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Clears misfolded Abeta from the brain while limiting inflammation.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Signal of activity in milder AD patients in Phase 2 studies:</I></B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>ABBY cognition study: although the study did not meet its co-primary endpoints, which were assessments under the ADAS-cog and
CDR-Sum of boxes, the sample size was not expected to have adequate power to detect a modest but clinically significant difference
between active medication and placebo at the 5% significance level (as is commonly the case in Phase&nbsp;2 studies in AD). Instead,
consistent trends across different endpoints and dose dependency are considered indicators of a response in this learning phase
of development, with confirmation then sought in Phase 3. The results showed trends favoring crenezumab in the milder patient population.
Notably, in an exploratory analysis, the high-dose crenezumab arm showed a non-significant slowing of cognition in the overall
and mildly demented populations, which was statistically significant (p=0.036) with a 35% slowing of the rate of cognitive decline
measured by the ADAS-cog Scale over 73 weeks in patients with the non-pre-specified milder cognitive impairment (Mini-Mental State
Examination score, or MMSE, of 22-26). The MMSE is a widely used test of overall cognitive function, which assesses memory, orientation
and ability to perform simple tasks. Scores range from 0 (worst) to 30 (best) with a score of 0-11 indicating severe dementia,
a score of 12-19 indicating moderate dementia and a score of 20-26 indicating mild dementia. Statistical significance is an indicator
of the likelihood of an observed effect being due to the study drug rather than due to chance. The &ldquo;p&rdquo; value is the
probability of an event occurring by chance alone. When the p value is less than 5% (0.05) the results are considered to be statistically
significant.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>BLAZE biomarker study: the high-dose crenezumab arm showed a consistent trend of reduced Abeta accumulation in the brain over
time and a significant increase in cerebrospinal fluid, or CSF, which suggests that Abeta is being removed from the brain when
patients are treated with crenezumab.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Favorable safety profile allowing for potentially higher dosing:</I></B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Unique mechanism of action linked to the reduced ability to cause inflammation-related vasogenic edema, an accumulation of
fluid in the brain that can lead to headaches, loss of coordination and disorientation.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Phase 2 clinical data showed a very low incidence of vasogenic edema.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A Phase 1 study is ongoing to study crenezumab at higher doses to potentially increase the efficacy signal. The results of
an interim analysis of the first two cohorts of this study are supportive of the design and dose of the Phase 3 clinical study.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Two of our other clinical product candidates,
ACI-24 and ACI-35, are being developed using our SupraAntigen platform and target AD through active immunization, where the immune
system is stimulated to make its own antibodies against pathological proteins:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>ACI-24 is our wholly-owned anti-Abeta vaccine candidate that is T-cell independent, meaning it can generate an antibody response
against Abeta in the absence of Abeta specific T-cells. This product candidate is currently in a Phase 1/2a clinical study to evaluate
safety, tolerability, immunogenicity and biomarker endpoints in patients with mild to moderate AD in Europe. The analysis of the
immune response data as well as further treatment in cohort 4 is ongoing. An interim analysis of the first three doses (cohort
1-3) revealed positive safety and tolerability. The study was not powered to examine efficacy but a trend towards reduction in
accumulation in brain amyloid measured by PET imaging was observed in cohort 3. A similar pattern of reduction of clinical decline
assessed by the CDR-SB was observed in cohort 3 compared to placebo at week 52 although this did not reach statistical significance.
While the highest dose group is</TD></TR></TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">still ongoing the Phase 2 clinical
design is scheduled to be completed in the second half of fiscal year 2017. ACI-24 is also being studied in a Phase 1 clinical
study in people with Down syndrome, a population which is at high risk for developing AD-like symptoms and we expect to present
data from this study in 2018. A protocol amendment for the Phase 1b study of ACI-24 was submitted to the FDA in September 2015
and the clinical study has started in December 2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>We are developing the anti-tau vaccine ACI-35 under a collaboration agreement with Janssen, which we entered into in
                                                                                                               December
                                                                                                               2014.                                                                                                                A
                                                                                                               Phase                                                                                                                     1b
                                                                                                               clinical study to evaluate the safety, tolerability and immunogenicity of ACI-35 in patients with mild to moderate
                                                                                                               AD is ongoing in Finland and the United Kingdom. The study includes 5 cohorts with escalating doses and different dosing
                                                                                                               schedules. To date, safety and tolerability is considered satisfactory as assessed by the Data Safety Monitoring Board. An
                                                                                                               interim analysis showed a dose-dependent and target-specific antibody response to pTau. Further results, which we expect to
                                                                                                               have completed in the second half of fiscal 2017, will be the basis for the program&rsquo;s future development. Janssen is
                                                                                                               expected to
                                                                                                               assume responsibility for the clinical development of phase 2 and beyond, as well as the regulatory approval, manufacturing
                                                                                                               and commercialization of ACI-35.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Additionally, our passive anti-tau monoclonal
antibody candidate is being developed under a collaboration agreement with Genentech, which we entered into in the second quarter
of fiscal year 2012. The anti-tau antibody candidate is a humanized monoclonal antibody that is believed to bind specifically to
tau. A Phase 1 clinical study conducted by Genentech will evaluate the safety, tolerability and pharmacokinetics in patients with
mild to moderate Alzheimer&rsquo;s disease and healthy volunteers. The Phase 1 clinical study commenced in the second quarter of
2016, with results expected in the first half of 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Clinical evidence suggests that early detection
of neurodegenerative diseases is critical to enhancing the effectiveness of both symptomatic and disease-modifying therapies. As
such, we are using our Morphomer platform to develop complementary diagnostic product candidates such as positron emission tomography,
or PET, ligands which are tracers that can directly measure misfolded tau and alpha-synuclein in the brain, to enable early and
reliable disease diagnoses:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>We commenced a Phase 1 clinical study of our tau PET imaging agent in the fourth quarter of fiscal year 2016 under a collaboration
agreement with Piramal Imaging.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>We are also developing PET imaging diagnostics for diseases resulting from the misfolding of alpha-synuclein proteins, such
as PD.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>In April 2016, we entered into a non-exclusive collaboration with Biogen to develop PET imaging diagnostics for neurodegenerative
diseases resulting from the misfolding of alpha-synuclein proteins and TDP-43, which is a protein that has been recently linked
to neurodegeneration in diseases including AD, PD and amyotrophic lateral sclerosis (commonly known as ALS or Lou Gehrig&rsquo;s
disease). We expect to commence a Phase 1 clinical study of our alpha-synuclein PET imaging agent in 2017.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We use our two unique proprietary platform
technologies, SupraAntigen (conformation-specific biologics) and Morphomer (conformation-specific small molecules), to discover,
design and develop medicines and diagnostics to target misfolded proteins. These platforms are our engines for generating novel
molecules that are designed to bind to their targets with high affinity and conformational specificity, meaning they are enabled
to differentiate between misfolded proteins and normally-folded proteins. All of our product candidates and our development programs
have been derived from our proprietary platforms. Neurodegenerative diseases, such as AD and PD as well as other neuro-orphan diseases,
such as progressive supranuclear palsy, amyotrophic lateral sclerosis, or ALS, and Huntington&rsquo;s disease, are all associated
with pathologies that involve misfolded proteins. Research has shown that misfolded proteins are unable to carry out their normal
functions and aggregate to form certain types of deposits such as Abeta plaques or tau tangles that damage brain tissue. Our SupraAntigen
and Morphomer platforms seek to produce conformationally specific molecules in order to prevent or disrupt the formation of misfolded
proteins. We believe that our proprietary platforms also have the potential to generate additional molecules for indications that
relate to protein misfolding outside of neurodegenerative diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The diagram below summarizes the status
of our research and development programs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: Red"><IMG SRC="p47.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Neurodegenerative diseases and other diseases
associated with protein misfolding are prevalent, but there is currently an absence of reliable, early-stage diagnosis and disease-modifying
treatments for these diseases. The growth in the number of people with neurodegenerative diseases has been significant as evidenced
by the prevalence of people affected by AD and PD, two of the most common neurodegenerative diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>AD is the most common form of dementia, which affects an estimated worldwide patient population of 47&nbsp;million in 2015,
and is expected to grow to 75&nbsp;million by 2030 and 132&nbsp;million by 2050, according to the World Alzheimer Report 2015.
The estimated aggregate cost of prevention and treatments in the United States was $172 billion in 2010 and is estimated by Alzheimer&rsquo;s
Disease International, or ADI, to grow to $408 billion in 2030 and $1,078 billion in 2050. ADI estimated that the cost of prevention
and treatments in the United States could be reduced from over a trillion dollars to $631 billion in 2050 if the onset of AD could
be delayed by five years in the patient population. In addition, at autopsy, AD has been reported in 80% of people with Down syndrome
over age 40 and 100% over age 60. Down syndrome affects approximately one in 1,000 live births worldwide.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">AD is typically diagnosed by neurologists
and psychiatrists through a series of cognitive and functioning tests once symptoms are clinically present, resulting in diagnosis
at later stages of the disease after irreversible loss of neurons has already occurred. Currently approved AD treatments include
medications that only treat the symptoms of the disease. The clinical benefit derived from these symptomatic treatments is typically
incomplete. Only between 40 and 70 percent of patients with AD benefit from taking symptomatic treatments and the symptoms improve
for 6 to 12 months in most cases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">Therapeutic development for AD is
increasingly focused on treating early stages of the disease to delay or prevent progression and to preserve the maximum amount
of cognitive function before irreversible neuronal damage occurs. Most clinical studies now target mild stages of the disease,
increasing the need for accurate diagnosis that is independent of potentially subjective and otherwise sub-optimal cognitive metrics.
Diagnostics therefore have a crucial role in selecting more uniform and stage-specific clinical study subjects, tracking patient
progress and results, managing patients receiving treatment and ultimately diagnosing the disease at its earliest stage for immediate
treatment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>PD, the second most common neurodegenerative disease worldwide, affects an estimated 7 to 10&nbsp;million people. In PD, the
use of symptomatic treatments, such as levodopa, is associated with the loss of control of motor functions in approximately 50%
of patients who have taken the drug for 5 years or longer.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">There remains a significant unmet medical
need for reliable and accurate diagnostics to enable early diagnosis and disease-modifying treatments that slow the progress of
neurodegenerative diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have assembled an outstanding management
team with relevant scientific, clinical and regulatory expertise. Our scientific founders, Dr.&nbsp;Jean-Marie Lehn, Dr.&nbsp;Claude
Nicolau, Dr.&nbsp;Roscoe Brady and Dr.&nbsp;Fred van Leuven, are regarded as pioneers in their respective scientific domains, including
in the study of AD. Our co-founder and Chief Executive Officer, Dr.&nbsp;Andrea Pfeifer, a pharmacologist with a Ph.D. in cancer
research and former National Institute of Health researcher, has a 30 year track record in product innovation and implementation
and was formerly head of Nestl&eacute; Global Research and the co-founder of Nestl&eacute; Venture Fund. Our Chief Scientific Officer,
Dr.&nbsp;Andreas Muhs, has more than 20 years of experience in various aspects of discovery research and drug development, including
working on multiple drug development programs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Our Strategy</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our goal is to become a global leader in
the treatment of neurodegenerative diseases by developing therapies and complementary diagnostics that target neurodegenerative
diseases with significant unmet medical need using our proprietary SupraAntigen and Morphomer technology platforms. Key elements
of our strategy are to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B>Advance our product candidates, in partnership or alone, through clinical development to regulatory approval and potential
commercialization.</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Crenezumab</I></B><I>.</I> Our collaboration partner, Genentech, will advance crenezumab through Phase 3 clinical studies
and seek regulatory approval. We believe that crenezumab&rsquo;s efficacy, coupled with its safety profile, has the potential to
become a best-in-class disease-modifying treatment for AD.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>ACI-24</I></B><I>. </I>We will continue to advance ACI-24, both through completion of an ongoing Phase 1/2a clinical
study to evaluate the safety, tolerability, immunogenicity and biomarker endpoints in people with mild to moderate AD and, if the
Phase 1/2a results are favorable, through a Phase 2/3 clinical study in people with AD. Our Phase 1 clinical study of ACI-24 in
people with Down syndrome is intended to assess safety and started in December 2015. We own the global rights to ACI-24 and we
intend to continue to develop ACI-24 in-house as a therapeutic candidate.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>ACI-35</I></B>. The ongoing Phase 1b clinical study in collaboration with Janssen includes different doses and
                                                                                                              dosing schedules. Further results, which we expect to have completed in the second half of fiscal year 2017 will be the basis
                                                                                                              for the program&rsquo;s future development.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Our Anti-tau antibody candidate</I></B>.<I>&nbsp;</I>Our collaboration partner, Genentech, is advancing an anti-tau antibody
candidate through a Phase 1 clinical study.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Diagnostic candidates</I></B>. In addition to the above product candidates, we will continue to develop our complementary
diagnostic product candidates and to advance these through clinical development, either independently or with collaboration partners.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B>Expand into other neurodegenerative and neuro-orphan diseases.</B> We intend to leverage our proprietary technology platforms
to develop product candidates that share the same disease targets as misfolded Abeta, tau and alpha-synuclein proteins, which are
the key features in the pathology of many neurodegenerative diseases. We plan to pursue selected neuro-orphan indications, such
as progressive supranuclear palsy, or PSP, and Huntington&rsquo;s disease, as well as tau-related orphan diseases, such as frontotemporal
dementia and corticobasal degeneration. Pursuing neuro-orphan indications may enable us to obtain a streamlined regulatory approval
pathway and favorable reimbursement treatment of any approved product.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B>Accelerate the advancement of our diagnostic portfolio.</B> We are also developing a complementary diagnostic portfolio.
We currently have three diagnostics candidates in our pipeline that we developed</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">using our Morphomer platform that
targets Abeta, tau and alpha synuclein. Our tau PET imaging agent is currently undergoing First-in-Man studies and we intend to
work with our partner, Piramal Imaging, to advance this product candidate through the clinical development process. We are also
developing PET imaging diagnostics for diseases resulting from the misfolding of alpha-synuclein proteins.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Leverage the duality of our therapeutic and diagnostic approaches to become the leader in personalized treatment of neurodegenerative
diseases. Personalized medicine involves the development of diagnostics, therapies and treatment procedures best suited for an
individual patient, taking into consideration the stage of the disease, as well as genetic and environmental factors. The biggest
limitation in neurodegenerative disease management is the lack of appropriate biomarkers and reliable diagnostics for early disease
detection and the absence of approved disease-modifying therapies. We believe that the future treatment paradigm for neurodegenerative
diseases will likely involve early disease diagnosis and combination therapy, leveraging both symptomatic and disease-modifying
treatments, with different disease-modifying treatments used at various points in the progression of the disease. We believe that
our multi-pronged approach to neurodegenerative disease diagnosis and treatment may result in the generation of individualized
treatment options for patients and improve clinical outcomes.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B>Strategically collaborate or selectively partner for the development and commercialization of product candidates.</B> Historically,
we have relied on collaboration agreements with leading pharmaceutical companies to leverage their scientific, development, manufacturing
and commercialization expertise and other resources in order to accelerate the development of our product candidates. To date,
we have entered into collaboration agreements with leading global pharmaceutical companies, including two collaborations with Genentech
and one with Janssen, a Johnson&nbsp;&amp; Johnson company. We believe that these partnerships validate our core strategy of discovering
safe and efficacious therapies using our proprietary platforms and advancing them through the various stages of regulatory approval.
In the future, for any approved products targeting large markets, we may selectively partner with leading companies that we believe
can contribute manufacturing and marketing expertise, geographic reach and other resources and know-how that can enhance the value
of these approved products.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Our Approach to Treating Diseases Related to Protein Misfolding</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Protein folding and unfolding are important
ways of regulating the protein&rsquo;s biological activity and cellular location. Misfolding of proteins occurs due to a breakdown
of cellular quality control systems, and is a common feature of many neurodegenerative diseases. Research has shown that misfolded
proteins are not only unable to carry out their normal functions, but also aggregate to form deposits in the brain that eventually
lead to neuronal damage and cell death. The progression of neurodegenerative diseases, such as AD and PD, is linked to the misfolded
conformations of proteins, such as Abeta, tau and alpha-synuclein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p49.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The diagram above shows how, in today&rsquo;s
understanding, misfolded proteins play a key role in the pathology of neurodegenerative diseases. Typically, protein misfolding
occurs during cellular stress, which can be triggered by many different causes, including oxidation and a lack of growth factors.
A cascade of molecular events begins with the misfolding of single proteins within a cell that then continue to aggregate to ultimately
form plaques and tangles. These misfolded proteins are then exported and spread to healthy cells nearby, causing normal proteins
to misfold in a process known as seeding. This process eventually leads to cell death in various areas of the brain and is linked
to a decline in cognitive function.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Challenges in targeting misfolded proteins</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The central challenge in targeting misfolded
proteins for therapeutic effect is a product&rsquo;s ability to differentiate, or conformationally select, between a misfolded
protein and a normally-folded protein. This ability to conformationally select for the misfolded protein prevents the therapeutic
candidate from interfering with the function of the normally-folded protein, thereby reducing the risk of side effects.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Benefits of our approach</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The key aspect of both our SupraAntigen
and Morphomer technology platforms is conformational specificity, which we believe is central to the development of effective therapeutics
for neurodegenerative diseases. Our SupraAntigen platform targets misfolded proteins through antigens displayed on the surface
of liposomes which mimic the targeted pathological form of the protein. In a complementary approach, our Morphomer platform uses
small molecular weight compounds to target the aggregation and seeding process, which prevents the misfolded proteins from aggregating
inside the cell and the formation of new misfolded proteins in healthy neighboring cells through a seeding mechanism. Small molecules
derived from our Morphomer platform, which we refer to as Morphomers, also promote disaggregation of already formed pathological
protein aggregates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p50.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The diagram above shows how we believe
our therapies aim to intervene in the key pathology steps involved in neurodegenerative diseases: (1)&nbsp;prevent misfolding;
(2)&nbsp;promote disaggregation; (3)&nbsp;inhibit spreading; and (4)&nbsp;prevent seeding in healthy cells.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Current Treatment Paradigm for Neurodegenerative Disease</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Current diagnostic and treatment paradigms
for neurodegenerative diseases are suboptimal. Diagnosis typically takes the form of observation of cognitive, functional and behavioral
impairment and other symptoms of the diseases, which are generally only apparent after irreversible neuronal damage has already
occurred. These symptoms are treated with medicines capable of providing cognitive benefit and functional improvement but fail
to affect the progression of the disease. For AD, there are currently four approved therapies, all of which only provide modest
efficacy in treating the symptoms of AD, while having significant side effect risks, and fail to address the progression of the
disease. Despite these shortcomings, marketed therapies, such as Eisai and Pfizer&rsquo;s Aricept, have achieved peak annual global
sales of approximately $4&nbsp;billion prior to loss of exclusivity. Similarly, in the treatment of PD, the current standard of
care is intended only to alleviate physical symptoms. In both AD and PD, there are no approved disease-modifying treatments that
slow or stop the course of disease progression.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Modifying the progression of the disease
requires targeting the underlying biological processes that drive disease progression. Unfortunately, these processes evolve over
the course of many years prior to manifestation of symptoms and a high percentage of neurons may be lost prior to clinical manifestation.
Many of the failed clinical studies for disease-modifying treatments targeted patients with moderate stages of the disease, when
irreversible neuronal damage and death had already occurred. This had led to the conclusion that early intervention is necessary
to slow the disease progression and that disease-modifying therapies should be studied in patients with milder stages of the disease.
As a result of this, in recent years, there has been a movement towards early intervention in clinical development. Early intervention,
however, requires accurate disease detection prior to physical manifestation of symptoms, using new and sophisticated technologies
that are superior to the subjective rating scales currently used</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">to assess patients. Thus, new diagnostic technologies
are critical to the clinical development process of disease-modifying therapies and ultimately better disease management of patients
with neurodegenerative diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Opportunity for AC Immune in Neurodegenerative
Diseases</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We intend to change the way that neurodegenerative
diseases are treated by combining reliable diagnostic tools that facilitate intervening at earlier stages of the disease with therapies
that treat the underlying disease process, as shown in the diagram below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p51.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We believe that our lead product candidate,
crenezumab, is ideally positioned to be at the forefront of disease-modifying and preventative medicine due to its demonstrated
efficacy in milder AD subjects and favorable safety profile. Unlike the current standard of care, crenezumab seeks to modify the
course of AD by intervening at an earlier stage of the disease progression prior to irreversible neuronal damage. Beyond AD, we
believe that we can leverage our proprietary platforms to generate additional molecules that treat the causes of other neurodegenerative
and neuro-orphan diseases, such as PSP, ALS and Huntington&rsquo;s disease. We believe that the future treatment paradigm for neurodegenerative
diseases will involve different disease-modifying treatments used at various points in the progression of the disease. One such
combination may be passive immunization targeting Abeta, such as crenezumab together with anti-tau antibodies or immunotherapies
and small molecules targeting Abeta or tau.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We believe that we are a leader in discovering
new PET imaging agents to improve the timing and accuracy of diagnoses in neurodegenerative diseases. We have three diagnostic
candidates in our pipeline that were developed through our Morphomer platform and that target Abeta, tau and alpha-synuclein. We
believe our tau-PET imaging program has received external validation through our partnership with Piramal Imaging, a leader in
imaging agents. We are also developing an Abeta and tau <I>in&nbsp;vitro</I> diagnostic agent for AD and an alpha-synuclein PET
imaging agent for PD. We believe that our diagnostic product candidate pipeline will complement our disease-modifying treatment
product candidate pipeline, with the ultimate goal of reshaping the clinical course and treatment of neurodegenerative diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Our Proprietary Technology Platforms</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our research and development program is
based on our two unique proprietary technology platforms: our SupraAntigen platform, which is our biological and immunological
platform, and our Morphomer platform, which is our small molecule, chemical platform. These platforms are designed to generate
antibodies and small molecules, respectively, which selectively bind to misfolded proteins which are common in a broad range of
neurodegenerative diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our SupraAntigen platform generates humanized
monoclonal antibodies and vaccines for use as passive and active immunotherapies that are highly specific for pathological, or
misfolded, forms of Abeta and tau typically found in AD and certain other neurodegenerative diseases. In addition to the high target
specificity, the generated antibodies clear the misfolded proteins from the brain without generating inflammation. This characteristic
was</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">clinically confirmed in the Phase 2 clinical
studies of crenezumab, where a favorable safety profile was demonstrated. Similarly, ACI-35 and ACI-24 have been well tolerated
in their respective Phase&nbsp;1b and 1/2a clinical studies. Our diagnostic portfolio is also an important part of our strategy,
as PET and molecular diagnostics should enable earlier diagnosis of neurodegeneration than current approaches that are based on
clinical symptoms, a result that we believe will result in better clinical outcomes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Research has shown that misfolded proteins
are not only unable to carry out their normal functions but that they also aggregate to form deposits commonly known as plaques
and tangles that damage neuronal tissue and lead to cell death. Our SupraAntigen and Morphomer platforms seek to produce conformationally
specific molecules, which are molecules that are able to differentiate between misfolded proteins and normally-folded proteins,
and target misfolded proteins with minimal side effects on normally-folded proteins. We believe that our platforms can also generate
compounds in indications related to protein misfolding outside of neurodegenerative disease, such as in glaucoma where aggregated
Abeta peptides and tau proteins have been shown to cause damage to the optic nerve.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our platforms address two key issues in
the development of drugs against diseases of protein misfolding:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The body does not make antibodies against misfolded proteins because, although pathogenic, they are still recognized as &ldquo;self-proteins&rdquo;
and do not trigger an immune response.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The difference between a normal protein and a pathological protein is only related to a conformational change in protein structure
making drug specificity difficult to achieve.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p52.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The diagram above shows the process by
which conformationally-specific molecules break down the aggregation of misfolded proteins. We expect that antibodies and Morphomers
should prevent or disrupt the formation of insoluble plaques and stabilize soluble non-pathological proteins.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p52b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The SupraAntigen platform was created by
our scientific founders Dr.&nbsp;Claude Nicolau in collaboration with Dr.&nbsp;Fred Van Leuven. This technology generates conformation-sensitive
antibodies and is used by us to create product candidates for both passive and active immunization. Passive immunization involves
the application of therapeutic antibodies, whereas active immunization stimulates the human body to make its own antibodies against
pathological proteins, as shown in the diagram above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">SupraAntigen Platform: Active Immunization</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our product approach is based on the ability
of antigens attached to liposomes to elicit the immune system to produce antibodies against self-proteins. The liposome is constructed
of cholesterol, phospholipids and monophospholipid-A as an adjuvant. The liposome can accommodate antigens, or peptides, of different
lengths that are chemically modified with palmitic acids to &ldquo;anchor&rdquo; them in the liposomal membrane. The interaction
between the charged liposome surface and the peptides force the peptide into the pathological conformation that mimics the targeted
misfolded proteins. The diagram below shows the vaccine construct which is used as a basis for ACI-24 and ACI-35 vaccine candidates.
ACI-24 and ACI-35 are vaccine candidates developed using our SupraAntigen platform for active immunization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p53.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">SupraAntigen Platform: Passive Immunization</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our SupraAntigen platform can also be used
to develop passive immunization product candidates. The antibodies are created by injecting the SupraAntigen constructs in mice
and by selecting the antibodies for their ability to break up aggregated fibers. The antibodies eliminate protein aggregates such
as plaques and tangles by changing the equilibrium from the insoluble pathological to the soluble fibers which are depleted by
the antibodies. Both crenezumab and the anti-tau antibodies were derived from this platform.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Morphomer Platform</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our Morphomer platform represents a highly
promising technology to identify and develop therapeutic small molecules for the treatment of diseases resulting from misfolded
proteins. This proprietary platform enables us to generate small molecules that bind to their target and break up neurotoxic protein
aggregates. As of March&nbsp;31, 2016, the Morphomer library consisted of more than 2,400 compounds. Our key platform assets have
been validated for selective binding to Abeta, tau and alpha-synuclein through <I>in vitro</I> efficacy studies and have a validated
mechanism of action through reproducible <I>in vivo</I> efficacy for Abeta, tau and alpha-synuclein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The figure above shows a Morphomer blocking
amyloid growth. Only one end of aggregated amyloid fibers grows, and these molecules are designed to inhibit that growing end as
shown in the above diagram.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Most molecules involved in neurodegenerative
diseases follow the same overall disease development and aggregation process, including Abeta in AD, alpha-synuclein in PD and
huntingtin in Huntington&rsquo;s disease.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The key advantages of our Morphomer platform
include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>High specificity for the targeted misfolded protein;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>One Morphomer can inhibit multiple protein units in oligomers and fibers; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Early inhibition of aggregation and seeding.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our Morphomer platform was developed through
a collaboration of our scientific founders Dr. Jean-Marie Lehn, a recipient of the Nobel Prize in chemistry, and Dr. Claude Nicolau,
a former Harvard University professor, and our board member Dr. Detlev Riesner.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Our AD Programs</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Crenezumab</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Crenezumab is a humanized, conformation-specific
monoclonal antibody that targets the misfolded version of Abeta and has a broad binding profile. Crenezumab was developed using
our proprietary SupraAntigen platform. In 2006, we licensed crenezumab to Genentech and a company with a long history of developing
and commercializing innovative biologics.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Abeta is produced by the breakdown of a
larger protein called amyloid precursor protein, or APP. The Abeta fragment containing 42 amino acids, or Abeta <FONT STYLE="font-size: 10pt"><SUB>1&ndash;42</SUB></FONT>,
is believed to be associated with the highest toxicity of the Abeta fragments. Misfolded Abeta subunits combine to form oligomers
and fibrils that are found in amyloid plaques. Data resulting from preclinical and clinical studies show that crenezumab binds
with high affinity to amino acids 12&ndash;24 of Abeta <FONT STYLE="font-size: 10pt"><SUB>1&ndash;42</SUB></FONT>, as well as multiple
forms of Abeta, including monomers, oligomers, and fibrils, which reduces Abeta <FONT STYLE="font-size: 10pt"><SUB>1&ndash;42</SUB></FONT>
induced cytotoxicity. Furthermore, these data indicate that crenezumab enhances the uptake of neurotoxic Abeta oligomers by microglial
cells, the resident immune cells of the brain, which normally respond to neuronal damage and remove the damaged cells for subsequent
disposal and clearance from the brain.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A challenge with agents acting to remove
Abeta is the potential to induce inflammation leading to vasogenic edema, which is accumulation of fluid in the brain that can
lead to headaches, loss of coordination and disorientation. The fluid can be seen clearly on MRI scans and is referred to as Amyloid
Related Imaging Abnormality-Edema, or ARIA-E. Crenezumab is engineered on an IgG4 backbone, which was selected because IgG4 antibodies
are associated with a greatly reduced risk of causing inflammation. As a result, crenezumab&rsquo;s IgG4 structure activates microglial
cells to clear Abeta without producing inflammation and associated vasogenic edema, as demonstrated in the Phase 2 clinical studies.
In contrast, ARIA-E and other inflammation-related side effects have been observed in other antibodies with an IgG1 backbone.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Abeta1-42 oligomers&#9;Reduces Abeta 1-42 oligomer toxicity</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red"><IMG SRC="p55.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Abeta 1-42 oligomers + MABT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red"><IMG SRC="p55b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">MABT is equivalent to crenezumab, mMABT is the parental murine
version of crenezumab</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p56.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Reduces microglia inflammatory activation</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p56b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The figure above shows that crenezumab
promotes Abeta oligomer engulfment by microglia without inflammatory activation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We believe crenezumab may have the following
important competitive advantages relative to other drugs targeting Abeta in development:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Unique mechanism of action:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Crenezumab recognizes and binds to multiple forms of Abeta, including monomeric, oligomeric and fibrillar Abeta that are found
in amyloid plaques. In contrast, certain other antibodies in development such as solanezumab and aducanumab have only been shown
in studies to recognize a subset of Abeta forms.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Due to its binding to the multiple forms of Abeta, with high specificity to oligomers, crenezumab also protects against oligomer-induced
neurotoxicity.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Linked to its unique epitope, crenezumab has been shown to promote disaggregation of existing Abeta aggregates and disrupt
their assembly to prevent amyloid plaque formation.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Crenezumab has been designed with an IgG4 backbone to reduce effector function on microglia and to clear Abeta from the brain
while limiting inflammation.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p57.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Signal of activity in milder AD patients (MMSE 22-26):</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>In the proof-of-concept Phase 2 studies of crenezumab, a positive trend in cognition was observed with a greater effect on
cognition in patients with a milder stage of AD (MMSE 22-26).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>In the ABBY cognition study there was a statistically significant 35% reduction in the rate of cognitive decline in the non-pre-specified
milder AD patient population (MMSE 22-26) for the high-dose arm.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>In the BLAZE biomarker study, the high-dose arm showed a consistent trend of reduced Abeta accumulation in the brain over time,
as shown in two independent exploratory analyses of florbetapir-PET data. In addition, it has been shown that crenezumab has the
ability to enhance the removal of these proteins from the brain as evidenced by a significant increase in CSF Abeta, confirming
target engagement by crenezumab.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Favorable safety profile allowing for potentially higher dosing:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Phase 2 data from ABBY and BLAZE studies suggested that there were no imbalances in overall rate of Adverse Events, or AEs,
and overall rate of AEs was not dose-related, with only one case of asymptomatic ARIA-E (0.4% in ABBY, 0.3% on active pooled) in
crenezumab patients. AEs also included inflammation of the throat and nasal passages, urinary tract infections and upper respiratory
infections. However, no patients in the studies experienced serious adverse events that we believe were related to the administration
of crenezumab.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Crenezumab is a member of the IgG4 isotype subclass of antibodies. This isotype was selected because IgG4 antibodies are associated
with a greatly reduced ability to cause inflammation. By contrast, all other antibody products currently in development that target
Abeta are of the IgG1 isotype subclass, which is associated with a higher incidence of inflammation-related ARIA-E. Dose limiting
toxicities are a major risk for failure of competing antibody products. Potential safety at high doses is a key product feature
of crenezumab.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Due to its favorable safety profile, there is an ongoing Phase 1 study in which crenezumab is being studied at higher doses
to potentially increase its efficacy signal.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The table below sets forth the relative
incidence of ARIA-E of crenezumab and other competitive product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p58.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; color: Red"><FONT STYLE="color: Black">______________</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; color: Red"></P>



<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>10 mg/kg dose cohort</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>6 mg/kg dose cohort</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">Reduced effector function</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">**</TD><TD>Full effector function</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Phase 2 Studies</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Phase 2 Study Design Overview</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Crenezumab has been studied in two Phase
2 clinical studies, the ABBY proof-of-concept study and the BLAZE biomarker study. These two studies enrolled a total of 522 patients.
The purpose of these studies was to investigate whether crenezumab could delay cognitive and functional decline and reduce the
accumulation of brain amyloid in patients with mild to moderate AD. The sample size of the studies was not expected to have adequate
power to detect a modest but clinically significant difference between active medication and placebo at the 5% significance level
(as is commonly the case in Phase 2 studies in AD). Instead, consistent trends across different endpoints and dose dependency are
considered indicators of a response in this learning phase of development, with confirmation then sought in Phase 3. Both studies
had two active arms: a low dose arm receiving 300mg subcutaneous injection, which is an injection administered beneath the skin,
every two weeks and a higher dose arm receiving 15mg/kg intravenously every four weeks. The primary analysis was conducted at 73
weeks, after 68 weeks of treatment. Safety and tolerability measures included repeated MRI scans to assess for the development
of Amyloid Related Imaging Abnormalities, both vasogenic edema and hemorrhages.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">ABBY Study Design</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The ABBY study was a randomized, double-blind,
parallel group, placebo-controlled study to evaluate the safety and efficacy of crenezumab in patients with mild to moderate AD,
with an MMSE score at screening of 18-26 points. 444 patients were enrolled into the study including 13 patients who were included
in a safety run-in cohort to support the use of the 15 mg/kg intravenous dose, which had not been tested in Phase 1. Since these
patients received active medication after the second infusion and were then no longer blinded, they were included in the safety,
but not the primary efficacy, analysis. The remaining 431 patients were randomized separately to receive crenezumab, either subcutaneously
at a dose of 300 mg every two weeks (low dose) or intravenously at a dose of 15 mg/kg once every 4 weeks (high-dose), with a 2:1
active:placebo ratio in each dose group. In the subcutaneous injection dose arm, 122 patients received crenezumab and 62 patients
received placebo. In the intravenous dose arm, 163 patients received crenezumab and 84 patients received placebo.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Co-primary endpoints were cognition assessed
using the Alzheimer Disease Assessment Scale-Cognitive Subscale, or ADAS-cog 12 scale, and global function assessed by the Clinical
Dementia Rating-Sum of Boxes (CDR-Sum of boxes). Secondary endpoints such as the MMSE score and Digit Symbol Substitution Test,
or DSST, were also included in the study. ADAS-cog is a widely used scale in clinical studies that measures a patient&rsquo;s performance
on tests of memory and other areas of cognition, especially orientation, praxis and language. Scores range from 0 (best) to 70
(worst). The ADAS-cog 12 score includes an additional item of delayed recall, leading to a highest possible score of 80 points.
On average, the score of patients with mild to moderate AD increases by 5 to 8 points per year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The CDR-Sum of boxes is an assessment of
&ldquo;global&rdquo; (overall) function of the patient in daily life. The patient&rsquo;s performance in the six domains of memory,
orientation, judgment and problem solving, community affairs, home and hobbies and personal care are assessed through interviews
with the patient and caregiver. Each domain is scored from 0 (best) to 3 (worst) based on the level of impairment. The scores for
the six domains are then summed up and the resulting score or &ldquo;sum of boxes&rdquo; ranges from 0 to 18, with a higher score
indicating greater impairment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The DSST is a classic paper and pencil
test used to assess a patient&rsquo;s processing speed in the so-called digit symbol substitution test during which the patient
is asked to insert a symbol in place of a digit according to a scheme as quickly as possible over a set period of time. The DSST
measures the number of correct symbols the patient inserts within the allowed time, i.e. 90 or 120 seconds. A higher score demonstrates
better performance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ABBY Study Disposition</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: Red"><IMG SRC="p59.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">ABBY Study Results</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the ABBY study, a positive trend in
cognition was observed with a greater effect on cognition in patients with a milder stage of AD (MMSE 22-26), although the study
did not meet its co-primary endpoints in mild-to-moderate AD (MMSE 18-26) patients. There was no significant change in cognition
in patients who received low-dose subcutaneous crenezumab. Results of an exploratory analysis of the high-dose intravenous arm
demonstrated that patients with the mildest cognitive impairment at screening (MMSE 22-26) showed a statistically significant</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">35% slowing of the rate of cognitive decline
over 73 weeks. The effect became greater over time, as shown by the increasing separation of the crenezumab (solid line) and placebo
(dashed line) curves in the diagram below. The milder group was not pre-specified, meaning the group of milder AD patients was
not identified before commencing the Phase 2 clinical studies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ABBY High Dose Arm: Change in ADAS-Cog
12</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p60.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p60b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">An exploratory subanalysis in a non-pre-specified
subgroup of patients with milder symptoms (MMSE&nbsp;22-26) showed a 35.4% reduction in cognitive decline. The sample size of the
study was not expected to have adequate power to detect a modest but clinically significant difference between active medication
and placebo at the 5% significance level (as is commonly the case in Phase 2 studies in AD). Instead, consistent trends across
different endpoints and dose dependency are considered indicators of a response in this learning phase of development, with confirmation
then sought in Phase&nbsp;3. In the pre-specified subgroup analysis in patients with mild AD (MMSE 20-26), treatment with high-dose
intravenous crenezumab led to a 23.8% reduction in cognitive decline. In patients with mild-to-moderate AD (MMSE 18-26) treated
with high-dose intravenous crenezumab, there was a 16.8% reduction in cognitive decline. Effect sizes and p-values for exploratory
analyses were not adjusted for multiplicity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">ABBY High Dose Arm: Change in DSST</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p61.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p61b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The ABBY high-dose arm result for DSST
was significant in the milder patient sub-group (MMSE 22-26). The mild and milder patients that were given crenezumab intravenously
showed no further cognitive deterioration between 12 and 18 months.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the ABBY study, patients in the high-dose
crenezumab arm showed less decline on the measure of global function, CDR-Sum of boxes, as compared to placebo. In mild-to-moderate
AD (MMSE 18-26), a non-significant 3.1% reduction in global functional decline was observed. In the pre-specified subgroup analysis
in patients with mild AD (MMSE 20-26), treatment with high-dose intravenous crenezumab did not show reduction in global functional
decline (1.0% reduction; p=0.96). An exploratory analysis in two cohorts of patients with milder symptoms showed a 19.6% (MMSE
22-26) and 45% (MMSE 24-26) reduction in global functional decline.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Greater relative reductions were observed
in the crenezumab arm compared with placebo in the CDR subdomains Memory, Orientation, Judgment &amp; Problem Solving and Home
&amp; Hobbies in progressively milder patients. Treatment effects were less consistent in progressively milder patients for the
CDR subdomains Community Affairs and Personal Care.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="font-family: Symbol">D</FONT>
CDR subdomains=difference in change from baseline to Week 73 in CDR subdomain scores between treatment and control groups. Diamonds
represent LS mean change from baseline at Week 73, error bars 95% present CI. Positive values indicate less decline in crenezumab
group.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Although the overall results were not statistically
significant, it should be noted that the sample size of the study was not expected to have adequate power to detect a modest but
clinically significant difference between active medication and placebo at the 5% significance level (as is commonly the case in
Phase 2 studies in AD). Instead, consistent trends across different endpoints and timepoints and dose dependency are considered
indicators of a</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">response in this learning phase of development,
with confirmation then sought in Phase 3. Trends favoring crenezumab were not observed in the activities of daily living scale
(ADCS-ADL) although the study was significantly underpowered for this type of assessment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">BLAZE Study Design</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The BLAZE study was a randomized, double-blind,
parallel-group, placebo-controlled study to evaluate the effects of crenezumab on brain amyloid burden as assessed by amyloid PET
imaging and other biomarker endpoints in patients with mild to moderate AD. The primary endpoint was to measure the change in brain
amyloid load using florbetapir-PET. The terms brain amyloid burden and brain amyloid load refer to the total amount of amyloid
deposited in the brain. Each of these typically increases over time in an AD patient. Other endpoints included changes from baseline
in other biomarkers (CSF, volumetric MRI), cognition (ADAS-cog12), global function (CDR-Sum of boxes), and activities of daily
living (ADCS-ADL). Enrollment required florbetapir-PET positive scans, or patients who were amyloid positive. Ninety-one patients
were included in the study.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">BLAZE Study Disposition</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p64.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">BLAZE Study Results</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The primary end point of change in brain
amyloid load by florbetapir-PET was not met, but the study was not powered to detect statistically significant results. When assessing
the amyloid load, the amount of amyloid in a region of the brain is determined by comparing the amount of an amyloid tracer to
that found in a region with little or no amyloid, such as the cerebellum or the white matter, usually in the cortex. Recent studies
have shown that the variability from scan to scan in the same patient over time is much higher when using the cerebellum than with
the white matter, making the white matter a more powerful point of comparison for use in longitudinal studies. The higher variability
of the cerebellum may be due to difficulties in exact positioning between scans and higher background levels. Taking this into
account, the exploratory analyses of the BLAZE amyloid PET results using white matter reference region were conducted independently
by two laboratories, the Banner Alzheimer&rsquo;s Institute and MNI Laboratories. The analyses produced analogous results where
a trend in the reduction of Abeta accumulation was observed in the high-dose arm.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The BLAZE biomarker study high-dose intravenous
cohort showed a consistent trend of reduced Abeta accumulation in the brain over time shown by two independent exploratory analyses
of florbetapir-PET data. Using white matter rather than cerebellum as the key reference region in the brain is generally considered
a more robust method of showing treatment effects of AD therapies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the BLAZE study, patients also showed
a statistically significant increase in CSF Abeta<FONT STYLE="font-size: 10pt"><SUB>1&ndash;42</SUB></FONT>, which we believe confirms
target engagement by crenezumab. Similar results were observed in the ABBY study where CSF was assessed in 49 patients. These results
suggest that Abeta is being eliminated from the brain when treated with crenezumab.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">BLAZE High Dose Arm: Crenezumab Increases
CSF Total Abeta Relative to Placebo</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p65b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">BLAZE Study Results: Effects on Cognition
and Global Function</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A similar and consistent pattern of response
was observed in the BLAZE study with slowing of loss of cognition compared to placebo observed at the high-dose intravenous crenezumab
arm, and having the most effect in patients with more mild MMSE scores. There was no significant cognitive change in patients who
received low-dose subcutaneous crenezumab. Importantly, the sample size of the study was not expected to have adequate power to</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">detect a modest but clinically significant
difference between active medication and placebo at the 5% significance level (as is commonly the case in Phase 2 studies in AD).
BLAZE study results suggest that Abeta is being eliminated from the brain as patients showed a statistically significant increase
in CSF Abeta <FONT STYLE="font-size: 10pt"><SUB>1&ndash;42</SUB></FONT>, which confirms target engagement by crenezumab.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">BLAZE High Dose Arm: Change in ADAS-Cog
12</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p66.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The BLAZE high-dose arm showed increasing
separation over time of the curves of decline on ADAS-Cog 12 for placebo (dashed line) and intravenous crenezumab (solid line)
in the mild subgroup of patients (MMSE 20-26). In a post-hoc analysis of a group of patients with mild AD (MMSE 20-26) treated
with high-dose intravenous crenezumab, there was a 52.0% reduction in cognitive decline (p=0.29). In patients with mild-to-moderate
AD (MMSE 18-26) treated with high-dose intravenous crenezumab, there was a 10.3% reduction in cognitive decline (p=0.84). Importantly,
the sample size of the study was not expected to have adequate power to detect a modest but clinically significant difference between
active medication and placebo at the 5% significance level (as is commonly the case in Phase 2 studies in AD). Effect sizes and
p-values were not adjusted for multiplicity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the BLAZE study, patients in the high-dose
crenezumab arm showed less cognitive decline on the measure of global function, CDR-Sum of boxes, as compared to placebo. In mild-to-moderate
AD (MMSE 18-26), a 7.4% reduction in global functional decline (p=0.84) was observed. In a post-hoc analysis in patients with mild
AD (MMSE 20-26), treatment with high-dose intravenous crenezumab resulted in a 41.5% reduction in global functional decline (p=0.44).
Although the results were not statistically significant, the sample size of the study was not expected to have adequate power to
detect a modest but clinically significant difference between active medication and placebo at the 5% significance level (as is
commonly the case in Phase 2 studies in AD).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Safety Data from ABBY and BLAZE Studies</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Crenezumab demonstrated favorable safety
and tolerability in Phase 2 clinical studies even at high doses. Crenezumab&rsquo;s safety profile is especially reflected in a
low incidence of ARIA-E (0.3%) in Phase 2 clinical studies. ARIA-E was observed in only one patient who received high-dose intravenous
crenezumab in the ABBY study. No case of ARIA-E was reported in the placebo arm or the BLAZE study. Favorable pharmacokinetic properties
coupled with a favorable safety and tolerability profile enables crenezumab to penetrate the brain more readily at therapeutically
relevant doses. Since dose limiting toxicities are a potential reason for the failure of other antibodies to demonstrate efficacy,
crenuzamab&rsquo;s potential safety at high doses is a key distinguishing product feature.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">There was no imbalance in the overall rate
of AEs. AEs were observed in 91.3% of patients treated with crenezumab versus 90.3% of patients who received placebo. AEs were
generally mild-to-moderate and transient. AEs did not appear to be related to crenezumab exposure. Five deaths occurred during
ABBY and BLAZE, all in</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">patients who received crenezumab during the
randomized placebo-controlled period (1.4% of the crenezumab-treated population). The overall rate of deaths is consistent with
the background rate of death in the elderly AD population. There was no consistent pattern for the cause of death and none were
considered by the investigators to be related to crenezumab. It was reported that 3.2% of crenezumab-treated patients developed
pneumonia versus 0.6% in placebo-treated patients in ABBY and BLAZE, but the rate of pneumonia cases in crenezumab-treated patients
is consistent with the expected rate in the elderly population (2.5%&ndash;4.4%) and no drug-related mechanism for pneumonia was
identified.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Genentech has not disclosed detailed information
about serious adverse events associated with crenezumab either publicly or to us. However, at the 2014 Alzheimer&rsquo;s Association
International Conference, it was reported that in the combined Phase 2 study populations, serious adverse events occurred at similar
rates in patients treated with crenezumab (16.5%) and in patients given a placebo (11.9%).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Ongoing Phase 1 Study</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To explore safety at higher doses, crenezumab
is currently being tested in a Phase 1b dose escalation clinical study (NCT02353598) conducted in the United States. This randomized,
placebo-controlled, double-blind, four parallel-arm study will evaluate the safety and tolerability of at least two doses of intravenous
crenezumab in up to 72 patients with mild to moderate AD (MMSE 18-28) between the ages of 50 to 90. An optional open-label extension
stage will be offered to patients after completion of the double-blind stage of the study. This study is expected to be completed
in May 2017. At the 2016 CTAD meeting, Genentech presented the results of the first two cohorts in 52 patients with mild-to-moderate
Alzheimer&rsquo;s disease. No dose-limiting toxicities were observed at 30, 45 and 60mg/kg doses of crenezumab. No events of Amyloid
Related Imaging Abnormality-Edema (ARIA-E) were observed in the Phase 1b study and only few patients (6 of 52) showed asymptomatic
Amyloid Related Imaging Abnormality-Hemsiderin (ARIA-H).The pharmacokinetic profile of crenezumab is dose proportional up to the
60mg/kg dose and is consistent with historical data. The serum concentrations at this dose are four times higher than in the 15mg/kg
dose used in the Phase 2 trials. These safety and pharmacokinetic data of the Phase 1b dose escalation study support the continued
treatment of patients with crenezumab at the higher dose of 60mg/kg.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Phase 2 AD Prevention Study</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2012, crenezumab was independently selected
from among twenty five product candidates for use in the first-ever AD prevention study. The study, a $100 million collaboration
between the NIH, Banner Alzheimer&rsquo;s Institute and Genentech, is the cornerstone of the global Alzheimer&rsquo;s Prevention
Initiative. Crenezumab is being administered pre-symptomatically to 300 members of an extended Colombian family, of which 200 members
carry a mutation that causes early-onset AD. Family members usually develop symptoms before the age of 45. The five-year study
has cognitive endpoints. An interim analysis is expected in 2017, but the data and results of that analysis may not be made public
given patient sensitivity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Ongoing Phase 3 Studies (CREAD 1 and
2)</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Genentech entered Phase 3 clinical development
of crenezumab in the first quarter of 2016. The CREAD Study is ongoing. This randomized, double-blind, placebo-controlled, parallel
group Phase 3 study will enroll about 750 participants with prodromal or mild AD at the age of 50-85 years. A high dose of crenezumab
(60mg/kg) is administered intravenously once every 4 weeks for 100 weeks. Primary outcome measure is change from baseline to week
105 in Clinical Dementia Rating - Sum of Boxes (CDR-SB) score. An exposure-response model to evaluate the best dose of crenezumab
for the treatment of Alzheimer&rsquo;s disease was established and predicts an improved outcome of the CREAD Phase 3 study by using
the higher dose of 60mg/kg relative to the Phase 2 trials. Final data collection date for primary outcome measures is expected
by August 2020, with study completion by July 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On February 28, 2017, AC Immune announced
that its partner Genentech, member of the Roche Group, had decided to start a second Phase 3 clinical trial of crenezumab.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Exposure-response model results: correlation between crenezumab
exposure (AUC at steady state) and treatment effect reaching asymptote at projected exposure of 60mg/kg</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p68b.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Exposure-response model results: clinical trial simulations
of Phase 3 study design predict 41% relative reduction on ADAS-Coq12 and 44% on CDR-SB in the milder AD population (MMSE 22-26)</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">ACI-24</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">ACI-24 is a vaccine candidate that is in
a combined Phase 1/2a clinical study for AD. ACI-24 was developed utilizing our SupraAntigen platform, and is designed to stimulate
a patient&rsquo;s immune system to produce antibodies that specifically target the misfolded Abeta conformer to prevent plaque
accumulation and to enhance plaque clearance. Pre-clinical data demonstrated significant activity in plaque reduction and memory
restoration. ACI-24 has a favorable safety profile, characterized by a lack of observed local inflammation and a mechanism of action
independent of inflammatory T-cells.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Phase 1/2a Study</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To be considered a Phase 1/2a study, a
study or part of it must include as a primary goal the assessment of efficacy in a patient population, assessed using either clinical
endpoints or biomarkers. This is in contrast to a Phase&nbsp;1 study where the primary goal typically includes safety and pharmacokinetic
or pharmacodynamic measures.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">The ACI-24 study is an adaptive design study
where, after completion of a first step assessment of safety and immunogenicity at different doses, the study may be expanded to
assess the efficacy at the best dose in a Phase 2a-type design.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Phase 1 part of the combined Phase
1/2a study is currently ongoing. The efficacy, tolerability and immunogenicity of ACI-24 are being tested in mild to moderate AD
patients with four different doses. It is a randomized, placebo controlled, double blind study. The different doses are tested
via an ascending dose design in four consecutive cohorts with 12 patients each (9 on active, 3 on placebo treatment). ACI-24 is
administered by subcutaneous injection with multiple injections per cohort. Each dose cohort is followed by a two-year treatment-free
safety follow-up period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Analysis of the immune response data as
well as further treatment in cohort 4 is ongoing. An interim analysis of the first three doses (cohort 1-3) revealed positive safety
and tolerability. The study was not powered to examine efficacy but a trend towards reduction in accumulation in brain amyloid
measured by PET imaging was observed in cohort 3. A similar pattern of reduction of clinical decline assessed by the CDR-SB was
observed in cohort 3 compared to placebo at week 52 although this did not reach statistical significance. While the highest dose
group is still ongoing the Phase 2 clinical design is scheduled to be completed in the second half of 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">ACI-24 is also being studied in a Phase
1 clinical study in people with Down syndrome, a population which is at high risk for developing AD-like symptoms. The clinical
study started in December 2015 and we expect to present data from this study in 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Pre-clinical Study</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pre-clinical results showed that ACI-24
induced a rapid and significant anti-Abeta antibody response in a T-cell independent manner, which is linked to a more favorable
safety profile. The antibody response following treatment with ACI-24 reduced the Abeta brain burden and restored the memory capacity
in double-transgenic AD mice. Anti-Abeta antibodies induced by ACI-24 preferentially bind to both pathologically aggregated Abeta
species such as oligomers and fibrils. Relative to other anti-Abeta vaccines currently or previously in clinical development ACI-24
has shown differentiation in pre-clinical studies on the basis of mechanism of action, safety and efficacy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p69.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As shown in the diagram above, immunization
of an AD mouse model with ACI-24 led to a significant decrease of insoluble, plaque-related (black bars) and soluble (grey bars)
oligomeric Abeta <FONT STYLE="font-size: 10pt"><SUB>1-40</SUB></FONT> and Abeta <FONT STYLE="font-size: 10pt"><SUB>1-42</SUB></FONT>.
This target engagement was accompanied by the significant improvement of cognitive memory capacity in the novel object recognition
test, or ORT. In contrast, immunization with ACI-01, the vaccine candidate which did not present the antigen in its pathological
conformation, did not result in any restoration of memory.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">ACI-24 in Down Syndrome</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Individuals with Down syndrome have an
extra copy of chromosome 21 where the gene for APP resides. These individuals have a rate of AD that is three to five times that
of the general population and develop the disease at a</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">much younger age. At autopsy, AD has been
reported in 80% of people with Down syndrome over age 40 and 100% over age 60.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">ACI-24 is a vaccine candidate against the
pathological form of Abeta in plaques of AD patients. It contains a palmitic-acid Abeta peptide corresponding to amino acids 1-15
of the Abeta molecule anchored in liposomes and adopts the conformation of the pathological Abeta conformers found in plaques.
ACI-24 has a novel mode of action whereby antibody production is induced through direct B-cell (antibody producing cell) activation
that is independent of T-helper cells.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">An Investigational New Drug (IND) to study
the disease-modifying properties of ACI-24 for the prevention of cognitive decline with Down syndrome was filed and cleared by
the FDA. ACI-24 commenced the Phase 1 clinical study for Down syndrome at the end of 2015 The study is supported by a substantial
NIH grant and other grants from the LuMind Research Down Syndrome Foundation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p70.jpg" ALT="">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The diagram above, based on work published
by AC Immune in collaboration with Dr.&nbsp;Mobley of University of California, San Diego in March 2016, shows in a Down syndrome
mouse model (Ts65Dn) a 20% significant improvement of the memory&nbsp;(left) and a 27% reduction of Abeta in the brain following
vaccination with ACI-DS-01, the mouse equivalent of ACI-24 (right).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">ACI-35</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">ACI-35 is a vaccine candidate directed
against another key component of the pathology of AD: phosphorylated tau proteins, or p-tau, found in tau tangles. ACI-35 is designed
to stimulate a patient&rsquo;s immune system to produce antibodies against the misfolded and phosphorylated pathogenic conformers
of tau protein that aggregate to create the neurofibrillary tangles that characterize AD. ACI-35 is the first vaccine candidate
against phosphorylated pathological tau in clinical studies, and is currently in Phase 1b clinical testing in patients with mild
to moderate AD. In 2014, we entered into a partnership with Janssen Pharmaceuticals, a subsidiary of Johnson&nbsp;&amp; Johnson,
for the research, clinical development, manufacture and commercialization of ACI-35.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The dendrites and axons, or nerve endings,
of the neurons contain an elaborate series of thin tubes, or microtubules, which serve to support them and transport nutrients
down to the nerve endings. Tau proteins are a key component of these microtubules, and, hence, are known as microtubule associated
proteins.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In AD, tau protein is misfolded, becomes
hyperphosphorylated and aggregates into neurotoxic oligomers that ultimately form neurofibrillary tangles within neurons. The degree
of tau pathology correlates strongly with the degree of cognitive loss in AD. Approaches to reducing the level of abnormal tau
proteins and slowing their build-up in the brain are considered important targets for new AD therapies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We developed ACI-35 using our SupraAntigen
technology. In pre-clinical testing, the vaccine candidate induced an antibody response that was highly specific to misfolded and
phosphorylated tau. This antibody response resulted in a reduction of phosphorylated misfolded tau and an improvement in cognitive
clinical parameters.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Phase 1b Study</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Phase 1b Study Design</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Safety, tolerability and immunogenicity
of ACI-35 are being tested in an ongoing Phase 1b study in mild to moderate AD patients. It is a randomized, placebo controlled
double blind study, where ACI-35 is administered via subcutaneous injection. Different doses and dosing schedules are being investigated
in an ascending dose design. Multiple injections of ACI-35 are administered per cohort for active or placebo treatment in a three-to-one
ratio. To date, ACI-35 has been generally safe and well tolerated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Pre-clinical Study</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In research and pre-clinical studies, ACI-35
demonstrated:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A high and specific anti-p-tau IgG antibody response in wild-type mice, tau transgenic mice and primates (cynomolgus and rhesus
monkeys);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The induction of highly specific antibodies that are able to recognize p-tau over non-phosphorylated tau peptide and yield
a 30-100 fold higher titer for p-tau over non-phosphorylated tau;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A favorable safety profile by showing that multiple doses in mice and monkeys induced strong antibody responses that were well
tolerated and not associated with organ toxicity. The main adverse events were local reactions observed at the injection site and
were consistent with a normal granulomatous inflammatory reaction after subcutaneous injection of a foreign body;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>No observable toxicity at the highest dose used in cynomolgus monkeys or mice; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>No cross-reactivity to any human tissue with the antibodies induced in monkeys by ACI-35 immunization.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">ACI-35 generated antibodies that are phosphor-specific
for the full-length p-tau protein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p71.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The left graph shows that the ACI-35 vaccination
raised highly-specific antibodies against phosphorylated tau protein in both transgenic and wild type mice. On the other hand,
the right graph shows that a classical vaccine, composed of a p-tau peptide adsorbed to aluminum phosphate, raised antibody responses
that do not discriminate between phosphorylated tau and non-phosphorylated tau protein in both wild type and tau transgenic mice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Our Anti-Tau Antibody Candidate</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our anti-tau monoclonal antibody program
generated humanized monoclonal antibodies for use as passive immunotherapies that are highly specific for pathological forms of
tau found in AD brains and other tauopathies. Results from studies conducted in pre-clinical development demonstrate a significant
reduction in pathological tau with reduced effector function, meaning decreased ability to affect the function of tau, as well
as improvement of long-term spatial memory. A lead development candidate has been selected, and Genentech, our collaboration partner
for the anti-tau antibody program commenced a Phase 1 clinical study in Q2 2016. The Phase 1 clinical study tests the safety, tolerability
and pharmacokinetics of various dosing regimens of the anti-tau antibody in patients with mild to moderate AD as well as in healthy
volunteers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pre-clinical and Discovery Stage Therapeutic Programs</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Using our SupraAntigen and Morphomer platforms,
we have generated additional discovery and pre-clinical stage molecules targeting neurodegenerative diseases, and diagnostics targeting
both Abeta and tau. We currently have four therapeutic product candidates and two diagnostic product candidates in various stages
of pre-clinical development. A number of our therapeutic product candidates in pre-clinical development are focused on indications
outside of AD and evidence our expansion strategy. Based on the data we have received to date, we believe that our technology platforms
can be applied to misfolded proteins across a broad range of indications. The table below lists our three pre-clinical Morphomer
product candidates and the lead indication being pursued:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="2" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 20%; border: Black 1pt solid; font-size: 8pt; text-align: center; font-weight: bold">Product Candidate</TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 8pt; text-align: center; font-weight: bold">Target</TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 8pt; text-align: center; font-weight: bold">Lead Indication</TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 8pt; text-align: center; font-weight: bold">Partner</TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 8pt; text-align: center; font-weight: bold">Platform</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">Morphomer tau</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">tau</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">AD</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">N/A</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">Morphomer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">Morphomer abeta</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">Abeta</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">Glaucoma</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">N/A</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">Morphomer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">Morphomer alpha-synuclein</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">alpha-synuclein</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">PD</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">N/A</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; text-align: center">Morphomer</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B><I>Anti-tau Morphomers:</I></B> Anti-tau
Morphomers are small molecule compounds designed to inhibit tau aggregation with the aim of interacting with the beta sheet conformation
present in misfolded aggregated tau protein. Our anti-tau Morphomers show a significant inhibition of full length tau aggregation,
size-reduction and solubilization of full length tau aggregates and intracellular target engagement by reduction of cellular, aggregated
and phosphorylated tau. Importantly, research data show that our compounds reduce cytotoxicity induced by tau. These data were
further confirmed by the reduction of misfolded tau in the brain and memory improvement in a tau disease mouse model.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B><I>Morphomer abeta:</I></B> Our Morphomer
abeta product candidate is a small molecule that inhibits and disrupts Abeta propagation and aggregation, and is currently being
evaluated for the treatment of glaucoma, where its anti-Abeta properties represent a novel mechanism of action for that disease.
In pre-clinical testing, Morphomer abeta demonstrated a strong ability to protect the eyes of rats exposed to increased ocular
pressure and chronic ocular hypertension which are clinical features of glaucoma.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B><I>Morphomer alpha-synuclein:</I></B>
Our Morphomer alpha-synuclein product candidate is a small molecule that reduces the cytotoxicity of alpha-synuclein aggregates
by a decrease in their beta sheet content. In pre-clinical studies, Morphomer alpha-synuclein significantly reduced <I>in vivo</I>
the formation of alpha-synuclein pathological structures accompanied by improvement of a neuronal marker relevant to PD. Ongoing
activities are focused on increasing potency and pharmacokinetic properties and preparing compounds for pre-clinical development
activities. In a mouse model of tauopathies, our lead compounds show improvement of learning and memory deficit and reduce brain
atrophy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Diagnostics</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Scientists increasingly believe that early
detection of neurodegenerative diseases is critical to enhancing the effectiveness of both symptomatic and disease-modifying therapies.
As a result, therapeutic development for AD increasingly focuses on treating early stage disease to delay or prevent progression
and to preserve the maximum amount of cognitive function before it is irreversibly lost. Most clinical studies now target mild
stages of the disease increasing the need for accurate diagnosis that is independent of potentially subjective cognitive metrics.
At least one study estimates that as many as one-third of patients in previous AD studies did not in fact have AD. Accurate and
early diagnosis of AD is thus a substantial unmet market need, and diagnostic products will have a key role in generating a new
treatment paradigm, including by selecting more uniform and stage-specific clinical study subjects, tracking patient progress and
results, managing patients receiving treatment, and ultimately diagnosing disease at its earliest stage for immediate treatment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are developing two diagnostic product
candidates using our Morphomer technology platform. These product candidates are PET ligands, that are tracers that can be used
to target tau and alpha-synuclein aggregates. In May 2014, we established a collaboration agreement for our tau-PET imaging program
with Piramal Imaging. Piramal Imaging commenced a Phase 1 clinical study of the program in the fourth quarter of fiscal year 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our PET tracers are designed to bind specifically
to tau tangles and have demonstrated their ability to cross the blood-brain barrier. The severity of cognitive impairment in AD
patients is correlated with the presence of tau</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">protein tangles, leading us to believe that
an imaging agent for tau is equally important. Our tau-PET tracers are more selective for tau than Abeta when compared to current
published tau-PET agents in development and can be readily radiolabelled. While PET imaging has improved the diagnosis of AD by
targeting Abeta, tau imaging will further enhance the diagnosis of early AD. To date, there are no approved tau tracers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red"><IMG SRC="p73.jpg" ALT=""></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; color: Red">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The diagrams above show that our lead tau-PET
imaging compound has high selectivity and can identify tau aggregates as early as stage one of the six stages of the Braak scale,
which is the pre-symptomatic stage (as indicated with arrows in the far left diagram), and have a favorable uptake in the brain
(right diagram).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">AD diagnostics are a major market opportunity
that will be driven by the growth in the aging population and the testing and availability of disease-modifying drugs. We believe
a best-in-class tau tracer has the potential to achieve a substantial market share in this large and growing market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Alongside our AD diagnostics activities,
we have a program targeting PET imaging agents for alpha-synuclein, an important protein involved in PD, and which progressively
accumulates in structures in the PD brain. Scientists believe that the misfolding of alpha-synuclein is central to the neurodegenerative
process of PD, as well as a number of other disorders, collectively called synucleinopathies, such as Lewy Body Dementia and Multiple
System Atrophy, making it a priority target for drug development. We have identified molecules from our Morphomer library that
stain selectively alpha-synuclein pathological structures in human PD brain sections. Ongoing work to optimize the potency, selectivity
and pharmacokinetics of these tracers is being funded by the Michael J. Fox Foundation for Parkinson&rsquo;s Research and Biogen
under the non-exclusive research and development agreement signed in April 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Currently there are no imaging products
in the market that target alpha-synuclein. This provides us with a unique opportunity to become the market leader in alpha-synuclein
PET imaging. We believe the ability to image alpha-synuclein deposits in the brain will enable:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The diagnosis of PD at much earlier premotor stages than is now possible, thereby enabling early therapeutic intervention and
corresponding better patient outcomes;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The use of alpha-synuclein as a surrogate marker in clinical studies of novel therapeutic regimens designed to slow or halt
progression of PD; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The diagnosis of sub-populations of PD and other synucleinopathies.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">These applications of alpha-synuclein PET
imaging agents have the potential to fundamentally change the approach of treating PD and other similar diseases.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The PD market size is estimated to grow
from $3.6 billion in 2012 to approximately $5.3 billion in 2022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">License Agreements and Collaborations</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our SupraAntigen and Morphomer platforms
have generated large numbers of clinical assets that address diseases related to protein misfolding, such as AD, PD and Down syndrome.
Select key assets in the product pipeline have been licensed for upfront payments, milestones and royalties to help offset the
cost of our research and internal product development. Discussions with other companies are ongoing. We have signed a number of
licensing agreements with leading pharmaceutical companies to assist and accelerate the development of our product pipeline, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A worldwide licensing agreement with Genentech signed in November 2006 (and amended in May 2015) for crenezumab for AD, under
which we may become eligible to receive payments totaling up to approximately $340 million, excluding royalties.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A worldwide licensing agreement with Genentech signed in June 2012 for anti-tau antibodies for AD, under which we may become
eligible to receive payments potentially greater than $400 million, excluding royalties.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A worldwide licensing agreement with Janssen signed in December 2014 for therapeutic anti-tau vaccines for AD, and potentially
other tauopathies, under which we may become eligible to receive payments totaling up to CHF 500&nbsp;million, excluding royalties.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>A worldwide licensing agreement with Piramal Imaging signed in May 2014 for small molecule tau ligands for use as PET tracers
under which we may become eligible to receive payments totaling up to &euro;157&nbsp;million, excluding royalties.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In April 2016, we entered into a non-exclusive
research and development agreement with Biogen International GmbH, or Biogen to collaborate in the research and early clinical
development of our alpha-synuclein PET Tracer program for Parkinson&rsquo;s disease and other synucleinopathies, and a second program
for the identification, research and development of novel PET ligands against TDP-43, a protein recently linked to neurodegeneration
in diseases such as amyotrophic lateral sclerosis.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Genentech</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have two partnership agreements with
Genentech, a company with a reputation for scientific excellence and a history of bringing innovative protein therapeutics to market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Crenezumab Collaboration Agreement of 2006</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We signed our first agreement with Genentech
in November 2006 and amended the agreement in May 2015. This is an exclusive, worldwide licensing agreement for crenezumab, our
humanized monoclonal antibody targeting misfolded Abeta. The agreement provides for a second therapeutic product based on the same
intellectual property and anti-Abeta antibody compound, as well as an anti-Abeta diagnostic product. Genentech commenced Phase
3 clinical studies for crenezumab in the first quarter of 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the agreement with Genentech, we
may become eligible to receive payments totaling up to approximately $340 million, excluding royalties. The agreement includes
upfront and milestone payments. In addition, we will receive royalties on sales. The structure of the collaboration agreement is
as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>An upfront payment</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Clinical milestone payments</I> are payable upon commencement of each of Phase 1 and Phase 2 of clinical developments, and
upon the earlier of Genentech&rsquo;s decision to authorize Phase 3 or the commencement of Phase 3 of clinical developments. In
addition, for a second indication, clinical milestone payments would be payable upon commencement of Phase 2 of clinical developments
and upon the earlier of Genentech&rsquo;s decision to authorize Phase 3 or the commencement of Phase 3 of clinical developments.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Regulatory milestone payments</I> upon making regulatory filings in the U.S. and Europe, respectively, and milestone payments
upon obtaining marketing approval in each of the U.S. and Europe. In addition, for a second indication, additional regulatory and
approval milestones would be payable.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Royalties</I> on sales with different royalty rates applicable in the U.S. and Europe. Royalty levels are tied to annual
sales volumes. We will receive royalties on sales of crenezumab with the percentage rates ranging from net high single digits to
the mid-teens.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, we have received total payments
of $65 million which comprise upfront and clinical milestone payments. We received a $25 million upfront payment at the time of
signing of the collaboration agreement and have since then obtained three milestone payments totaling $40 million, including the
Phase 3 milestone payment we received in July 2015.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the terms of the agreement, Genentech
bears all the costs of developing crenezumab through the clinical phases. In addition, Genentech is responsible for the costs associated
with seeking and obtaining regulatory and marketing approvals, manufacturing costs, sales and marketing costs. Intellectual property
costs related to any crenezumab-related intellectual property filed solely by us and any costs associated with filing, maintaining
and protecting intellectual property filed jointly we share with Genentech. The agreement will terminate by its terms on the date
on which all obligations between the parties with respect to the payment of milestones or royalties for licensed products have
passed or expired. However, Genentech may terminate the agreement at any time by providing three months&rsquo; notice to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Anti-tau Antibody Collaboration Agreement
of 2012</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In June 2012, we entered into a
second partnership with Genentech to commercialize our anti-tau antibodies for use as immunotherapeutics. The value of this
exclusive, worldwide alliance is potentially greater than CHF 400&nbsp;million and includes upfront and milestone payments.
In addition to milestones, we will be eligible to receive royalties on sales at percentage rates ranging from the mid-single
digits to high single digits. The agreement also provides for collaboration on two additional indications built on the same
anti-tau antibody program, as well as a potential anti-tau diagnostic product.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, we have received payments totaling
CHF 45&nbsp;million, including a CHF 14&nbsp;million milestone payment recognized in the second quarter of 2016 and received in
July 2016, associated with the recent announcement of the commencement of the Phase 1 clinical study of the lead anti-tau antibody
candidate and a CHF 14 million milestone payment received in 2015 in connection with the ED-GO decision.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The structure of the collaboration agreement
is as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>An upfront payment</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Preclinical and clinical milestone payments</I> upon selection of a lead candidate, commencement of each of Phase 1, 2 and
3 of clinical development. In addition, for a second indication, clinical milestone payments would be payable upon commencement
of each of Phase 2 and 3 of clinical development.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Regulatory milestones payments</I> upon making regulatory filings for marketing approvals in the U.S., Europe, and Japan,
respectively. In addition, for a second indication, similar regulatory milestones would be payable.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Commercialization milestones</I> payable upon making a first commercial sale in each of the U.S., Europe and Japan. For
a second indication, commercialization milestones exist for each of the U.S., Europe and Japan which are triggered by the first
commercial sale for the second indication in each of those jurisdictions.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Royalties</I> on sales with royalty rates differing based on the source of the intellectual property underlying the commercial
product.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the terms of the agreement, Genentech
bears all the costs of developing the anti-tau antibody compound through the clinical phases. In addition, Genentech is responsible
for the costs associated with seeking and obtaining regulatory and marketing approvals, manufacturing costs, sales and marketing
costs. Intellectual property costs related to any anti-tau antibody-related intellectual property filed solely by us and any costs
associated with filing, maintaining and protecting intellectual property filed jointly we share with Genentech. The agreement will
terminate by its terms on the date on which all obligations between the parties with respect to the payment of milestones or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">royalties for licensed products have passed
or expired. However, Genentech may terminate the agreement at any time by providing three months&rsquo; notice to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Janssen Pharmaceuticals</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In December of 2014, we entered into a
partnership with Janssen Pharmaceuticals to develop and commercialize therapeutic anti-tau vaccines for the treatment of AD and
potentially other tauopathies. The partnership includes a worldwide exclusive license and research collaboration. We and Janssen
will co-develop the lead therapeutic vaccine candidate, ACI-35, through Phase 1b completion. From Phase 2 and onward, Janssen is
expected to assume responsibility for the clinical development, manufacturing and commercialization of ACI-35. ACI-35 is an active
therapeutic vaccine candidate stimulating the patient&rsquo;s immune system to produce a polyclonal antibody response against phosphorylated
tau protein. The agreement also allows for the collaboration to be expanded to include a second indication based on the same anti-tau
vaccine program and intellectual property related to this program.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, we have received an upfront payment
of CHF 25.9 million, a research contribution of CHF 1.5&nbsp;million and a CHF 4.9 million clinical milestone payment. We are eligible
to receive development, regulatory and commercialization milestone payments potentially totaling up to CHF 500&nbsp;million for
AD and a potential second indication outside of AD. Additionally, we will receive royalties on sales at a percentage rate ranging
from the low double digits to mid-teens. We have entered into a three-year joint research collaboration to further characterize
and develop novel vaccine therapies for the treatment of tauopathies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The structure of the collaboration agreement
is as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>An upfront payment</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Clinical milestone payments</I> upon completion of Phase 1b, commencement of each of Phase 2 and 3 of clinical development.
For a second cohort, a milestone payment is payable to us upon commencement of Phase 2 clinical studies. In addition, for a second
indication, clinical milestone payments would be payable upon commencement of Phase 3 clinical studies.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Regulatory milestone payments</I> upon making regulatory filings in the U.S., Europe, and Japan, respectively. In addition,
for a second indication, similar regulatory milestones would be payable. Also, for a second indication, additional regulatory milestone
payments are payable by Janssen to us upon receipt of each of the regulatory approvals in the U.S., Europe and Japan.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Commercialization milestones</I> payable upon making a first commercial sale in each of the U.S., Europe and Japan, and
upon achieving certain commercial milestones.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Royalties</I> on sales with royalty rates differing based on the level of annual sales.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The agreement will terminate by its terms
on the date on which all royalty obligations have been paid thereunder. However, under the terms of the agreement, Janssen may
terminate the agreement at any time after completion of the Phase 1b clinical study by providing 90 days&rsquo; notice to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Piramal Imaging</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In May 2014, we entered into our first
diagnostic partnership with Piramal Imaging, one of the world leaders in imaging products. The agreement with Piramal is for a
compound from the Morphomer chemical library that binds to pathogenic tau for use as a PET tracer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The exclusive, worldwide licensing agreement
with Piramal Imaging includes upfront and milestone payments totaling up to &euro;157&nbsp;million, plus royalties on sales at
percentage rates ranging from mid-single digits to low teens.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The structure of the collaboration agreement
is as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>An upfront payment</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Clinical milestone payments</I> upon the commencement of the Phase 1 study in PSP, commencement of Phase 2 and 3 for generation
of data intended to support a regulatory submission in the US or EU. We would be entitled to further clinical milestone payments
for the commencement of Phase 2 and 3 for a second indication</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Regulatory approval and marketing approval milestones</I> upon filing and approval in each of the U.S. and Europe</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Sales milestones</I> tied to specific net sales amounts</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The agreement will terminate by its terms
on the date of expiration of the last-to-expire royalty term, where each royalty term under the agreement expires on a product-by-product
basis and country-by-country basis on the later of (i) ten years after the first commercial sale of the relevant product in such
country or (ii) the date on which the patent covering the sale of such product in such country is no longer valid or enforceable.
However, Piramal Imaging may terminate the agreement at any time after the first eighteen months from the effective date of this
agreement by providing three months&rsquo; notice to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Alpha-synuclein and TDP-43 PET Imaging
Tracers &ndash; Collaboration with Biogen</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In April 2016, we entered into a non-exclusive
research and development agreement with Biogen International GmbH, or Biogen.&nbsp;Under the agreement, we and Biogen have agreed
to collaborate in the research and early clinical development of our alpha-synuclein PET Tracer program for Parkinson&rsquo;s disease
and other synucleinopathies, and a second program for the identification, research and development of novel PET ligands against
TDP-43, a protein recently linked to neurodegeneration in diseases such as amyotrophic lateral sclerosis. In addition, we have
agreed to share the costs of the collaboration with Biogen, with Biogen primarily funding the majority of research costs, subject
to a cap, which includes an upfront technology access fee and funding towards research and development personnel and activities.&nbsp;We
will own all intellectual property rights to any invention relating to alpha-synuclein or TDP-43 PET tracers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Unless earlier terminated, the agreement
will expire upon the later of three years or the completion of the collaboration, but in no event later than four years, unless
we and Biogen mutually agree to extend the term of the agreement.&nbsp;Biogen may terminate the agreement for any reason upon thirty
days&rsquo; written notice to us.&nbsp;Following the expiration of the agreement, we may be required to negotiate and enter into
a supply agreement with Biogen pursuant to which we would supply Biogen with PET tracers created under the collaboration for Biogen&rsquo;s
continued development activities.&nbsp;Under certain circumstances, including prior to the expiration of the collaboration agreement,
we may also be required to grant Biogen a license or other rights to develop and commercialize such PET tracers outside of the
collaboration.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">National Institutes of Health/Banner
Alzheimer&rsquo;s Institute</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2013, the NIH and Banner Alzheimer&rsquo;s
Institute selected crenezumab for the first ever AD prevention study before onset of symptoms in highest-risk individuals. This
landmark study is being performed on a family clan in Colombia with Paisa mutation leading to Abeta accumulation and early onset
AD. The $100 million multi-year study is being funded with grants from the NIH, Banner Alzheimer&rsquo;s Institute and our partner,
Genentech.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Michael J. Fox Foundation for Parkinson&rsquo;s
Research</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2015, we were awarded an important grant
from the Michael J. Fox Foundation for Parkinson&rsquo;s Research (MJFF). The grant is funding the development of a diagnostic
imaging agent capable of detecting PD at an early stage. The project focuses on alpha-synuclein PET tracers. We have identified
molecules from our Morphomer library that stain selectively alpha-synuclein pathological structures in human PD brain sections.
We are optimizing the potency, selectivity and pharmacokinetics of these tracers and expect to select a lead candidate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Nestl&eacute; Institute of Health Sciences
SA</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In September 2015, we entered into a research
collaboration agreement with the Nestl&eacute; Institute of Health Sciences SA, or NIHS, a fundamental research institute of the
global nutrition, health and wellness company Nestl&eacute;, to develop a novel, minimally invasive tau diagnostic assay for the
early diagnosis of AD. Under the terms of the agreement, we will provide expertise in the biology and pathology of tau as well
as commit our laboratory</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">capabilities to support the collaborative
research program. NIHS will apply its proprietary multiplexed antibody technology platform to the research program with the goal
of identifying and validating a highly sensitive diagnostic assay for the detection of tau in human cerebrospinal fluid and blood
plasma.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Competition</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The biopharmaceuticals industry is highly
competitive across all therapeutic fields. In the field of neurodegenerative diseases, there are many public and private companies
or institutions that are actively engaged in the discovery and development of therapeutic and diagnostic products. Some of these
products may have a similar target to our product candidates or address similar markets. The industry is still in its infancy in
terms of defining the pathology of neurodegenerative diseases. As disease understanding progresses, the number of novel product
candidates may well increase and broaden the therapeutic and diagnostic options in our product markets.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Currently, there are no approved disease-modifying
products for AD or any other neurodegenerative disease. Current approved therapies seek to treat the symptoms of AD, such as cognitive
decline, but do not slow or stop the progression of the disease. In addition, commonly, there is off-label prescription of antidepressant
and antipsychotic agents for more advanced AD patients who may suffer from agitation, aggressive behaviors, psychosis and depression.
No new drugs have been approved for the treatment of AD since 2003.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We expect there to be several classes of
disease-modifying agents that will enter the AD market. One such class is monoclonal antibodies that target Abeta plaques, the
same target as for our candidate product crenezumab. Another target for monoclonal antibodies is pathological tau protein. Therapeutic
vaccines are a second class of disease-modifying therapies, and include our candidate products ACI-24, that targets Abeta plaque,
and ACI-35, that targets aggregated tau protein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The availability of novel diagnostic agents
to visualize the disease development in AD patients is critical for successful clinical development of disease-modifying products
in AD. At the forefront of this new diagnostic effort are PET agents for in-life imaging of disease, and in particular, tau-targeting
PET agents which we believe will allow precise assessment of disease AD patients.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Crenezumab:</I></B> If crenezumab is approved, it would compete with other monoclonal antibody products that target Abeta
plaques and act as disease-modifying agents. Currently, no product has been approved that is a disease-modifying agent targeting
Abeta plaques; however, two such product candidates are in clinical development. These are gantenerumab and aducanumab, each of
which is in Phase 3 clinical study and which are being advanced by Roche and Biogen, respectively. Roche&rsquo;s collaboration
partner MorphoSys also announced in March 2017 that Roche plans to initiate Phase 3 program for gantenerumab in patients with prodromal
to mild AD. Biogen has a second product candidate known as BAN2401, which is currently in Phase 2 clinical study. Aducanumab received
Fast Track designation from the FDA in 2016 as did crenezumab in 2008.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>ACI-24 in AD:</I></B> ACI-24, if approved, would compete with other approved anti-Abeta-targeting therapeutic vaccines.
Several potential competing product candidates have not continued through the regulatory approval process, including ACC-001 (Janssen
/ Pfizer) and AN-1792 (Elan / Janssen), both of which were discontinued after completing Phase 2 studies. Other potential competing
product candidates for ACI-24 include ABvac 40 (Araclon Bioscience) which has completed a Phase 1 study and CAD-106 (Novartis International
AG), which has completed a Phase 2 study.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>ACI-24 in Down syndrome:</I></B> ACI-24 is the first disease-modifying vaccine candidate addressing AD in Down syndrome,
with a potential preventive and therapeutic application. While there are symptomatic treatments of Down syndrome in clinical development,
to our knowledge there are no other disease-modifying treatments for AD in Down syndrome.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>ACI-35:</I></B> ACI-35, if approved, would compete with other approved tau-targeting therapeutic vaccines. This includes
AADVAC1, being advanced by Axon Neuroscience. It is an anti-tau vaccine product candidate and is currently in a Phase 2 clinical
trial to examine safety and efficacy in patients with mild AD.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Anti-tau Antibodies:</I></B> The anti-tau monoclonal antibody BMS-986168 (Bristol-Myers Squibb Company) is currently
in Phase 1 clinical development in the orphan indication PSP, a tau protein-based</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">neurodegenerative disease. In the
fourth quarter of fiscal year 2016 ABBV-812E (Abbvie) entered into Phase 2 clinical studies in PSP and in early stage AD.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Anti-tau Morphomers:</I></B> A potential competitor to our anti-tau Morphomers is LMTX (also known as TRx0237). LMTX
is a methylene blue derivative that is being advanced by TauRx Therapeutics and is intended to target tau protein aggregation.
LMTX entered Phase 3 clinical study in September 2012. In the third quarter of fiscal year 2016 it was announced that LMTX failed
to slow cognitive or functional decline in mild to moderate AD.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><B><I>Diagnostics:</I></B> Currently, there are no approved tau PET imaging products. However, should our tau PET imaging agent
be approved, it would compete with other approved tau-PET agents. These include (i)&nbsp;Flortaucipir (previously known as F-AV-1451
or T807), which is being advanced by Eli Lilly and is currently in Phase 3 clinical studies, (ii)&nbsp;THK-5351, is being advanced
by GE Healthcare under license from the Tohoku University School of Medicine and is currently in Phase 1 studies, (iii)&nbsp;PBB3,
a product candidate in Phase 1 studies and being advanced by the National Institute of Radiological Services, (iv)&nbsp;Roche is
evaluating internal tau PET imaging ligands in Phase 1 clinical studies in AD patients, (v) Genentech is developing F-GTP1 in Phase
1 studies and (vi) Merck is evaluating F-MK-6240 in Phase 1 clinical trials.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Many of our competitors have significantly
greater financial, technical and human resources than we have available. Mergers and acquisitions in the pharmaceutical and biotechnology
industries may result in even more resources being concentrated among a smaller number of our competitors. Our commercial opportunity
and our success will be based in part on our ability to identify, develop and manage a portfolio of product candidates that are
safer and more effective than competing products. However, this opportunity could be eroded or even eliminated if our competitors
develop and/or market products that are novel and have superior safety and efficacy profiles, that may be brought to the market
more rapidly due to greater available resources, or that are less costly than our current or future product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Commercialization Strategy</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our strategy to date has been to focus
on identifying partnerships for our early stage product candidates as both a way to secure non-dilutive capital to fund our other
research and development programs but also as a way to accelerate the development of these partnered products by leveraging our
partners&rsquo; extensive knowledge in clinical studies, drug development, manufacturing and commercialization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">With greater financial resources at our
disposal but also given the significant knowledge acquired by our scientists and scientific leadership, we intend to retain selected
promising product candidates in-house for a longer period of time and fund their development from our own resources. This will
allow us to generate greater value from these product candidates, allowing us to demand more significant terms from a prospective
partner. For example, our current plan is to retain full control of our two Abeta vaccine programs focused on AD and Down syndrome,
meaning that we would fund the planned Phase 2 and Phase 2/3 studies, respectively, from our financial resources. In the field
of diagnostics, the parallel development of therapeutic compounds and companion diagnostics is of growing importance to the pharmaceutical
industry. The development timeframe of a PET diagnostic agent is significantly shorter than for a therapeutic product providing
the prospect for potential diagnostic product revenues to be realized quicker than potential therapeutic product revenues. Our
Morphomer platform is particularly well suited to generate molecules for use in the development of companion diagnostics.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Given our current stage of product development,
we currently do not have a commercialization infrastructure. If any of our diagnostic product candidates is granted marketing approval,
we intend to focus our initial commercial efforts in the United States and select European markets, which we believe represent
the largest market opportunities for us. In those markets, we expect our commercial operations to include our own specialty sales
force that will target neurologists and gerontologists, both in hospitals and in private practice. In other markets, we expect
to seek partnerships that would maximize our products&rsquo; commercial potential.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Intellectual Property</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We strive to protect the proprietary technology
that we believe is important to our business, including seeking and maintaining U.S. and foreign patents intended to cover our
products and compositions, their methods of use and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">processes for their manufacture, as well as
our proprietary technology platforms, diagnostic candidates, and any other inventions that are commercially important to the development
of our business. We also rely on trade secrets and know-how to protect aspects of our business that are not amenable to, or that
we do not consider appropriate for, patent protection.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our success will significantly depend on
our ability to obtain and maintain patent and other proprietary protection for commercially important technology, inventions and
know-how related to our business, defend and enforce patents, preserve the confidentiality of our trade secrets and operate our
business without infringing any patents and other intellectual property or proprietary rights of third parties. See the section
titled &ldquo;Risk Factors&mdash; Risks Related to Intellectual Property&rdquo; for additional information.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of February 1, 2017 we owned or co-owned
approximately 23 issued U.S. patents and 198 issued patents in other jurisdictions, as well as 19 pending U.S. patent applications
and 282 pending foreign patent applications. As of February 1, 2017 we licensed approximately 13 issued U.S. patents and 13 pending
U.S. patent applications, as well as 131 issued patents in other jurisdictions and 222 pending foreign patent applications.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The patent portfolios for our three most
advanced product candidates as of February 1, 2017 are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Crenezumab</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our patent portfolio relating to crenezumab
includes patents and patent applications with claims directed to composition of matter (including claims directed to the crenezumab
antibody or a fragment thereof, a polynucleotide encoding the crenezumab antibody or a fragment thereof, a cell line used to produce
the crenezumab antibody as well as pharmaceutical compositions comprising the crenezumab antibody), claims directed to treating
certain indications using the crenezumab antibody including AD, claims directed to a method of manufacturing the crenezumab antibody,
and claims directed to diagnostic and prognostic uses of the crenezumab antibody.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our patent portfolio relating to crenezumab
includes patents and patent applications that we own or co-own in four different patent families. As of February 1, 2017, we owned
or co-owned approximately 24 patents (not including the patents in the individual countries where the issued European patent was
validated) and 38 patent applications in 34 countries in our main patent family directed to the crenezumab antibody and methods
of using the crenezumab antibody to treat certain indications, including AD. This patent portfolio includes three issued U.S. patents
and one pending U.S. patent application, which, if the appropriate maintenance or other governmental fees are paid, are expected
to expire in 2027, excluding any additional term for patent term adjustments or patent term extensions. This patent portfolio also
includes a PCT patent application which was filed on July 13, 2007. If the appropriate maintenance, renewal, annuity, or other
governmental fees are paid, national stage applications issuing from this PCT patent application, are expected to expire in 2027,
excluding any additional term for patent term adjustments or patent term extensions, as applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">ACI-24</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our patent portfolio for ACI-24 includes
composition of matter claims (including claims directed to the ACI-24 antigenic construct) claims directed to treating certain
indications using ACI-24 including AD, and claims directed to using ACI-24 to induce an immune response.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our patent portfolio for ACI-24 consists
of approximately 24 issued patents and 10 pending patent applications in 30 countries. With respect to the U.S., we own two issued
U.S. patents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The patents in this patent portfolio claim
the benefit of a PCT application with a filing date of December&nbsp;8, 2006. The issued patents in this patent portfolio, if the
appropriate maintenance, renewal, annuity or other governmental fees are paid, are expected to expire in 2026, excluding any additional
term for patent term adjustments or patent term extensions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">ACI-35</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our patent portfolio for ACI-35 includes
composition of matter claims (including claims directed to the ACI-35 antigenic peptide and a pharmaceutical composition comprising
such an antigenic peptide), claims directed to</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">treating certain indications using ACI-35
including AD, and claims directed to using ACI-35 to induce an immune response.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our patent portfolio for ACI-35 consists
of approximately 16 issued patents and 14 pending patent applications in 27 countries. With respect to the U.S., we own one issued
U.S. patent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The patents in this patent portfolio claim
the benefit of a PCT application with a filing date of April&nbsp;1, 2010. The issued patents in this patent portfolio, if the
appropriate maintenance, renewal, annuity or other governmental fees are paid, are expected to expire in 2030, excluding any additional
term for patent term adjustments or patent term extensions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Manufacturing and Supply</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Background</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The manufacturing and supply of the clinical
study materials are currently done in collaboration with our collaboration partners ( <I>e.g.</I> , Genentech in the case of crenezumab
and anti-tau antibodies and Piramal Imaging in the case of tau PET imaging) or contract manufacturing organizations ( <I>e.g.</I>
, for ACI-35 and ACI-24) for the supply of raw materials, drug substances and drug products.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have an established standard operating
procedure to properly select the contract manufacturing organization to which the manufacturing tasks will be assigned. In the
assessment, we consider the availability of the technical skills necessary to support the project, the business and commercial
aspects related to the collaboration and the compliance of our providers with local and international regulations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Collaboration Partners and Contract Manufacturing
Organizations</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Genentech, a leading biotech company with
extensive experience in developing, producing and distributing products worldwide from pre-clinical to commercial stages of development,
manufactures and supplies clinical study materials for crenezumab and anti-tau antibodies. Tau-PET imaging compounds are produced
in collaboration with Piramal, a well-established Indian company with a strong chemical background supported by an India based
contract manufacturing organization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">ACI-24 and ACI-35 APIs (active pharmaceutical
ingredients) are produced by Bachem AG, which is an experienced company specialized in manufacturing synthetic peptides and based
in Switzerland. Drug products for the advancement of ACI-24 are manufactured by Polymun GmbH, a company based in Austria with significant
experience in developing and producing Liposomal formulations, while drug products for the advancement of ACI-35 are produced by
Evonik Canada Inc., a company based in Canada with a strong and long experience in the field of liposomal formulation and production.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Compliance with Governing Rules and Quality
Requirements</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The facilities used by our collaboration
partners and contract manufacturing organizations to manufacture our product candidates are systematically audited by local authorities
and occasionally inspected by competent authorities where the clinical studies are ongoing. The facilities where the commercial
productions are performed must be approved by the FDA or other relevant regulatory authorities pursuant to inspections that are
conducted after we submit our NDA or comparable marketing applications. We perform periodic quality audits of the manufacturing
facilities and contract manufacturing organizations to monitor their compliance with the regional laws, regulations and applicable
cGMP standards and other laws and regulations, such as those related to environmental health and safety matters. The scope of our
audits also involves monitoring the ability of our providers to maintain adequate quality controls and quality assurance systems
including personnel qualification.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">After manufacturing, our products are submitted
to extensive characterization and quality control testing plans performed by using properly developed analytical methods that are
qualified or validated; this ensures the accuracy of the results generated and provides evidence of the quality of our products.
In addition, our products are submitted to detailed and standardized stability programs aimed at demonstrating the stability during
the storage period; this, while it guarantees the safety of the products, supports the definition of a suitable supply chain that
may encompass the distribution of the products in different continents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Contractual framework</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have established, with each contract
manufacturing organization supplying drug substances or drug products, quality agreements and master service agreements. Quality
agreements define the quality standards required to develop, produce and supply the product. Quality agreements also define the
responsibilities related to the collaboration with regards to the quality related aspects. Master service agreements define the
framework under which the quality agreements operate. Any failure to achieve and maintain compliance with the laws, regulations
and standards, suspension of the manufacturing of our product candidates or revoke of cGMP permissions which would adversely affect
our business and reputation are defined in the master service agreements and quality agreements. The risk that any third-party
providers may breach the agreements they have with us because of factors beyond our control and the possibility they may also terminate
or refuse to renew their agreements because of their own financial difficulties or business priorities, potentially at a time that
is costly or otherwise inconvenient for us is managed by us with constant investments toward maintaining reserve stocks and in-depth
process know-how. The latter is supported by continuous in-house process development and production activities of small-scale/research
grade materials that may offer the chance to rapidly identify alternative contract manufacturers to which the manufacturing process
could be transferred providing continuity for the clinical study.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Interaction with collaboration partners
and contract manufacturing organizations</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Finally, our partnership with contract
manufacturing organizations is managed through an efficient project management platform in which teams are formed with the representatives
of each key function from both parties. Meetings occur either by telephone conferences aimed at updating short term actions or
face-to-face when mid-long term development plans are discussed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Government Regulation and Our Regulatory Department</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our regulatory department has a strong
culture of regulatory compliance, operating under three guiding principles, to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Provide constructive regulatory input for development products.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Ensure smooth regulatory approvals by anticipating hurdles.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Build confidence with regulators by continuous communication.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The quality assurance group is included
within the regulatory department with the mission to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Create and maintain a corporate quality management system.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Ensure GCP, GMP, GLP and GDP compliance.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A science driven approach is the cornerstone
of our interactions and this has helped us to build and maintain a high level of trust with regulators. Besides informal conversations
with the authorities, our regulatory department has conducted several pre-IND meetings with the FDA (ACI-24 for AD and Down syndrome,
and tau-PET Imaging) and six Scientific Advice meetings, which are the European equivalent of pre-IND meetings (with German BfArM,
Swedish Medical Products Agency; Medicine &amp; Healthcare Products Regulatory Agency (UK), Finnish Medicines Agency, and the European
Medicines Agency). Since 2008, our regulatory department has filed a total of six clinical study applications in the EU (Germany,
Austria, Denmark, Sweden, UK and two in Finland) and one IND in the US. Given the seriousness of AD and public pressure for new
therapeutics, we consider regulatory agencies to be important stakeholders in our clinical studies. We are committed to working
closely with world regulatory authorities to adhere to and achieve the highest levels of safety in the most timely and efficient
manner. The transparency we have achieved and our goal of a close working relationship with the regulatory agencies, in particular
the FDA, are intended to facilitate expeditious execution through the regulatory approval process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our regulatory department contains a quality
assurance (QA) group. As every quality issue ultimately requires regulatory involvement and input, this approach is intended to
lead to rapid resolution of issues and ensure full compliance to satisfy both the reviewers and the inspectors at the government
health authorities. Our regulatory department is charged with keeping our entire organization directly or indirectly involved in
the clinical study application process in a state of &ldquo;inspection readiness.&rdquo; To that end, we ensure that the Trial
Master Files are</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">complete and regularly updated. Our regulatory
department is also tasked with generating our annual quality plan. The personnel tasked with QA have issued a set of approximately
30 standard operating procedures and continuously train the relevant staff. Our QA personnel conduct regular audits, including
in-person audits of the contract manufacturers, contract research organizations and laboratories conducting primary end-point analysis.
In addition, we have recently added a corporate documentation specialist to ensure good documentation practice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Product Approval Process</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The clinical studies, manufacturing, labeling,
storage, distribution, record keeping, advertising, promotion, import, export and marketing, among other things, of our product
candidates are subject to extensive regulation by governmental authorities in the United States and other countries. The U.S. Food
and Drug Administration, or FDA, under the Federal Food, Drug, and Cosmetic Act, or FDCA, regulates pharmaceutical products in
the United States. The steps required before a drug may be approved for marketing in the United States generally include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the completion of pre-clinical laboratory tests and animal tests conducted under Good Laboratory Practice, or GLP, regulations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the submission to the FDA of an Investigational New Drug, or IND, application for human clinical testing, which must become
effective before human clinical studies commence;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>obtaining a positive opinion from the Ethics Committee (Europe) / Institutional Review Board (United States) to commence study
on human subjects;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the performance of adequate and well-controlled human clinical studies to establish the safety and efficacy of the product
candidate for each proposed indication and conducted in accordance with current Good Clinical Practice, or cGCP, requirements;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>pre-New Drug Application (NDA) submission meeting with FDA (highly recommended);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the submission to the FDA of a NDA;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the FDA&rsquo;s acceptance of the NDA;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>satisfactory completion of an FDA Pre-Approval Inspection (PAI) of the manufacturing facilities at which the product is made
to assess compliance with current Good Manufacturing Practice, or cGMP, requirements;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the FDA&rsquo;s review and approval of an NDA prior to any commercial marketing or sale of the drug in the United States; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>having a parallel scientific advice from the European Medicines Agency or Health-Technology-Assessment body where the payors
are involved at the outset (Phase 2), which is intended to facilitate the design of clinical studies to primarily target populations
with a high chance of obtaining reimbursement and accelerate the process of time-to-reimbursement.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The FDA has various programs, including
fast track, priority review, accelerated approval, and breakthrough therapy designation, that are intended to increase agency interactions,
expedite or facilitate the process for reviewing drug candidates, and/or provide for initial approval on the basis of surrogate
endpoints. We believe that one or more of our product candidates may qualify for some of these expedited development and review
programs. Even if a drug candidate qualifies for one or more of these programs, the FDA may later decide that the drug candidate
no longer meets the conditions for qualification.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Fast Track program is intended to expedite
or facilitate the process for reviewing new drugs that meet certain criteria. Specifically, new drugs are eligible for Fast Track
designation if they are designed to treat a serious or life-threatening condition and demonstrate the potential to address unmet
medical needs for the condition. Fast Track designation applies to the combination of the product and the specific indication for
which it is being studied. The sponsor of a new drug may request the FDA to designate the drug as a Fast Track product at any time
during the clinical development of the product. AD, for example, meets both pre-requisites&mdash;it is life-threatening and</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">constitutes an unmet medical need. Unique
to a Fast Track product, the FDA may consider for review sections of the marketing application on a rolling basis before the complete
application is submitted, if the sponsor provides a schedule for the submission of the sections of the application, the FDA agrees
to accept sections of the application and determines that the schedule is acceptable, and the sponsor pays any required user fees
upon submission of the first section of the application.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any product submitted to the FDA for marketing,
including under a Fast Track program, may be eligible for other types of FDA programs intended to expedite development and review,
such as priority review and accelerated approval. Any product is eligible for priority review if it has the potential to provide
safe and effective therapy where no satisfactory alternative therapy exists or a significant improvement in the treatment, diagnosis
or prevention of a disease compared to marketed products. The FDA will attempt to direct additional resources to the evaluation
of an application for a new drug designated for priority review in an effort to facilitate the review. Additionally, a product
may be eligible for accelerated approval. Drug candidates studied for their safety and effectiveness in treating serious or life-threatening
illnesses and that provide meaningful therapeutic benefit over existing treatments may receive accelerated approval, which means
that they may be approved on the basis of adequate and well-controlled clinical studies establishing that the product has an effect
on a surrogate endpoint that is reasonably likely to predict a clinical benefit, or on the basis of an effect on a clinical endpoint
other than survival or irreversible morbidity. As a condition of approval, the FDA may require that a sponsor of a drug receiving
accelerated approval perform adequate and well-controlled post-marketing clinical studies. Failure to conduct required post-approval
trials, or the inability to confirm a clinical benefit during post-marketing trials, may allow the FDA to withdraw the drug from
the market on an expedited basis. In addition, the FDA currently requires as a condition for accelerated approval pre-approval
of promotional materials, which could adversely impact the timing of the commercial launch of the product. Fast Track designation,
priority review and accelerated approval do not change the standards for approval but may expedite the development or approval
process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Food and Drug Administration Safety
and Innovation Act of 2012 also amended the FDCA to require FDA to expedite the development and review of a breakthrough therapy.
A drug can be designated as a breakthrough therapy if it is intended to treat a serious or life-threatening disease or condition
and preliminary clinical evidence indicates that it may demonstrate substantial improvement over existing therapies on one or more
clinically significant endpoints. A sponsor may request that a drug be designated as a breakthrough therapy at any time during
the clinical development of the product. If so designated, FDA shall act to expedite the development and review of the product&rsquo;s
marketing application, including by meeting with the sponsor throughout the product&rsquo;s development, providing timely advice
to the sponsor to ensure that the development program to gather nonclinical and clinical data is as efficient as practicable, involving
senior managers and experienced review staff in a cross-disciplinary review, assigning a cross-disciplinary project lead for the
FDA review team to facilitate an efficient review of the development program and to serve as a scientific liaison between the review
team and the sponsor, and taking steps to ensure that the design of the clinical trials is as efficient as practicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The testing and approval process requires
substantial time, effort and financial resources, and the receipt and timing of any approval is uncertain. Given this paradigm,
AD has been given a Life Threatening Disease status by the FDA and therefore AD therapies are eligible for the expanded access
program for investigational drugs and other pathways like Breakthrough Therapy, Accelerated Approval and Priority Review. Also,
a single well-designed, well-conducted pivotal clinical study could be sufficient to trigger market approval pending a successful
PAI.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pre-clinical studies include laboratory
evaluations of the product candidate, as well as animal studies to assess the potential safety and efficacy of the product candidate.
The results of the pre-clinical studies, together with manufacturing information and analytical data, are submitted to the FDA
as part of the IND, which must become effective before clinical studies may be commenced. The IND will become effective automatically
30 days after receipt by the FDA, unless the FDA raises concerns or questions about the conduct of the studies as outlined in the
IND prior to that time. In this case, the IND sponsor and the FDA must resolve any outstanding concerns before clinical studies
can proceed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Clinical studies involve the administration
of the product candidates to healthy volunteers or patients with the disease to be treated under the supervision of a qualified
principal investigator. Clinical studies are conducted under protocols detailing, among other things, the objectives of the study,
the parameters to be used in monitoring safety, and the efficacy criteria to be evaluated. A protocol for each clinical study and
any subsequent protocol amendments must be submitted to the FDA as part of the IND. Further, each clinical study must be reviewed
and approved by an independent institutional review board, or IRB, either centrally or individually at each institution at which
the</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">clinical study will be conducted. The IRB
will consider, among other things, ethical factors, the safety of human subjects and the possible liability of the institution.
There are also requirements governing the reporting of ongoing clinical studies and clinical study results to public registries.
The FDA, the IRB or the clinical study sponsor may suspend or terminate clinical studies at any time on various grounds, including
a finding that the subjects or patients are being exposed to an unacceptable health risk. Additionally, some clinical studies are
overseen by an independent group of qualified experts organized by the clinical study sponsor, known as a data safety monitoring
board or committee. This group provides authorization for whether or not a study may move forward at designated check points based
on access to certain data from the study. We may also suspend or terminate a clinical study based on evolving business objectives
and/or competitive climate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Clinical studies are typically conducted
in three sequential phases prior to approval, but the phases may overlap. These phases generally include the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Phase 1.&#9;Phase 1 clinical studies represent
the initial introduction of a product candidate into human subjects, frequently healthy volunteers. In Phase 1, the product candidate
is usually tested for safety, including adverse effects, dosage tolerance, absorption, distribution, metabolism, excretion and
pharmacodynamics.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Phase&nbsp;2.&#9;Phase 2 clinical studies
usually involve studies in a limited patient population to (1) evaluate the efficacy of the product candidate for specific indications,
(2) determine dosage tolerance and optimal dosage and (3) identify possible adverse effects and safety risks.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Phase&nbsp;3.&#9;If a product candidate
is found to be potentially effective and to have an acceptable safety profile in Phase 2 studies, the clinical study program will
be expanded to Phase 3 clinical studies to further demonstrate clinical efficacy, optimal dosage and safety within an expanded
patient population at geographically dispersed clinical study sites.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Phase 4 clinical studies are conducted
after approval to gain additional experience from the treatment of patients in the intended therapeutic indication and to document
a clinical benefit in the case of drugs approved under accelerated approval regulations, or when otherwise requested by the FDA
in the form of post-market requirements or commitments. Failure to promptly conduct any required Phase 4 clinical studies could
result in withdrawal of approval.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The results of pre-clinical studies and
clinical studies, including negative or ambiguous results as well as positive findings, together with detailed information on the
manufacture, composition and quality of the product, are submitted to the FDA in the form of an NDA requesting approval to market
the product. The NDA must be accompanied by a significant user fee payment. The FDA has substantial discretion in the approval
process and may refuse to accept any application or decide that the data is insufficient for approval and require additional pre-clinical,
clinical or other studies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We estimate that it generally takes 10
to 15 years, or possibly longer, to discover, develop and bring to market a new pharmaceutical product in the United States. Several
years may be needed to complete each phase, including discovery, preclinical, Phase 1, 2 or 3, or marketing authorization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, under the Pediatric Research
Equity Act, or PREA, an NDA or supplement to an NDA must contain data to assess the safety and effectiveness of the drug for the
claimed indications in all relevant pediatric subpopulations and to support dosing and administration for each pediatric subpopulation
for which the product is safe and effective. Recently, the Food and Drug Administration Safety and Innovation Act, or FDASIA, which
was signed into law on July&nbsp;9, 2012, amended the FDCA. FDASIA requires that a sponsor who is planning to submit a marketing
application for a drug or biological product that includes a new active ingredient, new indication, new dosage form, new dosing
regimen or new route of administration submit an initial Pediatric Study Plan, within sixty days of an end-of-phase 2 meeting or
as may be agreed between the sponsor and FDA. The initial Pediatric Study Plan must include an outline of the pediatric study or
studies that the sponsor plans to conduct, including study objectives and design, age groups, relevant endpoints and statistical
approach, or a justification for not including such detailed information, and any request for a deferral of pediatric assessments
or a full or partial waiver of the requirement to provide data from pediatric studies along with supporting information. FDA and
the sponsor must reach agreement on the Pediatric Study Plan. A sponsor can submit amendments to an agreed-upon initial Pediatric
Study Plan at any time if changes to the pediatric plan need to be considered based on data collected from nonclinical studies,
early phase clinical trials, and/or other clinical development programs.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The cost of preparing and submitting an
NDA is substantial. Under federal law, NDAs are subject to substantial application user fees and the sponsor of an approved NDA
is also subject to annual product and establishment user fees. Under the Prescription Drug User Fee Act, or PDUFA, as amended,
each NDA must be accompanied by a user fee. The FDA adjusts the PDUFA user fees on an annual basis. According to the FDA&rsquo;s
fee schedule, effective through September 30, 2017, the user fee for each NDA application requiring clinical data is $2,038,100.
PDUFA also imposes an annual product fee for drugs ($97,750), and an annual establishment fee ($512,200) on facilities used to
manufacture prescription drugs. Fee waivers or reductions are available in certain circumstances, including a waiver of the application
fee for the first application filed by a small business. Additionally, no user fees are assessed on NDAs for products designated
as orphan drugs, unless the product also includes a non-orphan indication.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Once the NDA submission has been submitted,
the FDA has 60 days after submission of the NDA to conduct an initial review to determine whether it is sufficient to accept for
filing. Under the Prescription Drug User Fee Act, or PDUFA, the FDA sets a goal date by which it plans to complete its review.
This is typically 12 months from the date of submission of the NDA application. The review process is often extended by FDA requests
for additional information or clarification. Before approving an NDA, the FDA will inspect the facilities at which the product
is manufactured and will not approve the product unless the manufacturing facility complies with cGMPs and may also inspect clinical
study sites for integrity of data supporting safety and efficacy. The FDA may also convene an advisory committee of external experts
to provide input on certain review issues relating to risk, benefit and interpretation of clinical study data. The FDA is not bound
by the recommendations of an advisory committee, but generally follows such recommendations in making its decisions. The FDA may
delay approval of an NDA if applicable regulatory criteria are not satisfied and/or the FDA requires additional testing or information.
The FDA may require post-marketing testing and surveillance to monitor safety or efficacy of a product.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">After the FDA evaluates the NDA and conducts
inspections of manufacturing facilities where the drug product and/or its API will be produced, it may issue an approval letter
or a Complete Response Letter. An approval letter authorizes commercial marketing of the drug with specific prescribing information
for specific indications. A Complete Response Letter indicates that the review cycle of the application is complete and the application
is not ready for approval. A Complete Response Letter may require additional clinical data and/or an additional pivotal Phase 3
clinical study(ies), and/or other significant, expensive and time-consuming requirements related to clinical studies, pre-clinical
studies or manufacturing. Even if such additional information is submitted, the FDA may ultimately decide that the NDA does not
satisfy the criteria for approval. The FDA could also approve the NDA with a Risk Evaluation and Mitigation Strategy, or REMS,
plan to mitigate risks, which could include medication guides, physician communication plans, or elements to assure safe use, such
as restricted distribution methods, patient registries and other risk minimization tools. The FDA also may condition approval on,
among other things, changes to proposed labeling, development of adequate controls and specifications, or a commitment to conduct
one or more post-market studies or clinical studies. Such post-market testing may include Phase 4 clinical studies and surveillance
to further assess and monitor the product&rsquo;s safety and effectiveness after commercialization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Special Protocol Assessment</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The FDA and an IND sponsor may agree in
writing on the design and size of clinical studies intended to form the primary basis of a claim of effectiveness in an NDA. This
process is known as a special protocol assessment, or SPA. Upon a specific request for a SPA by an IND sponsor, the FDA will evaluate
the protocol. If a SPA agreement is reached, however, it is not a guarantee of product approval by the FDA or approval of any permissible
claims about the product. The FDA retains significant latitude and discretion in interpreting the terms of the SPA agreement and
the data and results from any study that is the subject of the SPA agreement. In particular, the SPA agreement is not binding on
the FDA if previously unrecognized public health concerns later come to light, other new scientific concerns regarding product
safety or efficacy arise, the IND sponsor fails to comply with the protocol agreed upon, or the relevant data, assumptions, or
information provided by the IND sponsor when requesting a SPA agreement change, are found to be false statements or misstatements,
or are found to omit relevant facts. A SPA agreement may not be changed by the sponsor or the FDA after the study begins except
with the written agreement of the sponsor and the FDA, or if the FDA determines that a substantial scientific issue essential to
determining the safety or effectiveness of the drug was identified after the testing began.</P>

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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Orphan Drug Designation</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the Orphan Drug Act, the FDA may
grant orphan designation to a drug or biological product intended to treat a rare disease or condition, which is a disease or condition
that affects fewer than 200,000 individuals in the US, or if it affects more than 200,000 individuals in the US there is no reasonable
expectation that the cost of developing and making a drug product available in the US for this type of disease or condition will
be recovered from sales of the product. Orphan product designation must be requested before submitting an NDA. After the FDA grants
orphan product designation, the identity of the therapeutic agent and its potential orphan use are disclosed publicly by the FDA.
Orphan product designation does not convey any advantage in or shorten the duration of the regulatory review and approval process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If a product that has orphan designation
subsequently receives the first FDA approval for the disease or condition for which it has such designation, the product is entitled
to orphan product exclusivity, which means that the FDA may not approve any other applications to market the same drug or biological
product for the same indication for seven years, except in limited circumstances, such as a showing of clinical superiority to
the product with orphan exclusivity. The designation of such drug also entitles a party to financial incentives such as opportunities
for grant funding towards clinical study costs, tax advantages and user-fee waivers. Competitors, however, may receive approval
of different products for the indication for which the orphan product has exclusivity or obtain approval for the same product but
for a different indication for which the orphan product has exclusivity. Orphan product exclusivity also could block the approval
of one of our products for seven years if a competitor obtains approval of the same drug or biological product as defined by the
FDA or if our drug candidate is determined to be contained within the competitor&rsquo;s product for the same indication or disease.
If a drug product designated as an orphan product receives marketing approval for an indication broader than what is designated,
it may not be entitled to orphan product exclusivity. Orphan drug status in the European Union has similar but not identical benefits
in that jurisdiction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Disclosure of Clinical Trial Information</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Sponsors of clinical trials (other than
Phase 1 trials) of FDA-regulated products, including drugs, are required to register and disclose certain clinical trial information.
Information related to the product, comparator, patient population, phase of investigation, trial sites and investigators and other
aspects of the clinical trial is made public as part of the registration. Sponsors are also obligated to disclose the results of
their clinical trials after completion. Disclosure of the results of certain trials may be delayed until the new product or new
indication being studied has been approved. However, there are evolving rules and increasing requirements for publication of trial-related
information, and it is possible that data and other information from trials involving drugs that never garner approval could in
the future be required to be disclosed. In addition, publication policies of major medical journals mandate certain registration
and disclosures as a pre-condition for potential publication, even when this is not presently mandated as a matter of law. Competitors
may use this publicly available information to gain knowledge regarding the progress of development programs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Post-Approval Requirements</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Drugs manufactured or distributed pursuant
to FDA approvals are subject to pervasive and continuing regulation by the FDA, including, among other things, requirements relating
to recordkeeping, periodic reporting, product distribution, advertising and promotion and reporting of adverse experiences with
the product. After approval, most changes to the approved product, such as adding new indications or other labeling claims are
subject to prior FDA review and approval. There also are continuing, annual user fee requirements for any marketed products and
the establishments at which such products are manufactured, as well as new application fees for supplemental applications with
clinical data.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, drug manufacturers and other
entities involved in the manufacture and distribution of approved drugs are required to register their establishments with the
FDA and state agencies, and are subject to periodic unannounced inspections by the FDA and these state agencies for compliance
with cGMP requirements. Changes to the manufacturing process are strictly regulated and often require prior FDA approval before
being implemented. FDA regulations also require investigation and correction of any deviations from cGMP and impose reporting and
documentation requirements upon the sponsor and any third-party manufacturers that the sponsor may decide to use. Accordingly,
manufacturers must continue to expend time, money, and effort in the area of production and quality control to maintain cGMP compliance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Once an approval is granted, the FDA may
withdraw the approval if compliance with regulatory requirements and standards is not maintained or if problems occur after the
product reaches the market. Later discovery of previously unknown problems with a product, including adverse events of unanticipated
severity or frequency, or with manufacturing processes, or failure to comply with regulatory requirements, may result in revisions
to the approved labeling to add new safety information; imposition of post-market studies or clinical studies to assess new safety
risks; or imposition of distribution or other restrictions under a REMS program. Other potential consequences include, among other
things:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>restrictions on the marketing or manufacturing of the product, complete withdrawal of the product from the market or product
recalls;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>fines, warning letters or holds on post-approval clinical studies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>refusal of the FDA to approve pending NDAs or supplements to approved NDAs, or suspension or revocation of product license
approvals;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>product seizure or detention, or refusal to permit the import or export of products; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>injunctions or the imposition of civil or criminal penalties.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The FDA strictly regulates marketing, labeling,
advertising and promotion of products that are placed on the market. Drugs may be promoted only for the approved indications and
in accordance with the provisions of the approved label. The FDA and other agencies actively enforce the laws and regulations prohibiting
the promotion of off-label uses, and a company that is found to have improperly promoted off-label uses may be subject to significant
liability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Patent Term Restoration and Marketing
Exclusivity</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Depending upon the timing, duration, and
specifics of FDA approval of the use of our drug candidates, some of our U.S. patents may be eligible for limited patent term extension
under the Drug Price Competition and Patent Term Restoration Act of 1984, referred to as the Hatch-Waxman Act. The Hatch-Waxman
Act permits a patent term to be extended up to five years as compensation for patent term effectively lost due to the FDA&rsquo;s
pre-market approval requirements. However, patent term restoration cannot extend the remaining term of a patent beyond a total
of 14 years from the product&rsquo;s approval date. The patent term restoration period is generally one-half the time between the
effective date of an IND and the submission date of an NDA, plus the time between the submission date of an NDA and the approval
of that application, except that the review period is reduced by any time during which the applicant failed to exercise due diligence.
Only one patent applicable to an approved drug is eligible for the extension. Extensions are not granted as a matter of right and
the extension must be applied for prior to expiration of the patent and within a 60 day period from the date the product is first
approved for commercial marketing. The U.S. Patent and Trademark Office, in consultation with the FDA, reviews and approves the
application for any patent term extension or restoration. Where a product contains multiple active ingredients, if any one active
ingredient has not been previously approved, it can form the basis of an extension of patent term provided the patent claims that
ingredient or the combination.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the future, we may apply for patent
term restoration for some of our presently owned patents to add patent life beyond their current expiration date, depending on
the expected length of clinical studies and other factors involved in the submission of the relevant NDA; however, there can be
no assurance that any such extension will be granted to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Biologics Price Competition and Innovation
Act of 2009 provides up to twelve years of non-patent data exclusivity within the United States to the first applicant to gain
approval of a BLA for a new biologic product that has not previously been approved by the FDA, which we refer to as a reference
product. This twelve-year data exclusivity may prohibit the FDA from approving a biosimilar or interchangeable product of such
reference product until twelve years after the licensure of such reference product. In addition, the FDA will not accept a biosimilar
or interchangeable product application for review until four years after the date of first licensure of such reference product.
Moreover, pediatric exclusivity, if granted, may add six months of exclusivity if the reference product has been studied with respect
to a pediatric indication in accordance with certain regulatory requirements. A reference product may also be granted seven years
of orphan-drug exclusivity for the treatment of a rare disease or condition</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">under section 527(a) of FDCA, which would
run in parallel with the twelve years of data exclusivity of the reference product, if applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Non-U.S. Regulation</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In order to market any product outside
of the United States, we would need to comply with numerous and varying regulatory requirements of other countries and jurisdictions
regarding quality, safety and efficacy and governing, among other things, clinical studies, marketing authorization, commercial
sales and distribution of our products. Whether or not we obtain FDA approval for a product, we would need to obtain the necessary
approvals by the comparable foreign regulatory authorities before we can commence clinical studies or marketing of the product
in foreign countries and jurisdictions. Although many of the issues discussed above with respect to the United States apply similarly
in the context of the European Union, the approval process varies between countries and jurisdictions and can involve additional
product testing and additional administrative review periods, as described in greater detail below. The time required to obtain
approval in other countries and jurisdictions might differ from and be longer than that required to obtain FDA approval. Regulatory
approval in one country or jurisdiction does not ensure regulatory approval in another, but a failure or delay in obtaining regulatory
approval in one country or jurisdiction may negatively impact the regulatory process in others.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">European Union Drug Review Approval</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the European Economic Area, or EEA (which
is comprised of the 28 Member States of the European Union plus Norway, Iceland and Liechtenstein), medicinal products can only
be commercialized after obtaining a Marketing Authorization, or MA. There are two types of marketing authorizations: the Community
MA, which is issued by the European Commission through the Centralized Procedure based on the opinion of the Committee for Medicinal
Products for Human Use, or CHMP, a body of the EMA, and which is valid throughout the entire territory of the EEA; and the National
MA, which is issued by the competent authorities of the Member States of the EEA and only authorizes marketing in that Member State&rsquo;s
national territory and not the EEA as a whole.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Centralized Procedure is compulsory
for human medicines for the treatment of human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS), cancer,
diabetes, neurodegenerative diseases, auto-immune and other immune dysfunctions, and viral diseases; for veterinary medicines for
use as growth or yield enhancers; for medicines derived from biotechnology processes, such as genetic engineering; for advanced-therapy
medicines, such as gene-therapy, somatic cell-therapy or tissue-engineered medicines; and for officially designated &lsquo;orphan
medicines&rsquo; (medicines used for rare human diseases). The Centralized Procedure is optional for products containing a new
active substance not yet authorized in the EEA, or for products that constitute a significant therapeutic, scientific or technical
innovation or for products which are in the interest of public health in the European Union. The National MA is for products not
falling within the mandatory scope of the Centralized Procedure. Where a product has already been authorized for marketing in a
Member State of the EEA, this National MA can be recognized in another Member State through the Mutual Recognition Procedure. If
the product has not received a National MA in any Member State at the time of application, it can be approved simultaneously in
various Member States through the Decentralized Procedure. Under the Decentralized Procedure an identical dossier is submitted
to the competent authorities of each of the Member States in which the MA is sought, one of which is selected by the applicant
as the Reference Member State, or RMS. If the RMS proposes to authorize the product, and the other Member States do not raise objections,
the product is granted a national MA in all the Member States where the authorization was sought. Before granting the MA, the EMA
or the competent authorities of the Member States of the EEA make an assessment of the risk-benefit balance of the product on the
basis of scientific criteria concerning its quality, safety and efficacy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Regulation in the European Union</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Product development, the regulatory approval
process, and safety monitoring of medicinal products and their manufacturers in the European Union proceed in much the same manner
as they do in the United States. Therefore, many of the issues discussed above apply similarly in the context of the European Union.
In addition, drugs are subject to the extensive price and reimbursement regulations of the various European Union Member States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Clinical Studies</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As is the case in the United States, the
various phases of pre-clinical and clinical research in the European Union are subject to significant regulatory controls. The
Clinical Trials Directive 2001/20/EC, as amended (and which will be replaced from May 2016 or later by Regulation (EU) No 536/2014)
provides a system for the approval of clinical studies in the European Union via implementation through national legislation of
the Member States. Under this system, approval must be obtained from the competent national authorities of the European Union Member
States in which the clinical trial is to be conducted. Furthermore, a clinical trial may only be started after a competent ethics
committee has issued a favorable opinion on the clinical trial application, which must be supported by an investigational medicinal
product dossier with supporting information prescribed by the Clinical Trials Directive and corresponding national laws of the
Member States and further detailed in applicable guidance documents. A clinical trial may only be undertaken if provision has been
made for insurance or indemnity to cover the liability of the investigator or sponsor. In certain countries, the sponsor of a clinical
trial has a strict (faultless) liability for any (direct or indirect) damage suffered by trial subjects. The sponsor of a clinical
trial, or its legal representative, must be based in the European Economic Area. European regulators and ethics committees also
require the submission of adverse event reports during a study and a copy of the final study report.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Marketing Approval</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Marketing approvals under the European
Union regulatory system may be obtained through a centralized or decentralized procedure. The centralized procedure results in
the grant of a single marketing authorization that is valid for all (currently 28) European Union Member States and three EFTA
members (Norway, Iceland, Liechtenstein).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to Regulation (EC) No.&nbsp;726/2004,
as amended, the centralized procedure is mandatory for drugs developed by means of specified biotechnological processes, advanced
therapy medicinal products, drugs for human use containing a new active substance for which the therapeutic indication is the treatment
of specified diseases, including but not limited to acquired immune deficiency syndrome, neurodegenerative disorders, auto-immune
diseases and other immune dysfunctions, as well as drugs designated as orphan drugs. The CHMP also has the discretion to permit
other products to use the centralized procedure if it considers them sufficiently innovative or they contain a new active substance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the marketing authorization application,
or MAA, the applicant has to properly and sufficiently demonstrate the quality, safety and efficacy of the drug. Under the centralized
approval procedure, the CHMP, possibly in conjunction with other committees, is responsible for drawing up the opinion of the EMA
on any matter concerning the admissibility of the files submitted in accordance with the centralized procedure, such as an opinion
on the granting, variation, suspension or revocation of a marketing authorization, and pharmacovigilance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The CHMP and other committees are also
responsible for providing guidelines and have published numerous guidelines that may apply to our product candidates. These guidelines
provide additional guidance on the factors that the EMA will consider in relation to the development and evaluation of drug products
and may include, among other things, the pre-clinical studies required in specific cases; and the manufacturing and control information
that should be submitted in a MAA; and post-approval measures required to monitor patients and evaluate the long term efficacy
and potential adverse reactions. Although these guidelines are not legally binding, we believe that our compliance with them is
likely necessary to gain approval for any of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The maximum timeframe for the evaluation
of an MAA by the CHMP under the centralized procedure is 210 days after receipt of a valid application. This period will be suspended
until such time as the supplementary information requested by the CHMP, has been provided by the applicant. Likewise, this time-limit
will be suspended for the time allowed for the applicant to prepare oral or written explanations. When an application is submitted
for a marketing authorization in respect of a drug which is of major interest from the point of view of public health and in particular
from the viewpoint of therapeutic innovation, the applicant may request an accelerated assessment procedure. If the CHMP accepts
such request, the time-limit of 210 days will be reduced to 150 days but it is possible that the CHMP can revert to the standard
time-limit for the centralized procedure if it considers that it is no longer appropriate to conduct an accelerated assessment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If the CHMP concludes that the quality,
safety and efficacy of the product are sufficiently proven, it adopts a positive opinion. This is sent to the European Commission
which drafts a decision. After consulting with the</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Member States, the European Commission adopts
a decision and grants a marketing authorization, which is valid for the whole of the European Economic Area, or EEA. The marketing
authorization may be subject to certain conditions, which may include, without limitation, the performance of post-authorization
safety and/or efficacy studies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">European Union legislation also provides
for a system of regulatory data and market exclusivity. According to Article 14(11) of Regulation (EC) No.&nbsp;726/2004, as amended,
and Article 10(1) of Directive 2001/83/EC, as amended, upon receiving marketing authorization, new chemical entities approved on
the basis of a complete independent data package benefit from eight years of data exclusivity and an additional two years of market
exclusivity. Data exclusivity prevents regulatory authorities in the European Union from referencing the innovator&rsquo;s data
to assess a generic (abbreviated) application. During the additional two-year period of market exclusivity, a generic marketing
authorization can be submitted, and the innovator&rsquo;s data may be referenced, but no generic medicinal product can be marketed
until the expiration of the market exclusivity. The overall ten-year period will be extended to a maximum of eleven years if, during
the first eight years of those ten years, the marketing authorization holder, or MAH, obtains an authorization for one or more
new therapeutic indications which, during the scientific evaluation prior to their authorization, are held to bring a significant
clinical benefit in comparison with existing therapies. Even if a compound is considered to be a new chemical entity and the innovator
is able to gain the period of data exclusivity, another company nevertheless could also market another version of the drug if such
company obtained marketing authorization based on an MAA with a complete independent data package of pharmaceutical test, pre-clinical
tests and clinical studies. However, products designated as orphan medicinal products enjoy, upon receiving marketing authorization,
a period of 10 years of orphan market exclusivity. See also &ldquo;&mdash;Orphan Drug Regulation&rdquo; below. Depending upon the
timing and duration of the EU marketing authorization process, products may be eligible for up to five years&rsquo; supplementary
protection certification, or SPC, pursuant to Regulation (EC) No.&nbsp;469/2009. Such SPCs extend the rights under the basic patent
for the drug.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Additional rules apply to medicinal products
for pediatric use under Regulation (EC) No.&nbsp;1901/2006. Potential incentives include a six-month extension of any supplementary
protection certificate granted pursuant to Regulation (EC) No.&nbsp;469/2009, but not in cases in which the relevant product is
designated as orphan medicinal products pursuant to Regulation (EC) No.&nbsp;141/2000, as amended. Instead, medicinal products
designated as orphan medicinal product may enjoy an extension of the ten-year market exclusivity period granted under Regulation
(EC) No.&nbsp;141/2000 to twelve years subject to the conditions applicable to orphan drugs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Orphan Drug Regulation</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the European Union, Regulation (EC)
No.&nbsp;141/2000, as amended, states that a drug will be designated as an orphan drug if its sponsor can establish:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>that it is intended for the diagnosis, prevention or treatment of a life-threatening or chronically debilitating condition
affecting not more than five in ten thousand persons in the Community when the application is made, or that it is intended for
the diagnosis, prevention or treatment of a life-threatening, seriously debilitating or serious and chronic condition in the European
Union and that without incentives it is unlikely that the marketing of the drug in the European Union would generate sufficient
return to justify the necessary investment; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>that there exists no satisfactory method of diagnosis, prevention or treatment of the condition in question that has been authorized
in the European Union or, if such method exists, that the drug will be of significant benefit to those affected by that condition.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Regulation (EC) No.&nbsp;847/2000 sets
out further provisions for implementation of the criteria for designation of a drug as an orphan drug. An application for the designation
of a drug as an orphan drug must be submitted at any stage of development of the drug before filing of a marketing authorization
application.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If a European Union-wide community marketing
authorization in respect of an orphan drug is granted or if all the European Union Member States have granted marketing authorizations
in accordance with the procedures for mutual recognition, the European Union and the Member States will not, for a period of 10
years, accept another application for a marketing authorization, or grant a marketing authorization or accept an application to
extend an existing marketing authorization, for the same therapeutic indication, in respect of a similar drug. This period may
however be reduced to six years if, at the end of the fifth year, it is established, with respect to the drug concerned,</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">that the criteria for orphan drug designation
are no longer met, in other words, when it is shown on the basis of available evidence that the product is sufficiently profitable
not to justify maintenance of market exclusivity. Notwithstanding the foregoing, a marketing authorization may be granted, for
the same therapeutic indication, to a similar drug if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the holder of the marketing authorization for the original orphan drug has given its consent to the second applicant;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the holder of the marketing authorization for the original orphan drug is unable to supply sufficient quantities of the drug;
or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>the second applicant can establish in the application that the second drug, although similar to the orphan drug already authorized,
is safer, more effective or otherwise clinically superior.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Other incentives available to orphan drugs
in the European Union include financial incentives such as a reduction of fees or fee waivers and protocol assistance. Orphan drug
designation does not shorten the duration of the regulatory review and approval process.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Manufacturing and Manufacturers&rsquo;
License</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to Directive 2003/94/EC, as transposed
into the national laws of the Member States, the manufacturing of investigational medicinal products and approved drugs is subject
to a separate manufacturer&rsquo;s license and must be conducted in strict compliance with cGMP requirements, which mandate the
methods, facilities, and controls used in manufacturing, processing, and packing of drugs to assure their safety and identity.
Manufacturers must have at least one qualified person permanently and continuously at their disposal. The qualified person is ultimately
responsible for certifying that each batch of finished product released onto the market has been manufactured in accordance with
cGMP and the specifications set out in the marketing authorization or investigational medicinal product dossier. cGMP requirements
are enforced through mandatory registration of facilities and inspections of those facilities. Failure to comply with these requirements
could interrupt supply and result in delays, unanticipated costs and lost revenues, and subject the applicant to potential legal
or regulatory action, including but not limited to warning letters, suspension of manufacturing, seizure of product, injunctive
action or possible civil and criminal penalties.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Wholesale Distribution and License</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to Directive 2001/83/EC, the wholesale
distribution of medicinal products is subject to the possession of an authorization to engage in activity as a wholesaler in medicinal
products. Possession of a manufacturing authorization includes authorization to distribute by wholesale the medicinal products
covered by that authorization. The distribution of medicinal products must comply with the principles and guidelines of good distribution
practices, or GDP.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Advertising</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the European Union, the promotion of
prescription medicines is subject to intense regulation and control, including EU and national legislation as well as self-regulatory
codes (industry codes). Advertising legislation inter alia includes a prohibition on direct-to-consumer advertising. All prescription
medicines advertising must be consistent with the product&rsquo;s approved summary of products characteristics, and must be factual,
accurate, balanced and not misleading. Advertising of prescription medicines pre-approval or off-label is not allowed. Some jurisdictions
require that all promotional materials for prescription medicines be subjected to either prior internal or regulatory review and
approval.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Other Regulatory Requirements</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A marketing authorization holder, or MAH,
for a medicinal product is legally obliged to fulfill a number of obligations by virtue of its status as an MAH. The MAH can delegate
the performance of related tasks to third parties, such as distributors or marketing partners, provided that this delegation is
appropriately documented and the MAH maintains legal responsibility and liability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>The obligations of an MAH include:</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Manufacturing and batch release</I>&mdash;MAHs should guarantee that all manufacturing operations comply with relevant laws
and regulations, applicable good manufacturing practices, with the product specifications and manufacturing conditions set out
in the marketing authorization and that each batch of product is subject to appropriate release formalities.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Availability and continuous supply</I>&mdash;Pursuant to Directive 2001/83/EC, as transposed into the national laws of the
Member States, the MAH for a medicinal product and the distributors of the said medicinal product actually placed on the market
in a Member State shall, within the limits of their responsibilities, ensure appropriate and continued supplies of that medical
product to pharmacies and persons authorized to supply medicinal products so that the needs of patients in the Member State in
question are covered.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Pharmacovigilance</I>&mdash;MAHs are obliged to establish and maintain a pharmacovigilance system, including a qualified
person responsible for oversight, submit safety reports to the regulators and comply with the good pharmacovigilance practice guidelines
adopted by the EMA.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Advertising and promotion</I>&mdash;MAHs remain responsible for all advertising and promotion of its products, including
promotional activities by other companies or individuals on their behalf and in some cases must conduct internal or regulatory
pre-approval of promotional materials. Regulation in this area also covers interactions with healthcare practitioners and/or patient
groups, and in some jurisdictions legal or self-regulatory obligations to disclose such interactions exist.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Medical affairs/scientific service</I>&mdash;MAHs are required to disseminate scientific and medical information on its
medicinal products to healthcare professionals, regulators and patients. Legal representation and distributor issues. MAHs are
responsible for regulatory actions or inactions of their distributors and agents.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD><I>Preparation, filing and maintenance of the application and subsequent marketing authorization</I>&mdash; MAHs must maintain
appropriate records, comply with the marketing authorization&rsquo;s terms and conditions, fulfill reporting obligations to regulators,
submit renewal applications and pay all appropriate fees to the authorities. We may hold any future marketing authorizations granted
for our product candidates in our own name, or appoint an affiliate or a collaboration partner to hold marketing authorizations
on our behalf. Any failure by an MAH to comply with these obligations may result in regulatory action against an MAH and ultimately
threaten our ability to commercialize our products.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Price and Reimbursement</P>

<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the European Union, the pricing and
reimbursement mechanisms by private and public health insurers vary largely by country and even within countries. The public systems
reimbursement for standard drugs is determined by guidelines established by the legislator or responsible national authority. The
approach taken varies by Member State. Some jurisdictions operate positive and negative list systems under which products may only
be marketed once a reimbursement price has been agreed. Other Member States allow companies to fix their own prices for medicines,
but monitor and control company profits and may limit or restrict reimbursement. The downward pressure on healthcare costs in general,
particularly prescription drugs, has become very intense. As a result, increasingly high barriers are being erected to the entry
of new products and some of EU countries require the completion of studies that compare the cost-effectiveness of a particular
product candidate to currently available therapies in order to obtain reimbursement or pricing approval. Special pricing and reimbursement
rules may apply to orphan drugs. Inclusion of orphan drugs in reimbursement systems tend to focus on the medical usefulness, need,
quality and economic benefits to patients and the healthcare system as for any drug. Acceptance of any medicinal product for reimbursement
may come with cost, use and often volume restrictions, which again can vary by country. In addition, results based rules of reimbursement
may apply.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Other Healthcare Laws</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition to FDA restrictions on marketing
of pharmaceutical products, federal and state healthcare laws restrict certain business practices in the biopharmaceutical industry.
These laws include, but are not limited to, anti-kickback, false claims, data privacy and security, and transparency statutes and
regulations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The federal Anti-Kickback Statute prohibits,
among other things, knowingly and willfully offering, paying, soliciting or receiving remuneration, directly or indirectly, to
induce, or in return for, purchasing, leasing, ordering or arranging for the purchase, lease or order of any good, facility, item
or service reimbursable under Medicare, Medicaid or other federal healthcare programs. The term &ldquo;remuneration&rdquo; has
been broadly interpreted to include anything of value, including for example, gifts, discounts, the furnishing of supplies or equipment,
credit arrangements, payments of cash, waivers of payment, ownership interests and providing anything at less than its fair market
value. The Anti-Kickback Statute has been interpreted to apply to arrangements between pharmaceutical manufacturers on one hand
and prescribers, purchasers and formulary managers on the other. Although there are a number of statutory exceptions and regulatory
safe harbors protecting certain common activities from prosecution, the exceptions and safe harbors are drawn narrowly, and our
practices may not in all cases meet all of the criteria for a statutory exception or safe harbor protection. Practices that involve
remuneration that may be alleged to be intended to induce prescribing, purchases or recommendations may be subject to scrutiny
if they do not qualify for an exception or safe harbor. Failure to meet all of the requirements of a particular applicable statutory
exception or regulatory safe harbor does not make the conduct per se illegal under the Anti-Kickback Statute. Instead, the legality
of the arrangement will be evaluated on a case-by-case basis based on a cumulative review of all of its facts and circumstances.
Several courts have interpreted the statute&rsquo;s intent requirement to mean that if any one purpose of an arrangement involving
remuneration is to induce referrals of federal healthcare covered business, the statute has been violated. The Patient Protection
and Affordable Care Act as amended by the Health Care and Education Reconciliation Act, or collectively, PPACA, amended the intent
requirement under the Anti-Kickback Statute and criminal healthcare fraud statutes (discussed below) such that a person or entity
no longer needs to have actual knowledge of the statute or the specific intent to violate it in order to have committed a violation.
In addition, PPACA provides that the government may assert that a claim including items or services resulting from a violation
of the federal Anti-Kickback Statute constitutes a false or fraudulent claim for purposes of the civil False Claims Act (discussed
below). Further, the civil monetary penalties statute imposes penalties against any person or entity that, among other things,
is determined to have presented or caused to be presented a claim to a federal health program that the person knows or should know
is for an item or service that was not provided as claimed or is false or fraudulent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The federal false claims laws prohibit,
among other things, any person or entity from knowingly presenting, or causing to be presented, a false or fraudulent claim for
payment or approval to the federal government or knowingly making, using or causing to be made or used a false record or statement
material to a false or fraudulent claim to the federal government. As a result of a modification made by the Fraud Enforcement
and Recovery Act of 2009, a claim includes &ldquo;any request or demand&rdquo; for money or property presented to the U.S. government.
Recently, several pharmaceutical and other healthcare companies have been prosecuted under these laws for, among other things,
allegedly providing free product to customers with the expectation that the customers would bill federal programs for the product.
Other companies have been prosecuted for causing false claims to be submitted because of the companies&rsquo; marketing of the
product for unapproved, and thus non-covered, uses. The federal Health Insurance Portability and Accountability Act of 1996, or
HIPAA, created new federal criminal statutes that prohibit knowingly and willfully executing, or attempting to execute, a scheme
to defraud any healthcare benefit program, including private third-party payors and knowingly and willfully falsifying, concealing
or covering up a material fact or making any materially false, fictitious or fraudulent statement in connection with the delivery
of, or payment for, healthcare benefits, items or services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, we may be subject to data
privacy and security regulation by both the federal government and the states in which we conduct our business. HIPAA, as amended
by the Health Information Technology for Economic and Clinical Health Act, or HITECH, and its implementing regulations, imposes
certain requirements relating to the privacy, security and transmission of individually identifiable health information. Among
other things, HITECH makes HIPAA&rsquo;s privacy and security standards directly applicable to business associates&mdash;independent
contractors or agents of covered entities that receive or obtain protected health information in connection with providing a service
on behalf of a covered entity. HITECH also created four new tiers of civil monetary penalties, amended HIPAA to make civil and
criminal penalties directly applicable to business associates, and gave state attorneys general new authority to file civil actions
for damages or injunctions in federal courts to enforce the federal HIPAA laws and seek attorney&rsquo;s fees and costs associated
with pursuing federal civil actions. In addition, state laws govern the privacy and security of health information in certain circumstances,
many of which differ from each other in significant ways and may not have the same effect, thus complicating compliance efforts.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Additionally, the PPACA also included the
federal Physician Payments Sunshine Act, which requires that certain manufacturers of drugs, devices, biologicals and medical supplies
for which payment is available under</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Medicare, Medicaid or the Children&rsquo;s
Health Insurance Program (with certain exceptions) to report information related to certain payments or other transfers of value
made or distributed to physicians and teaching hospitals, or to entities or individuals at the request of, or designated on behalf
of, the physicians and teaching hospitals and to report annually certain ownership and investment interests held by physicians
and their immediate family members.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Also, many states have similar healthcare
statutes or regulations that apply to items and services reimbursed under Medicaid and other state programs, or, in several states,
apply regardless of the payor. Certain states require the posting of information relating to clinical studies, pharmaceutical companies
to implement a comprehensive compliance program that includes a limit on expenditures for, or payments to, individual medical or
health professionals and track and report gifts and other payments made to physicians and other healthcare providers. If our operations
are found to be in violation of any of the health regulatory laws described above or any other laws that apply to us, we may be
subject to penalties, including potentially significant criminal, civil and/or administrative penalties, damages, fines, disgorgement,
individual imprisonment, exclusion of products from reimbursement under government programs, contractual damages, reputational
harm, administrative burdens, diminished profits and future earnings and the curtailment or restructuring of our operations, any
of which could adversely affect our ability to operate our business and our results of operations. To the extent that any of our
products will be sold in a foreign country, we may be subject to similar foreign laws and regulations, which may include, for instance,
applicable post-marketing requirements, including safety surveillance, anti-fraud and abuse laws and implementation of corporate
compliance programs and reporting of payments or transfers of value to healthcare professionals.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pharmaceutical Coverage, Pricing and Reimbursement</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In both domestic and foreign markets, our
sales of any approved products will depend in part on the availability of coverage and adequate reimbursement from third-party
payors. Third-party payors include government authorities, managed care providers, private health insurers and other organizations.
Patients who are prescribed treatments for their conditions and providers performing the prescribed services generally rely on
third-party payors to reimburse all or part of the associated healthcare costs. Patients are unlikely to use our products, if approved,
unless coverage is provided and reimbursement is adequate to cover a significant portion of the cost of our products. Sales of
our products will therefore depend substantially, both domestically and abroad, on the extent to which the costs of our products
will be paid by third-party payors. These third-party payors are increasingly focused on containing healthcare costs by challenging
the price and examining the cost-effectiveness of medical products and services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, significant uncertainty exists
as to the coverage and reimbursement status of newly approved healthcare product candidates. The market for our product candidates
for which we may receive regulatory approval will depend significantly on access to third-party payors&rsquo; drug formularies,
or lists of medications for which third-party payors provide coverage and reimbursement. The industry competition to be included
in such formularies often leads to downward pricing pressures on pharmaceutical companies. Also, third-party payors may refuse
to include a particular branded drug in their formularies or otherwise restrict patient access to a branded drug when a less costly
generic equivalent or other alternative is available. Because each third-party payor individually approves coverage and reimbursement
levels, obtaining coverage and adequate reimbursement is a time-consuming, costly and sometimes unpredictable process. We may be
required to provide scientific and clinical support for the use of any product to each third-party payor separately with no assurance
that approval would be obtained, and we may need to conduct expensive pharmacoeconomic studies in order to demonstrate the cost-effectiveness
of our products. This process could delay the market acceptance of any product and could have a negative effect on our future revenues
and operating results. We cannot be certain that our product candidates will be considered cost-effective. Because coverage and
reimbursement determinations are made on a payor-by-payor basis, obtaining acceptable coverage and reimbursement from one payor
does not guarantee the Company will obtain similar acceptable coverage or reimbursement from another payor. If we are unable to
obtain coverage of, and adequate reimbursement and payment levels for, our product candidates from third-party payors, physicians
may limit how much or under what circumstances they will prescribe or administer them and patients may decline to purchase them.
This in turn could affect our ability to successfully commercialize our products and impact our profitability, results of operations,
financial condition and future success.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Furthermore, in many foreign countries,
particularly the countries of the European Union, the pricing of prescription drugs is subject to government control. In some non-U.S.
jurisdictions, the proposed pricing for a drug must be approved before it may be lawfully marketed. The requirements governing
drug pricing vary widely from country to country. For example, the European Union provides options for its member states to restrict
the range of</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">medicinal products for which their national
health insurance systems provide reimbursement and to control the prices of medicinal products for human use. A member state may
approve a specific price for the medicinal product or it may instead adopt a system of direct or indirect controls on the profitability
of the company placing the medicinal product on the market. We may face competition for our product candidates from lower-priced
products in foreign countries that have placed price controls on pharmaceutical products. In addition, there may be importation
of foreign products that compete with our own products, which could negatively impact our profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Healthcare Reform</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the United States and other jurisdictions,
there have been, and we expect there will continue to be, a number of legislative and regulatory changes to the healthcare system
that could affect our future results of operations as we begin to directly commercialize our products.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In particular, there have been and continue
to be a number of initiatives at the U.S. federal and state level that seek to reduce healthcare costs. Initiatives to reduce the
federal deficit and to reform healthcare delivery are increasing cost-containment efforts. We anticipate that Congress, state legislatures
and the private sector will continue to review and assess alternative benefits, controls on healthcare spending through limitations
on the growth of private health insurance premiums and Medicare and Medicaid spending, the creation of large insurance purchasing
groups, price controls on pharmaceuticals and other fundamental changes to the healthcare delivery system. Any proposed or actual
changes could limit or eliminate our spending on development projects and affect our ultimate profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In March 2010, the Patient Protection and
Affordable Care Act, as amended by the Health Care and Education Reconciliation Act, or collectively, the Health Care Reform Law
was signed into law. The Health Care Reform Law has the potential to substantially change the way healthcare is financed by both
governmental and private insurers. The Health Care Reform Law among other things, established an annual, nondeductible fee on any
entity that manufactures or imports certain branded prescription drugs and biologic agents; revised the methodology by which rebates
owed by manufacturers for covered outpatient drugs under the Medicaid Drug Rebate Program are calculated; increased the minimum
Medicaid rebates owed by most manufacturers under the Medicaid Drug Rebate Program; extended the Medicaid Drug Rebate program to
utilization of certain injectable outpatient drugs, as well as prescriptions of individuals enrolled in Medicaid managed care organizations;
required manufacturers to offer 50% point-of-sale discounts on negotiated prices of applicable brand drugs to eligible beneficiaries
during their coverage gap period, as a condition for the manufacturer&rsquo;s outpatient drugs to be covered under Medicare Part
D; and implemented payment system reforms including a national pilot program on payment bundling to encourage hospitals, physicians
and other providers to improve the coordination, quality and efficiency of certain healthcare services through bundled payment
models.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The future of the Health Care Reform Law
remains uncertain. In January 2017, Congress voted to adopt a budget resolution for fiscal year 2017, or the Budget Resolution,
that authorizes the implementation of legislation that would repeal portions of the Health Care Reform Law. Further, on January
20, 2017, President Trump signed an Executive Order directing federal agencies with authorities and responsibilities under the
Health Care Reform Law to waive, defer, grant exemptions from, or delay the implementation of any provision of the Health Care
Reform Law that would impose a fiscal or regulatory burden on states, individuals, healthcare providers, health insurers, or manufacturers
of pharmaceuticals or medical devices. Congress also could consider subsequent legislation to replace elements of the Health Care
Reform Law that are repealed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In the future, there may continue to be
additional proposals relating to the reform of the United States healthcare system, some of which could further limit the prices
we are able to charge for our products candidates, or the amounts of reimbursement available for our product candidates. If future
legislation were to impose direct governmental price controls and access restrictions, it could have a significant adverse impact
on our business. Managed care organizations, as well as Medicaid and other government agencies, continue to seek price discounts.
Some states have implemented, and other states are considering, price controls or patient access constraints under the Medicaid
program, and some states are considering price-control regimes that would apply to broader segments of their populations that are
not Medicaid-eligible. Due to the volatility in the current economic and market dynamics, we are unable to predict the impact of
any unforeseen or unknown legislative, regulatory, payor or policy actions, which may include cost containment and healthcare reform
measures. Such policy actions could have a material adverse impact on our profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Moreover, the recently enacted federal
Drug Supply Chain Security Act imposes new obligations on manufacturers of pharmaceutical products, among others, related to product
tracking and tracing. Among the requirements of this new federal legislation, manufacturers will be required to provide certain
information regarding the drug product to individuals and entities to which product ownership is transferred, label drug product
with a product identifier, and keep certain records regarding the drug product. Further, under this new legislation, manufacturers
will have drug product investigation, quarantine, disposition, and notification responsibilities related to counterfeit, diverted,
stolen, and intentionally adulterated products, as well as products that are the subject of fraudulent transactions or which are
otherwise unfit for distribution such that they would be reasonably likely to result in serious health consequences or death.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Physician Payment Sunshine Act</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Physician Payment Sunshine Act requires
most pharmaceutical manufacturers to report annually to the Secretary of HHS any and all financial arrangements, payments, or other
transfers of value made by that entity to physicians and teaching hospitals. The payment information is made publicly available
in a searchable format on a CMS website. Over the next several years, we will need to dedicate significant resources to establish
and maintain systems and processes in order to comply with these regulations. Failure to comply with the reporting requirements
can result in significant civil monetary penalties. Similar laws have been enacted or are under consideration in foreign jurisdictions,
including France which has adopted the Loi Bertrand, or French Sunshine Act, which became effective in 2013.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Environmental, Health and Safety Laws and Regulations</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are subject to numerous environmental,
health and safety laws and regulations and permitting requirements, including those governing laboratory procedures, decontamination
activities and the handling, transportation, use, remediation, storage, treatment, and disposal of hazardous materials and wastes.
Our operations involve the use of hazardous and flammable materials, and the risk of injury, contamination or noncompliance with
environmental, health and safety requirements cannot be eliminated. Although compliance with such laws and regulations and permitting
requirements has not had a material effect on our capital expenditures, earnings or competitive position, environmental, health
and safety laws and regulations and permitting requirements have tended to become increasingly stringent and, to the extent legal
or regulatory changes occur in the future, they could result in, among other things, increased costs to us or the impairment of
our research, development or production efforts.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Organizational structure</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a Swiss stock corporation (<I>soci&eacute;t&eacute;
anonyme</I>) organized under the laws of Switzerland. We were formed as a Swiss limited liability company (<I>soci&eacute;t&eacute;
&agrave; responsabilit&eacute; limit&eacute;e</I>) on February 13, 2003 with our registered office and domicile in Basel, Switzerland.
We converted to a Swiss stock corporation (<I>soci&eacute;t&eacute; anonyme</I>) under the laws of Switzerland on August 25, 2003.
Prior to our initial public offering, we were a privately owned company. Our domicile and registered office is in Ecublens, near
Lausanne, Canton of Vaud, Switzerland. Our registered and principal executive offices are located at EPFL Innovation Park, Building
B, 1015 Lausanne, Switzerland, our general telephone number is (41) 21 345 91 21 and our internet address is www.acimmune.com.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We did not have any subsidiaries as of
December 31, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Property, plant and equipment</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Facilities</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We lease approximately 13,200 square feet
of space at the Innovation Park of the EPFL (&Eacute;cole Polytechnique F&eacute;d&eacute;rale Lausanne), Switzerland. This property
serves as our corporate headquarters, our research facility and laboratories. We believe that using the EPFL facilities instead
of building our own infrastructure helps us to maximize the value of our research and development capital and make efficient use
of our funds as we continue to build and develop our pipeline. Due to the expansion of our research and development team and addition
of scientists, we have entered into discussions with EPFL to lease additional space in the Innovation Park by the end of 2017.
We believe that once we have this additional space, our existing facilities will be sufficient to meet our current needs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 4A. UNRESOLVED STAFF COMMENTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">None.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 5. OPERATING AND FINANCIAL REVIEW AND PROSPECTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">You should read the following discussion
and analysis of our financial condition and results of operations together with the information under &ldquo;Item 3. Key Information&mdash;A.
Selected Financial Data&rdquo; and our consolidated audited financial statements, including the notes thereto, included in this
Annual Report. The following discussion is based on our financial information prepared in accordance with IFRS as issued by the
IASB, which might differ in material respects from generally accepted accounting principles in other jurisdictions. The following
discussion includes forward-looking statements that involve risks, uncertainties and assumptions. Our actual results may differ
materially from those anticipated in these forward-looking statements as a result of many factors, including but not limited to
those described under &ldquo;Item 3. Key Information&mdash;D. Risk Factors&rdquo; and elsewhere in this Annual Report.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Operating results</TD>
</TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Overview</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a clinical stage biopharmaceutical
company leveraging our two proprietary technology platforms to discover, design and develop novel, proprietary medicines for prevention,
diagnosis and treatment of neurodegenerative diseases associated with protein misfolding. Our lead product candidate is crenezumab,
a humanized, monoclonal, conformation-specific anti-Abeta antibody that we developed using our proprietary SupraAntigen platform.
Crenezumab commenced Phase&nbsp;3 clinical studies in the first quarter of 2016 and we believe it has the potential to become a
best-in-class disease-modifying treatment for Alzheimer&rsquo;s disease, or AD. Genentech, Inc., a wholly owned subsidiary of Roche,
or Genentech, is advancing crenezumab for the treatment of AD under a collaboration agreement with us, pursuant to which it is
responsible for the clinical development of crenezumab, including the costs associated with seeking and obtaining regulatory and
marketing approvals, manufacturing costs and sales and marketing costs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Two of our other clinical product candidates,
ACI-24 and ACI-35, are being developed using our SupraAntigen platform and target AD through active immunization, where the immune
system is stimulated to make its own antibodies against pathological proteins:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>ACI-24 is our wholly-owned anti-Abeta vaccine candidate currently in a Phase 1/2a study. While the analysis of the immune response
as well as further treatment of the highest dose cohort 4 is still ongoing the preparation of the Phase 2 clinical protocol is
planned to be completed in the second half of fiscal 2017. ACI-24 is also being studied in a Phase&nbsp;1 clinical study in people
with Down syndrome, a population that is at high risk for developing AD-like symptoms.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>ACI-35 is an anti-tau vaccine candidate that we are developing under a collaboration agreement with Janssen. We and
                                                                                                               Janssen are co-developing ACI-35 through the ongoing Phase 1b clinical study. Further results, which we expect to have
                                                                                                               completed in the second half of fiscal year 2017, will be the basis for the program&rsquo;s future development. Janssen is
                                                                                                               expected to assume responsibility for the clinical development of phase 2 and beyond as well as regulatory approval,
                                                                                                               manufacturing and commercialization of ACI-35.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Additionally, a passive anti-tau monoclonal
antibody candidate is being developed under a collaboration agreement with Genentech. The Phase 1 clinical study in patients with
AD and healthy volunteers commenced in the second quarter of 2016, with results expected in the first half of 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are also using our Morphomer platform
to develop complementary diagnostic products such as positron emission tomography, or PET, ligands, which are tracers that can
directly measure misfolded tau and alpha-synuclein in the brain, to enable early and reliable disease diagnoses.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We use our two unique proprietary platform
technologies, SupraAntigen (conformation-specific biologics) and Morphomer (conformation-specific small molecules), to discover,
design and develop medicines and diagnostics to target misfolded proteins. These platforms are our engines for generating novel
molecules that are designed to bind to their targets with high affinity and conformational specificity, meaning they are enabled
to differentiate between</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">misfolded proteins and normally-folded proteins.
All of our product candidates and our development programs have been derived from our proprietary platforms.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, we have primarily financed our
operations through the proceeds from our initial public offering, private placements of preferred securities, and upfront and milestone
payments from our collaboration partners. We have no products approved for commercialization and have never generated any revenues
from product sales. Biopharmaceutical product development is a highly speculative undertaking and involves a substantial degree
of risk. It may be several years, if ever, before we or our collaboration partners complete pivotal clinical studies and have a
product candidate approved for commercialization and we begin to generate revenue and royalties from product sales. Since our inception,
we have received upfront and milestone payments from our collaboration partners and certain other revenue. However, we have also
incurred significant operating losses. For example, we incurred net losses of CHF 7.1&nbsp;million for the fiscal year ended December
31, 2016.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Strategic Collaborations and Licensing Agreements</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Since our inception, we have entered into
strategic collaboration agreements with a range of partners covering a number of our product candidates. We entered into a strategic
collaboration with Genentech in November 2006 (as amended in May 2015) regarding the development, manufacture and commercialization
of crenezumab, and we refer to this agreement as the 2006 Genentech agreement. In June 2012, we entered into an additional strategic
collaboration agreement with Genentech regarding the development, manufacture and commercialization of our anti-tau antibodies,
and we refer to this agreement as the 2012 Genentech agreement. We expect to capitalize on Genentech&rsquo;s drug development and
regulatory expertise and commercial capabilities to bring our partnered therapeutic products to market. In May 2014, we entered
into a collaboration agreement with Piramal Imaging, a leader in imaging agents, covering our tau PET Imaging tracer. In December
2014, we entered into a strategic collaboration agreement with Janssen regarding the development, manufacture and commercialization
of ACI-35, an anti-tau vaccine. We expect to capitalize on Janssen and Johnson&nbsp;&amp; Johnson&rsquo;s extensive regulatory
expertise and experience in developing, manufacturing and, if approved, commercializing vaccines to bring ACI-35 to market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In April 2016, we entered into a non-exclusive
collaboration with Biogen covering our alpha-synuclein PET imaging tracer and future initiatives targeted at TDP-43 PET imaging
tracers, which is a protein that has been recently linked to neurodegeneration in diseases including AD, PD and amyotrophic lateral
sclerosis (commonly known as ALS or Lou Gehrig&rsquo;s disease).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Crenezumab&mdash;Collaboration with Genentech</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the 2006 Genentech agreement, we
may become entitled to receive upfront and milestone payments totaling up to approximately $340 million, excluding royalties. We
received an upfront payment of $25&nbsp;million in 2006 and are entitled to various milestone payments based on the achievement
of specified development and commercialization milestones. To date, we have received payments totaling $65 million from Genentech,
including the $25 million upfront payment and milestone payments totaling $40 million for crenezumab entering into Phase 1, Phase
2 and Phase 3 clinical studies. Under the 2006 Genentech agreement, we are entitled to various regulatory and marketing approval
milestone payments. If crenezumab receives regulatory approval, we will be entitled to receive royalties that are tied to annual
sales volumes with different royalty rates applicable in the U.S. and Europe. These percentage rates range from net high single
digits to the mid-teens.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The 2006 Genentech agreement also provides
for a second indication for which we would be eligible to receive clinical milestone payments payable upon commencement of each
of Phase 2 and 3 of clinical development as well as regulatory and marketing milestone payments similar to those applicable to
crenezumab. If this second indication receives regulatory approval, we will be entitled to receive royalties that are tied to annual
sales volumes at the same rates applicable to crenezumab.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Anti-Tau Antibodies&mdash;Collaboration
with Genentech</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the 2012 Genentech agreement, we
are entitled to receive upfront and milestone payments in excess of CHF 400&nbsp;million, excluding royalties. We received an upfront
payment of CHF 17&nbsp;million in 2012 and are entitled to various milestone payments based on the achievement of specified clinical,
regulatory and commercialization milestones. To date, we have received payments totaling CHF 45&nbsp;million from Genentech including
a milestone payment of CHF 14 million recognized in the second quarter of 2016 and received in July 2016, upon the</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">commencement of the Phase 1 clinical study.
In addition to milestones, we will be eligible to receive royalties on sales at a percentage rate ranging from the mid-single digits
to low double digits.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The 2012 Genentech agreement also provides
for a second indication for which we would be eligible to receive clinical milestone payments payable upon commencement of each
of Phase 2 and 3 of clinical development as well as regulatory and marketing milestone payments. If this second indication receives
regulatory approval, we will be entitled to receive royalties that are tied to annual sales volumes at the same rates applicable
to the lead indication.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Tau PET Imaging Tracer&mdash;Collaboration
with Piramal Imaging</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under our agreement with Piramal Imaging
covering our anti-tau PET imaging agent, we received an upfront payment of &euro;0.5&nbsp;million in May 2014 and are entitled
to various clinical milestone payments totaling up to &euro;7&nbsp;million based on the achievement of specified development milestones.
In addition, we are entitled to further regulatory and sales-based milestones totaling &euro;150.0 million.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">ACI-35&mdash;Collaboration with Janssen</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the collaboration agreement with
Janssen regarding the development of ACI-35, we may become entitled to receive upfront and milestone payments totaling up to CHF
500&nbsp;million, plus royalties on sales at a percentage rate ranging from low double digits to mid-teens. To date, we have received
an upfront payment of CHF 25.9 million and a research contribution of CHF 1.5&nbsp;million and a CHF 4.9 million clinical milestone
payment. The total future payments that we would be entitled to under the agreement for clinical milestones amounts to CHF 78.6&nbsp;million.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Alpha-synuclein and TDP-43 PET Imaging
Tracers&mdash;Collaboration with Biogen</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In April 2016, we entered into a non-exclusive
research and development agreement with Biogen covering the research and early clinical development of our alpha-synuclein PET
Tracer program for Parkinson&rsquo;s disease and other synucleinopathies, and a second program for the identification, research
and development of novel PET ligands against TDP-43, a protein recently linked to neurodegeneration in diseases such as amyotrophic
lateral sclerosis. Under the agreement, we were entitled to a technology access fee and receive funding from Biogen towards FTE
and research and development activities on both PET imaging programs. The CHF 1.5 million technology access fee is being deferred
and recognized over a twelve month period. We will retain all intellectual property rights to any PET product developed for further
commercialization.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Grants</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In February 2015, we were awarded a grant
from the Michael J. Fox Parkinson&rsquo;s Foundation for the further research and development of an alpha-synuclein diagnostic
imaging agent. Under the terms of the grant, we retain all rights, results and intellectual property relating to the program. The
grant covered research and development work over a 1.5 year period. We recognized revenues from this grant on a straight line basis
over the life of the grant.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In January 2016, we were awarded a grant
from the LuMind Research Down Syndrome Foundation to support our ACI-24 Phase&nbsp;1 clinical study in patients with Down Syndrome.
We recognized revenues from this grant on a straight line basis over the annual grant life period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Internal Control over Financial Reporting</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In preparing our financial statements as
of and for the years ended December 31, 2014, 2015 and 2016, a material weakness in our internal control over financial reporting
was identified, as defined in the SEC guidelines for public companies. The material weakness identified relates specifically to
the accounting for and disclosure of non-routine and complex accounting transactions and the related internal controls and processes
supporting these areas. As a result, there is a reasonable possibility that a material misstatement of our consolidated financial
statements will not be prevented or detected on a timely basis.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are in the process of implementing improvements
and remedial measures in response to these assessments and recommendations, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27.35pt"></TD><TD STYLE="width: 18pt"><FONT STYLE="font-family: Symbol">&#183;</FONT></TD><TD>assembling a team from our finance department to be responsible for the preparation of financial statements under U.S. Securities
laws, including hiring additional qualified personnel as necessary; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 27.35pt"></TD><TD STYLE="width: 18pt"><FONT STYLE="font-family: Symbol">&#183;</FONT></TD><TD>setting up an internal audit department to review our internal control processes, policies and procedures to ensure compliance
with the Sarbanes-Oxley Act.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Although we have been implementing these
measures, the implementation of these measures has not fully remediated the material weakness and they may not fully address this
material weakness in our internal control over financial reporting, and we therefore may not be able to conclude that it has been
fully remedied.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Critical Accounting Policies and Significant Judgments
and Estimates</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Revenue Recognition</P>

<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have historically generated revenues
from funds received under collaboration and license agreements as well as research grants. Revenues from research activities made
under collaboration arrangements are recognized when there is persuasive evidence that an arrangement exists, services have been
rendered, the price is fixed or determinable and collectability is reasonably assured. Since our inception, we have entered into
strategic collaboration agreements with a range of partners covering a number of our product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For collaborations established on programs
	in pre-clinical stage, we recognize revenue from upfront payments under our collaboration agreements ratably over the term of our
	estimated period of performance under each agreement. For collaboration agreements on product candidates that are (i)&nbsp;in clinical
	development, (ii)&nbsp;where the upfront payment reflects a payment for past investments we have made in the development of the
	product candidate, access to the product candidate, the associated intellectual property and our knowledge, and (iii)&nbsp;where
	there is no further performance commitment, we recognize the fair value of the upfront payment at the time of entering into the
	collaboration agreement. For collaboration agreements with product candidates in clinical development but where the conditions
	described in clauses (ii)&nbsp;and (iii)&nbsp;are not met, we recognize the upfront payments ratably over the term of our estimated
	period of performance under each agreement.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We record amounts received prior to satisfying
	the above revenue recognition criteria as deferred revenue until all applicable revenue recognition criteria are met. Deferred
	revenue represents the portion of research or license payments received that have not been earned.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Milestones are considered substantive if
	all of the following conditions are met: (i)&nbsp;the milestone is non-refundable, (ii)&nbsp;achievement of the milestone was not
	reasonably assured at the inception of the arrangement, (iii)&nbsp;substantive effort is involved to achieve the milestone and
	(iv)&nbsp;the amount of the milestone appears reasonable in relation to the effort expended, and the other milestones in the arrangement
	and the related risk associated with the achievement of the milestone and any ongoing research and development or other services
	are priced at fair value. Such payments that are contingent upon achievement of a substantive milestone are recognized entirely
	as revenues in the period in which the milestone is achieved. To the extent that non-substantive milestones are achieved and we
	have remaining performance obligations, milestones are deferred and recognized as revenue over the estimated remaining period of
	performance. If there are no remaining performance obligations, we recognize the revenue in the period it is earned.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Grants provide funding for certain types
	of expenditures in connection with research and development activities over a contractually-defined period. Revenue related to
	grants is recognized in the period during which the related costs are incurred and the related services are rendered, provided
	that the applicable performance obligations under the grants have been met. We intend to continue to evaluate pursuing additional
	grant opportunities on a case-by-case basis.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Accrued Research and Development Costs</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We record accrued expenses for estimated
	costs of our research and development activities conducted by third party service providers, which include amongst others the conduct
	of preclinical studies and clinical studies and contract manufacturing activities. We record accrued expenses for estimated costs
	of our research and development activities based upon the estimated amount of services provided but not yet invoiced, and we include
	these costs in accrued liabilities on the balance sheets and within research and development expenses in the statement of operations
	and comprehensive income. These costs are a significant component of our research and development expenses. We record accrued expenses
	for these costs based on the estimated amount of work completed in accordance with agreements established with these third parties.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We estimate the amount of work completed
	through discussions with our project leaders and external service providers as to the progress or stage of completion of the services
	and the agreed-upon fee to be paid for such services. We make significant judgments and estimates in determining the accrued balance
	in each reporting period. As actual costs become known, we adjust our accrued estimates. Although we do not expect our estimates
	to be materially different from amounts actually incurred, our understanding of the status and timing of services performed, the
	number of patients enrolled and the rate of patient enrollment may vary from our estimates and could result in us reporting amounts
	that are too high or too low in any particular period. Our accrued expenses are dependent, in part, upon the receipt of timely
	and accurate reporting from CROs and other third-party service providers. To date, there have been no material differences from
	our accrued expenses to actual expenses.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Share-Based Compensation</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company operates an equity-settled,
	share-based compensation plan. The fair value of the employee services received in exchange for the grant of options and shares
	is recognized as an expense. The total amount to be expensed over the vesting period is determined by reference to the fair value
	of the instruments granted, excluding the impact of any non-market vesting conditions. Non-market vesting conditions are included
	in assumptions about</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">the number of instruments that are expected
	to become exercisable. At each balance sheet date, the Company revises its estimates of the number of instruments that are expected
	to become exercisable. It recognizes the impact of the revision of original estimates, if any, in the income statement, and a corresponding
	adjustment to equity over the remaining vesting period.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Key assumptions in determining the fair
	value of share options granted utilizing the Black-Scholes valuation method include the following:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Expected Term</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The expected term represents the period
	that share-based awards are expected to be outstanding. We used the simplified method to determine the expected term, which is
	calculated as the mid-point between the vesting date and the end of the contractual term of the options.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Expected Volatility</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For grants issued prior to being a public
	company we did not have any trading history for our common shares, the expected volatility was estimated based on the average historical
	volatilities of common shares of comparable publicly traded entities over a period equal to the expected term of the stock option
	grants. The comparable companies were chosen based on similar geographic location, similar size, and similar stage in the life
	cycle or area of specialty. We will continue to apply this process until a sufficient amount of historical information regarding
	the volatility of our own stock price becomes available.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Risk-Free Interest Rate</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The risk-free rate is based on long dated
	Swiss government zero coupon bond issues in effect at the time of the grant for periods corresponding with the expected term of
	the option.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Expected Dividends</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have never paid dividends on our common
	shares and have no plans to pay dividends on our common shares. Therefore, we used an expected dividend yield of zero percent.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition to Black-Scholes assumptions,
	we estimate our forfeiture rate based on our actual and expected forfeitures and we continue to evaluate the adequacy of the forfeiture
	rate based on the actual forfeiture experience, analysis of employee turnover behavior and other factors. The impact from any forfeiture
	rate adjustment would be recognized in full in the period of adjustment, and if the actual number of future forfeitures differs
	from our estimates, we might be required to record adjustments to share-based compensation in future periods.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Historically, for all periods prior to
	the IPO, the fair value of the common shares underlying our share-based awards was estimated on each grant date by our management
	and approved by our board of directors. In order to determine the fair value of our common shares underlying option grants, our
	board of directors considered, among other things, the breadth of our product candidate portfolio, the stages of development of
	our various product candidates and major changes to stage of development, the progress and additions to our collaboration agreements,
	risks inherent in our activities, the lack of liquidity of our companies securities and the valuations and sentiment toward biotech
	companies. Given the absence of a public trading market for our common shares, our board of directors exercised reasonable judgment
	and considered a number of objective and subjective factors to determine the best estimate of the fair value of our common shares,
	including our stage of development, progress of our research and development efforts, the strength of our balance sheets and capital
	base, equity market conditions affecting comparable public companies and the lack of liquidity marketability of our common shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Amendment of 2015 Option Plan</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">We grant options at the outset of the award
	period with the options vesting over a four year period. In line with IFRS accounting principles for option awards, we are using
	the graded methodology to expense the fair value of the awards on a straight line basis over the four year vesting period of the
	options. Specifically, the accounting rules require us to recognize that four separate options with four separate option periods
	were issued. Consequently, in year one, we need to expense (i)&nbsp;the fair value of the awards issued in the first year, (ii)&nbsp;one
	half of the fair value of the awards to be issued in year two, (iii)&nbsp;one third of the value of the awards to be issued in
	year three and</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(iv)&nbsp;one quarter of the fair value of the options issued
	to be in year four. The result in the change in the way we expense options means that we are recognizing a larger expense in years
	one and two (relative to the traditional straight line expensing method) while recognizing a smaller expense in years three and
	four (relative to the traditional straight line expensing method).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Amendment of Plan A Stock Option Plan</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2015, we amended the Plan A stock option
	plan that we established in 2004. Two key amendments were made to the program: (i)&nbsp;the duration of the stock option plan was
	increased by two years from 10.5 to 12.5 years and (ii)&nbsp;the split adjusted strike price of the option was reduced from CHF
	0.93188 to a split adjusted strike price of CHF 0.14548. The lengthening of the plan&rsquo;s term and lowering of the strike price
	was effected to bring the plan in line with our other plans, and resulted in a material increase in the value of the options to
	the option holders and required us to recognize the increase of the transfer in value on our accounts in the first half of 2015.
	The impact of the amendment of the Plan A stock option plan totaled CHF 0.4 million. There are no further expenses that we need
	to recognize in the future associated with this plan.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Acceleration of Options</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The original terms of our Stock Option
	Plan of 2005 (Plan C) contained a provision that would result in the automatic acceleration of all unvested options upon the consummation
	of an initial public offering.&nbsp;Pursuant to a board resolution on October 13, 2015 the Stock Option Plan of 2005 was amended
	and the automatic acceleration feature was removed.&nbsp;Instead, employees had the right, but not the obligation, to have their
	unvested options accelerated such that they vest immediately.&nbsp;Accordingly, a total of 1,250 options were accelerated as a
	result of AC Immune&rsquo;s IPO in September 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our board of directors had the authority
	to accelerate the vesting of all outstanding unvested options granted to employees prior to July 2014, in the event of an initial
	public offering. Pursuant to a board decision on September 18, 2015, 76,000 options previously granted to directors and executive
	officers were accelerated upon consummation of AC Immune&rsquo;s IPO in September 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Financial Operations Overview</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Revenue</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Given our stage of development, we have
	not generated any revenue from product sales. Our revenue to date has been derived primarily from four separate collaboration agreements
	on some of our product candidates in various stages of pre-clinical and clinical developments and a number of research grants we
	have secured. For collaborations established on programs in pre-clinical stage, we recognize revenue from upfront payments under
	our collaboration agreements ratably over the term of our estimated period of performance under each agreement. For collaboration
	agreements on product candidates that are (i)&nbsp;in clinical development, (ii)&nbsp;where the upfront payment reflects a payment
	for past investments we have made in the development of the product candidate, access to the product candidate, the associated
	intellectual property and our knowledge, and (iii)&nbsp;where there is no further performance commitment, we recognize the fair
	value of the upfront payment at the time of entering into the collaboration agreement. For collaboration agreements with product
	candidates in clinical development but where the conditions described in clauses (ii)&nbsp;and (iii)&nbsp;above are not met, we
	recognize the upfront payments ratably over the term of our estimated period of performance under each agreement. For all of our
	collaboration agreements, in addition to receiving upfront payments, we are entitled to milestone and other contingent payments
	upon achieving pre-defined objectives. Revenue from milestones, if they are non-refundable and deemed substantive, are recognized
	upon successful accomplishment of the milestones. To the extent that non-substantive milestones are achieved and we have remaining
	performance obligations, milestones are deferred and recognized as revenue over the estimated remaining period of performance.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our revenues have experienced fluctuations
	over the past three years as a result of securing new collaboration agreements, the timing of milestone achievement and the size
	of each milestone payment. We expect that any revenue we generate from our two collaboration agreements with Genentech, our collaboration
	agreements with each of Janssen and Piramal Imaging, research and development grants, and any other current or future collaboration
	partners will fluctuate from year to year as a result of the timing and amount of milestones and other payments.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Research and Development Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Research and development expenses comprise
	direct research costs, including the use of CROs, consultants and experts hired to assist on our research and development activities,
	consumables used for research and development purposes, employment compensation for our research and development, intellectual
	property, regulatory affairs, quality control and manufacturing personnel, as well as expenses related to regulatory affairs and
	quality control. Our research and development costs include the costs associated with our recurrent maintenance costs associated
	with our portfolio of intellectual property including patents. In addition, research and development expenditures include the depreciation
	of fixed assets used in research and development.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The largest component of our total operating
	expenses has historically been, and will continue to be, our investment in research and development activities, including the clinical
	development of our product candidates. Historically, research and development expenses have represented over 80% of our total annual
	operating costs. Research and development expenses represent costs incurred to conduct research, such as the discovery and development
	of our product candidates, as well as development of new product candidates from our SupraAntigen and Morphomer platforms as well
	as the development of product candidates pursuant to our collaboration agreements with Genentech, Janssen and Piramal Imaging.
	We recognize all research and development costs as they are incurred. Clinical study costs, contract manufacturing and other development
	costs incurred by third parties are expensed as the contracted work is performed. At present, our research activities comprise
	five major areas:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>AD therapies;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Non-AD therapies that are not neuro-orphans therapies;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Neuro-orphan disease therapies;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Diagnostics; and</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>New discovery projects.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Due to the limited financial resources
	of the Company, we have historically allocated over 70% of our research and development budget to AD therapies. We expect our research
	and development expenses to increase substantially in the future and expect to fund a broader number of projects. Specifically,
	the planned capital raising will impact our research strategy in four key ways:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;we
	expect to undertake later-stage research and development of our product candidates and, if approved, to take some of those product
	candidates into commercialization;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;we
	will allocate more funding to existing programs to advance the development of these programs;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iii)&nbsp;&nbsp;&nbsp;we
	will increase our research and development efforts on non-AD indications including neuro-orphans; and</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(iv)&nbsp;&nbsp;&nbsp;we
	will initiate a number of new research initiatives that are complementary to our existing and planned research initiatives.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As a result, research initiatives targeting
	AD will continue to be the primary focus of our research efforts. However, other indications including PD, selected neuro-orphans
	and diagnostics are likely to consume an increasing share of the total research and development expenditures.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The table below provides a breakdown of
	our research and development costs, including direct research and development costs and manufacturing costs related to research
	and development, by major development program for the periods covered by this Annual Report. These research and development costs
	exclude employment costs, regulatory, quality assurance and intellectual property costs. With the exception of ACI-35, research
	costs that are subject to collaboration agreements typically have a limited amount of research expenses since our partners bear
	most or all of the research and development costs. We have shown below our research and development costs associated with advancing
	ACI-35, the tau vaccine candidate that is being developed jointly with Janssen, since pursuant to our agreement we were required
	to provide significant research support for this program until the end of 2016. Our research and development costs for ACI-24 for
	AD and Down syndrome are expected to increase significantly in the coming years as we fund Phase 2b and Phase 1 clinical studies
	for ACI-24 in AD and ACI-24 in</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Down syndrome, respectively. Research and
	development costs for our alpha-synuclein PET tracer diagnostics program and other new discovery areas are also likely to rise
	substantially in the coming years.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Detailed Research and Development Expenditures
	by Major Development Program</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year ended December 31,</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Year Ended December 31,</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 34%; text-align: left; padding-left: 10pt; text-indent: -10pt">Programs subject to collaboration agreements(1)&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,439</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,292</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">147</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,292</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,269</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">23</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-left: 10pt; text-indent: -10pt">ACI-35&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,642</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,611</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,031</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,611</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,389</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,222</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">ACI-24 (for AD and Down syndrome)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5,124</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,495</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,629</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,495</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,918</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(423</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">PD (therapeutics and diagnostics)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,551</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">757</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">794</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">757</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">685</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">72</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt; padding-left: 10pt; text-indent: -10pt">New discovery programs&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,925</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,315</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,610</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,315</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,064</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(749</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 2.5pt; padding-left: 10pt; text-indent: -10pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">16,681</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,470</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,211</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,470</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,325</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">145</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 1pt solid; width: 25%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="margin-top: 0; margin-bottom: 0"></P>



	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Includes research and development expenditures for crenezumab, anti-tau antibodies and tau PET imaging tracer. Does not include
	research and development expenditures for ACI-35.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">General and Administrative Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">General and administrative expenses include
	personnel costs, expenses for outside professional services, and all other allocated expenses. Personnel costs consist of salaries,
	cash bonuses, benefits and share-based compensation. Outside professional services consist of legal, accounting and audit services,
	IT and other consulting fees. Allocated expenses consist of rent expense related to our office and research and development facility.
	We expect to incur additional expenses as a result of operating as a public company, including expenses related to compliance with
	the rules and regulations of the SEC, and those of any national securities exchange on which our securities are traded (NASDAQ),
	additional insurance expenses, investor relations activities and other administrative and professional services.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Financial Income and Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Financial expenses are bank fees associated
	with charges levied by banks on foreign payments and foreign exchange transactions.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Interest income consists of interest received
	from banks on our cash balances. Other financial income relates principally to gains that we have made historically on foreign
	currency transactions, which arise from the fact that some of our collaboration agreements such as the collaboration agreements
	with Genentech and Piramal Imaging are in currencies other than Swiss Francs, and selected purchases, which we effect in foreign
	currencies.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Taxation</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are subject to corporate taxation in
	Switzerland.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are also entitled under Swiss laws to
	carry forward any losses incurred for a period of seven years and can offset our losses carried forward against future taxes. As
	of December 31, 2016, we had tax loss carryforwards totaling CHF 36.7 million. There is no certainty that we will make sufficient
	profits to be able to utilize these tax loss carryforwards.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The corporate tax rate in the Canton of
	Vaud where we are domiciled is currently 21.2%. The Canton does from time to time, amend the level of taxation levied on corporations
	and there is no certainty that the tax rate currently in effect will not change in the future. At present, there are discussions
	on lowering the corporate tax rate in the Canton of Vaud to below 15% by 2021. The Swiss Federal government has recently proposed
	changes to align Swiss corporate taxation with international recommendations but voters in Switzerland voted against such proposals
	in a national referendum on February 12, 2017. As a result, uncertainty will continue about the future level of Swiss corporate
	income taxes that may apply to us until revised proposals are put forward and gain acceptance.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Value Added Tax, or VAT, is charged on
	all qualifying goods and services by VAT-registered businesses. An amount of 8.0% of the value of the goods or services is added
	to all sales invoices and is payable to the Swiss tax authorities. Similarly, VAT paid on purchase invoices is reclaimable from
	the Swiss tax authorities.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Results of Operations</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The numbers below have been derived from
	our audited financial statements included elsewhere herein. The discussion below should be read along with these condensed financial
	statements and it is qualified in its entirety by reference to them.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Comparison of the Years Ended December&nbsp;31, 2016 and
	2015</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Revenue</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our revenues
	during the years ended December&nbsp;31, 2016 and 2015:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended<BR> December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Collaboration and license revenue&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">22,737</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">38,745</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(16,008</TD><TD STYLE="width: 1%; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Grant revenue&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">469</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">316</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">153</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 1pt">Other&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">8</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">29</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(21</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total revenues&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">23,214</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">39,090</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(15,876</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our revenues experience fluctuations
 as 	a result of securing new collaboration agreements, the timing of milestone achievements and the size of each milestone
 payment. 	The decline in revenues in 2016 compared to the same period in 2015 is primarily related to the timing and size of
 clinical milestones 	recognized in each of those periods. Revenues in 2016 resulted from the recognition of a CHF 4.9 million
 clinical milestone and 	CHF 1.5 million recognized for research contributions received related to ACI-35 pursuant to our
 collaboration agreement with Janssen, 	the recognition of a CHF 14 million milestone payment for commencement of phase 1
 clinical studies for the anti-tau antibody under 	collaboration with Genentech, the recognition of an approximate CHF 1.0
 million share of the Biogen upfront payment received in 	April 2016 that we are recognizing over a twelve month period and
 CHF  1.1 million  in research contribution revenues related to 	the Biogen collaboration.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2015, we recognized revenue from two
	collaboration agreements, including a $25 million (CHF 24.3 million) milestone payment related to our collaboration with Genentech
	for crenezumab and a CHF 14&nbsp;million milestone payment associated with the Genentech collaboration agreement for our anti-tau
	antibody candidate.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Research and Development Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our research
	and development expenses during the years ended December&nbsp;31, 2016 and 2015:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	   <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Operating expenses&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">18,489</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,476</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">8,013</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Salaries and related costs (1)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">7,007</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6,286</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">721</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Depreciation of tangible fixed assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">278</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">287</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(9</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total research and development expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">25,774</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">17,049</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,725</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin: 1pt 5.5in 1pt 0in"><DIV STYLE="font-size: 1pt; border-top: Black 0.5pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Includes share-based compensation.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our research and development expenses increased
	to CHF 25.8&nbsp;million for the year ended December&nbsp;31, 2016, from CHF 17.0&nbsp;million, an increase of CHF 8.8&nbsp;million,
	as compared to year ended December&nbsp;31, 2015.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


	<!-- Field: Page; Sequence: 110; Value: 101 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; margin-bottom: 0pt; text-align: center"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->106<!-- Field: /Sequence --></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The increase in research and development
	spending in 2016 was driven by a CHF 1.0 million increase for research and development expenses related to ACI-35, a CHF 3.6 million
	increase in the outlays related to the two ACI-24 programs driven principally by investment in manufacturing, a CHF 0.8 million
	increase in Parkinson&rsquo;s disease focused program including the alpha synuclein PET imaging collaboration with Biogen, and
	a CHF 2.6 million increase in total research and development expenses for new discovery projects that we believe will help us to
	maintain a scientific leadership position in neurodegenerative diseases.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our salaries and costs related to our research
	and development activities rose by CHF 0.7&nbsp;million to CHF 7.0&nbsp;million for the year ended December&nbsp;31, 2016 from
	CHF 6.3&nbsp;million for the year ended December&nbsp;31, 2015. The increase is primarily due to growth of the Company&rsquo;s
	research and development organization to accelerate the development of its proprietary and partnered pipeline candidates.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">General and Administrative Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our general
	and administrative expenses during the years ended December&nbsp;31, 2016 and 2015:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended<BR> December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Salaries and related costs (1)&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">4,728</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2,040</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2,688</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Operating expenses&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,168</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,377</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,791</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total general and administrative expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">7,896</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,417</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">4,479</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Includes share-based compensation.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For the year ended December 31, 2016
 our 	general and administrative expenses totaled CHF 7.9 million, up CHF 4.5 million from CHF 3.4 million we incurred during
 the year 	ended December 31, 2015. The increase is due to a CHF 1.8 million increase in operating expenses driven by higher
 professional 	service costs, such as legal costs, related to AC Immune becoming a public company. The remaining increase is
 primarily attributable 	to salary and benefit related costs, including higher stock based compensation expense of CHF 0.6
 million relating primarily to a replacement 	grant issued to a departing executive officer, and 2016 bonus accruals.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Financial Income and Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our financial
	income and expenses during the years ended December&nbsp;31, 2016 and 2015:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended<BR> December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Finance cost&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(256</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(26</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(230</TD><TD STYLE="width: 1%; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Interest income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">55</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(12</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Finance income&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,573</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,617</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,956</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total financial income&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,360</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,646</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,714</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Net financial income increased to CHF 3.4&nbsp;million
	for the year ended December&nbsp;31, 2016, from CHF 1.6 million for the year ended December&nbsp;31, 2015. The increase was driven
	by gains related to foreign exchange rates on our cash balances in U.S. dollars offset by higher bank fees during 2016 as compared
	to 2015.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Comparison of the Years Ended December 31, 2015 and 2014</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Revenue</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our revenues
	during the years ended December 31, 2015 and 2014:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Years Ended<BR> December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	   <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Collaboration and license revenue&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">38,745</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">30,179</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">8,566</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Grant revenue&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">316</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">75</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">241</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 1pt">Other&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">29</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">15</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">14</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total revenues&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">39,090</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">30,269</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,821</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Total revenues rose to CHF 39.1 million
	for the year ended December 31, 2015 from CHF 30.3 million for the year ended December 31, 2014, an increase of CHF 8.8 million.
	The increase was principally due to collaboration and license revenues rising to CHF 38.8 million for the year ended December 31,
	2015 from CHF 30.2 million for the year ended December 31, 2014. In 2015, we recognized revenue from two collaboration agreements,
	including a $25 million (CHF 24.3 million) milestone payment related to our collaboration with Genentech for crenezumab and a CHF
	14 million milestone payment associated with the Genentech collaboration agreement for our anti-tau antibody.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Research and Development Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our research
	and development expenses during the years ended December 31, 2015 and 2014:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Years Ended December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Operating expenses&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,476</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">9,990</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">486</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Salaries and related costs(1)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6,286</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5,828</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">458</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Depreciation of tangible fixed assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">287</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">298</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(11</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total research and development expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">17,049</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">16,116</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">933</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin: 1pt 5.5in 1pt 0in"><DIV STYLE="font-size: 1pt; border-top: Black 0.5pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Includes share-based compensation.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our research and development expenses rose
	to CHF 17.0 million for the year ended December 31, 2015 from CHF 16.1 million, an increase of CHF 0.9 million, as compared to
	year ended December 31, 2014.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For the year ended December 31, 2015 our
	research and development operating costs increased by CHF 0.5 million to CHF 10.5 million due principally to the increase in expenditures
	related to ACI-35 which we are developing jointly with Janssen.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our salaries and related costs related
	to our research and development activities rose by CHF 0.5 million to CHF 6.3 million for the year ended December 31, 2015 from
	CHF 5.8 million for the year ended December 31, 2014. The increase is due to an average increase in the base compensation of 1.4%
	and the addition of two scientists to our research and development team.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our share based compensation related to
	our research and development employees rose to CHF 0.4 million for the year ended December 31, 2015 from CHF 0.2 million for the
	year ended December 31, 2014. The increase is primarily due to the fact that the company valuation used as the basis for expensing
	share based compensation was nearly doubled during 2015 compared to 2014.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">General and Administrative Expenses</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our general
	and administrative expenses during the years ended December 31, 2015 and 2014:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Years Ended December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Salaries and related costs&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2,040</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,999</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">41</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Operating expenses&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,377</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,437</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(60</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total general and administrative expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,417</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,436</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(19</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">General and administrative expenses for
	the year ended December 31, 2015 were CHF 3.4 million which is in line with the CHF 3.4 million for the year ended December 31,
	2014. It should be noted that CHF 2.2 million of costs associated with the preparations for becoming a public company in the United
	States were not expensed in the year ended December 31, 2015 but rather were accrued and carried forward into 2016 and appear under
	prepaid expenses on our balance sheet for the year ended December 31, 2015.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Financial Income and Expense</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our financial
	income and expenses during the years ended December 31, 2015 and 2014:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Years Ended December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Finance cost&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(26</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(4</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(22</TD><TD STYLE="width: 1%; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Interest income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">55</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">22</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">33</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Finance income&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,617</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">9</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,608</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total financial income&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,646</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">27</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,619</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Net financial income increased to CHF 1.6
	million for the year ended December 31, 2015 from CHF 27 thousand for the year ended December 31, 2014. The increase was driven
	primarily by gains related to foreign exchange rates on our cash balances in US dollars as well as an increase in the interest
	income due to significantly higher cash balances on hand during the year in 2015 as compared to 2014.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Liquidity and capital resources</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our operations have been financed primarily
	by proceeds from our initial public offering in September 2016, from collaboration and license agreements we have with a number
	of partners, and net proceeds from the issuance of preferred shares. At December 31, 2016, we had cash and cash equivalents of
	CHF 152.2&nbsp;million.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our primary uses of capital are, and we
	expect will continue to be, research and development expenses, compensation and related expenses, and other operating expenses
	including rent. Cash used to fund operating expenses is impacted by the timing of when we pay expenses, as reflected in the change
	in our outstanding accounts payable and accrued expenses. We expect to incur substantial expenses in connection with a number of
	our product candidates in various stages of clinical development including co-funding ACI-35 to the end of the ongoing Phase 1b
	clinical study, material increases in spending on ACI-24 in AD to fund a Phase 2 study, ACI-24 in Down syndrome, our PET imaging
	candidates focused on alpha-synuclein and TDP-43 which we are developing together with Biogen and a number of research initiatives
	focused on neurodegenerative orphan diseases other than AD.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We plan to continue to fund our operating
	and capital funding needs through proceeds received from collaboration and licensing agreements and through equity or other forms
	of financing. We may also consider entering into additional collaboration agreements and selectively partnering for clinical development
	and commercialization. The sale of additional equity would result in additional dilution to our shareholders.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Cash Flows</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Comparison of the Years Ended December&nbsp;31,
	2016 and 2015</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our cash
	flows for the periods indicated:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Years Ended December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Net cash provided by (used in):</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="width: 67%; text-align: left; padding-left: 10pt">Operating activities&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(5,646</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">44,084</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(49,730</TD><TD STYLE="width: 1%; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 10pt">Investing activities&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(899</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(244</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(655</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt">Financing activities&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">78,790</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">27,778</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">51,012</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Net change in cash and cash equivalents&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">72,245</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">71,618</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">627</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Operating activities</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The net cash used in operating activities
	was CHF 5.6&nbsp;million for the year ended December&nbsp;31, 2016, compared to net cash provided by operating activities of CHF
	44.1&nbsp;million for the year ended December&nbsp;31, 2015. The decrease in operating cash flows is driven by three factors: (i)
	reporting a net loss of CHF 7.1 million in 2016 compared with a CHF 20.3 million of income for 2015, (ii) no material changes in
	receivables balances in 2016 while in 2015 AC Immune received the CHF 25.9 million upfront payment from Janssen in connection with
	the ACI-35 collaboration, and (iii)&nbsp;offsets due to changes in working capital, for example, accounts payable and accrued expenses
	positively impacted cash provided by operating activities by CHF 4.2 million.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Investing activities</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Net cash used in investing activities
 was 	CHF 0.9&nbsp;million for the year ended December&nbsp;31, 2016, compared with CHF 0.2 million for the year ended
 December&nbsp;31, 	2015. The CHF 0.7&nbsp;million increase in cash used in investing activities was due to an increase in
 investments in fixed assets, 	primarily for laboratory equipment.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Financing activities</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Net cash provided by financing activities
	was CHF 78.8&nbsp;million for the year ended December&nbsp;31, 2016, compared to CHF 27.8&nbsp;million for the year ended December&nbsp;31,
	2015. The increase was driven primarily by the CHF 74.5 million in gross proceeds (CHF 65.3 million net underwriting fees and IPO
	related costs) raised from the IPO in September 2016. Additionally, there was a CHF 16.3 million reduction to Preferred Series
	E/D financing proceeds in 2016 as compared to 2015.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Operating Capital Requirements and Plan of
	Operations</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We do not expect to generate revenues from
	royalties based on product sales unless and until our partners obtain regulatory approval of and commercialize our current or any
	future product candidates. There can be no certainty as to the exact timing, or in fact whether any future milestone payments will
	ever be made given that these milestone payments are contingent on clear milestones being reached. As of December&nbsp;31, 2016
	we had cash balances totaling CHF 152.2&nbsp;million. The cash available for operating capital requirements and operations were
	primarily raised through financing activities totaling CHF 78.8 million for the year ended December 31, 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Accordingly, assuming we do not receive
	further milestone payments and based on our currently contemplated research and development strategy and expenditures, we believe
	that our existing capital resources, not including potential milestone payments, will be sufficient to meet our projected operating
	requirements through at least the fourth quarter of 2018.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We expect to generate losses for the foreseeable
	future, and these losses could increase as we continue product development and if we successfully achieve regulatory approvals
	for our product candidates and begin to commercialize any approved products. We are subject to all the risks pertinent to the development
	of new products, and we may encounter unforeseen expenses, difficulties, complications, delays and other unknown factors that may
	harm our business. Upon closing of the IPO, we incurred additional costs associated with operating a public company and we anticipate
	that we will need substantial additional funding in connection with our continuing operations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our future funding requirements will depend
	on many factors, including but not limited to the following:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
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	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The scope, rate of progress, results and cost of our pre-clinical and clinical studies and other related activities;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The cost of manufacturing clinical supplies and establishing commercial supplies of our product candidates and any other products
	we may develop;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The cost, timing and outcomes of regulatory approvals;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The costs and timing of establishing sales, marketing and distribution capabilities;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The terms and timing of any collaborative, licensing and other arrangements that we may establish, including any required milestone
	and royalty payments thereunder;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The emergence of competing technologies or other adverse market developments; and</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>The potential cost and timing of managing and protecting our portfolio of intellectual property.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Comparison of the Years Ended December 31, 2015 and 2014</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table summarizes our cash
	flows for the periods indicated:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Years Ended December 31,</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Change</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Net cash provided by (used in):</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="width: 67%; text-align: left; padding-left: 10pt">Operating activities&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">44,084</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(17,624</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">61,708</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 10pt">Investing activities&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(244</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(131</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(113</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt">Financing activities&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">27,778</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">9,801</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">17,977</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Net change in cash and cash equivalents&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">71,618</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,954</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">79,572</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Operating activities</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The net cash provided by operating activities
	rose to CHF 44.1 million for the year ended December 31, 2015 from net cash used by operating activities of CHF 17.6 million for
	the year ended December 31, 2014. The significant improvement is driven by three key factors: (i) a significant change in our current
	receivables which amounted to CHF 0.3 million for the year ended December 31, 2015 compared with CHF 25.9 million for the year
	ended December 31, 2014 driven by the receipt of the upfront payment from Janssen related to our collaboration on ACI-35, (ii)
	we generated a net income of CHF 20.3 million for the year ended December 31, 2015 compared with net income of CHF 10.7 million
	for the year ended December 31, 2014 and (iii) a reduction in the amount deferred revenue which declined to CHF 0.2 million for
	the year ended December 31, 2015 from CHF 3.7 million for the year ended December 31, 2014.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Investing activities</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Net cash used in investing activities was
	CHF 0.2 million for the year ended December 31, 2015, compared with CHF 0.1 million for the year ended December 31, 2014. The CHF
	0.1 million increase was due to a slight increase in investments in fixed assets in the laboratory.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Financing activities</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Net cash provided by financing activities
	was CHF 27.8 million for the year ended December 31, 2015, compared to CHF 9.8 million for the year ended December 31, 2014. The
	increase was driven primarily by the $30 million (CHF 29.4 million) Series E Private Placement which we completed in October 2015.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Research and development, patents and licenses, etc.</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;Item 4. Information on the Company
	&ndash; B. Business Overview&rdquo; and Item 5. Operating and Financial Review and Prospects &ndash;A. Operating Results &ndash;
	Results of Operations.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Trend information</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;Item 5. Operating and Financial
	Review and Prospects&rdquo;.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">E.</TD><TD>Off-balance sheet arrangements</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We do not have any material off-balance
	sheet arrangements or commitments.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">F.</TD><TD>Tabular disclosure of contractual obligations</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have been a tenant at our current location
	in the EPFL Innovation Park since shortly after our inception in 2003. We have entered into long-term rental lease agreements with
	respect to these facilities. However, our lease agreements are structured such that we can exit these lease agreements without
	penalty provided we give the owner of our premises sufficient notice.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table presents information
	relating to our contractual obligations as of December 31, 2016:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Payments Due by Period</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Less Than 1 Year</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Between 1 and 5 Years</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">(in thousands of CHF)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left; padding-bottom: 1pt">Operating lease obligations&#9;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 1pt solid; text-align: right">255</TD><TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 1pt solid; text-align: right">255</TD><TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">255</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">-</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">255</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Company has a contractual obligation that require the payment
	of royalties to a third party, which is associated with the achievement of program milestones. As of December 31, 2016, the Company&rsquo;s
	contractual obligation associated with this agreement was CHF 494 thousand.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">G.</TD><TD>Safe harbor</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;Forward-Looking Statements.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 6. DIRECTORS, SENIOR MANAGEMENT AND EMPLOYEES</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Directors and senior management</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Executive Officers, Other Key Employees and Board of Directors</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table presents information
	about our executive officers, other key employees and, directors and director nominees, including their ages, as of December 31,
	2016. The term of each of our directors is one year and, accordingly, will expire at our 2017 annual shareholder meeting to be
	held in May 2017.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="width: 32%; padding-right: 2pt; padding-left: 2pt">
	        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Name</P></TD>
	    <TD STYLE="width: 46%; padding-right: 2pt; padding-left: 2pt">
	        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Position</P></TD>
	    <TD STYLE="width: 7%; padding-right: 2pt; padding-left: 2pt">
	        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Age</P></TD>
	    <TD STYLE="width: 15%; padding-right: 2pt; padding-left: 2pt">
	        <P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">Initial
	Year of Appointment</P></TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt"><B>Executive Officers</B></TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Andrea Pfeifer, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Chief Executive Officer and Director Nominee</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">59</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2003</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Andreas Muhs, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Chief Scientific Officer</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">55</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2005</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Jean-Fabien Monin&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Chief Administrative Officer</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">46</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2009</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt"><B>Other Key Employees</B></TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Wolfgang Barth, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Director of Development</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">63</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2010</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 10pt">David A. Lowe, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Innovation Fellow</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">70</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2014</TD></TR>
	<TR>
	    <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Joseph Wettstein,&#9;Ph.D.</TD>
	    <TD STYLE="vertical-align: bottom; font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Chief Scientific Officer, Deputy and Head of Non-AD Proteinopathies</TD>
	    <TD STYLE="vertical-align: bottom; text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">62</TD>
	    <TD STYLE="vertical-align: bottom; text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2016</TD></TR>
	 <TR>
     <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Julian Gray, M.D., Ph.D.</TD>
     <TD STYLE="vertical-align: bottom; font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Clinical Advisor</TD>
     <TD STYLE="vertical-align: bottom; text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">60</TD>
                   <TD STYLE="vertical-align: bottom; text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2007</TD></TR>
<TR STYLE="vertical-align: top">
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt"><B>Non-Executive Directors</B></TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Martin Velasco&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Chairman and Director</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">62</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2003</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Detlev Riesner, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Director</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">75</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2004</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 20pt; text-indent: -10pt">Friedrich von
     Bohlen und Halbach, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Director</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">54</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2015</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Peter Bollmann, Ph.D.&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Director</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">63</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2015</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="vertical-align: top; font-size: 10pt; padding-right: 2pt; padding-left: 10pt">Thomas Graney(1)&#9;</TD>
	    <TD STYLE="font-size: 10pt; padding-right: 2pt; padding-left: 2pt">Director</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">52</TD>
	    <TD STYLE="text-align: center; font-size: 10pt; text-indent: 0in; padding-right: 2pt; padding-left: 2pt">2016</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>



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	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Thomas Graney was appointed as non-executive director on November 15, 2016 at the Annual General Meeting of the Company.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The current business addresses for our
	executive officers, other key employees, directors and director nominee is AC Immune SA, EPFL Innovation Park, Building B, 1015
	Lausanne, Switzerland.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Executive Officers</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Andrea Pfeifer, Ph.D., Co-Founder, Chief
	Executive Officer and Director:</B> Dr.&nbsp;Pfeifer co-founded AC Immune in April 2003, and has agreed to serve as a director
	on our board effective upon completion of the IPO. Prior to founding us, Dr.&nbsp;Pfeifer was head of Nestl&eacute;&rsquo;s Global
	Research in Lausanne, Switzerland. While at Nestl&eacute;, she led the scientific development of the first Functional Food, LC1,
	and one of the first Cosmoceutical products in a joint venture with L&rsquo;Oreal, Inn&eacute;ov Fermet&eacute;. She also co-founded
	the Nestl&eacute; Venture Capital Fund, a Life Sciences corporate venture fund. She serves as chairwoman of Investment Fund BioMedInvest,
	Basel and AB2 Bio, Lausanne and is a member of the Supervisory Board of Symrise AG, Holzminden. Dr.&nbsp;Pfeifer is a member of
	the CEOi Initiative on Alzheimer&rsquo;s Disease.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Dr.&nbsp;Pfeifer holds a Ph.D. in Toxicology,
	Cancer Research from the University of W&uuml;rzburg, Germany. She continued with post-doctoral work in Molecular Carcinogenesis
	at the National Institutes of Health, Human Carcinogenesis Branch, in Bethesda, Maryland. Dr.&nbsp;Pfeifer is a registered toxicologist
	and pharmacist. She received her habilitation from the University of Lausanne, Switzerland and is also an honorary professor at
	the &Eacute;cole Polytechnique F&eacute;d&eacute;rale de Lausanne (EPFL).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Andreas Muhs, Ph.D., Chief Scientific
	Officer:</B> Dr.&nbsp;Muhs has served as our Chief Scientific Officer since 2005. Prior to joining AC Immune in 2005, he was responsible
	for the development of the cardiac stem cell-based program to treat myocardial infarction, including worldwide pre-clinical program
	collaborations and technology transfers at ViaCell Inc., Cambridge, MA. Prior to ViaCell Inc., he was the Director of Pharmacology
	and Histology at Cardion AG where he developed research projects with translation into clinical applications in the fields of heart
	and circulation, angiogenesis and immunology and based on gene-, protein- and stem cell therapies. Dr.&nbsp;Muhs holds a Ph.D.
	in Biology from the University D&uuml;sseldorf, Germany, where he worked on regulation of endothelial barrier functions.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Jean-Fabien Monin, Chief Administrative
	Officer:</B> Mr.&nbsp;Monin was nominated Chief Administrative Officer in July 2015 following his role as our Chief Financial Officer
	from March 2009 to July 2015. Prior to AC Immune, he held several positions during his tenure of 14 years at bioM&eacute;rieux,
	a leading international <I>in vitro</I> diagnostics group, culminating in his nomination as Chief Financial Officer. His last position
	was CFO of bioM&eacute;rieux Central Europe based in Vienna, Austria from December 2006 to March 2009. Mr.&nbsp;Monin holds a Masters
	in Finance and International Business from the University of Paris-Dauphine, France.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, we announced on November 23,
	2016 that we had appointed <B>Mr. Joerg Hornstein as Chief Financial Officer</B> to replace Mr. George Pavey, who left the Company
	after the initial public offering. Mr. Hornstein is expected to begin his role as Chief Financial Officer on April 1, 2017. In
	the meantime, Mr. Monin is acting as our interim principal financial officer.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Prior to joining AC Immune, Mr. Hornstein
	served as Senior Vice President Group Controlling for Unternehmensgruppe Theo M&uuml;ller based in Luxembourg from January 2014
	to March 2017. Between 2002 and 2013 he worked for Merck KGaA, a leading science and technology company in healthcare, life science
	and performance materials, where he held various senior finance roles. Amongst others, he was CFO for Merck&rsquo;s operations
	in Indonesia and Merck Serono&rsquo;s operations in China. Furthermore, he served as Vice President Group Controlling for Merck
	Group Headquarters in Germany and as Divisional CFO for Merck Millipore in the U.S. Mr. Hornstein holds an MBA with Distinction
	from London Business School, UK, and a Bachelor of Business Administration from Baylor University in the U.S.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Other Key Employees</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Wolfgang Barth, Ph.D., Director of Development:</B>
	Dr.&nbsp;Barth has served as our Director of Development since June 2010. Prior to joining AC Immune, he was the Head of Development
	at TRIN-Pharma. Previous to TRIN-Pharma, Dr.&nbsp;Barth was at Bayer Healthcare, where he was the responsible project leader of
	numerous preclinical and clinical development projects. The most important project was the development of the PDE5 inhibitor Levitra
	which he led from the start of preclinical development until market launch. Wolfgang Barth holds a Ph.D. in Chemistry from the
	University of Marburg and received a NATO stipend for a postdoctoral staff position at the Ohio State University.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>David A. Lowe, Ph.D., Innovation Fellow:</B>
	Dr.&nbsp;Lowe has served as our Deputy Chief Scientific Officer and more recently as Innovation Fellow since January 2014. Previously,
	Dr.&nbsp;Lowe was the Chief Scientific Officer at PsychoGenics Inc., Chief Scientific Officer at Memory Pharmaceuticals (acquired
	by Roche), Executive Vice President and Chief Scientific Officer at Fidelity Biosciences Group in Boston, President, CEO and Director
	of Envivo Pharmaceuticals (now Forum Pharmaceuticals), Vice President and therapeutic area head at Roche Bioscience in Palo Alto,
	Vice President and global therapeutic area head at Bayer AG, and head of CNS Biology and deputy head of CNS Research at Sandoz
	Ltd (now Novartis). Dr.&nbsp;Lowe is also an adjunct professor of Neuroscience at the Icahn School of Medicine in New York City.
	He received his Ph.D. in Neurobiology from the University of Leeds, UK.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Joseph G. Wettstein, Ph.D., Chief
Scientific Officer Deputy and Department Head of non-AD Proteinopathies:</B> Dr.&nbsp;Wettstein has served as our Chief Scientific
Officer Deputy since February 2016 and leads all of our non-AD programs including our initiatives focused on Parkinson&rsquo;s
disease, Huntington&rsquo;s disease and TDP-43 across both therapeutic and diagnostic programs. Prior to AC Immune, Dr.&nbsp;Wettstein
was Vice President in Neuroscience with Roche Pharmaceuticals in Basel where he oversaw R&amp;D activities associated with programs
designed to discover drugs for patients covering a range of brain disorders including Parkinson&rsquo;s, schizophrenia, Huntington&rsquo;s,
Down syndrome, Alzheimer&rsquo;s, autism, bipolar disorder, depression and Fragile X. As Head of Systems Pharmacology, CNS Research
at Aventis, he played a critical role in the discovery of the immunomodulatory drug teriflunomide (Aubagio <FONT STYLE="font-size: 10pt"><SUP>&reg;</SUP></FONT>)
for multiple sclerosis. Dr.&nbsp;Wettstein holds a Ph.D. from the College of Medicine at the University of Kentucky and was a
Postdoctoral Fellow then instructor at Harvard Medical School.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Julian Gray, M.D., Ph.D., Clinical
Advisor</B>: Dr. Gray has served as Clinical Advisor to our programs in neurodegenerative diseases since January 2007 and works
in this function exclusively for AC Immune. He has previously held the position of Head of CNS Therapeutics at Eisai Ltd in London
leading the global development of early and late-stage CNS projects in Alzheimer&rsquo;s disease, Parkinson&rsquo;s disease and
other CNS areas. Prior to this he served as Head of Alzheimer Clinical Research at Hoffmann-La Roche in Basel where he conducted
large scale clinical trials in the US and Europe. After his studies he was Medical Expert at Sandoz Pharmaceuticals in Basel undertaking
clinical studies of different compounds in dementia and Parkinson&rsquo;s disease. Dr Gray holds the title of a Specialist in
Pharmaceutical Medicine (Switzerland). He received his medical degree (MBBS) from the University of London, a BA and Ph.D. from
the University of Oxford and an MBA from the Oxford Brookes University.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Non-Executive Directors</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Martin Velasco, Chairman and
 Director:</B> 	Mr.&nbsp;Velasco has served on our board of directors since December 2003.&nbsp;Martin Velasco is an
 entrepreneur and Business 	Angel with extensive experience in the IT, medical and biotech areas.&nbsp;He serves on the board
 of directors or advisory board 	of several other high-tech companies including: as Founder, Chairman and Chief Executive
 Officer of Anecova, an assisted reproductive 	technology (ART) company and World Economic Forum Technology Pioneer 2008 as
 Chairman of the Supervisory Board of Cocomore, a digital communications 	agency&nbsp;and IT services firm, as Board Member of
 Aridhia, a Health Informatics company, and as Board Member of Aleva Neurotherapeutics, 	a Deep Brain Stimulation (DBS)
 company. Martin is also the Founder and Chairman of Infantia Foundation, a philanthropic organization 	aiding children in the
 developing world. He is a member of the Board of BlueOrchard, the leading private microfinance investment 	advisory company,
 member of the Strategic Advisory Board of the EPFL, Vice President of the Board of the Foundation EPFL <B>+</B> 	and Vice
 Chairman of the European Tech Tour Association.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Detlev H. Riesner, Ph.D.,
 Director: </B>Prof. Riesner has served on our board since 2004. He held the Chair of Biophysics at the
 Heinrich-Heine-University in D&uuml;sseldorf, Germany from 1980 to 2007. He has also held the positions of Dean of the
 Science Faculty and Vice-President of Research. In 2007 he became member of the university&rsquo;s Board of Trustees. He
 worked as a research fellow at Princeton University and held a guest professorship at the department of Neurology at the
 University of California, San Francisco. Prof. Riesner is a co-founder of Qiagen N.V., Netherlands, was a member and from
 1999 to 2014 chairman of the Supervisory Board. He was also a member of the supervisory boards of NewLab Bioquality AG,
 Erkrath, Direvo AG, K&ouml;ln, and Alantos AG, Heidelberg. Currently, he is the chairman of the Advisory Board of Evoxx
 Technologies GmbH, Monheim am Rhein. Prof. Riesner was a member of the scientific advisory boards of the
 Friedrich-L&ouml;ffler-Institut, Isle of Riems, and PrioNet and APRI, both Canada. He received the Max-Planck
 Forschungspreis for International Co-operation and the Bundesverdienstkreuz 1. Klasse from the Bundespresident of
 Germany.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Friedrich von Bohlen und Halbach, Ph.D.,
	Director:</B> Dr. von Bohlen has served on our board since October 2015. He is co-founder and managing director of dievini Hopp
	BioTech holding GmbH &amp; Co. KG. He brings extensive industry experience from Fresenius AG, FAG Kugelfischer, and WASAG-Chemie
	AG, founded LION bioscience AG in 1997 (now SYGNIS Pharma AG) and served as the company&rsquo;s CEO. Dr. von Bohlen is a board
	member of various companies of the dievini portfolio and Chairman of Apogenix AG, CureVac AG and Novaliq GmbH. He holds a PhD in
	Neurobiology from the Swiss Federal Institute of Technology in Zurich, Switzerland.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Peter Bollmann, Ph.D., Director:</B>
	Dr. Bollmann has joined our board in December 2015. He has extensive management and finance experience in Switzerland and abroad
	as CEO, CFO and member of the board. His broad industry experience embraces biotechnology and medical technology firms including
	previous Board positions with Cytos Biotechnology and Prionics.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>Thomas Graney, Director: </B>Mr. Thomas
	Graney joined our board in November 2016. He has been the Chief Financial Officer and Senior Vice President of Finance &amp; Corporate
	Strategy at Ironwood Pharmaceuticals, Inc. since September 2014. Mr. Graney spent 20 years working with J&amp;J and its affiliates,
	serving for four years as worldwide Vice President of Finance and Chief Financial Officer of Ethicon. In addition, Mr. Graney has
	extensive global experience that spans corporate development, commercial strategy, portfolio management and supply chain management.
	A Chartered Financial Analyst charterholder, Mr. Graney holds a B.S. in Accounting from the University of Delaware and an M.B.A.
	in Marketing Finance and International Business from the Leonard N. Stern School of Business at New York University.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Compensation</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Compensation of Directors and Executive Officers</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For the year ended December&nbsp;31, 2016,
	the aggregate compensation accrued or paid to the members of our board of directors and our executive officers for services in
	all capacities was CHF 2.3 million.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">During the year ended December&nbsp;31,
	2016, the total fair value of stock options granted to directors and executive officers was CHF 674 thousand.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">The amount set aside or accrued by us to provide
	pension, retirement or similar benefits to members of our board of directors or executive officers amounted to a total of CHF 154,000
	in the year ended December&nbsp;31, 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We incorporate by reference into this Annual
	Report the information in &ldquo;Item 1.C&mdash;2015 Board Compensation&rdquo; and &ldquo;Item 2.C&mdash;2015 Executive Compensation&rdquo;
	of Exhibit 99.4 to our report on Form 6-K filed with the SEC on March 17, 2017.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Equity Incentive Plans</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We ceased issuing new grants under our
	existing equity incentive plans, which we refer to as the Prior Plans, and adopted a new omnibus equity incentive plan under which
	we have the discretion to grant a broad range of equity-based awards to eligible participants.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Prior Plans</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Since our inception in 2003, we have had
	four separate Prior Plans: Plan A, which were established in 2004 and amended in June 2015; Plan B, which was established in 2005;
	Plan C1, which was established in 2006; and Plan C2, which was also established in 2006 but which is intended specifically for
	members of our board of directors to purchase our common shares. Due to a change in the taxation of options in 2013, we introduced
	a new Equity Incentive Plan in 2013. As of December&nbsp;31, 2016, there were 403,375 and 1,284,525 common shares underlying outstanding
	unvested options and vested options granted pursuant to our Prior Plans, respectively.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Furthermore, pursuant to a board resolution
	on October 13, 2015 all options which were granted to directors and executive officers in connection with IPO were accelerated
	upon consummation of the IPO. This resulted in the acceleration of a total of 76,000 unvested options.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>Plan Administration</I>. Under each
	of the Prior Plans, an option, which can only be granted with the approval of our board of directors, is evidenced by an option
	agreement signed by the participant to indicate his or her acceptance of the option subject to the terms and conditions of the
	applicable Prior Plan.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>Eligibility</I>. Under Plans A, B and
	C1, options were granted to our directors, employees, advisors and agents. Under Plan C2, options were granted only to selected
	members of our board of directors. Under the Equity Incentive Plan 2013, options were granted to our director, employees, advisors
	and agents.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>Option Exercise Price</I>. With the
	exception of Plan A, the exercise price of all options issued under the Prior Plans is CHF 0.14548. The original exercise price
	for options issued under Plan A was CHF 0.93186. However, this exercise price was amended in June 2015 with the approval of our
	board of directors to be CHF 0.14548. As a result, as of December&nbsp;31, 2016, all options outstanding under our Prior Plans
	have an exercise price of CHF&nbsp;0.14548.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>Vesting Period</I>. The vesting periods
	of options issued under our Prior Plans vary. The options granted under Plan A vested immediately but were subject to a four year
	lockup period. The options granted under Plan B vested over a four year period with 25% of these options vested after one year
	of service and thereafter, 6.25% of the options granted vesting each quarter. Under Plan C1, the vesting period for options was
	four years with 25% of the options vesting each year. Under Plan C2, options were immediately exercisable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><I>Amendment</I>. Our board of directors
	has the authority to amend each of the Prior Plans.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">2016 Stock Option and Incentive Plan</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">At the November 15, 2016 AGM of the Company
	our board of directors approved the 2016 Stock Option and Incentive Plan (the &ldquo;2016 Plan&rdquo;).&nbsp; The maximum number
	of shares available for issuance under the 2016 Plan is 2,057,740 common shares.&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Plan Administration</I>.&nbsp; The 2016
	Plan is administered by the either our board of directors or the compensation committee, or a similar committee performing the
	functions of the compensation committee.&nbsp;&nbsp; Approval of the plan administrator is required for all grants of awards under
	the 2016 Plan, but the administer may delegate to our Chief Executive Officer the authority to grant awards, subject to certain
	limitations set forth on the plan.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Awards.&nbsp; </I>Awards may be granted
	in the form of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock units, restricted
	stock awards, unrestricted stock awards, performance share awards and dividend equivalent rights.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Eligibility. </I>Under the 2016 Plan,
	full or part-time officers and other employees, non-employee directors and consultants of the Company and its subsidiaries who
	are selected by the administrator are eligible to participate in the plan.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Option Exercise Price. </I>Under the
	2016 Plan, the option exercise price is determined by the plan administrator at the time of grant, but will not be less than fair
	market value (as defined in the 2016 Plan) on the grant date, and for incentive stock options granted to any employee who is a
	10 percent owner in the Company, will not be less than 110 percent of the fair market value on the grant date.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Vesting Period.&nbsp; </I>&nbsp;Vesting
	conditions are determined by the administrator at the time of grant and are specified in the applicable award certificate.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Accelerated Vesting. </I>&nbsp;The administrator
	may accelerate the exercisability or vesting of all or any portion of any award in circumstances involving the grantee&rsquo;s
	death, disability, retirement or termination of employment, or a change in control.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><I>Amendment</I>.&nbsp; Our board of directors
	has the authority to amend the 2016 Plan.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>


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	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Equity Compensation</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Since the beginning of the fiscal year
ended December 31, 2016, we have granted our executive officers, in the aggregate, options for the right to acquire 98,500 shares
at a price of CHF 0.14548 per share, that vest over a four year period with 25% vesting on each of July 14, 2017, July 14, 2018,
July 2019, and July 14, 2020. In connection with his departure in the fourth quarter of 2016, the Chief
Financial Officer forfeited his initial 2016 grant (included in the aggregate total above), and in its place was awarded 49,250
  options at an exercise price of CHF 0.14548, which will expire on March 31, 2019.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Board practices</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Board Composition and Election of Directors</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our board of directors is composed of six
	directors. Each director is elected for a one-year term. The current members of our board of directors were appointed at a shareholders&rsquo;
	meeting held on November 15, 2016 to serve until the 2017 shareholders&rsquo; meeting to be held in May 2017.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are a foreign private issuer. As a result,
	in accordance with the NASDAQ stock exchange listing requirements, we rely on home country governance requirements and certain
	exemptions thereunder rather than relying on the stock exchange corporate governance requirements. For an overview of our corporate
	governance principles, see &ldquo;Item 16G. Corporate governance.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Board Meetings</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-weight: normal">Our Board
	of Directors held in 2016 five physical meetings and several additional meetings by conference call. The Board discussed and analyzed
	the scientific, business, financial and organizational risks of the Company based on the external factors and internal changes
	impacting the risks for the Company in the future</FONT></P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Director Independence</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As a foreign private issuer, under the
	listing requirements and rules of NASDAQ, we are not required to have independent directors on our board of directors, except to
	the extent that our audit and finance committee is required to comply with independence requirements, subject to certain phase-in
	schedules. However, our board of directors has determined that, under current listing requirements and rules of NASDAQ (which we
	are not subject to) and taking account any applicable committee independence standards, Martin Velasco, Detlev Riesner , Friedrich
	von Bohlen Und Halbach, Peter Bollmann and Thomas Graney are &ldquo;independent directors.&rdquo; In making such determination,
	our board of directors considered the relationships that each non-employee director has with us and all other facts and circumstances
	our board of directors deemed relevant in determining the director&rsquo;s independence, including the number of ordinary shares
	beneficially owned by the director and his or her affiliated entities, if any.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Committees of the Board of Directors</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our board of directors established two
	separate committees: an audit and finance committee and a compensation, nomination and governance committee.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Audit and Finance Committee</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The audit and finance committee, which
	consists of Peter Bollmann, Thomas Graney and Martin Velasco, assists our board of directors in overseeing our accounting and financial
	reporting processes and the audits of our financial statements. In addition, the audit and finance committee is directly responsible
	for the appointment, compensation, retention and oversight of the work of our independent registered public accounting firm. Peter
	Bollmann serves as Chairman of the committee. The audit and finance committee consists exclusively of members of our supervisory
	board who are financially literate, and Peter Bollmann and Thomas Graney are considered to be &ldquo;audit committee financial
	experts&rdquo; as defined by the SEC. Our board of directors has determined that Peter Bollmann, Thomas Graney and Martin Velasco
	satisfy the &ldquo;independence&rdquo; requirements set forth in Rule 10A-3 under the Exchange Act.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The audit and finance committee is governed
	by a charter that complies with NASDAQ rules. The audit and finance committee has the responsibility to, among other things:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review and assess the qualifications, independence, performance and effectiveness of the independent auditor;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review the scope of the prospective audit by the independent auditor, the estimated fees, and any other matters pertaining
	to the audit;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>approve any audit and non-audit services proposed to be provided by the independent auditor to ensure independent auditor independence;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review and assess the independent auditor&rsquo;s report, management letters and take notice of all comments of the independent
	auditor on accounting procedures and systems of control, and review the independent auditor&rsquo;s reports with management;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>be responsible for the resolution of disagreements between the management and the independent auditor;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review and evaluate the lead audit partner of the independent audit team and confirm and evaluate their rotation;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review, discuss with the chief financial officer and the independent auditor and approve (i)&nbsp;the annual and quarterly
	financial statements, (ii)&nbsp;reports intended for publication and (iii)&nbsp;any other financial statements intended for publication
	to consider significant financial reporting issues and judgments made in connection with the preparation of our financial statements,
	including any significant changes in our selection or application of accounting principles;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review with the management, personnel responsible for the design and implementation of the internal audit function and the
	independent auditor in separate meetings any analysis or other written communication prepared by the management and/or the independent
	auditor setting forth significant financial reporting issues and judgments made in connection with the preparation of the financial
	statements, including critical accounting policies, the effect of regulatory and accounting initiatives, as well as off-balance
	sheet transactions and structures on our financial statements;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review and approve our quarterly financial statements for the first three quarters of each calendar year and the corresponding
	financial results releases;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review in cooperation with the independent auditor and the management whether the accounting principles applied are appropriate
	in view of our size and complexity;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>periodically review our policies and procedures for risk management and assess the effectiveness thereof including discussing
	with management our major financial risk exposures and the steps that have been taken to monitor and control such exposures;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>discuss with management and external advisors any legal matters that may have a material impact on our financial statements
	and any material reports or inquiries from regulatory or governmental agencies which could materially impact our contingent liabilities
	and risks;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>review our disclosure controls and procedures and internal control over financial reporting which shall include significant
	deficiencies and material weaknesses in the design or operation of internal controls over financial reporting;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>establish procedures for the receipt, retention and treatment of complaints received regarding accounting, internal accounting
	controls or auditing matters, and the confidential, anonymous submission by employees of concerns regarding questionable accounting
	or auditing matters; and</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>recommend to the board whether to approve and ratify any related person transaction in accordance with our related person transaction
	policy.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The audit and finance committee will meet
	as often as it determines is appropriate to carry out its responsibilities, but in any event will meet at least four times per
	year.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Compensation, Nomination and Governance
	Committee</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The compensation, nomination and governance
	committee, consists of Detlev Riesner (chair), Martin Velasco and Thomas Graney and will assist our board of directors in overseeing
	our cash compensation and equity award recommendations for our executive officers along with the rationale for such recommendations,
	as well as summary information regarding the aggregate compensation provided to our executive officers. Swiss law requires that
	we adopt a compensation committee, so in accordance with NASDAQ Listing Rule 5615(a)(3), we will follow home country requirements
	with respect to the compensation, nomination and governance committee. As a result, our practice will vary from the requirements
	of NASDAQ Listing Rule 5605(d), which sets forth certain requirements as to the responsibilities, composition and independence
	of compensation committees, and from the independent director oversight of director nominations requirements of NASDAQ Listing
	Rule 5605(e). We will be subject to the Swiss Ordinance Against Executive Compensation (&ldquo;Say on Pay&rdquo; Rule). This means
	that the compensation of our board of directors and Executive Officers must be presented by the board of directors to our shareholders
	and our shareholders must vote on the proposed compensation.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, this committee will also be
	responsible for director and board committee nominations as well as reviewing and amending, if required, our corporate governance
	framework and guidelines.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Employees</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December 31, 2016, we employed 67
	employees, 10 of whom were part-time employees. 42 of our employees hold Ph.D. degrees and 21 hold M.Sc. degrees. Our 67 employees
	are from over 20 countries. The average number of employees (calculated on full time equivalents) in 2016 was 58. We have never
	had a work stoppage, and none of our employees are represented by a labor organization or under any collective-bargaining arrangements.
	We consider our employee relations to be good.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">E.</TD><TD>Share ownership</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;Item 7. Major Shareholders and
	Related Party Transactions-A. Major shareholders.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 7. MAJOR SHAREHOLDERS AND RELATED PARTY TRANSACTIONS</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Major shareholders</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table presents information
	relating to the beneficial ownership of our common shares as of the date of this Annual Report by:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>each person, or group of affiliated persons, known by us to own beneficially 5% or more of our outstanding common shares;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>each of our executive officers and directors; and</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>all executive officers and directors as a group.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The number of common shares beneficially
	owned by each entity, person, executive officer or director is determined in accordance with the rules of the SEC, and the information
	is not necessarily indicative of beneficial ownership for any other purpose. Under such rules, beneficial ownership includes any
	common shares over which the individual has sole or shared voting power or investment power as well as any common shares that the
	individual has the right to acquire within 60 days of March 1, 2017 through the exercise of any option, warrant or other right.
	Except as otherwise indicated, and subject to applicable community property laws, the persons named in the table have sole voting
	and investment power with respect to all common shares held by that person.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The percentage of outstanding common shares
	is computed on the basis of 56,922,242 common shares outstanding as of March 1, 2017. Common shares that a person has the right
	to acquire within 60&nbsp;days of March 1, 2017 are deemed outstanding for purposes of computing the percentage ownership of the
	person holding such rights, but are not deemed outstanding for purposes of computing the percentage ownership of any other person,
	except with respect to the percentage ownership of all executive officers and directors as a group. Unless otherwise indicated
	below, the address for each beneficial owner is AC Immune, EPFL Innovation Park, Building B, Lausanne.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Shares Beneficially Owned</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Shareholder</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Percent</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">5% Shareholders</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">dievini Hopp BioTech holding GmbH &amp; Co KG(1)&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">18,041,000</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">31.7</TD><TD STYLE="width: 1%; text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Varuma AG(2)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11,400,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20.0</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">Executive Officers and Directors</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Andrea Pfeifer(3)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,076,500</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.4</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Andreas Muhs(4)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">898,500</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.6</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Jean-Fabien Monin(5)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Martin Velasco(6)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">974,750</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.7</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Detlev Riesner(7)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">769,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.4</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Friedrich von Bohlen und Halbach(8)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Peter Bollmann&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Thomas Graney&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">*</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">All executive officers and directors as a group (8 persons)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6,125,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10.8</TD><TD STYLE="text-align: left">%</TD></TR>
	</TABLE>

	<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin: 1pt 5.5in 1pt 0in"><DIV STYLE="font-size: 1pt; border-top: Black 0.5pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0in">*&#9;Indicates beneficial ownership
	of less than 1% of the total issued and outstanding common shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(1)</TD><TD>Represents 18,041,000 shares held by dievini Hopp BioTech holding CmbH &amp; Co KG. Dietmar Hopp controls the voting and investment
	decisions of the ultimate parent company of dievini Hopp BioTech holding CmbH &amp; Co KG. The shares registered in the name of
	dievini Hopp BioTech holding CmbH &amp; Co KG may also be deemed to be beneficially owned by Friedrich von Bohlen und Halbach and
	Matthias Hothum, each of whom is a managing director of dievini Hopp BioTech holding CmbH &amp; Co KG. The address for dievini
	Hopp BioTech holding CmbH &amp; Co KG, Friedrich von Bohlen und Halbach and Matthias Hothum is Johann-Jakob-Astor Str. 57, 69190
	Walldorf, Germany.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(2)</TD><TD>The address for Varuma AG is Aeschenvorstadt 55, CH-4051 Basel, Switzerland. Rudolf Maag controls the voting and investment
	decisions of Varuma AG.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(3)</TD><TD>Consists of 2,908,500 of our common shares and options to purchase 168,000 of our common shares exercisable within 60 days
	of December 31, 2016.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(4)</TD><TD>Consists of 581,750 of our common shares and options to purchase 316,750 of our common shares exercisable within 60 days of
	December&nbsp;31, 2016.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(5)</TD><TD>Consists of 265,000 of our common shares and options to purchase 62,500 of our common shares exercisable within 60 days of
	December&nbsp;31, 2016.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(6)</TD><TD>Consists of 964,500 of our common shares and options to purchase 10,250 of our common shares exercisable within 60 days of
	December&nbsp;31,&nbsp;2016. Includes shares held through an entity controlled by Mr. Velasco and, as such, Mr. Velasco has sole
	voting and dispositive power over such shares.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(7)</TD><TD>Consists of 769,000 of our common shares and options to purchase 5,000 of our common shares exercisable within 60 days of December&nbsp;31,
	2016. Includes shares held through an entity controlled by Dr. Riesner and, as such, Dr. Riesner has sole voting
and dispositive power over such shares.</P>

<P STYLE="margin: 0pt 0"></TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">(8)</TD><TD>Consists of 78,750 of our common shares, and excludes the 18,041,000 shares registered in the name of dievini Hopp BioTech
	holding CmbH &amp; Co KG that may also be beneficially owned by Friedrich von Bohlen und Halbach. See note (1) above.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Holders</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of March 10, 2017, we had 195 shareholders
	of record of our common stock.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Significant Changes in Ownership by Major Shareholders</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have experienced significant changes
	in the percentage ownership held by major shareholders as a result of our initial public offering. Prior to our initial public
	offering in September 2016, our principal shareholders were dievini Hopp BioTech holding GmbH &amp; Co KG (36.5%) and Varuma AG
	(23.1%).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In September 2016, we completed our initial
	public offering and listed our common shares on the NASDAQ Global Market. In the initial public offering, we issued and sold 6,900,000
	common shares, including 900,000</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">common shares sold to the underwriters pursuant
	to the underwriters&rsquo; over-allotment option. While none of our existing shareholders sold common shares in the initial public
	offering, the percentage ownership held by certain shareholders decreased as a result of the issuance of the common shares sold
	by us in the initial public offering.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Related party transactions</TD>
</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following discussion pertains to a
	Registration Rights Agreement entered by the Company, which represents the only related party transaction we have entered into
	since January&nbsp;1, 2014 with any of our executive officers, directors and holders of more than 10% of any class of our voting
	securities, or any member of the immediate family of any of the foregoing persons, other than the compensation arrangements we
	describe under &ldquo;Item 6. Directors, Senior Management and Employees&ndash;B.Compensation.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Registration Rights Agreement</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We entered into a registration rights agreement
	in connection with the Series E Private Placement with certain investors in the Series E Private Placement pursuant to which we
	granted them certain demand and piggyback registration rights for the resale of the common shares held by them, as described below.
	The shareholders party to the registration rights agreement hold an aggregate of 33,028,758 of our common shares, representing
	approximately 58.0% of the voting power of our common shares outstanding as of March 1, 2017. The registration rights described
	below will expire on the earlier to occur of (i)&nbsp;the fifth anniversary of the completion of our initial public offering and
	(ii)&nbsp;the date on which there are no remaining registrable securities held by the parties to the registration rights agreement.
	The registration rights agreement provides that we must pay certain registration expenses in connection with any demand, piggyback
	or shelf registration. The registration rights agreement contains customary indemnification and contribution provisions.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Demand Registration Rights</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the terms of the registration
	rights agreement, at any time after the date that is six months after completion of our initial public offering, or the trigger
	date, a shareholder or group of shareholders holding at least 10% of our outstanding common shares may request that we effect a
	registration under the Securities Act of all or any portion of such requesting shareholders&rsquo; registrable securities. At least
	10 business days prior to the anticipated filing date of the registration statement relating to such demand registration, we must
	give all other shareholders party to the registration rights agreement notice of such requested registration. Within five business
	days of such notice, any of the other shareholders party to the registration rights agreement may request that we also effect the
	registration of the registrable securities held by them. We will not be required to effect a registration of all such registrable
	securities unless the aggregate proceeds expected to be received from the sale of such registrable securities equals or exceeds
	$10&nbsp;million or such lesser amount that constitutes all of the requesting shareholders&rsquo; registrable securities (<I>provided</I>
	that such lesser amount is at least $5&nbsp;million). In no event will we be required to effect more than two demand registrations
	or underwritten take downs referred to under &ldquo;&mdash;Shelf Registration Rights&rdquo; below. Depending on certain conditions,
	we may postpone a demand registration on two occasions during any period of twelve consecutive months for up to 90 days.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Piggyback Registration Rights</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the terms of the registration
	rights agreement, at any time after the trigger date, if we propose to register any of our securities, whether or not for sale
	for our own account, we must give notice to the shareholders party to the registration rights agreement, and they will be entitled
	to certain piggyback registration rights allowing them to each their shares in the registration, subject to certain marketing and
	other limitations. As a result, whenever we propose to file a registration statement under the Securities Act, the holders of these
	shares are entitled to notice of the registration and to request that we include their shares in the registration.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Shelf Registration Rights</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Pursuant to the terms of the registration
	rights agreement, at any time after the first anniversary of the completion of our initial public offering, if we are eligible
	to use a shelf registration statement, then a shareholder or group of shareholders holding at least 10% of our outstanding common
	shares may request that we effect a shelf registration on similar terms as the demand registrations described above, except that
	offerings will be conducted as underwritten takedowns. We will only be required to effect one public offering from such shelf registration
	statement within any six month period, each of which shall be deemed to constitute a demand registration for</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">purposes of the number of demand registrations
	we are required to effect as described under &ldquo;&mdash;Demand Registration Rights&rdquo; above.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Related Person Transaction Policy</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Prior to our initial public offering, we
	entered into a new related person transaction policy under which any such transaction must be approved or ratified by the audit
	and finance committee.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indemnification Agreements</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In connection with our initial public offering,
	we entered into indemnification agreements with our executive officers and directors. The indemnification agreements and our Articles
	of Association require us to indemnify our executive officers and directors to the fullest extent permitted by law.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Interests of Experts and Counsel</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 8. FINANCIAL INFORMATION</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Consolidated statements and other financial information</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Financial statements</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;Item 18. Financial Statements,&rdquo;
	which contains our financial statements prepared in accordance with IFRS.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Legal Proceedings</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">From time to time we may become involved
	in legal proceedings that arise in the ordinary course of business. During the period covered by the financial statements contained
	herein, we have not been a party to or paid any damages in connection with litigation that has had a material adverse effect on
	our financial position. No assurance can be given that future litigation will not have a material adverse effect on our financial
	position. When appropriate in management&rsquo;s estimation, we may record reserves in our financial statements for pending litigation
	and other claims.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dividends and Dividend Policy</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have never declared or paid cash dividends
	on our capital stock. We intend to retain all available funds and any future earnings, if any, to fund the development and expansion
	of our business and we do not anticipate paying any cash dividends in the foreseeable future. Any future determination related
	to dividend policy will be made at the discretion of our board of directors.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under Swiss law, any dividend must be proposed
	by our board of directors and approved by our shareholders. In addition, our auditors must confirm that the dividend proposal of
	our board of directors conforms to Swiss statutory law and our articles of incorporation. A Swiss corporation may pay dividends
	only if it has sufficient distributable profits brought forward from the previous business years (&ldquo;<I>report des b&eacute;n&eacute;fices</I>&rdquo;)
	or if it has distributable reserves (&ldquo;<I>r&eacute;serves &agrave; libre disposition</I>&rdquo;), each as evidenced by its
	audited standalone statutory balance sheet prepared pursuant to Swiss law and after allocations to reserves required by Swiss law
	and its articles of association have been deducted. Distributable reserves are generally booked either as &ldquo;free reserves&rdquo;
	(&ldquo;<I>r&eacute;serves libres</I>&rdquo;) or as &ldquo;reserve from capital contributions&rdquo; (&ldquo;<I>apports de capital</I>&rdquo;).
	Distributions out of nominal share capital, which is the aggregate nominal value of a corporation&rsquo;s issued shares, may be
	made only by way of a share capital reduction.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Significant changes</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A discussion of the significant changes
	in our business can be found under &ldquo;Item&nbsp;4. Information on the Company&ndash;A. History and development of the Company&rdquo;
	and &ldquo;Item 4. Information on the Company&ndash;B. Business Overview.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 9. THE OFFER AND LISTING</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Offering and listing details</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;&ndash;C. Markets&rdquo; below.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Plan of distribution</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Markets</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our common shares began trading on the
	Nasdaq Global Market on September 23, 2016 under the symbol &ldquo;ACIU&rdquo;. The following table sets forth the high and low
	sales prices as reported in USD by NASDAQ for the periods presented:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">High</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Low</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold">Year Ended December 31, 2016:</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="width: 78%; text-align: left">Third Quarter&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">19.97</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">14.11</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Fourth Quarter&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">18.95</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10.36</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold">Month Ended:</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>September 30, 2016&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">19.97</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">14.11</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>October 31, 2016&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">18.95</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.01</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>November 30, 2016&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">17.47</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10.36</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>December 31, 2016&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">15.00</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.48</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>January 31, 2017&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">14.06</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.70</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>February 28, 2017&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.67</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.62</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>March 2017 (through March 10, 2017)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.39</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.50</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Selling shareholders</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">E.</TD><TD>Dilution</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">F.</TD><TD>Expenses of the issue</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 10. ADDITIONAL INFORMATION</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Share capital</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Memorandum and articles of association</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On September 25, 2016, we adopted the Articles
	of Association filed as Exhibit 1.1 hereto.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We incorporate by reference into this annual
	report on Form 20-F the description of our Articles of Association contained in our Registration Statement on Form F-1 (File No.
	333-211714) filed with the SEC on September 23, 2016. Such description sets forth a summary of certain provisions of our articles
	of association as currently in effect.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Material contracts</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Except as otherwise disclosed in this Annual
	Report on Form 20-F (including the Exhibits), we are not currently, and have not been in the last two years, party to any material
	contract, other than contracts entered into in the ordinary course of business.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Exchange controls</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">There are no Swiss governmental laws, decrees
	or regulations that restrict, in a manner material to us, the export or import of capital, including any foreign exchange controls,
	or that generally affect the remittance of dividends or other payments to non-residents or non-citizens of Switzerland who hold
	our common shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">E.</TD><TD>Taxation</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following summary contains a description
	of the material Swiss and U.S. federal income tax consequences of the acquisition, ownership and disposition of common shares,
	but it does not purport to be a comprehensive description of all the tax considerations that may be relevant to a decision to purchase
	common shares. The summary is based upon the tax laws of Switzerland and regulations thereunder and on the tax laws of the United
	States and regulations thereunder as of the date hereof, which are subject to change.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Taxation of AC Immune SA</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As disclosed in Note 14 of the financial
	statements, the Company has tax losses which are subject to expiration. These tax losses represent potential value to the Company
	to the extent that the Company is able to create taxable profits before the expiry period of these tax losses.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Consistent with prior years, the Company
	has not recognized any deferred tax asset relating to tax losses available for offset against future profits as the recognition
	criteria have not been met as of the balance sheet date.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Switzerland is currently in the process
	of reforming certain elements of its corporate tax law (Swiss Corporate Tax Reform III, &ldquo;CTR III&rdquo;) to align Swiss corporate
	taxation with international recommendations. The recent dispatch of CTR III included proposed changes which may impact the taxation
	of AC Immune SA (including the abolition of the holding taxation at cantonal level). Voters in Switzerland rejected a CTR III tax
	reform proposed by the Swiss Federal government in a national referendum on February 12, 2017. As a result, uncertainty will continue
	regarding the future level of Swiss corporate income taxes that may apply to us until revised proposals are put forward and gain
	acceptance.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Swiss Tax Considerations</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Swiss federal, cantonal and communal
	individual income tax and corporate income tax</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Non-Resident Shareholders</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Shareholders who are not resident in Switzerland
	for tax purposes, and who, during the relevant taxation year, have not engaged in a trade or business carried on through a permanent
	establishment or fixed place of business situated in Switzerland for tax purposes (all such shareholders for purposes of this section,
	&ldquo;Non-Resident Shareholders&rdquo;), will not be subject to any Swiss federal, cantonal and communal income tax on dividends
	and similar cash or in-kind distributions on Shares (including dividends on liquidation proceeds and stock dividends) (such dividends
	for the purposes of this, &ldquo;Dividends&rdquo;), distributions based upon a capital reduction (<I>remboursements li&eacute;s
	&agrave; la r&eacute;duction de la valeur nominale des actions</I> ) and reserves paid out of capital contributions (<I>apports
	de capital</I>) on Shares, or capital gains realized on the sale or other disposition of Shares (see, however, &ldquo;&mdash;S<I>wiss
	Federal Withholding Tax&rdquo;</I> below for a summary of Swiss federal withholding tax on Dividends, and &ldquo;&mdash; <I>Foreign
	final withholding tax&rdquo;</I> below for a summary on final withholding taxes in respect of Shares held in Swiss accounts by
	Non-Resident Shareholders).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Resident Private Shareholders</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Swiss resident individuals who hold their
	Shares as private assets are required to include Dividends, but not distributions based upon a capital reduction (<I>remboursements
	li&eacute;s &agrave; la r&eacute;duction de la valeur nominale des actions</I>) and reserves paid out of capital contributions
	(<I>Apports de capital</I>), in their personal income tax return and are subject to Swiss federal, cantonal and communal income
	tax on any net taxable income for the relevant taxation period, including the Dividends, but not the distributions based upon a
	capital reduction (<I>remboursements li&eacute;s &agrave; la r&eacute;duction de la valeur nominale des actions</I>) and reserves
	paid out of capital contributions (<I>apports de capital)</I>. Capital gains resulting from the sale or other disposition of Shares
	are not subject to Swiss federal, cantonal and communal income tax, and conversely, capital losses are not tax-deductible for Resident
	Private Shareholders (the</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">shareholders referred to in this paragraph
	for the purposes of this section, &ldquo;Resident Private Shareholders&rdquo;). See &ldquo;&mdash; <I>Domestic Commercial Shareholders</I>&rdquo;
	below for a summary of the taxation treatment applicable to Swiss resident individuals, who, for income tax purposes, are classified
	as &ldquo;professional securities dealers&rdquo;.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Domestic Commercial Shareholders</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Corporate and individual shareholders who
	are resident in Switzerland for tax purposes, and corporate and individual shareholders who are not resident in Switzerland, and
	who, in each case, hold their Shares as part of a trade or business carried on in Switzerland, in the case of corporate and individual
	shareholders not resident in Switzerland, through a permanent establishment or fixed place of business situated, for tax purposes,
	in Switzerland, are required to recognize Dividends, distributions based upon a capital reduction (<I>remboursements li&eacute;s
	&agrave; la r&eacute;duction de la valeur nominale des actions</I>) and reserves paid out of capital contributions (<I>apports
	de capital</I>) received on Shares and capital gains or losses realized on the sale or other disposition of Shares in their income
	statement for the relevant taxation period and are subject to Swiss federal, cantonal and communal individual or corporate income
	tax, as the case may be, on any net taxable earnings for such taxation period. The same taxation treatment also applies to Swiss-resident
	private individuals who, for income tax purposes, are classified as &ldquo;professional securities dealers&rdquo; for reasons of,
	<I>inter alia</I>, frequent dealing, or leveraged investments, in shares and other securities (the shareholders referred to in
	this paragraph for purposes of this section, &ldquo;Domestic Commercial Shareholders&rdquo;). Domestic Commercial Shareholders
	who are corporate taxpayers may be eligible for dividend relief (<I>r&eacute;duction pour participations</I>) in respect of Dividends
	and distributions based upon a capital reduction (<I>remboursements li&eacute;s &agrave; la r&eacute;duction de la valeur nominale
	des actions</I>) and reserves paid out of capital contributions (<I>apports de capital</I>) if the Shares held by them as part
	of a Swiss business have an aggregate market value of at least CHF&nbsp;1 million.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Swiss cantonal and communal private wealth
	tax and capital tax</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Non-Resident Shareholders</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Non-Resident Shareholders, in
 principle, are not subject to Swiss cantonal and communal private wealth tax or capital tax.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Resident Private Shareholders and Domestic
	Commercial Shareholders</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Resident Private Shareholders and Domestic
	Commercial Shareholders who are individuals are required to report their Shares as part of private wealth or their Swiss business
	assets, as the case may be, and will be subject to Swiss cantonal and communal private wealth tax on any net taxable wealth (including
	Shares), in the case of Domestic Commercial Shareholders to the extent the aggregate taxable wealth is allocable to Switzerland.
	Domestic Commercial Shareholders who are corporate taxpayers are subject to Swiss cantonal and communal capital tax on taxable
	capital to the extent the aggregate taxable capital is allocable to Switzerland.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Swiss Federal Withholding Tax</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Dividends that the Company pays on the
	Shares are subject to Swiss Federal withholding tax <I>(imp&ocirc;t anticip&eacute;)</I> at a rate of 35% on the gross amount of
	the Dividend. The Company is required to withhold the Swiss federal withholding tax from the Dividend and remit it to the Swiss
	Federal Tax Administration. Distributions based upon a capital reduction (<I>remboursements li&eacute;s &agrave; la r&eacute;duction
	de la valeur nominale des actions</I>) and reserves paid out of capital contributions (<I>apports de capital</I>) are not subject
	to Swiss federal withholding tax.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Swiss federal withholding tax on a
	Dividend will be refundable in full to a Resident Private Shareholder and to a Domestic Commercial Shareholder, who, in each case,
	<I>inter alia,</I> as a condition to a refund, duly reports the Dividend in his individual income tax return as income or recognizes
	the Dividend in his income statement as earnings, as applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A Non-Resident Shareholder may be entitled
	to a partial refund of the Swiss federal withholding tax on a Dividend if the country of his or her residence for tax purposes
	has entered into a bilateral treaty for the avoidance of double taxation with Switzerland and the conditions of such treaty are
	met. Such shareholders should be aware that the procedures for claiming treaty benefits (and the time required for obtaining a
	refund) might differ from country to country. For example, a shareholder who is a resident of the U.S. for the purposes of the
	bilateral tax treaty between the U.S. and Switzerland is eligible for a partial refund of the amount of the withholding tax in
	excess of the 15% treaty rate, provided such shareholder: (i)&nbsp;qualifies for benefits under this treaty and qualifies as beneficial</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">owner of the Dividends; (ii)&nbsp;holds, directly
	or indirectly, less than 10% of the voting stock of the Company; (iii)&nbsp;does not qualify as a pension scheme or retirement
	arrangement for the purpose of the bilateral treaty; and (iv)&nbsp;does not conduct business through a permanent establishment
	or fixed base in Switzerland to which the Shares are attributable. Such an eligible U.S. share may apply for a refund of the amount
	of the withholding tax in excess of the 15% treaty rate. The applicable refund request form may be filed with the Swiss Federal
	Tax Administration following receipt of the Dividend and the relevant deduction certificate, however no later than 31&nbsp;December
	of the third year following the calendar year in which the Dividend was payable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Swiss Federal Stamp Taxes</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company will be subject to and pay
	to the Swiss Federal Tax Administration a 1% Swiss federal issuance stamp tax (<I>taxe sur les &eacute;missions</I>) on the consideration
	received by it for the issuance of the Shares less certain costs incurred in connection with the issuance. The issuance of the
	Shares to the initial shareholders at the offering price is not subject to Swiss federal securities turnover tax (<I>droit de timbre
	de n&eacute;gociation</I>).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Any subsequent dealings in the Shares,
	where a bank or another securities dealer in Switzerland, as defined in the Swiss Federal Stamp Tax Act, acts as an intermediary,
	or is a party, to the transaction, are, subject to certain exemptions provided for in the Swiss Federal Stamp Tax Act, subject
	to Swiss securities turnover tax at an aggregate tax rate of up to 0.15% of the consideration paid for such Shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Foreign Final Withholding Tax</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On January&nbsp;1, 2013, treaties on final
	withholding taxes of Switzerland with the United Kingdom and Austria entered into force (each, a &ldquo;Contracting State&rdquo;).
	The treaties require a Swiss paying agent, as defined in the treaties, to levy a flat-rate final withholding tax (<I>imp&ocirc;t
	lib&eacute;ratoire</I>) at rates specified in the treaties on certain capital gains and income items (interest, dividends, other
	income items, all as defined in the treaties), deriving from assets, including the Shares, held in accounts or deposits with a
	Swiss paying agent by (i)&nbsp;an individual resident in a Contracting State or, (ii)&nbsp;if certain requirements are met, by
	a domiciliary company ( <I>soci&eacute;t&eacute; de domicile</I> ), an insurance company in connection with a so-called insurance
	wrapper (<I>contrat d&rsquo;assurance vie utilis&eacute; comme enveloppe</I>) or other individuals if the beneficial owner is an
	individual resident in a Contracting State. The flat-rate tax withheld substitutes the ordinary income tax on the respective capital
	gains and income items in the Contracting State where the individual is tax resident. In order to avoid the withholding of the
	flat-rate tax by the Swiss paying agent, such individuals may opt for a disclosure of the respective capital gains and income items
	to the tax authorities of the Contracting State where they are tax residents. If Swiss federal withholding tax of 35% has been
	withheld on dividends, the Swiss paying agent will&mdash;to the extent provided in the applicable bilateral treaty for the avoidance
	of double taxation between Switzerland and the Contracting State&mdash;in its own name and on behalf of the relevant shareholder
	file with the Swiss tax authorities a request for the partial refund of the Swiss federal withholding tax. The Swiss federal withholding
	tax, which is not refundable according to the bilateral tax treaty (residual tax), is credited against the flat-rate final withholding
	tax. Switzerland may conclude similar treaties with other European countries.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Material U.S. Federal Income Tax Considerations for U.S.
	Holders</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following is a description of the material
	U.S. federal income tax consequences to U.S. Holders, as defined below, of owning and disposing our common shares. It does not
	describe all tax considerations that may be relevant to a particular person&rsquo;s decision to acquire common shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">This discussion applies only to a U.S.
	Holder that holds common shares as capital assets for U.S. federal income tax purposes. In addition, it does not describe all of
	the U.S. federal income tax consequences that may be relevant in light of a U.S. Holder&rsquo;s particular circumstances, including
	alternative minimum tax consequences, the potential application of the provisions of the Code known as the Medicare contribution
	tax and tax consequences applicable to U.S. Holders subject to special rules, such as:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>certain financial institutions;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>dealers or traders in securities who use a mark-to-market method of tax accounting;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>persons holding common shares as part of a hedging transaction, straddle, wash sale, conversion transaction or other integrated
	transaction or persons entering into a constructive sale with respect to the common shares;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>U.S. Holder whose functional currency for U.S. federal income tax purposes is not the U.S. dollar;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>entities classified as partnerships for U.S. federal income tax purposes;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>tax-exempt entities, including an &ldquo;individual retirement account&rdquo; or &ldquo;Roth IRA&rdquo;;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>persons that own or are deemed to own ten percent or more of our voting shares; or</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>persons holding common shares in connection with a trade or business conducted outside of the United States.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If an entity that is classified as a partnership
	for U.S. federal income tax purposes holds common shares, the U.S. federal income tax treatment of a partner will generally depend
	on the status of the partner and the activities of the partnership. Partnerships holding common shares and partners in such partnerships
	should consult their tax advisers as to the particular U.S. federal income tax consequences of owning and disposing of the common
	shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">This discussion is based on the Code, administrative
	pronouncements, judicial decisions, final, temporary and proposed Treasury regulations, and the income tax treaty between Switzerland
	and the United States (the &ldquo;Treaty&rdquo;) all as of the date hereof, any of which is subject to change or differing interpretations,
	possibly with retroactive effect.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A &ldquo;U.S. Holder&rdquo; is a holder
	who, for U.S. federal income tax purposes, is a beneficial owner of common shares, who is eligible for the benefits of the Treaty
	and who is:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>a citizen or individual resident of the United States;</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>a corporation, or other entity taxable as a corporation, created or organized in or under the laws of the United States, any
	state therein or the District of Columbia; or</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>an estate or trust the income of which is subject to U.S. federal income taxation regardless of its source.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">U.S. Holders should consult their tax advisers
	concerning the U.S. federal, state, local and non-U.S. tax consequences of owning and disposing of common shares in their particular
	circumstances.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Taxation of Distributions</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As discussed above under &ldquo;Dividends
	and Dividend Policy,&rdquo; we do not currently expect to make distributions on our common shares. In the event that we do make
	distributions of cash or other property, subject to the passive foreign investment company rules described below, distributions
	paid on common shares, other than certain pro rata distributions of common shares, will generally be treated as dividends to the
	extent paid out of our current or accumulated earnings and profits (as determined under U.S. federal income tax principles). Because
	we do not maintain calculations of our earnings and profits under U.S. federal income tax principles, we expect that distributions
	generally will be reported to U.S. Holders as dividends. For so long as our common shares are listed on NASDAQ or we are eligible
	for benefits under the Treaty, dividends paid to certain non-corporate U.S. Holders will be eligible for taxation as &ldquo;qualified
	dividend income&rdquo; and therefore, subject to applicable limitations, will be taxable at rates not in excess of the long-term
	capital gain rate applicable to such U.S. Holder.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">U.S. Holders should consult their tax advisers
	regarding the availability of the reduced tax rate on dividends in their particular circumstances. The amount of a dividend will
	include any amounts withheld by us in respect of Swiss income taxes. The amount of the dividend will be treated as foreign-source
	dividend income to U.S. Holders and will not be eligible for the dividends-received deduction generally available to U.S. corporations
	under the Code. Dividends will be included in a U.S. Holder&rsquo;s income on the date of the U.S. Holder&rsquo;s receipt of the
	dividend. The amount of any dividend income paid in euros will be the U.S. dollar amount calculated by reference to the exchange
	rate in effect on the date of actual or constructive receipt, regardless of whether the payment is in fact converted into U.S.
	dollars at that time. If the dividend is converted into U.S. dollars on the date of receipt, a U.S.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">Holder should not be required to recognize
	foreign currency gain or loss in respect of the dividend income. A U.S. Holder may have foreign currency gain or loss if the dividend
	is converted into U.S. dollars after the date of receipt.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Subject to applicable limitations, some
	of which vary depending upon the U.S. Holder&rsquo;s particular circumstances, Swiss income taxes withheld from dividends on common
	shares at a rate not exceeding the rate provided by the Treaty will be creditable against the U.S. Holder&rsquo;s U.S. federal
	income tax liability. The rules governing foreign tax credits are complex and U.S. Holders should consult their tax advisers regarding
	the creditability of foreign taxes in their particular circumstances. In lieu of claiming a foreign tax credit, U.S. Holders may,
	at their election, deduct foreign taxes, including any Swiss income tax, in computing their taxable income, subject to generally
	applicable limitations under U.S. law. An election to deduct foreign taxes instead of claiming foreign tax credits applies to all
	foreign taxes paid or accrued in the taxable year.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Sale or Other Disposition of Common Shares</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Subject to the passive foreign investment
	company rules described below, gain or loss realized on the sale or other disposition of common shares will be capital gain or
	loss, and will be long-term capital gain or loss if the U.S. Holder held the common shares for more than one year. The amount of
	the gain or loss will equal the difference between the U.S. Holder&rsquo;s tax basis in the common shares disposed of and the amount
	realized on the disposition, in each case as determined in U.S. dollars. This gain or loss will generally be U.S.-source gain or
	loss for foreign tax credit purposes. The deductibility of capital losses is subject to various limitations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Passive Foreign Investment Company Rules</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the Code, we will be a PFIC for any
	taxable year in which, after the application of certain &ldquo;look-through&rdquo; rules with respect to subsidiaries, either (i)&nbsp;75%
	or more of our gross income consists of &ldquo;passive income,&rdquo; or (ii)&nbsp;50% or more of the average quarterly value of
	our assets consist of assets that produce, or are held for the production of, &ldquo;passive income.&rdquo; For purposes of the
	above calculations, we will be treated as if we hold our proportionate share of the assets of, and receive directly our proportionate
	share of the income of, any other corporation in which we directly or indirectly own at least 25%, by value, of the shares of such
	corporation. Passive income generally includes interest, dividends, rents, certain non-active royalties and capital gains. Based
	on our business plan and certain estimates and projections, including as to the relative values of our assets, we do not believe
	that we were a PFIC for our 2016 taxable year and do not expect to be a PFIC in the immediately foreseeable future. However, there
	can be no assurance that the IRS will agree with our conclusion. In addition, whether we will be a PFIC in 2017 or any future years
	is uncertain because, among other things, (i)&nbsp;we currently own, and will own after the completion of the IPO, a substantial
	amount of passive assets, including cash, and (ii)&nbsp;the valuation of our assets that generate non-passive income for PFIC purposes,
	including our intangible assets, is uncertain and may vary substantially over time. Accordingly, there can be no assurance that
	we will not be a PFIC for any taxable year. If we are a PFIC for any year during which a U.S. Holder holds common shares, we generally
	would continue to be treated as a PFIC with respect to that U.S. Holder for all succeeding years during which the U.S. Holder holds
	common shares, even if we ceased to meet the threshold requirements for PFIC status.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If we were a PFIC for any taxable year
	during which a U.S. Holder held common shares (assuming such U.S. Holder has not made a timely mark-to-market election, as described
	below), gain recognized by a U.S.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Holder on a sale or other disposition (including
	certain pledges) of the common shares would be allocated ratably over the U.S. Holder&rsquo;s holding period for the common shares.
	The amounts allocated to the taxable year of the sale or other disposition and to any year before we became a PFIC would be taxed
	as ordinary income. The amount allocated to each other taxable year would be subject to tax at the highest rate in effect for individuals
	or corporations, as appropriate, for that taxable year, and an interest charge would be imposed on the amount allocated to that
	taxable year. Further, to the extent that any distribution received by a U.S. Holder on its common shares exceeds 125% of the average
	of the annual distributions on the common shares received during the preceding three years or the U.S. Holder&rsquo;s holding period,
	whichever is shorter, that distribution would be subject to taxation in the same manner as gain, described immediately above.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A U.S. Holder can avoid certain of the
	adverse rules described above by making a mark-to-market election with respect to its common shares, provided that the common shares
	are &ldquo;marketable.&rdquo; Common shares will be marketable if they are &ldquo;regularly traded&rdquo; on a &ldquo;qualified
	exchange&rdquo; or other market within the meaning of applicable Treasury regulations. If a U.S. Holder makes the mark-to-market
	election, it generally will recognize as ordinary</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">income any excess of the fair market value
	of the common shares at the end of each taxable year over their adjusted tax basis, and will recognize an ordinary loss in respect
	of any excess of the adjusted tax basis of the common shares over their fair market value at the end of the taxable year (but only
	to the extent of the net amount of income previously included as a result of the mark-to-market election). If a U.S. Holder makes
	the election, the holder&rsquo;s tax basis in the common shares will be adjusted to reflect the income or loss amounts recognized.
	Any gain recognized on the sale or other disposition of common shares in a year when we are a PFIC will be treated as ordinary
	income and any loss will be treated as an ordinary loss (but only to the extent of the net amount of income previously included
	as a result of the mark-to-market election).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, in order to avoid the application
	of the foregoing rules, a United States person that owns stock in a PFIC for U.S. federal income tax purposes may make a &ldquo;qualified
	electing fund&rdquo; election (a &ldquo;QEF Election&rdquo;) with respect to such PFIC if the PFIC provides the information necessary
	for such election to be made. If a United States person makes a QEF Election with respect to a PFIC, the United States person will
	be currently taxable on its pro rata share of the PFIC&rsquo;s ordinary earnings and net capital gain (at ordinary income and capital
	gain rates, respectively) for each taxable year that the entity is classified as a PFIC and will not be required to include such
	amounts in income when actually distributed by the PFIC. We do not intend to provide information necessary for U.S. Holders to
	make qualified electing fund elections.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, if we were a PFIC or, with
	respect to particular U.S. Holder, were treated as a PFIC for the taxable year in which we paid a dividend or for the prior taxable
	year, the preferential dividend rates discussed above with respect to dividends paid to certain non-corporate U.S. Holders would
	not apply.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If a U.S. Holder owns common shares during
	any year in which we are a PFIC, the holder generally must file annual reports containing such information as the U.S. Treasury
	may require on IRS Form 8621 (or any successor form) with respect to us, generally with the holder&rsquo;s federal income tax return
	for that year.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">U.S. Holders should consult their tax advisers
	concerning our potential PFIC status and the potential application of the PFIC rules.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Information Reporting and Backup Withholding</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Payments of dividends and sales proceeds
	that are made within the United States or through certain U.S.-related financial intermediaries generally are subject to information
	reporting, and may be subject to backup withholding, unless (i)&nbsp;the U.S. Holder is a corporation or other exempt recipient
	or (ii)&nbsp;in the case of backup withholding, the U.S. Holder provides a correct taxpayer identification number and certifies
	that it is not subject to backup withholding.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The amount of any backup withholding from
	a payment to a U.S. Holder will be allowed as a credit against the holder&rsquo;s U.S. federal income tax liability and may entitle
	it to a refund, provided that the required information is timely furnished to the IRS.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Information With Respect to Foreign Financial
	Assets</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Certain U.S. Holders who are individuals
	(and, under proposed regulations, certain entities) may be required to report information relating to an interest in our common
	shares, subject to certain exceptions (including an exception for common shares held in accounts maintained by certain U.S. financial
	institutions). U.S. Holders should consult their tax advisers regarding the effect, if any, of this legislation on their ownership
	and disposition of the common shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">F.</TD><TD>Dividends and paying agents</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">G.</TD><TD>Statement by experts</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">H.</TD><TD>Documents on display</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We are subject to the informational requirements
	of the Exchange Act. Accordingly, we are required to file reports and other information with the SEC, including annual reports
	on Form 20-F and reports on Form 6-K. You may inspect and copy reports and other information filed with the SEC at the Public Reference
	Room at 100 F Street, N.E., Washington, D.C. 20549. Information on the operation of the Public Reference Room may be obtained by
	calling the SEC at 1-800-SEC-0330. In addition, the SEC maintains an Internet website that contains reports and other information
	about issuers, like us, that file electronically with the SEC. The address of that website is www.sec.gov.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Additionally, pursuant to Swiss law, any
	shareholder of record has the right to receive a free copy of this Annual Report and to inspect this Annual Report at any time
	at our registered office in Lausanne.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As a foreign private issuer, we are exempt
	under the Exchange Act from, among other things, the rules prescribing the furnishing and content of proxy statements, and our
	executive officers, directors and principal shareholders are exempt from the reporting and short-swing profit recovery provisions
	contained in Section 16 of the Exchange Act. In addition, we will not be required under the Exchange Act to file periodic reports
	and financial statements with the SEC as frequently or as promptly as U.S. companies whose securities are registered under the
	Exchange Act.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">I.</TD><TD>Subsidiary information</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 11. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT
	MARKET RISK</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company&rsquo;s activities expose it
	to the following financial risks: market risk (currency and interest risk), credit risk and liquidity risk. The Company&rsquo;s
	overall risk management program focuses on the unpredictability of financial markets and seeks to minimize potential adverse effects
	on the Company&rsquo;s financial performance.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Market risk arises from our exposure to
	fluctuation in interest rates and currency exchange rates. We are exposed to market risks in the ordinary course of our business,
	which are principally limited to foreign currency exchange rate fluctuations and to a lesser degree, interest rate fluctuations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Market Risk</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Foreign exchange risk</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company is exposed to foreign exchange
	risk arising from currency exposures, primarily with respect to the EUR, USD and to a lesser extent to GBP, DKK and SEK. The currency
	exposure is not hedged. However, the Company has the policy of matching its cash holdings to the currency structure of its expenses,
	which means that the Company holds predominately CHF, EUR and USD (see also Notes 3, 19 and 20 of the financial statements).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have a number of collaboration agreements
	where the upfront payments, milestone payments and future royalty payments are not denominated in Swiss Francs, our reporting currency.
	Furthermore, many of our research and development activities are subcontracted to parties outside of Switzerland and we purchase
	materials from suppliers outside of Switzerland. As a result, we are exposed to foreign exchange risk. Approximately 40% of our
	total costs are incurred in currencies other than the Swiss Franc. Due to the size of some of the income received from collaboration
	agreements but also the high percentage of our costs indirectly being in foreign currencies, a hypothetical 10% change in exchange
	rates relative to the Swiss Franc could have a material impact on our financial statements.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Interest rate risk</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December 31, 2016 we had cash and
	cash equivalents of CHF 152.2&nbsp;million, which consisted exclusively of bank deposits. Such interest-earning instruments carry
	a degree of interest rate risk. However, historical fluctuations of interest income have not been significant and have been principally
	impacted by the change in our cash balances as opposed to changes in interest rates received on the cash balances.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have not been exposed nor do we anticipate
	being exposed to material risks due to changes in interest rates. A hypothetical 10% change in interest rates during any of the
	periods presented would not have had a material impact on our financial statements.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Credit risk</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The majority of the cash and cash equivalents
	is held within one bank. However, the credit risk on liquid funds is limited because the counterparties are banks with high credit-ratings
	assigned by international credit-rating agencies. The maximum amount of credit risk is the carrying amount of the financial assets.
	Trade and other receivables are fully performing, not past due and not impaired (see Note 7 to the financial statements).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Liquidity risk</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Inherent in the Company&rsquo;s business
	are various risks and uncertainties, including its limited operating history and the high uncertainty that new therapeutic concepts
	will succeed. AC Immune&rsquo;s success may depend in part upon its ability to (i)&nbsp;establish and maintain a strong patent
	position and protection, (ii)&nbsp;enter into collaborations with partners in the biotech and pharmaceutical industry, (iii)&nbsp;acquire
	and keep key personnel employed, and (iv)&nbsp;acquire additional capital to support its operations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company&rsquo;s approach of managing
	liquidity is to ensure sufficient cash to meet its liabilities when due. Therefore, management closely monitors the cash position
	on rolling forecasts based on expected cash flow to enable the Company to finance its operations for at least 24 months.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Based on the current cash position, the
	Company is well financed until the end of 2018.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 12. DESCRIPTION OF SECURITIES OTHER THAN EQUITY SECURITIES</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Debt securities</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Warrants and rights</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Other securities</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>American Depositary Shares</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">PART II</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 13. DEFAULTS, DIVIDEND ARREARAGES AND DELINQUENCIES</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Defaults</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">No matters to report.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Arrears and delinquencies</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">No matters to report.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 14. MATERIAL MODIFICATIONS TO THE RIGHTS OF SECURITY
	HOLDERS AND USE OF PROCEEDS</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">E.</TD><TD>Use of Proceeds</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On September 23, 2016, we completed our
	initial public offering of common shares pursuant to a Registration Statement on Form F-1, as amended (Registration No.&nbsp;333-211714)
	that was declared effective on September 22, 2016. Under the registration statement, we sold an aggregate of 6,900,000 common shares
	(which includes 900,000 common shares from the full exercise of the underwriters&rsquo; over-allotment option to purchase additional
	shares). All of these common shares were sold at a price to the public of US$11.00 per share, yielding net proceeds of $70.5 million
	(CHF 69.4 million) after underwriting discounts and commissions.&nbsp;Credit Suisse, Jefferies LLC and Leerink Partners LLC were
	joint book-running managers for the initial public offering. We paid the offering expenses in connection with the initial public
	offering, which were approximately CHF 3.5 million ($3.6 million), and which included SEC registration fees, FINRA filing fees,
	NASDAQ listing fees and expenses, legal fees and expenses, printing expenses, transfer agent fees and expenses, accounting fees
	and expenses as well as other miscellaneous fees and expenses, but excluded the underwriting discounts and commissions. In addition,
	we received gross proceeds of approximately $13.5 million (CHF 13.2 million) from the Series&nbsp;E Private Placement Extension.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Between the effective date of the Registration
	Statement and December 31, 2016, we used approximately CHF 10.5 million of the net proceeds to fund research and development expenses
	for ACI-35, ACI-24 for AD, PD-focused programs, non-AD and Non-PD programs and general administrative expenses.&nbsp;None of the
	net proceeds were used to make payments (other than compensation paid to our executive officers, directors and an affiliate of
	one of our directors, each as described in this Annual Report), directly or indirectly, to (i)&nbsp;any of our directors, officers
	or their associates, (ii)&nbsp;any persons owning 10% or more of our common shares or (iii)&nbsp;any of our affiliates. The intended
	use of the remaining net proceeds has not changed from the information mentioned in the prospectus relating to the Registration
	Statement.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 15. CONTROLS AND PROCEDURES</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">A.</TD><TD>Disclosure Controls and Procedures</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December 31, 2016, under the supervision
and with the participation of our management, including our Chief Executive Officer and Principal Financial Officer, we performed
an evaluation of the effectiveness of the design and operation of our disclosure controls and procedures (as defined in Rule 13a-15(e)
under the Exchange Act). There are inherent limitations to the effectiveness of any disclosure controls and procedures system,
including the possibility of human error and circumventing or overriding them. Even if effective, disclosure controls and procedures
can provide only reasonable assurance of achieving their control objectives.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Based on such evaluation, our Chief
Executive Officer and Interim Principal Financial Officer concluded that our disclosure controls and procedures are not
effective due to the material weaknesses in our internal control over financial reporting identified during our preparation
for our initial public offering and annual financial statements as more fully described in &ldquo;Item 5. Operating and
Financial Review and Prospects&mdash;A. Operating Results&mdash;Internal Control Over Financial Reporting.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Management&rsquo;s Annual Report on Internal Control
	over Financial Reporting</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">This Annual Report does not include a report
	of management&rsquo;s assessment regarding internal control over financial reporting due to a transition period established by
	rules of the Securities and Exchange Commission for newly public companies.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Attestation Report of the Registered Public Accounting
	Firm</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">This Annual Report does not include an
	attestation report of our registered public accounting firm due to an exemption provided to emerging growth companies under the
	JOBS Act.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">D.</TD><TD>Changes in Internal Control over Financial Reporting</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">See &ldquo;Item 5. Operating and Financial
Review and Prospects&mdash;A. Operating Results&mdash;Internal Control Over Financial Reporting&rdquo; for changes in our internal
control over financial reporting (as defined in Rule 13a-15(f) under the Exchange Act) that occurred during the period covered
by this Annual Report that have materially affected, or are reasonably likely to materially affect, internal control over financial
reporting.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16. [RESERVED]</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16A. Audit committee financial expert</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our board of directors has determined that
	Peter Bollmann is the audit committee financial expert, as that term is defined by the SEC, and is independent for the purposes
	of SEC and NASDAQ rules.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16B. Code of ethics</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Code of business conduct and ethics</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have adopted a Code of Business Conduct
	and Ethics which covers a broad range of matters including the handling of conflicts of interest, compliance issues and other corporate
	policies such as insider trading and equal opportunity and non-discrimination standards. Our Code of Business Conduct applies to
	all of our directors, executive officers and employees. We have published our Code of Business Conduct and Ethics on our website,
	<I>www.acimmune.com</I>. The information contained on our website is not a part of this Annual Report.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16C. Principal accountant fees and services (in CHF
	and thousands)</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center">(in CHF thousands)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Audit Fees&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">340</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">600</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Audit-related Fees&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">419</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">162</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt; border-top: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid">Total Fees&#9;</TD><TD STYLE="padding-bottom: 1pt; border-top: Black 1pt solid; border-bottom: Black 1pt solid">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left; border-top: Black 1pt solid">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right; border-top: Black 1pt solid">759</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left; border-top: Black 1pt solid">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; border-top: Black 1pt solid; border-bottom: Black 1pt solid">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left; border-top: Black 1pt solid">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right; border-top: Black 1pt solid">762</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left; border-top: Black 1pt solid; border-right: Black 1pt solid">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For the year ended December 31,
 2016, Ernst &amp; Young AG was the Company&rsquo;s auditor for the IFRS and statutory accounts. At the ordinary annual
 general meeting on November 15, 2016, the shareholders appointed Ernst &amp; Young AG as the Company&rsquo;s auditor for a
 term of office of one year.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="font-family: Times New Roman, Times, Serif">Audit-related
fees in 2016 and 2015, included audit fees in connection with the Company&rsquo;s initial public offering activities. The 2016
fees also covered interim reviews and filings of interim financial statements, statutory audits, and review of the IPO registration
statement.</FONT></P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-indent: 0.25in"></P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Pre-Approval Policies and Procedures</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To ensure the independence and objectivity
	of the Company&rsquo;s external auditors, the provision of all non-audit services by the external auditors are pre- approved by
	the Audit Committee.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16D. Exemptions from the listing standards for audit
	committees</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16E. Purchases of equity securities by the issuer
	and affiliated purchasers</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2016, no purchases of our equity securities
	were made by or on behalf of AC Immune SA or any affiliated purchaser.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16F. Change in registrant&rsquo;s certifying accountant</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16G. Corporate governance</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Summary of Significant Corporate Governance
	Differences from NASDAQ Listing Standards</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our common shares are listed on the NASDAQ
	Global Market. We are therefore required to comply with certain of the NASDAQ&rsquo;s corporate governance listing standards, or
	the NASDAQ Standards. As a foreign private issuer, we may follow our home country&rsquo;s corporate governance practices in lieu
	of certain of the NASDAQ Standards. Our corporate governance practices differ in certain respects from those that U.S. companies
	must adopt in order to maintain a NASDAQ listing. A brief, general summary of those differences is provided as follows.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Independent Directors</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Swiss law does not require that a majority
	of our board of directors consist of independent directors. Our board of directors therefore may include fewer independent directors
	than would be required if we were subject to NASDAQ Listing Rule 5605(b)(1). In addition, we are not subject to NASDAQ Listing
	Rule 5605(b)(2), which requires that independent directors must regularly have scheduled meetings at which only independent directors
	are present.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Compensation Committee</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Although Swiss law also requires that we
	have a compensation committee, we will follow home country requirements with respect to such committee. As a result, our practice
	will vary from the requirements of NASDAQ Listing Rule 5605(d), which sets forth certain requirements as to the responsibilities,
	composition and independence of compensation committees.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Quorum requirements</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In accordance with Swiss law and generally
	accepted business practices, our articles of association do not provide quorum requirements generally applicable to general meetings
	of shareholders. Our practice thus varies from the requirement of NASDAQ Listing Rule 5620(c), which requires an issuer to provide
	in its bylaws for a generally applicable quorum, and that such quorum may not be less than one-third of the outstanding voting
	stock.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Solicitation of proxies</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Our articles of association provide for
	an independent proxy holder elected by our shareholders, who may represent our shareholders at a general meeting of shareholders,
	and we must provide shareholders with an agenda and other relevant documents for the general meeting of shareholders. However,
	Swiss law does not have a regulatory regime for the solicitation of proxies and company solicitation of proxies is prohibited for
	public companies in Switzerland. Thus, our practice will vary from the requirement of NASDAQ Listing Rule 5620(b), which sets forth
	certain requirements regarding the solicitation of proxies.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">Shareholder approval</P>

	<P STYLE="font: italic 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have opted out of shareholder approval
	requirements for the issuance of securities in connection with certain events such as the acquisition of stock or assets of another
	company, the establishment of or amendments to equity-based compensation plans for employees, a change of control of us and certain
	private placements. To this extent, our practice varies from the requirements of NASDAQ Listing Rule 5635, which generally requires
	an issuer to obtain shareholder approval for the issuance of securities in connection with such events.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 16H. Mine safety disclosure</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Not applicable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">PART III</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 17. Financial statements</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We have responded to Item 18 in lieu of
	this item.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 18. Financial statements</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Financial Statements are filed as part
	of this Annual Report, see page F-1.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">ITEM 19. Exhibits</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The
	following documents are filed as part of this registration statement:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
	<TR STYLE="vertical-align: top">
	    <TD STYLE="width: 9%">3.1</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt; width: 91%">Form of Articles of Association</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>2.1</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Registration Rights Agreement (incorporated herein by reference to Exhibit 4.1 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.1</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Research Collaboration and License Agreement between AC Immune SA Corporation and Genentech, Inc. dated November 6, 2006 (incorporated herein by reference to Exhibit 10.1 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.2</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Amendment to the Research Collaboration and License Agreement between AC Immune SA Corporation and Genentech, Inc. dated May 7, 2015 (incorporated herein by reference to Exhibit 10.2 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.3</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Research Collaboration and License Agreement between AC Immune SA Corporation and Genentech, Inc. dated June 15, 2012 (incorporated herein by reference to Exhibit 10.3 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.4</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">License and Collaboration Agreement between Piramal Imaging Ltd., Piramal Imaging SA and AC Immune SA, dated May 9, 2014 (incorporated herein by reference to Exhibit 10.4 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.5</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">License, Development and Commercialization Agreement between Janssen Pharmaceuticals, Inc. and AC Immune SA, dated December 24, 2014 (incorporated herein by reference to Exhibit 10.5 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.6</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Form of Indemnity Agreement (incorporated herein by reference to Exhibit 10.6 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.7</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">AC Immune SA 2013 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.7 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.8</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Subscription Agreement among Fidelity entities and AC Immune SA, dated October 16, 2015 (incorporated herein by reference to Exhibit 10.8 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.9</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Subscription Agreement among Temasek entities and AC Immune SA, dated October&nbsp;16, 2015 (incorporated herein by reference to Exhibit 10.9 to the Company&rsquo;s Registration Statement on Form F-1 (File No. 333-211714) filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.10</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Stock Option Plan - AC Immune of December 31, 2004 (incorporated by reference to the Registrant&rsquo;s Registration Statement on Form S-8, filed with the SEC on September 29, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.11</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Employee Stock Option and Share Plan of AC Immune (2005 Plan) (incorporated by reference to the Registrant&rsquo;s Registration Statement on Form S-8, filed with the SEC on September 29, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.12</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">AC Immune SA 2013 Equity Incentive Plan (incorporated by reference to the Registrant&rsquo;s Registration Statement on Form F-1, filed with the SEC on May 31, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>4.13</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">AC Immune SA 2016 Stock Option and Incentive Plan (incorporated by reference to the Registrant&rsquo;s Report on Form 6-K, filed with the SEC on October 13, 2016)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>12.1*</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Certification of Andrea Pfeifer pursuant to 17 CFR 240.13a-14(a)</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>12.2*</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Certification of Jean-Fabien Monin pursuant to 17 CFR 240.13a-14(a).</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>13.1*</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Certification of Andrea Pfeifer pursuant to 17 CFR 240.13a-14(b) and 18 U.S.C.1350</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>13.2*</TD>
	    <TD STYLE="padding-right: 2pt; padding-left: 2pt">Certification of Jean-Fabien Monin pursuant to 17 CFR 240.13a-14(b) and 18 U.S.C.1350</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
	<TR STYLE="vertical-align: top">
	    <TD STYLE="width: 9%">15.1*</TD>
	    <TD STYLE="width: 91%; padding-right: 2pt; padding-left: 2pt">Consent of Ernst &amp; Young AG</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
	<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin: 1pt 5.5in 1pt 0in"><DIV STYLE="font-size: 1pt; border-top: Black 0.5pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">#</TD><TD>Confidential treatment has been requested for portions of this exhibit. These portions have been omitted from the registration
	statement and submitted separately to the United States Securities and Exchange Commission.</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">* Filed herewith</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: -0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Financial
	Statement Schedules</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">None.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; margin-bottom: 0pt; text-align: center"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->136<!-- Field: /Sequence --></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Signatures</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The registrant hereby certifies that it
	meets all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this Annual
	Report on its behalf.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
	<TR STYLE="vertical-align: top">
	    <TD COLSPAN="3">AC IMMUNE SA</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD COLSPAN="3">&nbsp;</TD></TR>
	<TR>
	    <TD STYLE="vertical-align: bottom">By:</TD>
	    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: Black 1pt solid">/s/ Andrea Pfeifer</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="width: 8%">&nbsp;</TD>
	    <TD STYLE="width: 15%">Name:</TD>
	    <TD STYLE="width: 77%">Andrea Pfeifer</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>&nbsp;</TD>
	    <TD>Title:</TD>
	    <TD>Chief Executive Officer</TD></TR>
	</TABLE><BR STYLE="clear: both">
	<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="RIGHT" STYLE="font: 10pt Times New Roman, Times, Serif; width: 50%; border-collapse: collapse">
	<TR>
	    <TD STYLE="vertical-align: bottom">By:</TD>
	    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: Black 1pt solid">/s/ Jean-Fabien Monin</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="width: 8%">&nbsp;</TD>
	    <TD STYLE="width: 15%">Name:</TD>
	    <TD STYLE="width: 77%">Jean Fabien Monin</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD>&nbsp;</TD>
	    <TD>Title:</TD>
	    <TD>Chief Administrative Officer</TD></TR>
	</TABLE>
	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date: March 17, 2017</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">INDEX TO FINANCIAL STATEMENTS</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Audited Financial Statements &mdash; AC IMMUNE SA</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
	<TR STYLE="vertical-align: top">
	    <TD STYLE="width: 95%; padding-right: 5pt">Report of Independent Registered Public Accounting Firm</TD>
	    <TD STYLE="width: 5%; text-align: left; padding-right: 2pt; padding-left: 2pt">F-2</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 5pt">Balance Sheets as of December 31, 2016 and 2015</TD>
	    <TD STYLE="text-align: left; padding-right: 2pt; padding-left: 2pt">F-3</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 5pt">Statements of Income / (Loss) and Statements of Comprehensive Income / (Loss)</TD>
	    <TD STYLE="text-align: left; padding-right: 2pt; padding-left: 2pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 5pt">for the fiscal year ended December 31, 2016, 2015 and 2014</TD>
	    <TD STYLE="text-align: left; padding-right: 2pt; padding-left: 2pt">F-4</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 5pt">Statements of Changes in Equity for the fiscal years ended December 31, 2016, 2015 and 2014</TD>
	    <TD STYLE="text-align: left; padding-right: 2pt; padding-left: 2pt">F-5</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 5pt">Statements of Cash Flows for the fiscal years ended December 31, 2016, 2015 and 2014</TD>
	    <TD STYLE="text-align: left; padding-right: 2pt; padding-left: 2pt">F-6</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 5pt">Notes to the Financial Statements</TD>
	    <TD STYLE="text-align: left; padding-right: 2pt; padding-left: 2pt">F-7</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

	<!-- Field: Page; Sequence: 142; Options: NewSection; Value: 1 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">F-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->1<!-- Field: /Sequence --></FONT></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Report of Independent Registered Public
	Accounting Firm</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Board of Directors and Shareholders of AC Immune SA</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We have audited the accompanying balance sheets of AC Immune
	SA as of December 31, 2016 and 2015, and the related statements of income, comprehensive income<B>,</B> changes in equity and cash
	flows for each of the three years in the period ended December 31, 2016. These financial statements are the responsibility of the
	Company&rsquo;s management. Our responsibility is to express an opinion on these financial statements based on our audits.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We conducted our audits in accordance with the standards of
	the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain
	reasonable assurance about whether the financial statements are free of material misstatement. We were not engaged to perform an
	audit of the Company&rsquo;s internal control over financial reporting. Our audits included consideration of internal control over
	financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose
	of expressing an opinion on the effectiveness of the Company&rsquo;s internal control over financial reporting. Accordingly, we
	express no such opinion. An audit also includes examining, on a test basis, evidence supporting the amounts and disclosures in
	the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating
	the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In our opinion, the financial statements referred to above present
	fairly, in all material respects, the financial position of AC Immune SA at December 31, 2016 and 2015, and the results of its
	operations and its cash flows for each of the three years in the period ended December 31, 2016, in conformity with International
	Financial Reporting Standards as issued by the International Accounting Standards Board.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ernst &amp; Young AG</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ Ernst &amp; Young AG</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Geneva, Switzerland<BR>
	March 17, 2017</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


	<!-- Field: Page; Sequence: 143 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">F-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->2<!-- Field: /Sequence --></FONT></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Financial Statements (IFRS)</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Balance Sheets</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Notes</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">ASSETS</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Non-current assets</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="width: 67%; text-align: left; padding-left: 20pt; text-indent: -10pt">Property, plant and equipment&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 10%; text-align: right">4</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,120</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">500</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Financial assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">5</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">86</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">85</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt; padding-left: 20pt; text-indent: -10pt">Total non-current assets&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,206</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">585</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Current assets</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Prepaid expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">6</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,278</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,508</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Accrued income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">6</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">889</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">47</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Other current receivables&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">7</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">517</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">269</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt; padding-left: 20pt; text-indent: -10pt">Cash and cash equivalents&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">8</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">152,210</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">76,522</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total current assets&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">154,894</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">79,346</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total assets&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">156,100</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">79,931</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">SHAREHOLDERS&rsquo; EQUITY AND LIABILITIES</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Shareholders&rsquo; equity</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Share capital&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">9</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,135</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">928</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Share premium&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">188,166</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">110,496</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Accumulated losses&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(46,921</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(40,381</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total shareholders&rsquo; equity&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">142,380</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">71,043</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Non-current liabilities</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Net employee defined benefit liabilities&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">15</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,798</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,787</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total non-current liabilities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,798</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,787</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Current liabilities</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Trade payables &amp; other payables&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">10</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,035</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,719</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Accrued expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">10</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5,366</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,337</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Deferred income&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">10</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">521</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">45</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total current liabilities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,922</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">6,101</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total liabilities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">13,720</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">8,888</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total shareholders&rsquo; equity and liabilities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: center; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">156,100</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">79,931</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The accompanying notes are an integral
	part of these financial statements.<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Statements of Income / (Loss)</B></P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Notes</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">in CHF thousands except for share<BR> and per share data</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">Revenue</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt; width: 56%">Contract revenue&#9;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 10%; text-align: right; padding-bottom: 1pt">11</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 1pt solid; text-align: right">23,214</TD><TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 1pt solid; text-align: right">39,090</TD><TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 1pt solid; text-align: right">30,269</TD><TD STYLE="width: 1%; border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total revenue&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">23,214</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">39,090</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">30,269</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left">Operating expenses</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Research and development expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">12</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(25,774</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(17,049</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(16,116</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">General and administrative expenses&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">12</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(7,896</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(3,417</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(3,436</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total operating expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(33,670</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(20,466</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(19,552</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Operating income / (loss)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(10,456</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">18,624</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,717</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Finance income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,573</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,617</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Interest income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">55</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">22</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Finance cost&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(256</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(26</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(4</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Finance result, net&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,360</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,646</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">27</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Income / (loss) before tax&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(7,096</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20,270</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,744</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Income tax expense&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 1pt">14</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Income / (loss) for the period&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="text-align: right; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,096</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">20,270</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">10,744</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Earnings / (loss) per share (EPS):</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Basic, income / (loss) for the period attributable to equity holders&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">18</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(0.14</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.47</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.25</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Diluted, income / (loss) for the period attributable to equity holders&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(0.14</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.44</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.24</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Weighted-average number of shares used to compute EPS basic&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">50,096,859</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43,412,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">42,684,750</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Weighted-average number of shares used to compute EPS fully diluted&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">50,096,859</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">46,043,198</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">45,552,500</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Statements of Comprehensive Income / (Loss)</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center">in CHF thousands</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Income / (loss) for the period&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(7,096</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">20,270</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,744</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Other comprehensive income / (loss) not to be reclassified to income or loss in subsequent periods (net of tax)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">- Re-measurement losses on defined benefit plans (net of tax of CHF 0 for all periods)&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(761</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(736</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(1,318</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total comprehensive income / (loss), net of tax&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,857</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">19,534</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,426</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The accompanying notes are an integral
	part of these financial statements.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Statements of Changes in Equity</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: left">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Share capital</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Share premium</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Accumulated losses</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 56%; font-weight: bold">Balance as of January 1, 2014&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">812</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">73,211</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(70,092</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">3,931</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Net income for the period&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,744</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,744</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Other comprehensive loss&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(1,318</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(1,318</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total comprehensive income&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,426</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,426</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Share-based payments&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">211</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">211</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Issuance of preferred Series D shares&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">42</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9,854</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9,896</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 1pt">Exercise of options&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Balance as of December 31, 2014&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">854</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">83,068</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(60,455</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">23,467</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Share capital</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Share premium</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Accumulated losses</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 56%; font-weight: bold">Balance as of January 1, 2015&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">854</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">83,068</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(60,455</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">23,467</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Net income for the period&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20,270</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20,270</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Other comprehensive loss&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(736</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(736</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total comprehensive income&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">19,534</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">19,534</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Share-based payments&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">540</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">540</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Issuance of preferred Series E shares&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">62</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">29,437</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">29,499</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Exercise of options&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">130</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">142</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Transaction costs&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(2,139</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(2,139</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Balance as of December 31, 2015&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">928</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">110,496</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(40,381</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">71,043</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Share capital</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Share premium</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Accumulated losses</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 56%; font-weight: bold">Balance as of January 1, 2016&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">928</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">110,496</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(40,381</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">71,043</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Net&nbsp;&nbsp;loss for the period&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(7,096</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(7,096</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Other comprehensive loss&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(761</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(861</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total comprehensive loss&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,857</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,857</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Share-based payments&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,317</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,317</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Preferred Series E extension shares&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">28</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13,177</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13,205</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Proceeds from IPO net of underwriting fees&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">138</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">69,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">69,388</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Exercise of options&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">41</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">260</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">301</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Transaction costs&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(5,017</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(5,017</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Balance as of December 31, 2016&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,135</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">188,166</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(46,921</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">142,380</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The accompanying notes are an integral
	part of these financial statements.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Statements of Cash Flows</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">Operating activities</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left; padding-left: 20pt; text-indent: -10pt">Net income / (loss) for the period&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(7,096</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">20,270</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,744</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-left: 10pt; text-indent: -10pt">Adjustments to reconcile net income for the period to net cash flows:</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Depreciation of property, plant and equipment&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">278</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">287</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">298</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Finance result, net&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(3,360</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(1,646</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(27</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Share-based compensation expense&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,317</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">540</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">210</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Changes in pensions&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(359</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">164</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">Changes in working capital:</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Prepaid expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(494</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(2,135</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">141</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Accrued income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(842</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(53</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Other current receivables&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(248</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">25,666</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(25,744</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Accrued Expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,564</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,707</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Deferral of unearned revenue&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">476</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(160</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(3,717</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Accounts payable&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,592</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(141</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">341</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">Cash provided by/(used in) operating activities</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(5,563</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">44,035</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(17,641</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Interest income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">55</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">22</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Finance costs&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(126</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(6</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(5</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Net cash flows provided by/(used in) operating activities</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(5,646</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">44,084</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(17,624</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left">Investing activities</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Purchases of property, plant and equipment&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(899</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(244</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(128</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Other non-current assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Net cash flows used in investing activities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(899</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(244</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(131</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">Financing activities</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Proceeds from issuance of preferred Series E / D&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13,206</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">29,499</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,000</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Proceeds from issuance of common shares&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">69,388</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Transaction costs of issue of shares&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(4,105</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(1,859</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(200</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Proceeds from issuance of shares-option plans&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">301</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">87</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Cost on issue of shares-option plans&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(4</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(3</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Proceeds from employee loan repayments&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">&mdash;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">55</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Net cash flows provided by financing activities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">78,790</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">27,778</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,801</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Net increase / (decrease) in cash and cash equivalents&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">72,245</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">71,618</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,954</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Cash and cash equivalents at January 1&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">76,522</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,306</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11,251</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Exchange gains on cash and cash equivalents&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,443</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,598</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 20pt; text-indent: -10pt">Cash and cash equivalents at December 31&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">152,210</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">76,522</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,306</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Net increase / (decrease) in cash and cash equivalents&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">72,245</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">71,618</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(7,954</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Non-cash transactions: 2016 Proceeds from the issuance of common
	shares represents cash received relating to our initial public offering completed in September 2016 and is net of CHF 5.1 million
	in non-cash underwriting fees.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The accompanying notes are an integral part of these financial
	statements.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Notes to the Financial Statements</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">1.</TD><TD>General information</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">AC Immune SA (the &ldquo;Company&rdquo;
	or &ldquo;AC Immune&rdquo;) is a clinical stage biopharmaceutical company leveraging our two proprietary technology platforms to
	discover, design and develop novel, proprietary medicines for prevention, diagnosis and treatment of neurodegenerative diseases
	associated with protein misfolding. Misfolded proteins are generally recognized as the leading cause of neurodegenerative diseases,
	such as Alzheimer&rsquo;s disease, or AD, and Parkinson&rsquo;s disease, or PD, with common mechanisms and drug targets, such as
	Abeta, tau and alpha-synuclein. Our lead product candidate is crenezumab, a humanized, monoclonal, conformation-specific anti-Abeta
	antibody that we developed using our proprietary SupraAntigen platform. Phase 3 clinical studies for crenezumab were commenced
	in early 2016. We use our two unique proprietary platform technologies, SupraAntigen (conformation-specific biologics) and Morphomer
	(conformation-specific small molecules), to discover, design and develop medicines and diagnostics to target misfolded proteins.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company was initially incorporated
	as a limited liability company on February&nbsp;13, 2003 in Basel and effective August&nbsp;25, 2003 was transitioned into a stock
	company. The Company&rsquo;s corporate headquarters are located at EPFL Innovation Park Building B, Ecublens/Lausanne, Vaud, Switzerland.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">2.</TD><TD>Basis of preparation</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Going concern</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The financial statements have been prepared
	on the basis that the Company will continue as a going concern after considering the Company&rsquo;s cash position of CHF 152.2
	million as of December 31, 2016, which reflects $75.9 million (CHF 74.5 million) in gross proceeds raised in the initial public
	offering (&ldquo;IPO&rdquo;) in September 2016, the $13.5 million (CHF 13.2 million) the Company raised in the Series E Extension
	financing in April 2016, the receipt of payment in 2016 of CHF 14 million for the clinical milestone related to the collaboration
	with Genentech on the anti-tau antibody program and the receipt of payment of CHF 4.9 million in 2016 for the clinical milestone
	related to ACI-35 pursuant to its collaboration with Janssen.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">To date, the Company has financed its cash
	requirements primarily from share issuances and revenues from collaboration agreements. The Company is a clinical stage company
	and is exposed to all the risks inherent to establishing a business. Inherent to the Company&rsquo;s business are various risks
	and uncertainties, including the substantial uncertainty as to whether current projects will succeed. The Company&rsquo;s success
	may depend in part upon its ability to (i)&nbsp;establish and maintain a strong patent position and protection, (ii)&nbsp;enter
	into collaborations with partners in the biotech and pharmaceutical industry, (iii)&nbsp;successfully move its product candidates
	through clinical development, (iv)&nbsp;attract and retain key personnel, and (v)&nbsp;acquire capital to support its operations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Statement of compliance</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The financial statements have been prepared
	in accordance with International Financial Reporting Standards (&ldquo;IFRS&rdquo;) as issued by the International Accounting Standards
	Board (&ldquo;IASB&rdquo;). These financial statements have been approved for issue by the Board of Directors on March 17, 2017.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Basis of measurement</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The financial statements have been prepared
	under the historical cost convention except for items that are required to be accounted for at fair value.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Functional currency</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The financial statements of the Company
	are presented in Swiss Francs (CHF), which is also the functional currency of the Company. All financial information presented
	in Swiss Francs (except for share capital and earnings per share data) has been rounded to the nearest thousand CHF (CHF thousands),
	unless otherwise indicated. The Company also has transactions denominated in U.S. Dollars ($)&nbsp;and Euros (EUR) that are translated
	to CHF using prevailing exchange rates at the date of transaction or as of the balance sheet date.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">3.</TD><TD>Summary of significant accounting policies</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The principal accounting policies adopted
	in the preparation of these financial statements are set out below. These policies have been consistently applied to all the years
	presented, unless otherwise stated.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Current vs. non-current classification</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company presents assets and liabilities
	in the balance sheet based on current/non-current classification. The Company classifies all amounts to be realized or settled
	within twelve months after the reporting period to be current and all other amounts to be non-current.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Foreign currency transactions</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Foreign currency transactions are translated
	into the functional currency Swiss Francs (CHF) using prevailing exchange rates at the dates of the transactions. Monetary assets
	and liabilities denominated in foreign currencies are translated into CHF at rates of exchange prevailing at reporting date. Any
	gains or losses from these translations are included in the statement of income in the period in which they arise.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Revenue recognition</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Revenue includes upfront fees, milestone
	payments as well as revenue from research agreements associated with collaborations with third parties and grants from public institutions
	and foundations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Upfront fees</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Revenue from non-refundable, upfront license
	fees and performance milestones where the Company has continuing involvement is recognized over the estimated performance or agreement
	period, depending on the terms of the agreement. The recognition of revenue is prospectively changed for subsequent changes in
	the development or agreement period.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For collaboration agreements on product
	candidates (i)&nbsp;that are in clinical development, (ii)&nbsp;where the upfront fee reflects a payment for past investments the
	Company has made in the development of the product candidate, access to the product candidate, the associated intellectual property
	and our knowledge, and, (iii)&nbsp;where there is no further performance commitment, the Company recognizes the fair value of the
	upfront payment at the time of entering into the collaboration agreement. For collaboration agreements (i)&nbsp;in clinical development
	but where conditions (ii)&nbsp;and (iii)&nbsp;are not met, the Company recognizes revenue from upfront fees under our collaboration
	agreements pro-rata over the term of the estimated period of performance under each agreement.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For collaboration agreements, in addition
	to receiving upfront fees, the Company is also entitled to milestone and other contingent payments upon achieving pre-defined objectives.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Milestone payments</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Revenue from milestones, if they are non-refundable
	and deemed substantive, is recognized upon successful accomplishment of the milestones. To the extent that non-substantive milestones
	are achieved and the Company has remaining performance obligations, milestones are deferred and recognized as revenue over the
	estimated remaining period of performance.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Grant revenue</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Grants provide funding for certain types
	of expenditures in connection with research and development activities over a contractually-defined period. Revenue related to
	grants is recognized in the period during which the related costs are incurred and the related services are rendered, provided
	that the applicable performance obligations under the grants have been met.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Research and development expenditure</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Given the stage of development of the Company&rsquo;s
	products, all research expenditure is recognized as expense when incurred.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For external research contracts the &ldquo;stage
	of completion&rdquo; method is used to estimate the amount of accrued expense related to the research projects for its clinical
	studies. The Company estimates its accrued expenses as of the balance sheet date in the financial statement based on facts and
	circumstances known at the time.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Registration costs for patents are part
	of the expenditure for research and development projects. Therefore, registration costs for patents are expensed when incurred
	as long as the research and development project concerned does not meet the criteria for capitalization.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Upfront payments relating to in-licensing
	agreements are recognized over an appropriate, project-specific duration.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Property, plant and equipment</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Equipment is shown at historical acquisition
	cost, less accumulated depreciation and any accumulated impairment losses. Historical costs include expenditures that are directly
	attributable to the acquisition of the items. Depreciation is calculated using a straight-line method to write off the cost of
	each asset to its residual value over its estimated useful life as follows:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 50%; text-align: left">IT equipment&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 47%; text-align: right">3 years</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Laboratory equipment&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5 years</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Leaseholds improvements / furniture&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5 years</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The assets&rsquo; residual values and useful
	lives are reviewed, and adjusted if appropriate, at each balance sheet date. Where an asset&rsquo;s carrying amount is greater
	than its estimated recoverable amount, it is written down to its recoverable amount.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Profits and losses on disposals are determined
	by comparing the disposal proceeds with the carrying amount and are included in the income statement.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Financial assets&nbsp;and liabilities</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company&rsquo;s financial assets and
	liabilities are comprised of receivables, cash and cash equivalents and trade payables. The carrying amount for these financial
	assets and liabilities approximates fair value.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Receivables</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Receivables are non-derivative financial
	assets with fixed payments that are not quoted in an active market. They arise when the Company provides money, goods or services
	directly to a debtor with no intention of trading the receivable. They are included in current assets, except for maturities greater
	than 12 months after the balance sheet date, which are classified as long-term assets. Receivables are recognized at their billing
	value. An allowance for doubtful accounts is recorded for potential estimated losses when there is objective evidence of the debtor&rsquo;s
	inability to make required payments.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Cash and cash equivalents</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Cash and cash equivalents include deposits
	held with external financial institutions and cash on hand. All cash and cash equivalents are either in cash or in deposits with
	less than 3 months&rsquo; duration.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Trade payables</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Trade payables are recognized initially
	at fair value, which represents cost incurred.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company assesses at each period whether
	there is objective evidence that financial assets are impaired. Recognized impairment losses would be immediately recognized in
	the income statement.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Share capital and Initial Public Offering</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Ordinary (Common) Shares are classified
	as equity, as were all Preferred Shares previously outstanding. Expenses directly attributable to the issuance of new shares are
	shown in equity as a deduction, net of tax, from the proceeds.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Preferred Shares</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">AC Immune had five classes (Class A, B,
	C, D and E) of Preferred Shares outstanding as of December 31, 2015. These Preferred Shares remained outstanding until the Company
	completed an IPO in September 2016 and at that time the Preferred Shares were converted to Common Shares on a one-for-one basis.
	The Preferred Shares were a class of shares that AC Immune SA issued in connection with five separate capital increases and conveyed
	voting rights and certain other rights to their holders.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The holders of Preferred Shares owned 80.1%
	of the total amount of shares outstanding (assuming conversion of the Preferred Shares into Common Shares on a one-for-one basis)
	as of December 31, 2015 and the Company&rsquo;s Board of Directors were predominantly the holders of Preferred Shares. The Preferred
	Shares have been the primary source of equity financing for the Company over the past 13 years until the Company completed an IPO
	in September 2016, at which point all Preferred Shares were converted to Common Shares. The Preferred Shares did not have mandatory
	redemption features, however, the Shareholders&rsquo; Agreement provided for conversion of Preferred Shares into Common Shares
	as a result of an IPO. The redemption of the Preferred Shares was authorized by the Company&rsquo;s Board of Directors.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The voting rights associated with Preferred
	Shares were the same as for Common Shares. Each Preferred Share entitled the holder to one vote. No dividends were paid on the
	Preferred Shares and the holders of Preferred Shares were not entitled to any dividends unless dividends are paid on the Common
	Shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Preferred Shares had a liquidation
	preference wherein, in the event of a change of control or a liquidation of the Company, the holders of Preferred Shares were entitled
	to receive, prior and in preference to the holders of Common Shares, the amount corresponding to the price paid for each Preferred
	Share. Thereafter, all holders of Preferred Shares participated with the holders of Common Shares on an as-if-converted basis in
	any remaining proceeds.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On October&nbsp;23, 2015, AC Immune completed
	a 250-for-1 stock split.&nbsp;The split was applied to all of AC Immune&rsquo;s outstanding common shares, preferred shares (Series
	A, B, C, D and E) and vested and unvested options.&nbsp;The stock split impacted earnings per share (&ldquo;EPS&rdquo;).&nbsp;To
	facilitate a comparison of EPS figures, the 2015 and 2014 reported EPS figures were adjusted to reflect the stock split.&nbsp;2015
	and 2014 disclosures in notes 9 (share capital), 16 (share-based compensation) and 18 (earnings per share) have all been prepared
	taking into consideration the 250-for-1 stock split.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On April&nbsp;15, 2016, AC Immune completed
	a private placement of Series E preferred shares, each with a nominal value of CHF 0.02&nbsp;per share (the &ldquo;Series E Private
	Placement Extension&rdquo;). An aggregate 1,401,792 Series E preferred shares were issued at a price of $9.6384 per preferred share
	to certain strategic investors, individuals and existing shareholder in the Series E Private Placement Extension for an aggregate
	subscription amount of approximately $13.5 million. The Series E preferred shares had substantially the same terms as the Series
	A, B, C and D preferred shares and were accounted for as equity on AC Immune&rsquo;s balance sheet and subsequently converted to
	Common Shares as a result of the IPO.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Initial Public Offering (IPO)</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On September 22, 2016, AC Immune successfully
	priced a 6.0 million common share IPO at $11.00 per share. On the same day, the underwriters exercised the overallotment option
	which resulted in a further 900,000 common shares being placed in the market and took the total number of shares offered to investors
	to 6.9 million common shares. The gross proceeds received were $75.9 million (CHF 74.5 million) while the proceeds net of underwriting
	fees amounted to $70.6 million (CHF 69.3 million).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The IPO resulted in an increase of CHF
	64.2 million in the share premium of AC Immune excluding the effect of transaction costs associated with the IPO related to the
	issuance of new shares. Transaction costs associated with</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">the IPO and related to the issuance of new
	shares, were charged directly against the share premium account thereby reducing the total equity reported.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Employee benefits</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Post-employment benefits</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company operates the mandatory pension
	schemes for its employees in Switzerland. The schemes are generally funded through payments to insurance companies or trustee-administered
	funds. The Company has a pension plan designed to pay pensions based on accumulated contributions on individual savings accounts.
	However, this plan is classified as a defined benefit plan under IAS 19.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The net pension liability is the present
	value of the defined benefit obligation at the balance sheet date minus the fair value of plan assets. The defined benefit obligation
	is in all material cases calculated annually by independent actuaries using the projected unit credit method, which reflects services
	rendered by employees to the date of valuation, incorporates assumptions concerning employees&rsquo; projected salaries, pension
	increases as well as discount rates of highly liquid corporate bonds which have terms to maturity approximating the terms of the
	related liability.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Share-based compensation</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company operates an equity-settled,
	share-based compensation plan. The fair value of the employee services received in exchange for the grant of options is recognized
	as an expense. The total amount to be expensed over the vesting period is determined by reference to the fair value of the instruments
	granted, excluding the impact of any non-market vesting conditions. Non-market vesting conditions are included in assumptions about
	the number of instruments that are expected to become exercisable. At each balance sheet date, the Company revises its estimates
	of the number of instruments that are expected to become exercisable. It recognizes the impact of the revision of original estimates,
	if any, prospectively in the income statement, and a corresponding adjustment to equity over the remaining vesting period.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Stock options granted under the Company&rsquo;s
	stock option plans A, B and C are valued using the Black-Scholes option pricing model (see Note 16). This valuation model as well
	as parameters used such as expected volatility and expected term of the stock options are partially based on management&rsquo;s
	estimates.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The proceeds received net of any directly
	attributable transaction costs are credited to share capital (nominal value) and share premium when the options are exercised.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Provisions</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Provisions are recognized when the Company
	has a present legal or constructive obligation as a result of past events where it is more likely than not that an outflow of resources
	will be required to settle the obligation, and a reliable estimate of the amount can be made.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Taxation</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Current income tax assets and liabilities
	for the period are measured at the amount expected to be recovered from or paid to the taxation authorities. The tax rates and
	tax laws used to compute the tax amounts are those that are enacted or substantively enacted, at the reporting date in accordance
	with the fiscal regulations of the respective country where the Company operates and generates taxable income. Deferred tax is
	provided using the liability method on temporary differences between the tax bases of assets and liabilities and their carrying
	amounts for financial reporting purposes at the reporting date.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Deferred tax assets and liabilities are
	measured at the tax rates that are expected to apply in the year when the asset is realized or the liability is settled, based
	on tax rates (and tax laws) that have been enacted or substantively enacted at the reporting date. If required, deferred taxation
	is provided in full using the liability method, on all temporary differences at the reporting dates. It is calculated at the tax
	rates that are expected to apply to the period when it is anticipated the liabilities will be settled, and it is based on tax rates
	(and laws) that have been enacted or substantively enacted at the reporting date.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Deferred income tax assets are recognized
	to the extent that it is probable that future taxable profit will be available against which the temporary differences can be utilized.
	Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related
	tax benefit will be realized. Although the Company has substantial tax loss carryforwards, historically, due to the fact that the
	Company had limited certainty on the achievement of key milestones, it has not recognized any deferred tax assets.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Earnings per share</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company presents basic earnings per
	share for each period in the financial statements. The earnings per share is calculated by dividing the earnings of the period
	by the weighted average number of shares (common and preferred) outstanding during the period. Diluted earnings per share reflect
	the potential dilution that could occur if dilutive securities such as share options were vested or exercised into common shares
	or resulted in the issuance of common shares that would participate in net income. Anti-dilutive shares are excluded from basic
	and dilutive earnings per share calculation.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Critical judgments and accounting estimates</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The preparation of financial statements
	in conformity with IFRS requires management to make judgments, estimates and assumptions that affect the application of accounting
	policies and the reported amounts of assets, liabilities, income and expenses.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The areas where AC Immune has had to make
	judgments, estimates and assumptions relate to (i)&nbsp;revenue recognition on collaboration and licensing agreements, (ii)&nbsp;clinical
	development accruals, (iii)&nbsp;pensions, (iv)&nbsp;income taxes and (v)&nbsp;share-based compensation. Actual results may differ
	from these estimates. Estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates
	are recognized in the period in which the estimates are revised and in any future periods affected.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Income taxes</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As disclosed in Note 14, the Company has
	tax losses that can generally be carried forward for a period of 7 years from the period the loss was incurred. These tax losses
	represent potential value to the Company to the extent that the Company is able to create taxable profits before the expiry period
	of these tax losses. The Company has not recorded any deferred tax assets in relation to these tax losses.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Preferred shares</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Significant judgment was required in determining
	the classification of the Preferred Shares issued by the Company as either equity or liabilities. The Preferred shareholders received
	certain preference rights that represented a significant proportion of the net assets of the Company in the case of liquidation
	or certain exit events, the occurrence of which was outside the control of the Company. These Preferred Shares remained outstanding
	until the Company completed an IPO in September 2016 and at that time the Preferred Shares were converted from Preferred Shares
	to Common Shares on a one-for-one basis.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Segment reporting</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company has one segment. The Company
	currently focuses all of its resources on discovering and developing therapeutic and diagnostic products targeting misfolded proteins.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company is managed and operated as
	one business. A single management team that reports to the chief operating decision maker comprehensively manages the entire business.
	Accordingly, the Company views its business and manages its operations as one reportable segment. Non-current assets are located
	in and revenue is attributable to the Company&rsquo;s country of domicile, Switzerland.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <!-- Field: /Page -->

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Standards, amendments and interpretations effective in
	current reporting period but without impact on the Company financial statements</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following standards, amendments and
	interpretation currently are mandatory for accounting periods beginning on or after January&nbsp;1, 2016, but did not have a material
	effect on the Company&rsquo;s financial statements as a result of adoption:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Disclosure Initiative (Amendments to IAS 1)</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Annual Improvements to IFRSs 2012-2014 Cycle</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Clarification of Acceptable Methods of Depreciation and Amortization (Amendments to IAS 16 and IAS 38)</TD></TR></TABLE>

	<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Standards, amendments and interpretations to existing standards
	not yet effective</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Certain new standards, amendments and interpretations
	to existing standards have been published and are mandatory for accounting periods beginning on or after January&nbsp;1, 2017 or
	later periods but which the Company has not adopted early:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="width: 33%; padding-right: 4pt; padding-left: 4pt">
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Recently
	released Standards/ Interpretations</B></P></TD>
	    <TD STYLE="width: 15%; padding-right: 4pt; padding-left: 4pt">
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Date
	Issued</B></P></TD>
	    <TD STYLE="width: 27%; padding-right: 4pt; padding-left: 4pt">
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Effective
	date (mostly annual periods beginning on or after)</B></P>
         <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Early adoption is often permitted</B></P></TD>
	    <TD STYLE="width: 25%; padding-right: 4pt; padding-left: 4pt">
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>Planned
	application</B><BR>
	<B>by AC Immune</B></P></TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">IFRS 9 Financial instruments</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Nov 2009 to July 2014</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Effective Jan 1, 2018 with early adoption allowed</P>
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
	        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Early application of the own credit risk improvements,
	prior to any other changes in the accounting for financial instruments, is permitted by IFRS 9&nbsp;</P></TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2018</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">IFRS 15 Revenue from Contracts with Customers</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">May 2014</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Annual periods beginning on or after January 1, 2018. Earlier application permitted.</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2018</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">IFRS 16 Leases</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 2016</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Effective for annual periods beginning on or after 1 January 2019 (subject to EU endorsement)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2019</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Annual Improvements 2012-2014 Cycle (IAS 12 Income Taxes)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 2016</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Effective for annual period beginning on or after January 1, 2017</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2017</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Disclosure Initiative (Amendments to IAS 7)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 2016</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Effective for annual period beginning on or after January, 2017 (subject to EU endorsement)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2017</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Clarifications to IFRS 15 &ldquo;Revenue from Contracts with Customers&rdquo;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Apr 2016</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Effective for annual period beginning on or after January 1, 2018 (subject to EU endorsement)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2018</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Classification and Measurement of Share-based Payment Transactions (Amendments to IFRS 2)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jun 2016</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Effective for annual period beginning on or after January 1, 2018 (subject to EU endorsement)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2018</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: top">
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">IFRIC Interpretation 22 Foreign Currency Transactions and Advance Consideration</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Dec 2016</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Effective for annual period beginning on or after January 1, 2018 (subject to EU endorsement)</TD>
	    <TD STYLE="padding-right: 4pt; padding-left: 4pt">Jan 1, 2018</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

	<!-- Field: Page; Sequence: 154 -->
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	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company has not yet evaluated the impact
	of these revised standards and amendments on its financial statements. Further consideration of the pending adoption of IFRS 15
	is discussed below.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company is currently analyzing the
	impact of IFRS 15 Revenue from contracts with customers, which amends revenue recognition requirements and establishes principles
	for reporting information about the nature, amount, timing and uncertainty of revenue and cash flows arising from contracts with
	customers. The standard replaces IAS 18 Revenue and IAS 11 Construction contracts and related interpretations. This analysis includes
	reviewing current accounting policies and practices to identify potential differences that would result from applying the requirements
	under the new standard. The Company has initiated contract reviews and expects to complete the contract evaluations and validate
	results by the end of the third quarter of 2017. The Company is also evaluating its accounting policies and the new disclosure
	requirements and expects to complete its evaluations of the impacts of the accounting and disclosure requirements on its business
	processes and controls by the end of the third quarter of 2017. Full implementation will be completed by the end of 2017. The Company
	will continue to evaluate the method of adoption and the potential impact that IFRS 15 may have on our financial position and results
	of operations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">4.</TD><TD>Property, plant and equipment</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Laboratory Equipment</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">IT Equipment</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Leasehold Improvement / Furniture</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">Historical cost</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 56%; font-weight: bold; padding-bottom: 2.5pt">As of January 1, 2015&#9;</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 2.5pt double; text-align: right">1,815</TD><TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 2.5pt double; text-align: right">172</TD><TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 2.5pt double; text-align: right">146</TD><TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; border-bottom: Black 2.5pt double; text-align: right">2,133</TD><TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Acquisitions</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">243</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">243</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">As of December 31, 2015&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,058</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">172</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">146</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,376</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Acquisitions</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">735</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">126</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">37</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">898</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">As of December 31, 2016&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,793</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">298</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">183</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,274</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Accumulated depreciation</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">As of January 1, 2015&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,397</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">100</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">92</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,589</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Depreciation</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">232</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">38</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">17</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">287</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">As of December 31, 2015&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,629</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">138</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">109</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,876</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Depreciation</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">229</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">34</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">15</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">278</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">As of December 31, 2016&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,858</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">172</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">124</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,154</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Net book value December 31, 2015&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">429</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">34</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">37</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">500</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Net book value December 31, 2016&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">935</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">126</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">59</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,120</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">5.</TD><TD>Financial assets</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Rental deposit (restricted cash)&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">83</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">82</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Security Deposit&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">86</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">85</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


	<!-- Field: Page; Sequence: 155 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">F-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->14<!-- Field: /Sequence --></FONT></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">AC Immune has two deposits in escrow accounts
	totaling CHF 86&nbsp;thousand associated with the lease of the Company&rsquo;s premises.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">6.</TD><TD>Prepaid expenses and accrued income</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Prepaid expenses&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,278</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">339</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Deferred offering costs&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,169</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Accrued income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">889</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Grant receivable&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">47</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,167</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,555</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The prepaid expenses relate mainly to research
	contracts with down-payments at contract signature and the related activities will start or continue into 2017.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December 31, 2015, the deferred offering
	costs of CHF 2,169 thousand consisted primarily of direct incremental legal, accounting and printing costs relating to the Company&rsquo;s
	then planned IPO. Upon successful completion of the IPO in September 2016, the deferred offering costs were an offset against IPO
	proceeds within equity share premium (see Note 3).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Accrued income consists of 2016 services
	performed within our Biogen contract (see Note 11), which have not yet been invoiced.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">7.</TD><TD>Other current receivables</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Other receivables&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">182</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">103</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Swiss VAT&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">320</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">147</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Withholding tax&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">15</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">19</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">517</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">269</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The maturity of these assets is less than
	three months. The Company considers the counterparty risk as low and the carrying amount of these receivables is considered to
	correspond to their fair value.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">8.</TD><TD>Cash and cash equivalents</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%">Cash&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">152,210</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">76,522</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">152,210</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">76,522</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left">By Currency</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>CHF&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">41,322</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">19,812</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>EUR&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6,727</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,371</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 1pt">USD&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">104,161</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">54,339</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">152,210</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">76,522</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


	<!-- Field: Page; Sequence: 156 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">F-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->15<!-- Field: /Sequence --></FONT></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">At the balance sheet dates, Company funds
	were held in CHF, EUR and USD bank accounts. As of December 31, 2016, funds in EUR and USD were translated into CHF at a rate of
	1.0721 and 1.0160, respectively.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">9.</TD><TD>Share capital</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December&nbsp;31, 2016 and 2015,
	the issued share capital amounted to CHF 1,135,468 and CHF 928,050 respectively and comprised of 56,773,392 Common Shares and 46,402,500
	Common and Preferred Shares, respectively.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The table below summarizes the Company&rsquo;s
	capital structure:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="15" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">CHF</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">CHF</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 56%; text-align: left">Common shares with a nominal value of CHF 0.02 each&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">56,773,392</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,135,468</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">9,227,250</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">184,545</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Preferred shares Series A with a nominal value of CHF 0.02 per share&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,538,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">70,760</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Preferred shares Series B with a nominal value of CHF 0.02 per share&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">16,782,500</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">335,650</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Preferred shares Series C with a nominal value of CHF 0.02 per share&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9,619,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">192,380</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Preferred shares Series D with a nominal value of CHF 0.02 per share&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,122,500</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">82,450</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Preferred shares Series E with a nominal value of CHF 0.02 per share&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,113,250</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">62,265</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>56,773,392</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 2.5pt"><B>&nbsp;</B></TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>1,135,468</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 2.5pt"><B>&nbsp;</B></TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>46,402,500</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 2.5pt"><B>&nbsp;</B></TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>928,050</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Common and Preferred Shares nominal
	values of CHF 0.02 per share are fully paid in. On April&nbsp;15, 2016, AC Immune completed a private placement of Series E preferred
	shares, each with a nominal value of CHF 0.02&nbsp;per share (the &ldquo;Series E Private Placement Extension&rdquo;). An aggregate
	1,401,792 Series E preferred shares were issued at a price of $9.6384 per preferred share to certain strategic investors, individuals
	and existing shareholder in the Series E Private Placement Extension for an aggregate subscription amount of approximately $13.5
	million. The Series E preferred shares had substantially the same terms as the Series A, B, C and D preferred shares. As previously
	referenced in Note 3, all outstanding Preferred Shares were converted to common shares as a result of the IPO completed in September
	2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The change in common shares outstanding
	for the year ended December 31, 2016 represent 1) 6.9 million common shares issued as a result of the Company&rsquo;s 2016 IPO,
	2) 38,577,042 additional common shares as a result the conversion of all outstanding preferred shares (including the 1.4 million
	preferred Series E shares issued in April 2016) on a one-for-one basis as a result of the Company&rsquo;s 2016 IPO, and 3) 2,069,100
	share options exercised during 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On October&nbsp;23, 2015, AC Immune completed
	a 250-for-1 stock split. The split applies to all of AC Immune&rsquo;s outstanding common shares, preferred shares (Series A, B,
	C, D and E) and vested and unvested options. The stock split had an impact on the earnings per share (&ldquo;EPS&rdquo;). To facilitate
	a comparison of EPS figures, the 2015 and 2014 reported EPS figures were adjusted to reflect the stock split.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On October&nbsp;23, 2015 the Company successfully
	completed a preferred share financing round of USD 30&nbsp;million (CHF 29.4 million). The split-adjusted share price of the round
	was $9.63624 for each of the 3,113,250 Series E Preferred Shares.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">10.</TD><TD>Trade payables and accrued liabilities</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Trade payables and other payables&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">4,035</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,719</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Accrued research and development costs&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,265</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,661</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Accrued payroll expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,419</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,304</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Other accrued expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">682</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,372</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Deferred income&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">521</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">45</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,922</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">6,101</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">An accrual of CHF 1.0 million and CHF 880
	thousand was recognized for performance-related remuneration relating to 2016 and 2015, respectively.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Deferred income</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2016 we received a research contribution
	from Biogen for research collaboration of $1.5 million (CHF 1.5 million) for the alpha-synuclein and TDP-43 PET imaging programs.
	As of December 31, 2016, the remaining CHF 521 thousand is recorded as a current liability in deferred income and is expected to
	be recognized as revenue in 2017 as remaining performance obligations are completed.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2015 we received a grant from the Michael
	J. Fox Foundation for developing an alpha-synuclein protein positron emission tomography (PET) imaging agent. The grant covers
	an 18 month period. We recognized revenues on a straight line basis over the period of the grant. As of December&nbsp;31, 2015,
	the remaining CHF 45 thousand was recorded as a current liability in deferred income.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">11.</TD><TD>Revenues</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended<BR> December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Collaboration and license revenue&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">22,737</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">38,745</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">30,179</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Grant revenue&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">469</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">316</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">75</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 1pt">Other&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">8</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">29</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">15</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 2.5pt">Total</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">23,214</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">39,090</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">30,269</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Anti-Abeta antibody in AD - Collaboration
	agreement of 2006 with Genentech</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In November 2006, AC Immune signed an exclusive,
	worldwide licensing agreement for crenezumab, our humanized monoclonal antibody targeting misfolded Abeta. Genentech commenced
	Phase&nbsp;3 clinical studies for crenezumab in the first quarter of 2016. If crenezumab receives regulatory approval, we will
	be entitled to receive royalties that are tied to annual sales volumes with different royalty rates applicable in the U.S. and
	Europe. These percentage rates range from net high single digits to the mid-teens.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Under the agreement with Genentech, we
	may become eligible to receive payments totaling up to approximately $340 million, excluding royalties. As of December&nbsp;31,
	2016 we have received total payments of $65 million (CHF 70.1 million); $40 million (CHF 45.8 million) was received in three milestone
	payments prior to 2013 and $25 million (CHF 24.3 million) was received in July 2015.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We recognized the Phase 3 July 2015 payment
	as revenue in our 2015 fiscal year since there was no further performance requirement to be met by the Company. The agreement provides
	for a second therapeutic product based on the same intellectual property and anti-Abeta antibody compound as well as an anti-Abeta
	diagnostic product. Genentech may terminate the agreement at any time by providing three months&rsquo; notice to us. In such event
	all costs incurred are still refundable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Anti-tau antibody in AD &ndash; Collaboration
	agreement of 2012 with Genentech</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In June 2012, we entered into a second
	partnership with Genentech to commercialize our anti-tau antibodies for use as immunotherapeutics. The value of this exclusive,
	worldwide alliance is potentially greater than CHF 400&nbsp;million and includes upfront and milestone payments. In addition to
	milestones, we will be eligible to receive royalties on sales at a percentage rate ranging from the mid-single digits to high single
	digits. The agreement also provides for collaboration on two additional indications built on the same anti-tau antibody program
	as well as a potential anti-tau diagnostic product.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Until December 31, 2016, we have
 received 	payments totaling CHF 45&nbsp;million, including a CHF 14&nbsp;million milestone recognized in the second quarter
 of 2016 related to the start of phase 1 clinical trials for this program. Pursuant to the exclusive 	global license
 agreement, there was no further performance obligation attached to this payment, therefore we recognized the full 	amount as
 collaboration and license revenue in June 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Genentech may terminate the agreement at
	any time by providing three months&rsquo; notice to us. In such event all costs incurred are still refundable.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Tau Vaccine in AD &ndash; Collaboration
	agreement of 2014 with Janssen Pharmaceuticals</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In December of 2014, we entered into a
	partnership with Janssen Pharmaceuticals, a Johnson&nbsp;&amp; Johnson company, to develop and commercialize therapeutic anti-tau
	vaccines for the treatment of AD and potentially other tauopathies. The partnership includes a worldwide exclusive license and
	research collaboration. We and Janssen will co-develop the lead therapeutic vaccine, ACI-35, through Phase 1b completion. From
	Phase 2 and onward, Janssen will assume responsibility for the clinical development, manufacturing and commercialization of ACI-35.
	ACI-35 is an active therapeutic vaccine stimulating the patient&rsquo;s immune system to produce a polyclonal antibody response
	against phosphorylated tau protein.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The agreement also allows for the collaboration
	to be expanded to a second indication based on the same anti-tau vaccine program and intellectual property related to this program.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We received an upfront payment of CHF 25.9&nbsp;million
	which we recognized in 2014 and are eligible to receive development, regulatory and commercialization milestone payments for AD
	and a potential second indication outside of AD. Additionally, we will receive royalties on sales at a percentage rate ranging
	from the low double digits to mid-teens. The two companies have entered into a three-year joint research collaboration to further
	characterize and develop novel vaccine therapies for the treatment of tauopathies.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The recognition of the upfront payment
	from Janssen was recorded at the time of receipt as the Company determined that the license granted to Janssen was a separate,
	non-contingent deliverable under the agreement. The Company determined the license had stand-alone value based on Janssen&rsquo;s
	ability to create value from the license without our research and development support services due their extensive experience in
	vaccine development and production which would allow them to complete the phase 1b clinical trials.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In January 2016, we received payments of
	CHF 1.5 million for pre-payment of research and external research costs. Pursuant to the terms of the collaboration agreement,
	there is a performance obligation until the end of the year. As a result, we recognized the proceeds from the milestone payment
	over a 12-month period on a straight-line basis. In May 2016, we received a CHF 4.9 million payment for reaching a clinical milestone
	in the phase 1b study. As we met all performance obligations on reaching the milestone, we have recognized this income as revenue.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As part of this agreement, AC Immune and
	Janssen have committed to spend CHF 13.8 million in clinical development until the end of Phase 1b. Any remaining commitment not
	spent on the Phase 1b study will be carried forward to cover additional development costs with Janssen continuing to be responsible
	for any costs above the stated CHF 13.8 million. Under the terms of the agreement, Janssen may terminate the agreement at any time
	after completion of the Phase 1b clinical study by providing 90-day notice to us.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Tau-PET imaging agent in AD &ndash; Collaboration
	agreement of 2014 with Piramal Imaging</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In May 2014, AC Immune SA entered into
	our first diagnostic partnership with Piramal Imaging, a division of Piramal Enterprises, Ltd. The agreement with Piramal is an
	exclusive, worldwide licensing agreement for the research, development and commercialization of the Company&rsquo;s tau protein
	positron emission tomography (PET) tracers supporting the diagnosis and clinical management of AD and potential tau-related disorders
	and includes upfront and sales milestone payments totaling up to EUR 157&nbsp;million, plus royalties on sales at a percentage
	rate ranging from mid-single digits to low double digits.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The upfront payment of EUR 500&nbsp;thousand
	received from this collaboration was deferred over a period of 12 months which was the joint Research Collaboration period. As
	such, the residual balance in deferred revenue related to this collaboration at December 31, 2014, was recognized until May 2015.
	We are also entitled to further clinical milestones totaling EUR 7&nbsp;million should the compound make it through to Phase 3
	clinical studies and are further entitled to potential regulatory, commercialization and sales based milestones totaling EUR 150
	million.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Piramal may terminate the agreement by
	providing three months&rsquo; notice to the Company.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Alpha-synuclein and TDP-43 PET tracer
	in AD &ndash; Collaboration agreement of 2016 with Biogen</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">On April&nbsp;13, 2016, AC Immune entered
	into a non-exclusive research collaboration agreement with Biogen International GmbH, or Biogen. Under the agreement, we and Biogen
	have agreed to collaborate in the research and early clinical development of our alpha-synuclein PET Tracer program for Parkinson&rsquo;s
	disease and other synucleinopathies, and a second program for the identification, research and development of novel PET ligands
	against TDP-43, a protein recently linked to neurodegeneration in diseases such as amyotrophic lateral sclerosis. In addition,
	we have agreed to share the costs of the collaboration, with Biogen primarily funding the majority of research costs, subject to
	a cap, which includes an upfront technology access fee and funding towards research and development personnel. We will own all
	intellectual property rights to any invention relating to alpha-synuclein or TDP-43 PET tracers.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We expect to commence a Phase 1 clinical
	study of our alpha-synuclein PET imaging agent in 2017. As of December 31, 2016, we received CHF 1.5 million for the technology
	access fee, which is being deferred and recognized over a twelve month period. As of December 31, 2016, CHF 521 thousand is recorded
	as a current liability in deferred income and is expected to be recognized as revenue in 2017 as remaining performance obligations
	are completed, which is expected in the second quarter of 2017.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Grants</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In February 2015, we received a grant from
	the Michael J. Fox Foundation for developing an alpha-synuclein protein positron emission tomography (PET) imaging agent. The grant
	covers an 18 month period.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In January 2016, we were awarded a grant
	from the LuMind Research Down Syndrome Foundation to support our ACI-24 Phase&nbsp;1 clinical study in patients with Down Syndrome.
	The grant covers a 12 month period.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">We recognized revenues on a straight line
	basis over the period of the grant.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">12.</TD><TD>Expenses by category</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Research and Development</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Operating expenses&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">18,489</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,476</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">9,990</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Payroll expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6,450</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5,879</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5,669</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Share-based compensation&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">557</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">407</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">159</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Depreciation of tangible fixed assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">278</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">287</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">298</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total research and development expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">25,774</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">17,049</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">16,116</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">General and Administration</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Operating expenses&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">3,168</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,377</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,437</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Payroll expenses&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,969</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,908</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,947</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Share-based compensation&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">759</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">132</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">52</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 2.5pt">Total general and administrative expenses&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">7,896</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,417</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,436</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">13.</TD><TD>Related-party transactions</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Key management including the Board of Directors
	(five individuals excluding the CEO) and the Executive Management (four individuals) compensation is:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Short-term employee benefits&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2,251</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,776</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1,631</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Post-employment benefits&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">154</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">124</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">97</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Share-based compensation&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">832</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">8</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">8</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">3,237</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">1,908</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: right">1,736</TD><TD STYLE="border-bottom: Black 2.5pt double; font-weight: bold; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In July 2015, George Pavey joined AC Immune
	as Chief Financial Officer and a member of Executive Management. At the same time, Jean-Fabien Monin assumed the role of Chief
	Administrative Officer. He had previously been Chief Financial Officer since 2009. In April 2017, Joerg Hornstein will assume the
	responsibility as the Chief Financial Officer as a member of the Executive Management.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Friedrich von Bohlen and Peter Bollmann
	joined the Board of Directors of AC Immune in October and December 2015, respectively. Friedrich von Bohlen replaced Christof Hettich
	who stepped down from the Board in August 2015. Hans-Beat Guertler resigned from the board in December 2015. His position was assumed
	by Peter Bollmann. In November 2016, Mr. Thomas Graney joined the Board of Directors of AC Immune, replacing Mathias Hothum as
	his term expired.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Short-term employee benefits comprise of
	salaries, bonus payments, social security and expenses allowances.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">98,500, 45,000 and 62,500 options
 were 	granted in 2016, 2015 and 2014, respectively, to the Executive Management of the Company. Zero options were granted in
 2016, and 	2015, and 51,250 in 2014, respectively, to the Directors of the Company. In connection with his departure in the
 fourth quarter 	of 2016, the Chief Financial Officer forfeited his initial 2016 grant (included in the aggregate 2016 total
 above), and in its 	place was awarded 49,250   options. The fourth quarter 2016 grant date fair value of the
 replacement award was CHF 674 thousand.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">14.</TD><TD>Income taxes</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The Company recognized no income tax expense or deferred tax
	asset or liability positions for the years ended December 31, 2016, 2015, and 2014.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The income tax expense for each year can
	be reconciled to Income / (loss) before tax as follows:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Income / (loss) before income tax&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(7,096</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">20,270</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,744</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Tax expense / (benefit) calculated at the statutory rate of 21% (22% for 2015 and 2014)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(1,504</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,566</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,420</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Effect of Swiss Tax Holidays&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(2,420</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Permanent differences&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(166</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Effect of unrecognized carry forward tax loss&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(4,566</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Effect of unused tax losses and tax offsets not recognized as deferred tax assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,670</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Effective income tax rate benefit / (expense)&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The tax rate used for the 2016 reconciliations
	above is the corporate tax rate of 21% (22%: 2015 and 2014) payable by corporate entities in the Canton of Vaud, Switzerland on
	taxable profits under tax law in that jurisdiction.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In 2015, AC Immune was able to apply tax
	loss carryforwards to reduce its effective tax rate to zero.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company was granted by the Canton of
	Vaud, Switzerland, a 10-year tax holiday for all income and capital taxes on a communal and cantonal level, commencing in the fiscal
	year 2005 and valid through to December 31, 2014. It has also been granted a 9-year tax holiday for direct Swiss Federal tax commencing
	in the fiscal year 2006 through to December 31, 2014. Consequently, the effective tax rate for 2014 was zero.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left; padding-left: 10pt; text-indent: -10pt">Unrecognized deductible temporary differences, unused tax losses and unused tax credits</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Deductible temporary differences, unused tax losses and unused tax credits for which no deferred tax assets have been recognized are attributable to the following:</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left; padding-left: 10pt; text-indent: -10pt">- Tax losses&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">36,707</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">29,079</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">49,253</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt; padding-left: 10pt; text-indent: -10pt">- Deductible temporary differences related to the retirement benefit plan&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,798</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,787</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">2,410</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt">&nbsp;</TD>
	    <TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 1pt; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt; padding-left: 10pt; text-indent: -10pt"><B>Total&#9;</B></TD><TD STYLE="padding-bottom: 2.5pt"><B>&nbsp;</B></TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>40,505</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 2.5pt"><B>&nbsp;</B></TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>31,866</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="padding-bottom: 2.5pt"><B>&nbsp;</B></TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right"><B>51,663</B></TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left"><B>&nbsp;</B></TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Deductible temporary differences related
	to the retirement benefit plan do not expire. Tax losses expiry dates are shown in the table below:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">Tax losses split by expiry date</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: right">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%">December 31, 2017&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">-</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">-</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">11,961</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>December 31, 2018&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,175</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,175</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,388</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>December 31, 2019&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">16,566</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">16,566</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">16,566</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>December 31, 2020&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,338</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,338</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,388</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>December 31, 2021&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>December 31, 2022&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 1pt">December 31, 2023&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">7,628</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">36,707</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">29,079</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">49,253</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The tax losses available for future offset
	against taxable profits have increased by CHF 7.6&nbsp;million from 2015, representing the amount of tax losses that are additionally
	available as an offset, subject to expiration as disclosed in the table above, against future taxable income.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Consistent with prior years, the Company
	has not recorded any deferred tax assets in relation to the past tax losses available for offset against future profits as the
	recognition criteria have not been met at the balance sheet date.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">15.</TD><TD>Retirement benefit plan</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company participates in a collective
	foundation covering all of its employees including its executive officers. In addition to retirement benefits, the plan provides
	death or long-term disability benefits.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Contributions paid to the plan are computed
	as a percentage of salary, adjusted for the age of the employee and shared approximately 46% and 54% by employee and employer,
	respectively.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">This plan is governed by the Swiss Law
	on Occupational Retirement, Survivors and Disability Pension Plans (BVG), which requires contributions to be made to a separately
	administered fund. The fund has the legal form of a foundation and it is governed by the board of trustees, which consists of an
	equal number of employer&rsquo;s and employee&rsquo;s representatives. The board of trustees is responsible for the administration
	of the plan assets and for the definition of the investment strategy.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The collective foundation is governed by
	a foundation board. The board is made up of an equal number of employee and employer representatives of the different affiliated
	companies. The Company has no direct influence on the investment strategy of the foundation board.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The assets are invested by the pension
	plan, to which many companies contribute, in a diversified portfolio that respects the requirements of the Swiss BVG. Therefore
	disaggregation of the pension assets and presentation of plan assets in classes that distinguish the nature and risks of those
	assets is not possible. Under the Plan, both the Company and the employee share the costs equally. The structure of the plan and
	the legal provisions of the BVG mean that the employer is exposed to actuarial risks. The main risks are investment risk, interest
	risk, disability risk and the life expectancy of pensioners. Through our affiliation with the pension plan, the Company has minimized
	these risks, since they are shared between a much greater number of participants. On leaving the Company, a departing employee&rsquo;s
	retirement savings are transferred to the pension institution of the new employer or to a vested benefits institution. This transfer
	mechanism may result in pension payments varying considerably from year to year.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The pension plan is exposed to Swiss inflation,
	interest rate risks and changes in the life expectancy for pensioners.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For accounting purposes under IFRS, the
	plan is treated as a defined benefit plan. Liabilities are calculated annually by an independent actuary. Plan assets have been
	estimated at their fair market value and liabilities have been calculated according to the &ldquo;Projected Unit Credit&rdquo;
	method.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table sets forth the status
	of the defined benefit pension plan and the amount that should be recognized in the balance sheet:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Defined benefit obligation&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(11,596</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(9,439</TD><TD STYLE="width: 1%; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 1pt">Fair value of plan assets&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">7,798</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">6,652</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total liability&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(3,798</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(2,787</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following amounts have been recorded
	as net pension cost in the statement of income:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Service cost&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">742</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">641</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">521</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Interest cost&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">75</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">101</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">137</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Interest income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(56</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(76</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(118</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Impact of plan amendment&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(584</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">-</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Net pension cost&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">761</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">82</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">540</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The changes in defined benefit obligation,
	fair value of plan assets and unrecognized (gains) / losses are as follows:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">A. Change in defined benefit obligation</P>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%">Defined benefit obligation as of January 1&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(9,439</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(8,091</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(6,044</TD><TD STYLE="width: 1%; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Service cost&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(742</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(641</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(521</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Interest cost&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(75</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(101</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(137</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Change in demographic assumptions&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(389</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Change in financial assumptions&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(26</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(591</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(1,303</TD><TD STYLE="text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Other actuarial gains / (losses)&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(378</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(176</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Plan amendment&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">584</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&mdash;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Benefit payments&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(111</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(48</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">227</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Employees&rsquo; contributions&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(436</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(375</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(322</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Defined benefit obligation as of December 31&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(11,596</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(9,439</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">(8,091</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">)</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


	<!-- Field: Page; Sequence: 163 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">F-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->22<!-- Field: /Sequence --></FONT></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">B.</TD><TD>Change in fair value of plan assets</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%">Fair value of plan assets as of January 1&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">6,652</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">5,681</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Interest income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">56</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">76</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Employees&rsquo; contributions&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">436</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">375</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Employer&rsquo;s contributions&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">511</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">441</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Benefits payments&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">111</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">48</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Plan assets gains&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">32</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">31</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 2.5pt">Fair value of plan assets as of December 31&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">7,798</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">6,652</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Employer&rsquo;s contribution to the pension
	plan for the financial year 2017 are estimated to be CHF&nbsp;543 thousand.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">C.</TD><TD>Change in net defined benefit liability</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">in CHF thousands</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%">Net defined benefit liabilities as of January 1&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2,787</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2,410</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">929</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Net pension cost through statement of income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">761</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">82</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">540</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Re-measurement through other comprehensive income&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">761</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">736</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,318</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Employer&rsquo;s contribution&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(511</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(441</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(377</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 2.5pt">Net defined benefit liabilities as of December 31&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,798</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,787</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">2,410</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The fair value of the plan assets is the
	cash surrender value of the insurance with AXA. The investment strategy defined by the board of trustees follows a conservative
	profile.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The plan assets are primarily held within
instruments with quoted market prices in an active market, with the exception of real estate and mortgages.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The weighted average
duration of the defined benefit obligation is 22.7 years as of December 31, 2016.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The actuarial assumptions used for the
	calculation of the pension cost and the defined benefit obligation of the defined benefit pension plan for the year 2016, 2015
	and 2014 are as follows:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left">Discount rate&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.70</TD><TD STYLE="width: 1%; text-align: left">%</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.80</TD><TD STYLE="width: 1%; text-align: left">%</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1.25</TD><TD STYLE="width: 1%; text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Rate of future increase in compensations&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.50</TD><TD STYLE="text-align: left">%</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.50</TD><TD STYLE="text-align: left">%</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.50</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Rate of future increase in current pensions&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.50</TD><TD STYLE="text-align: left">%</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.50</TD><TD STYLE="text-align: left">%</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.50</TD><TD STYLE="text-align: left">%</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Mortality and disability rates&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">BVG 2015G</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">BVG 2010G</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">BVG 2010G</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In defining the benefits, the minimum requirements
	of the Swiss Law on Occupational Retirement, Survivors and Disability Pension Plans (BVG) and its implementing provisions must
	be observed. The BVG defines the minimum pensionable salary and the minimum retirement credits.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">A quantitative sensitivity analysis for
	significant assumption as of December&nbsp;31, 2016 is as shown below:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


	<!-- Field: Page; Sequence: 164 -->
	    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">F-<!-- Field: Sequence; Type: Arabic; Name: PageNo -->23<!-- Field: /Sequence --></FONT></P></DIV>
	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Discount rate</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Future salary increase</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Future pension cost</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; padding-left: 10pt; text-indent: -10pt">Assumptions</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">+0.5% increase</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">-0.5% decrease</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">+0.5% increase</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">-0.5% decrease</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">+0.5% increase</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">-0.5% decrease</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
	    <TD COLSPAN="23" STYLE="font-weight: bold; text-align: center">in CHF thousands</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 34%; text-align: left; padding-left: 10pt; text-indent: -10pt">Defined benefit obligation&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,264</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">12,857</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">11,700</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">11,499</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">12,215</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,763</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Impact on the net defined benefit obligation&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,332</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(1,261</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(104</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">97</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(619</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">833</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The sensitivity analyses above is subject
	to limitations and has been determined based on a method that extrapolates the impact on net defined benefit obligation as a result
	of reasonable changes in key assumptions occurring at the end of the reporting period.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">16.</TD><TD>Share-based compensation</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company has the following equity settled
	share-based compensation plans outstanding:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">PLAN</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of instruments awarded</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Vesting conditions</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Contractual life of options</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 41%; text-align: left">Stock option plan A&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 18%; text-align: right">362,750</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 18%; text-align: center">4 years&rsquo; service from grant date</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 18%; text-align: center">12.5 years</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Stock option plan B&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">819,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: center">4 years&rsquo; service from grant date</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: center">10.5 years</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Stock option plan C1&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6,775,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: center">4 years&rsquo; service from grant date</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: center">10 years</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Stock option plan C2&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">735,500</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: center">4 years&rsquo; service from grant date</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: center">10 years</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The number and weighted average exercise
	prices (in CHF) of options under the share option programs for Plans A, B and C1 are as follows:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of Options</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted Average Exercise Price</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Weighted Average Remaining<BR> Term (Years)</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%">Outstanding at January 1, 2014&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">3,768,000</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">0.22119</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">4.4</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Forfeited during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(4,500</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Cancelled during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(19,000</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Exercised during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(21,250</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Granted during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">283,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 1pt">Outstanding at December 31, 2014&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">4,006,500</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">0.21668</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">4.5</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Exercisable at December 31, 2014&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,370,000</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0.23013</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">4.2</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD>Outstanding at January 1, 2015&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,006,500</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.21668</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.5</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Forfeited during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(23,250</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Cancelled during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(15,250</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Exercised during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(594,250</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Granted during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">223,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 1pt">Outstanding at December 31, 2015&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3,597,000</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">0.14548</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">3.6</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Exercisable at December 31, 2015&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3,032,500</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0.14548</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">3.4</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>Outstanding at January 1, 2016&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3,597,000</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.14548</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.6</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Forfeited during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(106,000</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Cancelled during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(19,250</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left">Exercised during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(2,069,100</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left">Granted during the year&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">285,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">-</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-bottom: 1pt">Outstanding at December 31, 2016&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,687,900</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">0.14548</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">5.6</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; padding-bottom: 2.5pt">Exercisable at December 31, 2016&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">1,284,525</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0.14548</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">6.5</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


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	    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt">&nbsp;</DIV>
	    <!-- Field: /Page -->

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">All 2016 and 2015 option related activity
	in the table above occurred at a weighted average exercise price of CHF 0.14548.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The weighted average fair values of
 the 	options granted in 2016, 2015 and 2014 are CHF 5.85, CHF 1.77, and CHF 0.77, respectively. These fair values of options
 granted have 	been determined using the Black-Scholes option pricing model and an exercise price of CHF 0.14548 (2015 and
 2014: CHF 0.14548), 	a share price of CHF 5.96 (2015: CHF 1.91 and 2014: CHF 0.90), a risk-free interest rate of 0% (2015: 0%
 and 2014: 0.23%) and a 	volatility of 80% (2015 and 2014: 50%) with an expected duration of 6 years (2015 and 2014: 6
 years).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Prior to the IPO, the exercise price
 was 	set by the Board of Directors; there were no options granted in 2016 subsequent to the IPO. The volatility is based on
 the historical 	trend of an appropriate sample of companies operating in the biotech and pharmaceutical industry. The
 risk-free interest rate is 	based on the CHF swap rate for the expected life of the option. The weighted average share price
 of  common share options 	exercised in 2016 is CHF 6.22 (2015: CHF 1.91 and 2014: CHF 0.90).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The expense charged against the
 income 	statement for the financial year 2016 amounts to CHF 1.317 thousand (2015: CHF 539 thousand and 2014: 211 thousands).
 The expense 	is revised by the Company based on the number of instruments that are expected to become exercisable. This 2016
 expense also reflects 	a share based option award that was modified in 2016 to amend the option grant&rsquo;s contractual
 life and the issuance of a replacement 	award. An incremental fair value of CHF 238 thousand was immediately recognized in
 2016 as a result of the modification of the 	share options contractual life. Additionally, in connection with his departure
 in the fourth quarter of 2016, the Chief Financial 	Officer forfeited his initial 2016 grant (included in the aggregate 2016
 total of 98,500), and in its place was awarded 49,250 	  options, which has been accounted for as a new award
 granted on the date of forfeiture of the original award. The 	fourth quarter 2016 grant date fair value of the replacement
 award was CHF 674 thousand. The fair value of the modified award was measured 	using the Black-Scholes option pricing model with
 similar assumptions to the 2016 option.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">An incremental fair value of CHF 238 thousand
	was immediately recognized in 2016 as a result of the modification of the share options contractual life. Additionally, due to
	the departure of the Chief Financial Officer in the fourth quarter of 2016, the initial referenced grant of 98,500 was considered
	a forfeiture as the vesting conditions would not be met. Subsequently, an agreement was formalized whereby 50% of the previously
	forfeited options (49,250 options) would be awarded as a replacement grant with no remaining service condition, which has been
	accounted for as a new award granted on the date of forfeiture of the original award. The fourth quarter 2016 grant date fair value
	of the replacement award&nbsp;was CHF 674 thousand.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The fair value of the modified award was
	measured using the Black-Scholes option pricing model with similar assumptions to the 2016 option grants described above, except
	for a currently quoted common share price as of the date of the modification.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><B>17.</B></TD><TD><B>Commitments and contingencies</B></TD>
	</TR></TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">in CHF thousands</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>2016</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>2015</B></P> <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid">&nbsp;</P></TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 78%; text-align: left">Within one year&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">9,175</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">5,989</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Between one and five years&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,624</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">1,111</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="padding-bottom: 2.5pt">Total&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">10,799</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">7,100</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company has research contracts with
several external service providers. As of December&nbsp;31, 2016 external research projects for CHF 8.9&nbsp;million were committed
for 2017. Rental contract for laboratory and offices space at the EPFL Innovation Park in Ecublens/Lausanne can be cancelled within
a 6 month notice period. Lease expense in 2016 was CHF 391 thousand. As of December&nbsp;31, 2016, rental contracts for CHF 255&nbsp;thousand
were committed for 2017.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company has a contractual obligation that require the payment of royalties to a third party, which
is associated with the achievement of program milestones. As of December 31, 2016, the Company&rsquo;s contractual obligation
associated with this agreement was CHF 494 thousand.</P>

<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">18.</TD><TD>Earnings per share</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="11" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; padding-left: 10pt; text-indent: -10pt">in CHF thousands except for share and per share data</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2016</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2015</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">2014</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="width: 67%; text-align: left; padding-left: 10pt; text-indent: -10pt">Net income / (loss) attributable to owners of the Company&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">(7,096</TD><TD STYLE="width: 1%; text-align: left">)</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">20,270</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">10,744</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="padding-left: 10pt; text-indent: -10pt">Earnings per share (EPS):</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Basic, income / (loss) for the period attributable to equity holders&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(0.14</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.47</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.25</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Diluted, income / (loss) for the period attributable to equity holders&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(0.14</TD><TD STYLE="text-align: left">)</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.44</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.24</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Weighted-average number of shares used to compute EPS basic&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">50,096,859</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">43,412,250</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">42,684,750</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-left: 10pt; text-indent: -10pt">Weighted-average number of shares used to compute EPS fully diluted&#9;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">50,096,859</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">46,043,198</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">45,552,500</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For the years ended December&nbsp;31, 2016,
	2015 and 2014 basic and diluted earnings per share is based on the weighted average number of shares issued and outstanding. Weighted-average
	dilutive shares outstanding excludes antidilutive share options that totaled 1,687,900 from the computation of diluted income (loss)
	per common share for the year-ended December 31, 2016.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">19.</TD><TD>Financial instruments and risk management</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company&rsquo;s activities expose it
	to the following financial risks: market risk (currency risk), credit risk and liquidity risk. The Company&rsquo;s overall risk
	management program focuses on the unpredictability of financial markets and seeks to minimize potential adverse effects on the
	Company&rsquo;s financial performance.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The following table shows the carrying
	amounts of financial assets and financial liabilities:</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="7" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">For the Years Ended December 31,</TD></TR>
	<TR STYLE="vertical-align: bottom">
	    <TD STYLE="font-weight: bold">in CHF thousands</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>2016</B></P></TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 0.5pt solid"><B>2015</B></P></TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="font-weight: bold; text-align: left">Financial assets</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="width: 78%; text-align: left">Cash and cash equivalent&#9;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">152,210</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
	    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">76,522</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Other receivables&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">517</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">269</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total financial assets&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">152,727</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">76,791</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD>&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="font-weight: bold; text-align: left">Financial liabilities</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
	    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: rgb(213,234,234)">
	    <TD STYLE="text-align: left; padding-bottom: 1pt">Trade and accrued expenses&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">9,401</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">6,056</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
	<TR STYLE="vertical-align: bottom; background-color: White">
	    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Total financial liabilities&#9;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">9,401</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
	    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: right">6,056</TD><TD STYLE="border-bottom: Black 2.5pt double; text-align: left">&nbsp;</TD></TR>
	</TABLE>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Foreign exchange risk</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company is exposed to foreign exchange
	risk arising from currency exposures, primarily with respect to the EUR, USD and to a lesser extent to GBP, DKK and SEK. The currency
	exposure is not hedged. However, the Company has a policy of matching its cash holdings to the currency structure of its expenses,
	which means that the Company holds predominately CHF, EUR and USD (see also Notes 8 and 19). In the Company&rsquo;s income statements
	for the years ended December 31, 2016, 2015 and 2014 a gain of CHF 3.5 million, CHF 1.6 million and CHF 9 thousands, respectively,
	is recognized in the financial statement line item &ldquo;Finance Income.&rdquo;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Credit risk</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The majority of the cash and cash equivalents
	is held within one bank. However, the credit risk on liquid funds is limited because the counterparties are banks with high credit-ratings
	assigned by international credit-rating agencies. The maximum amount of credit risk is the carrying amount of the financial assets.
	Trade and other receivables are fully performing, not past due and not impaired (see Note 7).</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Liquidity risk</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Inherent in the Company&rsquo;s business
	are various risks and uncertainties, including its limited operating history and the high uncertainty that new therapeutic concepts
	will succeed. AC Immune&rsquo;s success may depend in part upon its ability to (i)&nbsp;establish and maintain a strong patent
	position and protection, (ii)&nbsp;enter into collaborations with partners in the biotech and pharmaceutical industry, (iii)&nbsp;acquire
	and keep key personnel employed, and (iv)&nbsp;acquire additional capital to support its operations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company&rsquo;s approach of managing
	liquidity is to ensure sufficient cash to meet its liabilities when due. Therefore, management closely monitors the cash position
	on rolling forecasts based on expected cash flow to enable the Company to finance its operations for at least 24 months.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Based on the current cash position, the
	Company is well financed through the end of 2018.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Foreign currency</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company undertakes certain transactions
	denominated in foreign currencies. Hence, exposure to exchange rate fluctuations arises. Exchange rate exposures are managed by
	matching its cash holdings to the currency structure of its expenses.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">As of December&nbsp;31, 2016, if the CHF
	had strengthened/weakened by 10% against the EUR and the USD with all other variables held constant, the net loss for the period
	would have been lower/higher by CHF 10.9 million (2015: CHF 5.6 million), mainly as a result of foreign exchange gains/losses on
	predominantly EUR/USD denominated cash and cash equivalents.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">Interest rates</P>

	<P STYLE="font: italic bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 9.35pt">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company is not materially exposed to
	any interest rates fluctuations.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">20.</TD><TD>Capital risk management</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">The Company&rsquo;s objectives when managing
	capital are to safeguard the Company&rsquo;s ability to continue as a going concern and to preserve the capital on the required
	statutory level in order to succeed in developing a cure against AD.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

	<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
	<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">21.</TD><TD>Post balance sheet events</TD>
	</TR></TABLE>

	<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">No events that would require adjustments
	to or disclosure in the financial statements occurred between the date of the balance sheet and the date these financial statements
	were approved by the Board of Directors of the Company.</P>

	<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>


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<TYPE>EX-12.1
<SEQUENCE>2
<FILENAME>dp74065_ex1201.htm
<DESCRIPTION>EXHIBIT 12.1
<TEXT>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Exhibit 12.1</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">CERTIFICATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">I, Andrea Pfeifer, certify that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;I have reviewed
this annual report on Form 20-F of AC Immune SA;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Based on my knowledge,
this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements
made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by
this report;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Based on my knowledge,
the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The company&rsquo;s
other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined
in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the company and have:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Designed such disclosure
controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that
material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Evaluated the effectiveness
of the company&rsquo;s disclosure controls and procedures and presented in this report our conclusions about the effectiveness
of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Disclosed in this
report any change in the company&rsquo;s internal control over financial reporting that occurred during the period covered by the
annual report that has materially affected, or is reasonably likely to materially affect, the company&rsquo;s internal control
over financial reporting; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The company&rsquo;s
other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting,
to the company&rsquo;s auditors and the audit committee of the company&rsquo;s board of directors (or persons performing the equivalent
functions):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All significant
deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably
likely to adversely affect the company&rsquo;s ability to record, process, summarize and report financial information; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any fraud, whether
or not material, that involves management or other employees who have a significant role in the company&rsquo;s internal control
over financial reporting.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date:&#9;March 17, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%">/s/ Andrea Pfeifer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Andrea Pfeifer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Chief Executive Officer</TD></TR>
</TABLE>



<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>






































































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<TYPE>EX-12.2
<SEQUENCE>3
<FILENAME>dp74065_ex1202.htm
<DESCRIPTION>EXHIBIT 12.2
<TEXT>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Exhibit 12.2</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">CERTIFICATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">I, Jean-Fabien Monin, certify that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;I have reviewed
this annual report on Form 20-F of AC Immune SA;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Based on my knowledge,
this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements
made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by
this report;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Based on my knowledge,
the financial statements, and other financial information included in this report, fairly present in all material respects the
financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The company&rsquo;s
other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined
in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the company and have:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Designed such disclosure
controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that
material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those
entities, particularly during the period in which this report is being prepared;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Evaluated the effectiveness
of the company&rsquo;s disclosure controls and procedures and presented in this report our conclusions about the effectiveness
of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Disclosed in this
report any change in the company&rsquo;s internal control over financial reporting that occurred during the period covered by the
annual report that has materially affected, or is reasonably likely to materially affect, the company&rsquo;s internal control
over financial reporting; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;The company&rsquo;s
other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting,
to the company&rsquo;s auditors and the audit committee of the company&rsquo;s board of directors (or persons performing the equivalent
functions):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;All significant
deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably
likely to adversely affect the company&rsquo;s ability to record, process, summarize and report financial information; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Any fraud, whether
or not material, that involves management or other employees who have a significant role in the company&rsquo;s internal control
over financial reporting.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date:&#9;March 17, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 50%">/s/ Jean-Fabien Monin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Jean-Fabien Monin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Interim Principal Financial Officer</TD></TR>
</TABLE>



<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>


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<DOCUMENT>
<TYPE>EX-13.1
<SEQUENCE>4
<FILENAME>dp74065_ex1301.htm
<DESCRIPTION>EXHIBIT 13.1
<TEXT>
<HTML>
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</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Exhibit 13.1</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">CERTIFICATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The certification set forth below is being submitted in connection
with AC Immune SA&rsquo;s annual report on Form 20-F for the year ended December 31, 2016 (the &ldquo;Report&rdquo;) for the purpose
of complying with Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 (the &ldquo;Exchange Act&rdquo;) and
Section 1350 of Chapter 63 of Title 18 of the United States Code.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Andrea Pfeifer, the Chief Executive Officer of AC Immune SA,
certifies that, to the best of her knowledge:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;the Report fully
complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;the information
contained in the Report fairly presents, in all material respects, the financial condition and results of operations of AC Immune
SA.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date:&nbsp;March 17, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">/s/ Andrea Pfeifer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 4%">Name:</TD>
    <TD STYLE="width: 46%">&nbsp;&nbsp;Andrea Pfeifer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Chief Executive Officer</TD></TR>
</TABLE>



<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>


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<DOCUMENT>
<TYPE>EX-13.2
<SEQUENCE>5
<FILENAME>dp74065_ex1302.htm
<DESCRIPTION>EXHIBIT 13.2
<TEXT>
<HTML>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">Exhibit 13.2</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">CERTIFICATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The certification set forth below is being submitted in connection
with AC Immune SA&rsquo;s annual report on Form 20-F for the year ended December 31, 2016 (the &ldquo;Report&rdquo;) for the purpose
of complying with Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 (the &ldquo;Exchange Act&rdquo;) and
Section 1350 of Chapter 63 of Title 18 of the United States Code.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Jean-Fabien Monin, the Interim Principal Financial Officer of
AC Immune SA, certifies that, to the best of his knowledge:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;the Report fully
complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;the information
contained in the Report fairly presents, in all material respects, the financial condition and results of operations of AC Immune
SA.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Date:&nbsp;March 17, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">/s/ Jean-Fabien Monin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 6%">Name:</TD>
    <TD STYLE="width: 44%">&nbsp;Jean-Fabien Monin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Interim Principal Financial Officer</TD></TR>
</TABLE>



<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>


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<DOCUMENT>
<TYPE>EX-15.1
<SEQUENCE>6
<FILENAME>dp74065_ex1501.htm
<DESCRIPTION>EXHIBIT 15.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">EXHIBIT 15.1</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">CONSENT OF INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We consent to the incorporation by reference in the
        following Registration Statements:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD>Registration Statement (Form S-8 No. 333-213865) pertaining
to the AC Immune SA 2013 Equity Incentive Plan, the Employee Stock Option and Share Plan of AC Immune (2005), and the Stock Option
Plan &ndash; AC Immune of December 31, 2004 of AC Immune SA, and</TD>
</TR></TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD>Registration Statement (Form S-8 No. 333-216539) pertaining
to the AC Immune SA 2016 Stock Option and Incentive Plan of AC Immune SA</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">of our report dated March 17, 2017, with
respect to the financial statements of AC Immune SA, included in this Annual Report (Form 20-F) for the year ended December 31,
2016.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ Ernst &amp; Young AG</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" STYLE="font-size: 10pt; width: 100%">
<TR>
    <TD STYLE="font: 11pt Calibri, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Geneva, Switzerland</FONT></TD></TR>
<TR>
    <TD STYLE="font: 11pt Calibri, Helvetica, Sans-Serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">March 17, 2017</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
